{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:16:16Z","timestamp":1773285376910,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.actbio.2005.12.002","type":"journal-article","created":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T12:16:52Z","timestamp":1138796212000},"page":"221-227","source":"Crossref","is-referenced-by-count":37,"title":["Biocompatibility and function of microencapsulated pancreatic islets"],"prefix":"10.1016","volume":"2","author":[{"given":"Marina","family":"Figliuzzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Plati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Cornolti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Adobati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Fagiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Remuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Remuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2005.12.002_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00125-001-0729-x","article-title":"Considerations for successful transplantation of encapsulated pancreatic islets","volume":"45","author":"De Vos","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.actbio.2005.12.002_bib2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1115\/1.2891229","article-title":"Bioengineering in development of the hybrid artificial pancreas","volume":"113","author":"Colton","year":"1991","journal-title":"J Biomech Eng"},{"key":"10.1016\/j.actbio.2005.12.002_bib3","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1172\/JCI118929","article-title":"Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression","volume":"98","author":"Sun","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.actbio.2005.12.002_bib4","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/00007890-199211000-00001","article-title":"Successful reversal of spontaneous diabetes in dogs by intraperitoneal microencapsulated islets","volume":"54","author":"Soon-Shiong","year":"1992","journal-title":"Transplantation"},{"key":"10.1016\/j.actbio.2005.12.002_bib5","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1126\/science.6776628","article-title":"Microencapsulated islets as bioartificial endocrine pancreas","volume":"210","author":"Lim","year":"1980","journal-title":"Science"},{"key":"10.1016\/j.actbio.2005.12.002_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/00007890-200101270-00006","article-title":"Islets in alginate macrobeads reverse diabetes despite minimal acute insulin secretory responses","volume":"71","author":"Trivedi","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.actbio.2005.12.002_bib7","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.2337\/diabetes.50.8.1698","article-title":"Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane","volume":"50","author":"Duvivier-Kali","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.actbio.2005.12.002_bib8","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3727\/000000004783983738","article-title":"Factors influencing functional survival of microencapsulated islet grafts","volume":"13","author":"De Vos","year":"2004","journal-title":"Cell Transplant"},{"key":"10.1016\/j.actbio.2005.12.002_bib9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/01.TP.0000048226.28357.0D","article-title":"Islet transplantation in the discordant tilapia-to-mouse model: a novel application of alginate microencapsulation in the study of xenograft rejection","volume":"75","author":"Dickson","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.actbio.2005.12.002_bib10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0142-9612(96)00135-4","article-title":"Effect of the alginate composition on the biocompatibility of alginate\u2013polylysine microcapsules","volume":"18","author":"De Vos","year":"1997","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2005.12.002_bib11","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1097\/00007890-199610150-00004","article-title":"Association between capsule diameter, adequacy of encapsulation, and survival of microencapsulated rat islet allografts","volume":"62","author":"De Vos","year":"1996","journal-title":"Transplantation"},{"key":"10.1016\/j.actbio.2005.12.002_bib12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/00007890-199210000-00004","article-title":"Histological and immunopathological analysis of recovered encapsulated allogeneic islets from transplanted diabetic BB\/W rats","volume":"54","author":"Wijsman","year":"1992","journal-title":"Transplantation"},{"key":"10.1016\/j.actbio.2005.12.002_bib13","first-page":"264","article-title":"The capsular overgrowth on microencapsulated pancreatic islet grafts in streptozotocin and autoimmune diabetic rats","volume":"7","author":"Fritschy","year":"1994","journal-title":"Transplant Int"},{"key":"10.1016\/j.actbio.2005.12.002_bib14","first-page":"758","article-title":"An immunologic basis for the fibrotic reaction to implanted microcapsules","volume":"23","author":"Soon-Shiong","year":"1991","journal-title":"Transplant Proc"},{"key":"10.1016\/j.actbio.2005.12.002_bib15","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1097\/00007890-200010150-00008","article-title":"Influence of donor age on bovine pancreatic islet isolation","volume":"70","author":"Figliuzzi","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.actbio.2005.12.002_bib16","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2337\/diabetes.35.6.649","article-title":"A method for the mass isolation of islets from the adult pig pancreas","volume":"35","author":"Ricordi","year":"1986","journal-title":"Diabetes"},{"key":"10.1016\/j.actbio.2005.12.002_bib17","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1681\/ASN.V32214","article-title":"Determination of glomerular size-selectivity in the normal rat with Ficoll","volume":"3","author":"Oliver","year":"1992","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.actbio.2005.12.002_bib18","first-page":"572","article-title":"Pathophysiologic implications of proteinuria in a rat model of progressive glomerular injury","volume":"67","author":"Remuzzi","year":"1992","journal-title":"Lab Invest"},{"key":"10.1016\/j.actbio.2005.12.002_bib19","first-page":"189","article-title":"Efficacy of tribromoethanol anesthesia in mice","volume":"43","author":"Papaioannou","year":"1993","journal-title":"Lab Anim Sci"},{"key":"10.1016\/j.actbio.2005.12.002_bib20","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/00007890-199003000-00005","article-title":"Human islet xenograft survival in diabetic rats. A functional and immunohistochemical study","volume":"49","author":"Tze","year":"1990","journal-title":"Transplantation"},{"key":"10.1016\/j.actbio.2005.12.002_bib21","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2337\/diabetes.44.1.104","article-title":"Function, mass, and replication of porcine and rat islets transplanted into diabetic nude mice","volume":"44","author":"Davalli","year":"1995","journal-title":"Diabetes"},{"key":"10.1016\/j.actbio.2005.12.002_bib22","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1097\/00007890-200104270-00002","article-title":"Diabetic rats transplanted with adult porcine islets and immunosuppressed with cyclosporine A, mycophenolate mofetil, and leflunomide remain normoglycemic for up to 100 days","volume":"71","author":"Wennberg","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.actbio.2005.12.002_bib23","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/01.TP.0000150021.06027.DC","article-title":"Inhibition of cellular immune responses to encapsulated porcine islet xenografts by simultaneous blockade of two different costimulatory pathways","volume":"79","author":"Safley","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.actbio.2005.12.002_bib24","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/01.tp.0000168107.79769.63","article-title":"Rapid destruction of encapsulated islet xenografts by NOD mice is CD4-dependent and facilitated by B-cells: innate immunity and autoimmunity do not play significant roles","volume":"80","author":"Xu","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.actbio.2005.12.002_bib25","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1034\/j.1399-3089.2003.01150.x","article-title":"Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats","volume":"10","author":"Omer","year":"2003","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.actbio.2005.12.002_bib26","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.transproceed.2004.04.021","article-title":"Short-term immunosuppression reduces fibrotic cellular infiltration around barium-M-alginate microbeads injected intraportally","volume":"36","author":"Mathe","year":"2004","journal-title":"Transplant Proc"},{"key":"10.1016\/j.actbio.2005.12.002_bib27","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1046\/j.1523-1755.1999.00632.x","article-title":"Peripheral donor leukocytes prolong survival of rat renal allografts","volume":"56","author":"Noris","year":"1999","journal-title":"Kidney Int"},{"key":"10.1016\/j.actbio.2005.12.002_bib28","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1097\/00007890-199904150-00008","article-title":"Transplantation of alginate microcapsules: generation of antibodies against alginates and encapsulated porcine islet-like cell clusters","volume":"67","author":"Kulseng","year":"1999","journal-title":"Transplantation"},{"key":"10.1016\/j.actbio.2005.12.002_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0169-409X(00)00054-5","article-title":"Immunocompatibility and biocompatibility of cell delivery systems","volume":"42","author":"Rihova","year":"2000","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.actbio.2005.12.002_bib30","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s001250050673","article-title":"Improved biocompatibility but limited graft survival after purification of alginate for microencapsulation of pancreatic islets","volume":"40","author":"De Vos","year":"1997","journal-title":"Diabetologia"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706105001765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706105001765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T11:29:58Z","timestamp":1627039798000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706105001765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S1742706105001765"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2005.12.002","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}