{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T15:10:10Z","timestamp":1774797010141,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30740061"],"award-info":[{"award-number":["30740061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["50573015"],"award-info":[{"award-number":["50573015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["707021"],"award-info":[{"award-number":["707021"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012164","name":"National High-tech Research and Development Program","doi-asserted-by":"publisher","award":["2007AA03Z316"],"award-info":[{"award-number":["2007AA03Z316"]}],"id":[{"id":"10.13039\/501100012164","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.actbio.2009.01.017","type":"journal-article","created":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T04:21:39Z","timestamp":1233202899000},"page":"1499-1507","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Novel iron\u2013polysaccharide multilayered microcapsules for controlled insulin release"],"prefix":"10.1016","volume":"5","author":[{"given":"Jian","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuli","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiufeng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2009.01.017_bib1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0169-409X(98)00075-1","article-title":"Oral insulin delivery","volume":"35","author":"Carino","year":"1999","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.actbio.2009.01.017_bib2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1021\/bc970180a","article-title":"Extending insulin action in vivo by conjugation to carboxymethyl dextran","volume":"9","author":"Baudys","year":"1998","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.actbio.2009.01.017_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1557-0843(06)80019-9","article-title":"Advances in insulin delivery systems and devices: beyond the vial and syringe","volume":"1","author":"Flood","year":"2006","journal-title":"Insulin"},{"key":"10.1016\/j.actbio.2009.01.017_bib4","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/j.2042-7158.1994.tb05705.x","article-title":"Effect of preservatives on systemic delivery of insulin by ocular instillation in rabbits","volume":"46","author":"Sasaki","year":"1994","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.actbio.2009.01.017_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0378-5173(95)00070-Y","article-title":"Dextran microspheres as a potential nasal drug delivery system for insulin \u2013 in vitro and in vivo properties","volume":"124","author":"Pereswetoff-Morath","year":"1995","journal-title":"Int J Pharm"},{"key":"10.1016\/j.actbio.2009.01.017_bib6","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.biopha.2004.09.008","article-title":"Future therapy of diabetes mellitus","volume":"58","author":"Takei","year":"2004","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.actbio.2009.01.017_bib7","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1248\/cpb.46.1613","article-title":"Preparation and characterization of enteric microspheres containing bovine insulin by a wow emulsion solvent evaporation method","volume":"46","author":"Nagareya","year":"1998","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.actbio.2009.01.017_bib8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1557-0843(07)80061-3","article-title":"An update on insulin injection devices","volume":"2","author":"Magnolti","year":"2007","journal-title":"Insulin"},{"key":"10.1016\/j.actbio.2009.01.017_bib9","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.medengphy.2006.08.014","article-title":"A new approach to diabetic control: fuzzy logic and insulin pump technology","volume":"29","author":"Grant","year":"2007","journal-title":"Med Eng Phys"},{"key":"10.1016\/j.actbio.2009.01.017_bib10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jdiacomp.2006.10.002","article-title":"Double diabetes: possible but unpublished complication of insulin pump therapy","volume":"22","author":"Cesura","year":"2008","journal-title":"J Diab Complicat"},{"key":"10.1016\/j.actbio.2009.01.017_bib11","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ijpharm.2007.08.051","article-title":"Beneficial properties for insulin absorption using superporous hydrogel containing interpenetrating polymer network as oral delivery vehicles","volume":"350","author":"Yin","year":"2008","journal-title":"Int J Pharm"},{"key":"10.1016\/j.actbio.2009.01.017_bib12","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0142-9612(00)00039-9","article-title":"Oral peptide drug delivery: polymer\u2013inhibitor conjugates protecting insulin from enzymatic degradation in vitro","volume":"21","author":"Marsch\u00fctz","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2009.01.017_bib13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ejps.2004.03.015","article-title":"Development and in vivo evaluation of an oral insulin-PEG delivery system","volume":"22","author":"Calceti","year":"2004","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.actbio.2009.01.017_bib14","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijpharm.2006.05.062","article-title":"Preparation of insulin nanoparticles and their encapsulation with biodegradable polyelectrolytes via the layer-by-layer adsorption","volume":"324","author":"Fan","year":"2006","journal-title":"Int J Pharm"},{"key":"10.1016\/j.actbio.2009.01.017_bib15","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jconrel.2006.12.003","article-title":"A novel vitamin B12-nanosphere conjugate carrier system for peroral delivery of insulin","volume":"117","author":"Chalasani","year":"2007","journal-title":"J Control Release"},{"key":"10.1016\/j.actbio.2009.01.017_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jconrel.2007.04.004","article-title":"Vesicles from pluronic\/poly(lactic acid) block copolymers as new carriers for oral insulin delivery","volume":"120","author":"Xiong","year":"2007","journal-title":"J Control Release"},{"key":"10.1016\/j.actbio.2009.01.017_bib17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.colsurfa.2008.01.024","article-title":"Two-step pattern in the kinetics of protein adsorption onto poly(ethylene glycol)-grafted phospholipid monolayers","volume":"321","author":"Rahmati","year":"2008","journal-title":"Colloids Surf A: Physicochem Eng Asp"},{"key":"10.1016\/j.actbio.2009.01.017_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jconrel.2004.03.010","article-title":"Formulation optimization of water-in-oil\u2013water multiple emulsion for intestinal insulin delivery","volume":"97","author":"Onuki","year":"2004","journal-title":"J Control Release"},{"key":"10.1016\/j.actbio.2009.01.017_bib19","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1021\/bi036163s","article-title":"Crystallographic and solution studies of N-lithocholyl insulin: a new generation of prolonged-acting human insulins","volume":"43","author":"Whittingham","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.actbio.2009.01.017_bib20","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0378-5173(98)00408-6","article-title":"Pharmacodynamics of insulin in polyethylene glycol-coated liposomes","volume":"180","author":"Kim","year":"1999","journal-title":"Int J Pharm"},{"key":"10.1016\/j.actbio.2009.01.017_bib21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.diabres.2007.04.001","article-title":"Insulin\u2019s 85th anniversary \u2013 an enduring medical miracle","volume":"78","author":"Heller","year":"2007","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.actbio.2009.01.017_bib22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.arcmed.2005.03.012","article-title":"Insulin therapy: current alternatives","volume":"36","author":"G\u00f3mez-P\u00e9reza","year":"2005","journal-title":"Arch Med Res"},{"key":"10.1016\/j.actbio.2009.01.017_bib23","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1016\/j.biomaterials.2006.03.024","article-title":"Control of drug accessibility on functional polyelectrolyte multilayer films","volume":"27","author":"Vodouh\u00ea","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2009.01.017_bib24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0378-5173(03)00055-3","article-title":"Insulin containing polyethylenimine\u2013dextran sulfate nanoparticles","volume":"255","author":"Tiyaboonchai","year":"2003","journal-title":"Int J Pharm"},{"key":"10.1016\/j.actbio.2009.01.017_bib25","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1021\/bc970218j","article-title":"Direct observation of fibrinogen\u2013heparinoid complexes formation using surface plasmon resonance","volume":"10","author":"Sakamoto","year":"1999","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.actbio.2009.01.017_bib26","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1021\/bm000006g","article-title":"Alternating bioactivity of polymeric layer-by-layer assemblies: anti- vs procoagulation of human blood on chitosan and dextran sulfate layers","volume":"1","author":"Serizawa","year":"2000","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2009.01.017_bib27","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1021\/bm0200027","article-title":"Alternating bioactivity of polymeric layer-by-layer assemblies: anticoagulation vs procoagulation of human blood","volume":"3","author":"Serizawa","year":"2002","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2009.01.017_bib28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0162-0134(94)00060-N","article-title":"The recharacterization of a polysaccharide iron complex (niferex)","volume":"58","author":"Coe","year":"1995","journal-title":"J Inorg Biochem"},{"key":"10.1016\/j.actbio.2009.01.017_bib29","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0955-2863(99)00078-9","article-title":"A comparison of iron availability from commercial iron preparations using an in vitro digestion\/Caco-2 cell culture model","volume":"11","author":"Glahn","year":"2000","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.actbio.2009.01.017_bib30","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0162-0134(94)00042-9","article-title":"Rod-like iron(III) oxyhydroxide particles in iron(III)-polysaccharide solutions","volume":"58","author":"Sipos","year":"1995","journal-title":"J Inorg Biochem"},{"key":"10.1016\/j.actbio.2009.01.017_bib31","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jconrel.2007.01.006","article-title":"A multifunctional nano device as non-viral vector for gene delivery: in vitro characteristics and transfection","volume":"118","author":"Gao","year":"2007","journal-title":"J Control Release"},{"key":"10.1016\/j.actbio.2009.01.017_bib32","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1016\/j.febslet.2005.02.071","article-title":"Evaluation of nuclear transfer and transcription of plasmid DNA condensed with protamine by microinjection: the use of a nuclear transfer score","volume":"579","author":"Masuda","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1016\/j.actbio.2009.01.017_bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.anireprosci.2005.03.005","article-title":"Protamine sulfate protects exogenous DNA against nuclease degradation but is unable to improve the efficiency of bovine sperm mediated transgenesis","volume":"91","author":"Alderson","year":"2006","journal-title":"Anim Reprod Sci"},{"key":"10.1016\/j.actbio.2009.01.017_bib34","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.carres.2007.06.025","article-title":"Enzymatic desorption of layer-by-layer assembled multilayer films and effects on the release of encapsulated indomethacin microcrystals","volume":"342","author":"Wang","year":"2007","journal-title":"Carbohydr Res"},{"key":"10.1016\/j.actbio.2009.01.017_bib35","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1002\/chem.200400579","article-title":"Novel formulations of vitamins and insulin by nanoengineering of polyelectrolyte multilayers around microcrystals","volume":"10","author":"Dai","year":"2004","journal-title":"Chem Eur J"},{"key":"10.1016\/j.actbio.2009.01.017_bib36","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1021\/la049706n","article-title":"pH-responsive properties of hollow polyelectrolyte microcapsules templated on various cores","volume":"20","author":"Dejugnat","year":"2004","journal-title":"Langmuir"},{"key":"10.1016\/j.actbio.2009.01.017_bib37","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1002\/1521-3765(20021018)8:20<4751::AID-CHEM4751>3.0.CO;2-P","article-title":"Highly stable and biocompatible Nafion-based capsules with controlled permeability for low-molecular-weight species","volume":"8","author":"Dai","year":"2002","journal-title":"Chem Eur J"},{"key":"10.1016\/j.actbio.2009.01.017_bib38","doi-asserted-by":"crossref","first-page":"9533","DOI":"10.1021\/la026491d","article-title":"Nanoengineering of polymeric capsules with a shell-in-shell structure","volume":"18","author":"Dai","year":"2002","journal-title":"Langmuir"},{"key":"10.1016\/j.actbio.2009.01.017_bib39","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1023\/B:BIRY.0000040200.61663.01","article-title":"Fabrication and characterization of polyelectrolyte microparticles with protein","volume":"69","author":"Balabushevich","year":"2004","journal-title":"Biochem (Moscow)"},{"key":"10.1016\/j.actbio.2009.01.017_bib40","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/(SICI)1521-4184(199804)331:4<133::AID-ARDP133>3.0.CO;2-H","article-title":"Controlled insulin release from chitosan microparticles","volume":"331","author":"Bugamelli","year":"1998","journal-title":"Arch Pharm"},{"key":"10.1016\/j.actbio.2009.01.017_bib41","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1021\/bc049871e","article-title":"Synthesis and biological properties of insulin-deoxycholic acid chemical conjugates","volume":"16","author":"Lee","year":"2005","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.actbio.2009.01.017_bib42","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijpharm.2007.05.012","article-title":"Bioeliminable polymeric nanoparticles for proteic drug delivery","volume":"343","author":"Chiellini","year":"2007","journal-title":"Int J Pharm"},{"key":"10.1016\/j.actbio.2009.01.017_bib43","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1016\/j.biomaterials.2005.01.030","article-title":"Incorporation and in vitro release of doxorubicin in thermally sensitive micelles made from poly (N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(d,l-lactide-co-glycolide) with varying compositions","volume":"26","author":"Liu","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2009.01.017_bib44","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1021\/bm0002813","article-title":"Calcification-resistant Nafion\/Fe3+ assemblies for implantable biosensors","volume":"1","author":"Galeska","year":"2000","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2009.01.017_bib45","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/1521-3927(20020501)23:8<474::AID-MARC474>3.0.CO;2-O","article-title":"Resealing of polyelectrolyte capsules after core removal","volume":"23","author":"Ibarz","year":"2002","journal-title":"Macromol Rapid Commun"},{"key":"10.1016\/j.actbio.2009.01.017_bib46","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/1439-2054(20011001)286:10<591::AID-MAME591>3.0.CO;2-I","article-title":"Permeability of ibuprofen in various polyelectrolyte multilayers","volume":"286","author":"Qiu","year":"2001","journal-title":"Macromol Mater Eng"},{"key":"10.1016\/j.actbio.2009.01.017_bib47","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1023\/A:1012160102740","article-title":"Chitosans as absorption enhancers for poorly absorbable drugs 2: mechanism of absorption enhancement","volume":"14","author":"Schipper","year":"1997","journal-title":"Pharmaceut Res"},{"key":"10.1016\/j.actbio.2009.01.017_bib48","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0378-5173(92)90353-4","article-title":"In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers","volume":"78","author":"Lehr","year":"1992","journal-title":"Int J Pharm"},{"key":"10.1016\/j.actbio.2009.01.017_bib49","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1152\/ajpcell.00215.2007","article-title":"In vivo leukocyte labeling with intravenous ferumoxides\/protamine sulfate complex and in vitro characterization for cellular magnetic resonance imaging","volume":"293","author":"Wu","year":"2007","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174270610900021X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174270610900021X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:26:13Z","timestamp":1761668773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S174270610900021X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S174270610900021X"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2009.01.017","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel iron\u2013polysaccharide multilayered microcapsules for controlled insulin release","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2009.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}