{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:51:46Z","timestamp":1791309106943,"version":"4.3.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.actbio.2011.04.021","type":"journal-article","created":{"date-parts":[[2011,4,30]],"date-time":"2011-04-30T15:37:13Z","timestamp":1304177833000},"page":"3042-3049","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Calcium phosphates compounds in conjunction with hydrogel as carrier for BMP-2: A study on ectopic bone formation in rats"],"prefix":"10.1016","volume":"7","author":[{"given":"Gry","family":"Hulsart-Billstr\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth B.","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"\u00c5berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruikang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sune","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6ns","family":"Hilborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2011.04.021_b0005","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","article-title":"An estimate of the worldwide prevalence and disability associated with osteoporotic fractures","volume":"17","author":"Johnell","year":"2006","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2011.04.021_b0010","series-title":"Musculoskeletal conditions in the United States","author":"Praemer","year":"1992"},{"key":"10.1016\/j.actbio.2011.04.021_b0015","doi-asserted-by":"crossref","first-page":"940","DOI":"10.2106\/00004623-199506000-00016","article-title":"Enhancement of fracture-healing","volume":"77","author":"Einhorn","year":"1995","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.actbio.2011.04.021_b0020","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.150.3698.893","article-title":"Bone: formation by autoinduction","volume":"150","author":"Urist","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.actbio.2011.04.021_b0025","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/mrd.1080320212","article-title":"The bone morphogenetic protein family and osteogenesis","volume":"32","author":"Wozney","year":"1992","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.actbio.2011.04.021_b0030","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/0092-8674(90)90694-A","article-title":"CD44 is the principal cell surface receptor for hyaluronate","volume":"61","author":"Aruffo","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2011.04.021_b0035","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2796.1997.00170.x","article-title":"Hyaluronan: its nature, distribution, functions and turnover","volume":"242","author":"Fraser","year":"1997","journal-title":"J Intern Med"},{"key":"10.1016\/j.actbio.2011.04.021_b0040","doi-asserted-by":"crossref","first-page":"30081","DOI":"10.1016\/S0021-9258(18)43775-1","article-title":"Intercellular adhesion molecule-1 is a cell surface receptor for hyaluronan","volume":"269","author":"McCourt","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.actbio.2011.04.021_b0045","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/jcb.22462","article-title":"Bone morphogenic protein 2 directly enhances differentiation of murine osteoclast precursors","volume":"109","author":"Jensen","year":"2010","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.actbio.2011.04.021_b0050","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1242\/jcs.03310","article-title":"Hyaluronan inhibits osteoclast differentiation via Toll-like receptor 4","volume":"120","author":"Chang","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.actbio.2011.04.021_b0055","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1021\/ma052545p","article-title":"Poly(vinyl alcohol)-based hydrogels formed by \u201cclick chemistry\u201d","volume":"39","author":"Ossipov","year":"2006","journal-title":"Macromolecules"},{"key":"10.1016\/j.actbio.2011.04.021_b0060","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/app.26455","article-title":"Formation of the first injectable poly(vinyl alcohol) hydrogel by mixing of functional PVA precursors","volume":"106","author":"Ossipov","year":"2007","journal-title":"J Appl Poly Sci"},{"key":"10.1016\/j.actbio.2011.04.021_b0065","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1021\/bm0701604","article-title":"Hyaluronic acid derivatives prepared in aqueous media by triazine-activated amidation","volume":"8","author":"Bergman","year":"2007","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2011.04.021_b0070","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1021\/ma800332c","article-title":"Poly(vinyl alcohol) cross-linkers for in vivo injectable hydrogels","volume":"41","author":"Ossipov","year":"2008","journal-title":"Macromolecules"},{"key":"10.1016\/j.actbio.2011.04.021_b0075","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1016\/j.biomaterials.2003.12.012","article-title":"Prolongation of sciatic nerve blockade by in situ cross-linked hyaluronic acid","volume":"25","author":"Jia","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2011.04.021_b0080","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.biomaterials.2003.08.014","article-title":"In situ crosslinkable hyaluronan hydrogels for tissue engineering","volume":"25","author":"Zheng Shu","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2011.04.021_b0085","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1039\/b506989k","article-title":"Injectable biodegradable hydrogels composed of hyaluronic acid\u2013tyramine conjugates for drug delivery and tissue engineering","author":"Kurisawa","year":"2005","journal-title":"Chem Commun (Camb)"},{"key":"10.1016\/j.actbio.2011.04.021_b0090","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10856-008-3540-0","article-title":"Synthesis and characterization of tyramine-based hyaluronan hydrogels","volume":"20","author":"Darr","year":"2009","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.actbio.2011.04.021_b0095","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/jbm.a.32289","article-title":"Injectable cell-free template for bone-tissue formation","volume":"91","author":"Bergman","year":"2009","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.actbio.2011.04.021_b0100","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1097\/PRS.0b013e3181d629dc","article-title":"Bone morphogenetic protein-2 delivered by hyaluronan-based hydrogel induces massive bone formation and healing of cranial defects in minipigs","volume":"125","author":"Docherty-Skogh","year":"2010","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.actbio.2011.04.021_b0105","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1021\/cr800427g","article-title":"Calcium phosphate-based osteoinductive materials","volume":"108","author":"LeGeros","year":"2008","journal-title":"Chem Rev"},{"key":"10.1016\/j.actbio.2011.04.021_b0110","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.14219\/jada.archive.1982.0408","article-title":"Tricalcium phosphate ceramic \u2013 a resorbable bone implant: review and current status","volume":"105","author":"Metsger","year":"1982","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.actbio.2011.04.021_b0115","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/0885328208096798","article-title":"Review paper. Behavior of ceramic biomaterials derived from tricalcium phosphate in physiological condition","volume":"23","author":"Kamitakahara","year":"2008","journal-title":"J Biomater Appl"},{"key":"10.1016\/j.actbio.2011.04.021_b0120","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/2041050a0","article-title":"Crystal structure of hydroxyapatite","volume":"204","author":"Kay","year":"1964","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2011.04.021_b0125","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00000658-192001000-00006","article-title":"Studies in bone growth: triple calcium phosphate as a stimulus to osteogenesis","volume":"71","author":"Albee","year":"1920","journal-title":"Ann Surg"},{"key":"10.1016\/j.actbio.2011.04.021_b0130","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/1471-2474-10-164","article-title":"Evaluation of a novel nanocrystalline hydroxyapatite paste Ostim in comparison to alpha-BSM \u2013 More bone ingrowth inside the implanted material with Ostim compared to alpha-BSM","volume":"10","author":"Huber","year":"2009","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.actbio.2011.04.021_b0135","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1039\/b705129h","article-title":"Role of hydroxyapatite nanoparticle size in bone cell proliferation","volume":"17","author":"Cai","year":"2007","journal-title":"J Mater Chem"},{"key":"10.1016\/j.actbio.2011.04.021_b0140","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1039\/b710936a","article-title":"Effect of crystallinity of calcium phosphate nanoparticles on adhesion, proliferation, and differentiation of bone marrow mesenchymal stem cells","volume":"17","author":"Hu","year":"2007","journal-title":"J Mater Chem"},{"key":"10.1016\/j.actbio.2011.04.021_b0145","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1002\/anie.200353652","article-title":"Dissolution at the nanoscale: self-preservation of biominerals","volume":"43","author":"Tang","year":"2004","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.actbio.2011.04.021_b0150","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.biomaterials.2003.08.003","article-title":"Effects of apatite cements on proliferation and differentiation of human osteoblasts in vitro","volume":"25","author":"Yuasa","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2011.04.021_b0155","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.biomaterials.2006.10.026","article-title":"Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery: influence of the synthesis parameters on transfection efficiency","volume":"28","author":"Olton","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2011.04.021_b0160","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1389-0344(02)00027-8","article-title":"Growth of osteoblast-like cells on porous hydroxyapatite ceramics: an in vitro study","volume":"19","author":"Cerroni","year":"2002","journal-title":"Biomol Eng"},{"key":"10.1016\/j.actbio.2011.04.021_b0165","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2214\/ajr.179.1.1790198","article-title":"Sterilization of barium for vertebroplasty: an effective, reliable, and inexpensive method to sterilize powders for surgical procedures","volume":"179","author":"Leibold","year":"2002","journal-title":"Am J Roentgenol"},{"key":"10.1016\/j.actbio.2011.04.021_b0170","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1073\/pnas.87.6.2220","article-title":"Recombinant human bone morphogenetic protein induces bone formation","author":"Wang","year":"1990","journal-title":"Proc Natl Acad Sci: Biochem"},{"key":"10.1016\/j.actbio.2011.04.021_b0175","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/S0142-9612(00)00075-2","article-title":"Enhanced functions of osteoblasts on nanophase ceramics","volume":"21","author":"Webster","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2011.04.021_b0180","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1039\/b815887h","article-title":"Pathways to biomineralization and biodemineralization of calcium phosphates: the thermodynamic and kinetic controls","author":"Wang","year":"2009","journal-title":"Dalton Trans"},{"key":"10.1016\/j.actbio.2011.04.021_b0185","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/15216540050022386","article-title":"Cells on the move: a dialogue between polarization and motility","volume":"49","author":"Manes","year":"2000","journal-title":"IUBMB Life"},{"key":"10.1016\/j.actbio.2011.04.021_b0190","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S0006-291X(02)00558-2","article-title":"The hyaluronan receptor for endocytosis (HARE) is not CD44 or CD54 (ICAM-1)","volume":"294","author":"Weigel","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"issue":"Suppl. 5","key":"10.1016\/j.actbio.2011.04.021_b0195","first-page":"S16","article-title":"Bone mineral crystal size","volume":"14","author":"Boskey","year":"2003","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2011.04.021_b0200","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/jbm.a.32192","article-title":"In vitro effects of nanophase hydroxyapatite particles on proliferation and osteogenic differentiation of bone marrow-derived mesenchymal stem cells","volume":"90","author":"Liu","year":"2009","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.actbio.2011.04.021_b0205","doi-asserted-by":"crossref","unstructured":"Mahamid J, Sharir A, Addadi L. Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: indications for an amorphous precursor phase. Proceedings of the \u2026, 2008.","DOI":"10.1073\/pnas.0803354105"},{"key":"10.1016\/j.actbio.2011.04.021_b0210","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.3390\/ma2041975","article-title":"Nanodimensional and nanocrystalline apatites and other calcium orthophosphates in biomedical engineering, biology and medicine","volume":"2","author":"Dorozhkin","year":"2009","journal-title":"Materials"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706111001863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706111001863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:33:27Z","timestamp":1761669207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706111001863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S1742706111001863"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2011.04.021","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Calcium phosphates compounds in conjunction with hydrogel as carrier for BMP-2: A study on ectopic bone formation in rats","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2011.04.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}