{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T01:24:30Z","timestamp":1767144270512,"version":"build-2238731810"},"reference-count":55,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.actbio.2011.06.015","type":"journal-article","created":{"date-parts":[[2011,6,25]],"date-time":"2011-06-25T20:36:08Z","timestamp":1309034168000},"page":"3656-3669","source":"Crossref","is-referenced-by-count":14,"title":["RETRACTED: Enhanced cellular uptake and in vivo pharmacokinetics of rapamycin loaded cubic phase nanoparticles for cancer therapy"],"prefix":"10.1016","volume":"7","author":[{"given":"Priyambada","family":"Parhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandana","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeeb Kumar","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2011.06.015_b0005","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrc1362","article-title":"The TOR pathway: a target for cancer therapy","volume":"4","author":"Bjornsti","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.actbio.2011.06.015_b0010","doi-asserted-by":"crossref","first-page":"6436","DOI":"10.1038\/sj.onc.1209886","article-title":"MTOR and cancer therapy","volume":"25","author":"Easton","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.actbio.2011.06.015_b0015","doi-asserted-by":"crossref","first-page":"6680","DOI":"10.1038\/sj.onc.1204091","article-title":"The rapamycin-sensitive signal transduction pathway as a target for cancer therapy","volume":"19","author":"Hidalgo","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.actbio.2011.06.015_b0020","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/00007890-199508000-00010","article-title":"Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells","volume":"60","author":"Muthukkumar","year":"1995","journal-title":"Transplantation"},{"key":"10.1016\/j.actbio.2011.06.015_b0025","first-page":"3895","article-title":"Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells","volume":"56","author":"Seufferlein","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.actbio.2011.06.015_b0030","first-page":"886","article-title":"Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells","volume":"59","author":"Hosoi","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.actbio.2011.06.015_b0035","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S1097-2765(03)00180-1","article-title":"Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53\/p21(Cip1)","volume":"11","author":"Huang","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.actbio.2011.06.015_b0040","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-5173(00)00617-7","article-title":"Solubilization of rapamycin","volume":"213","author":"Simamora","year":"2001","journal-title":"Int J Pharm"},{"key":"10.1016\/j.actbio.2011.06.015_b0045","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0009-9120(96)00157-9","article-title":"Distribution of sirolimus in rat tissue","volume":"30","author":"Napoli","year":"1997","journal-title":"Clin Biochem"},{"key":"10.1016\/j.actbio.2011.06.015_b0050","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2217\/nnm.09.28","article-title":"Sustained antibacterial activity of doxycycline-loaded poly(d,l-lactide-co-glycolide) and poly(epsilon-caprolactone) nanoparticles","volume":"4","author":"Misra","year":"2009","journal-title":"Nanomedicine (Lond.)"},{"key":"10.1016\/j.actbio.2011.06.015_b0055","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/S1359-6446(03)02903-9","article-title":"Nanotech approaches to drug delivery and imaging","volume":"8","author":"Sahoo","year":"2003","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.actbio.2011.06.015_b0060","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.nano.2006.11.008","article-title":"The present and future of nanotechnology in human health care","volume":"3","author":"Sahoo","year":"2007","journal-title":"Nanomedicine"},{"key":"10.1016\/j.actbio.2011.06.015_b0065","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0959-8049(01)00371-9","article-title":"Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: a randomised crossover trial in advanced colorectal cancer","volume":"38","author":"Borner","year":"2002","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.actbio.2011.06.015_b0070","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1200\/JCO.2001.19.6.1743","article-title":"Phase II comparator study of oral versus intravenous topotecan in patients with chemosensitive small-cell lung cancer","volume":"19","author":"von Pawel","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.actbio.2011.06.015_b0075","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2174\/0929867043455909","article-title":"Nanoparticles of biodegradable polymers for clinical administration of paclitaxel","volume":"11","author":"Feng","year":"2004","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.actbio.2011.06.015_b0080","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jbiotec.2004.06.007","article-title":"Challenges and solutions for the delivery of biotech drugs \u2013 a review of drug nanocrystal technology and lipid nanoparticles","volume":"113","author":"Muller","year":"2004","journal-title":"J Biotechnol"},{"key":"10.1016\/j.actbio.2011.06.015_b0085","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nbt1006-1211","article-title":"The emerging nanomedicine landscape","volume":"24","author":"Wagner","year":"2006","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.actbio.2011.06.015_b0090","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1158\/1535-7163.MCT-08-0476","article-title":"In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilities","volume":"7","author":"Bisht","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.actbio.2011.06.015_b0095","series-title":"Encyclopedia of nanoscience and nanotechnology","first-page":"881","article-title":"Cubosomes: bicontinuous cubic liquid crystalline nanostructured particles","author":"Spicer","year":"2003"},{"key":"10.1016\/j.actbio.2011.06.015_b0100","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1016\/j.biomaterials.2010.01.057","article-title":"Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy","volume":"31","author":"Dilnawaz","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2011.06.015_b0105","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijpharm.2004.02.014","article-title":"A novel in situ gel for sustained drug delivery and targeting","volume":"276","author":"Ganguly","year":"2004","journal-title":"Int J Pharm"},{"key":"10.1016\/j.actbio.2011.06.015_b0110","doi-asserted-by":"crossref","first-page":"6597","DOI":"10.1016\/j.biomaterials.2010.04.062","article-title":"The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation","volume":"31","author":"Mohanty","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2011.06.015_b0115","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1021\/am101196v","article-title":"Composite polymeric magnetic nanoparticles for co-delivery of hydrophobic and hydrophilic anticancer drugs and MRI imaging for cancer therapy","volume":"3","author":"Singh","year":"2011","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.actbio.2011.06.015_b0120","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1517\/17425240902780166","article-title":"Ligand-based targeted therapy for cancer tissue","volume":"6","author":"Das","year":"2009","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.actbio.2011.06.015_b0125","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0169-409X(02)00018-2","article-title":"Pluronic block copolymers: novel functional molecules for gene therapy","volume":"54","author":"Kabanov","year":"2002","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.actbio.2011.06.015_b0130","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijpharm.2006.06.013","article-title":"Self-assembled nanoparticles of poly(lactide)-vitamin E TPGS copolymers for oral chemotherapy","volume":"324","author":"Zhang","year":"2006","journal-title":"Int J Pharm"},{"key":"10.1016\/j.actbio.2011.06.015_b0135","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jconrel.2005.11.005","article-title":"Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers","volume":"111","author":"Collnot","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2011.06.015_b0140","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0168-3659(03)00163-9","article-title":"Relationships between the hydrophilic\u2013lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines","volume":"90","author":"Lo","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2011.06.015_b0145","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ijc.20405","article-title":"Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer","volume":"112","author":"Sahoo","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.actbio.2011.06.015_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(03)00295-3","article-title":"Fluorescence and electron microscopy probes for cellular and tissue uptake of poly(D, L-lactide-co-glycolide) nanoparticles","volume":"262","author":"Panyam","year":"2003","journal-title":"Int J Pharm"},{"key":"10.1016\/j.actbio.2011.06.015_b0155","doi-asserted-by":"crossref","first-page":"5737","DOI":"10.1016\/j.biomaterials.2009.07.008","article-title":"Targeted epidermal growth factor receptor nanoparticle bioconjugates for breast cancer therapy","volume":"30","author":"Acharya","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2011.06.015_b0160","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2217\/nnm.10.9","article-title":"Curcumin-encapsulated MePEG\/PCL diblock copolymeric micelles: a novel controlled delivery vehicle for cancer therapy","volume":"5","author":"Mohanty","year":"2010","journal-title":"Nanomedicine (Lond.)"},{"key":"10.1016\/j.actbio.2011.06.015_b0165","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.actbio.2010.08.010","article-title":"Epithelial cell adhesion molecule targeted nutlin-3a loaded immunonanoparticles for cancer therapy","volume":"7","author":"Das","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2011.06.015_b0170","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1016\/j.actbio.2010.02.010","article-title":"Enhanced antiproliferative activity of carboplatin-loaded chitosan\u2013alginate nanoparticles in a retinoblastoma cell line","volume":"6","author":"Parveen","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2011.06.015_b0175","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bbrc.2010.06.017","article-title":"Rapamycin promotes beta-amyloid production via ADAM-10 inhibition","volume":"398","author":"Zhang","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.actbio.2011.06.015_b0180","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1016\/j.biomaterials.2009.02.045","article-title":"Poly(lactide)-vitamin E derivative\/montmorillonite nanoparticle formulations for the oral delivery of Docetaxel","volume":"30","author":"Feng","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2011.06.015_b0185","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1208\/s12249-008-9063-7","article-title":"A novel nanoparticle formulation for sustained paclitaxel delivery","volume":"9","author":"Trickler","year":"2008","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.actbio.2011.06.015_b0190","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1093\/carcin\/bgi040","article-title":"Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells","volume":"26","author":"Qanungo","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.actbio.2011.06.015_b0195","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2217\/nnm.09.54","article-title":"Optimization of physicochemical parameters influencing the fabrication of protein-loaded chitosan nanoparticles","volume":"4","author":"Vandana","year":"2009","journal-title":"Nanomedicine (Lond.)"},{"key":"10.1016\/j.actbio.2011.06.015_b0200","doi-asserted-by":"crossref","first-page":"6589","DOI":"10.1158\/0008-5472.CAN-05-3018","article-title":"Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma","volume":"66","author":"Vega","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.actbio.2011.06.015_b0205","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejps.2009.11.010","article-title":"Intracellular trafficking of nuclear localization signal conjugated nanoparticles for cancer therapy","volume":"39","author":"Misra","year":"2010","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.actbio.2011.06.015_b0210","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1016\/j.biomaterials.2004.07.050","article-title":"Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs","volume":"26","author":"Win","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2011.06.015_b0215","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.1021\/ja0296935","article-title":"Multifunctional gold nanoparticle\u2013peptide complexes for nuclear targeting","volume":"125","author":"Tkachenko","year":"2003","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.actbio.2011.06.015_b0220","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1007\/s11095-009-9911-5","article-title":"The in vitro sub-cellular localization and in vivo efficacy of novel chitosan\/GMO nanostructures containing paclitaxel","volume":"26","author":"Trickler","year":"2009","journal-title":"Pharm Res"},{"key":"10.1016\/j.actbio.2011.06.015_b0225","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1021\/la0522909","article-title":"Nanoparticle agglutination: acceleration of aggregation rates and broadening of the analyte concentration range using mixtures of various-sized nanoparticles","volume":"22","author":"Costanzo","year":"2006","journal-title":"Langmuir"},{"key":"10.1016\/j.actbio.2011.06.015_b0230","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1021\/mp050032z","article-title":"Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention","volume":"2","author":"Sahoo","year":"2005","journal-title":"Mol Pharm"},{"key":"10.1016\/j.actbio.2011.06.015_b0235","doi-asserted-by":"crossref","first-page":"21953","DOI":"10.1074\/jbc.274.31.21953","article-title":"Caspase independent\/dependent regulation of K(+), cell shrinkage, and mitochondrial membrane potential during lymphocyte apoptosis","volume":"274","author":"Bortner","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.actbio.2011.06.015_b0240","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.actbio.2011.06.015_b0245","first-page":"5645","article-title":"Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors","volume":"62","author":"Kenerson","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.actbio.2011.06.015_b0250","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1038\/sj.bjc.6601396","article-title":"Incidence, mechanism and prognostic value of activated AKT in pancreas cancer","volume":"89","author":"Schlieman","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1016\/j.actbio.2011.06.015_b0255","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1038\/sj.onc.1209887","article-title":"When translation meets transformation: the mTOR story","volume":"25","author":"Averous","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.actbio.2011.06.015_b0260","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1093\/hmg\/ddn192","article-title":"Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1","volume":"17","author":"Rosner","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.actbio.2011.06.015_b0265","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.addr.2007.08.044","article-title":"Protein nanoparticles as drug carriers in clinical medicine","volume":"60","author":"Hawkins","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.actbio.2011.06.015_b0270","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1358\/dot.2007.43.10.1148059","article-title":"Temsirolimus","volume":"43","author":"Ma","year":"2007","journal-title":"Drugs Today (Barc.)"},{"key":"10.1016\/j.actbio.2011.06.015_b0275","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/00001813-200606000-00001","article-title":"Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway","volume":"17","author":"Smolewski","year":"2006","journal-title":"Anticancer Drugs"}],"updated-by":[{"DOI":"10.1016\/j.actbio.2013.04.006","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"record-id":"114"},{"DOI":"10.1016\/j.actbio.2013.04.006","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000}}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706111002522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706111002522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T06:21:24Z","timestamp":1560320484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706111002522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":55,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S1742706111002522"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2011.06.015","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}