{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:12:04Z","timestamp":1792703524778,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.actbio.2012.06.010","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T22:32:31Z","timestamp":1339540351000},"page":"3669-3677","source":"Crossref","is-referenced-by-count":33,"title":["The effect of adsorbed fibronectin and osteopontin on macrophage adhesion and morphology on hydrophilic and hydrophobic model surfaces"],"prefix":"10.1016","volume":"8","author":[{"given":"J.","family":"Maciel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.I.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2012.06.010_b0005","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.matsci.31.1.81","article-title":"Biological responses to materials","volume":"31","author":"Anderson","year":"2001","journal-title":"Annu Rev Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0010","series-title":"Proteins at interfaces","first-page":"1","article-title":"Proteins at interfaces: current issues and future prospects","author":"Horbett","year":"1987"},{"key":"10.1016\/j.actbio.2012.06.010_b0015","doi-asserted-by":"crossref","unstructured":"Dee KC, Puleo DA, Bizios R. Protein\u2013surface interactions. An introduction to tissue\u2013biomaterial interactions. New York: John Wiley & Sons Inc.; 2003. p. 37\u201352.","DOI":"10.1002\/0471270598.ch3"},{"key":"10.1016\/j.actbio.2012.06.010_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ten.2005.11.1","article-title":"Mediation of biomaterial\u2013cell interactions by adsorbed proteins: a review","volume":"11","author":"Wilson","year":"2005","journal-title":"Tissue Eng"},{"key":"10.1016\/j.actbio.2012.06.010_b0025","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1016\/j.biomaterials.2006.01.019","article-title":"Surface-induced changes in protein adsorption and implications for cellular phenotypic responses to surface interaction","volume":"27","author":"Allen","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2012.06.010_b0030","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/jbm.a.32971","article-title":"Macrophage and dendritic cell phenotypic diversity in the context of biomaterials","volume":"96A","author":"Kou","year":"2011","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0035","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/(SICI)1097-4636(199905)45:2<148::AID-JBM10>3.0.CO;2-U","article-title":"Spatial regulation and surface chemistry control of monocyte\/macrophage adhesion and foreign body giant cell formation by photochemically micropatterned surfaces","volume":"45","author":"DeFife","year":"1999","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0040","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/jbm.1225","article-title":"Adhesion behavior of monocytes, macrophages, and foreign body giant cells on poly(n-isopropylacrylamide) temperature-responsive surfaces","volume":"59A","author":"Collier","year":"2002","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0045","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1097-4636(199902)44:2<206::AID-JBM11>3.0.CO;2-D","article-title":"Effects of surface-coupled polyethylene oxide on human macrophage adhesion and foreign body giant cell formation in vitro","volume":"44","author":"Jenney","year":"1999","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0050","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/(SICI)1097-4636(199907)46:1<11::AID-JBM2>3.0.CO;2-Y","article-title":"Alkylsilane-modified surfaces: inhibition of human macrophage adhesion and foreign body giant cell formation","volume":"46","author":"Jenney","year":"1999","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0055","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/jbm.10043","article-title":"Protein and surface effects on monocyte and macrophage adhesion, maturation, and survival","volume":"60","author":"Collier","year":"2002","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0060","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1023\/A:1008971222932","article-title":"Protein-mediated macrophage adhesion and activation on biomaterials: a model for modulating cell behavior","volume":"10","author":"Kao","year":"1999","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.actbio.2012.06.010_b0065","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/(SICI)1097-4636(20000315)49:4<435::AID-JBM2>3.0.CO;2-Y","article-title":"Adsorbed serum proteins responsible for surface dependent human macrophage behavior","volume":"49","author":"Jenney","year":"2000","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0070","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/(SICI)1097-4636(20000605)50:3<281::AID-JBM1>3.0.CO;2-5","article-title":"Adsorbed IgG: a potent adhesive substrate for human macrophages","volume":"50","author":"Jenney","year":"2000","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0075","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/1097-4636(200104)55:1<79::AID-JBM110>3.0.CO;2-Z","article-title":"Fibronectin modulates macrophage adhesion and FBGC formation: the role of RGD, PHSRN, and PRRARV domains","volume":"55","author":"Kao","year":"2001","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0080","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/S0142-9612(99)00152-0","article-title":"Evaluation of protein-modulated macrophage behavior on biomaterials: designing biomimetic materials for cellular engineering","volume":"20","author":"Kao","year":"1999","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2012.06.010_b0085","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1021\/la104127q","article-title":"Fibronectin conformation switch induced by coadsorption with human serum albumin","volume":"27","author":"Giamblanco","year":"2010","journal-title":"Langmuir"},{"key":"10.1016\/j.actbio.2012.06.010_b0090","series-title":"Implantation biology: the host response and biomedical devices","first-page":"113","article-title":"The extracellular matrix and biomaterials","author":"Anderson","year":"1994"},{"key":"10.1016\/j.actbio.2012.06.010_b0095","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1242\/jcs.00059","article-title":"Fibronectin at a glance","volume":"115","author":"Pankov","year":"2002","journal-title":"J Cell Sci"},{"key":"10.1016\/j.actbio.2012.06.010_b0100","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/309030a0","article-title":"Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule","volume":"309","author":"Pierschbacher","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2012.06.010_b0105","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12079-009-0068-0","article-title":"The role of osteopontin in inflammatory processes","volume":"3","author":"Lund","year":"2009","journal-title":"J Cell Commun Signal"},{"key":"10.1016\/j.actbio.2012.06.010_b0110","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1146\/annurev.pharmtox.41.1.723","article-title":"Role of osteopontin in cellular signaling and toxicant injury","volume":"41","author":"Denhardt","year":"2001","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.actbio.2012.06.010_b0115","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1172\/JCI12980","article-title":"Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival","volume":"107","author":"Denhardt","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.actbio.2012.06.010_b0120","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1096\/fasebj.7.15.8262332","article-title":"Osteopontin: a protein with diverse functions","volume":"7","author":"Denhardt","year":"1993","journal-title":"FASEB J"},{"key":"10.1016\/j.actbio.2012.06.010_b0125","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/jcb.21558","article-title":"Control of osteopontin signaling and function by post-translational phosphorylation and protein folding","volume":"102","author":"Kazanecki","year":"2007","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.actbio.2012.06.010_b0130","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.bone.2008.06.010","article-title":"Osteopontin functions as an opsonin and facilitates phagocytosis by macrophages of hydroxyapatite-coated microspheres: implications for bone wound healing","volume":"43","author":"Pedraza","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2012.06.010_b0135","first-page":"353","article-title":"Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo","volume":"152","author":"Giachelli","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.actbio.2012.06.010_b0140","doi-asserted-by":"crossref","first-page":"5835","DOI":"10.1016\/j.biomaterials.2005.03.003","article-title":"The role of osteopontin in foreign body giant cell formation","volume":"26","author":"Tsai","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2012.06.010_b0145","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/jbm.a.33166","article-title":"Osteopontin functionalization of hydroxyapatite nanoparticles in a PDLLA matrix promotes bone formation","volume":"99A","author":"Jensen","year":"2011","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0150","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.bb.25.060196.000415","article-title":"Using self-assembled monolayers to understand the interactions of man-made surfaces with proteins and cells","volume":"25","author":"Mrksich","year":"1996","journal-title":"Annu Rev Biophys Biomol"},{"key":"10.1016\/j.actbio.2012.06.010_b0155","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.biomaterials.2008.09.048","article-title":"The correlation between the adsorption of adhesive proteins and cell behaviour on hydroxyl-methyl mixed self-assembled monolayers","volume":"30","author":"Barrias","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2012.06.010_b0160","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1016\/S0142-9612(03)00244-8","article-title":"Albumin adsorption on alkanethiols self-assembled monolayers on gold electrodes studied by chronopotentiometry","volume":"24","author":"Martins","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2012.06.010_b0165","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1021\/la8036814","article-title":"Investigation of the effects of surface chemistry and solution concentration on the conformation of adsorbed proteins using an improved circular dichroism method","volume":"25","author":"Sivaraman","year":"2009","journal-title":"Langmuir"},{"key":"10.1016\/j.actbio.2012.06.010_b0170","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/jbm.a.32746","article-title":"The stability of self-assembled monolayers with time and under biological conditions","volume":"94A","author":"Maciel","year":"2010","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0175","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/jbm.a.10096","article-title":"Protein adsorption on mixtures of hydroxyl- and methyl-terminated alkanethiols self-assembled monolayers","volume":"67A","author":"Martins","year":"2003","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0180","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1109\/20.799086","article-title":"Ion beam deposition of Mn-Ir spin valves","volume":"35","author":"Gehanno","year":"1999","journal-title":"IEEE Trans Magn"},{"key":"10.1016\/j.actbio.2012.06.010_b0185","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/jbm.a.31849","article-title":"Molecularly designed surfaces for blood deheparinization using an immobilized heparin-binding peptide","volume":"88A","author":"Martins","year":"2009","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0190","doi-asserted-by":"crossref","first-page":"10119","DOI":"10.1073\/pnas.91.21.10119","article-title":"Complement C3 participation in monocyte adhesion to different surfaces","volume":"91","author":"McNally","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.actbio.2012.06.010_b0195","series-title":"Nanotechnology in regenerative medicine","first-page":"141","article-title":"Protein adsorption characterization","author":"Martins","year":"2012"},{"key":"10.1016\/j.actbio.2012.06.010_b0200","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1016\/j.biomaterials.2004.07.033","article-title":"Adsorption of a therapeutic enzyme to self-assembled monolayers: effect of surface chemistry and solution pH on the amount and activity of adsorbed enzyme","volume":"26","author":"Barrias","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2012.06.010_b0205","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/jbm.a.32723","article-title":"Bioactivity of immobilized EGF on self-assembled monolayers: optimization of the immobilization process","volume":"94A","author":"Goncalves","year":"2010","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0210","unstructured":"Amersham Life Science. Iodine-125. A guide to radioiodination techniques. Little Chalfont, UK: Amersham, International; 1993."},{"key":"10.1016\/j.actbio.2012.06.010_b0215","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/jbm.a.32011","article-title":"Selective protein adsorption modulates platelet adhesion and activation to oligo(ethylene glycol)-terminated self-assembled monolayers with C18 ligands","volume":"89A","author":"Goncalves","year":"2009","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0220","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/(SICI)1097-4636(199601)30:1<13::AID-JBM3>3.0.CO;2-U","article-title":"Effect of fibronectin amount and conformation on the strength of endothelial cell adhesion to HEMA\/EMA copolymers","volume":"30","author":"Burmeister","year":"1996","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0225","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/1097-4636(20011205)57:3<336::AID-JBM1176>3.0.CO;2-E","article-title":"The effects of surface chemistry and adsorbed proteins on monocyte\/macrophage adhesion to chemically modified polystyrene surfaces","volume":"57","author":"Shen","year":"2001","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0230","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1023\/A:1024951330265","article-title":"Effects of adsorbed heat labile serum proteins and fibrinogen on adhesion and apoptosis of monocytes\/macrophages on biomaterials","volume":"14","author":"Brodbeck","year":"2003","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.actbio.2012.06.010_b0235","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1242\/jcs.71.1.17","article-title":"The competitive effects of serum proteins on cell adhesion","volume":"71","author":"Curtis","year":"1984","journal-title":"J Cell Sci"},{"key":"10.1016\/j.actbio.2012.06.010_b0240","doi-asserted-by":"crossref","first-page":"8168","DOI":"10.1021\/ja042898o","article-title":"Interpretation of protein adsorption: surface-induced conformational changes","volume":"127","author":"Roach","year":"2005","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.actbio.2012.06.010_b0245","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1021\/jp972635z","article-title":"Molecular conformation in oligo(ethylene glycol)-terminated self-assembled monolayers on gold and silver surfaces determines their ability to resist protein adsorption","volume":"102","author":"Harder","year":"1998","journal-title":"J Phys Chem B"},{"key":"10.1016\/j.actbio.2012.06.010_b0250","doi-asserted-by":"crossref","first-page":"11550","DOI":"10.1021\/jp9015867","article-title":"Hydration of sulphobetaine and tetra(ethylene glycol)-terminated self-assembled monolayers studied by sum frequency generation vibrational spectroscopy","volume":"113","author":"Stein","year":"2009","journal-title":"J Phys Chem B"},{"key":"10.1016\/j.actbio.2012.06.010_b0255","series-title":"The encyclopedia of biomaterials and biomedical engineering","first-page":"270","article-title":"Biomaterials: protein\u2013surface interactions","author":"Latour","year":"2008"},{"key":"10.1016\/j.actbio.2012.06.010_b0260","doi-asserted-by":"crossref","first-page":"8033","DOI":"10.1021\/la034810a","article-title":"Adsorption-induced conformational changes in fibronectin due to interactions with well-defined surface chemistries","volume":"19","author":"Michael","year":"2003","journal-title":"Langmuir"},{"key":"10.1016\/j.actbio.2012.06.010_b0265","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/jbm.a.10537","article-title":"Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion","volume":"66A","author":"Keselowsky","year":"2003","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0270","doi-asserted-by":"crossref","first-page":"5947","DOI":"10.1016\/j.biomaterials.2004.01.062","article-title":"Surface chemistry modulates focal adhesion composition and signaling through changes in integrin binding","volume":"25","author":"Keselowsky","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2012.06.010_b0275","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.biomaterials.2006.09.037","article-title":"Fibronectin terminated multilayer films: protein adsorption and cell attachment studies","volume":"28","author":"Wittmer","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2012.06.010_b0280","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0002-9440(10)64882-1","article-title":"1 and \u03b22 integrins mediate adhesion during macrophage fusion and multinucleated foreign body giant cell formation","volume":"160","author":"McNally","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.actbio.2012.06.010_b0285","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/jbm.a.30221","article-title":"Controlling osteopontin orientation on surfaces to modulate endothelial cell adhesion","volume":"74A","author":"Liu","year":"2005","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2012.06.010_b0290","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/jbm.a.32879","article-title":"Osteopontin presentation affects cell adhesion \u2013 influence of underlying surface chemistry and nanopatterning of osteopontin","volume":"95A","author":"Malmstrom","year":"2010","journal-title":"J Biomed Mater Res"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706112002589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706112002589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T08:50:40Z","timestamp":1714035040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706112002589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":58,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S1742706112002589"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2012.06.010","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}