{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:04:10Z","timestamp":1791597850097,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["9P41-EB015871-26A1"],"award-info":[{"award-number":["9P41-EB015871-26A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK083242"],"award-info":[{"award-number":["DK083242"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL094270"],"award-info":[{"award-number":["R01HL094270"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF- 2012R1A1A1009082"],"award-info":[{"award-number":["NRF- 2012R1A1A1009082"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2009-0087691"],"award-info":[{"award-number":["2009-0087691"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007107","name":"Korea Advanced Institute of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007107","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.actbio.2012.07.011","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T06:35:28Z","timestamp":1342766128000},"page":"4130-4138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"title":["Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient"],"prefix":"10.1016","volume":"8","author":[{"given":"HeeSu","family":"Byun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Hillman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Diez-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangli","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Dao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandra R.","family":"Dasari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subra","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YongKeun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9442","key":"10.1016\/j.actbio.2012.07.011_b0005","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0140-6736(04)17192-4","article-title":"Sickle-cell disease","volume":"364","author":"Stuart","year":"2004","journal-title":"The Lancet"},{"issue":"23","key":"10.1016\/j.actbio.2012.07.011_b0010","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJM199406093302303","article-title":"Mortality in sickle cell disease \u2013 life expectancy and risk factors for early death","volume":"330","author":"Platt","year":"1994","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.actbio.2012.07.011_b0015","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1557\/mrs2010.571","article-title":"Shape and biomechanical characteristics of human red blood cells in health and disease","volume":"35","author":"Diez-Silva","year":"2010","journal-title":"MRS Bull: Mater Res Soc"},{"key":"10.1016\/j.actbio.2012.07.011_b0020","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nmat1001","article-title":"Cell and molecular mechanics of biological materials","volume":"2","author":"Bao","year":"2003","journal-title":"Nat Mater"},{"issue":"1","key":"10.1016\/j.actbio.2012.07.011_b0025","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.actbio.2004.09.001","article-title":"Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria","volume":"1","author":"Suresh","year":"2005","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2012.07.011_b0030","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-bioeng-070909-105339","article-title":"Sickle cell biomechanics","volume":"12","author":"Barabino","year":"2010","journal-title":"Annu Rev Biomed Eng"},{"issue":"4","key":"10.1016\/j.actbio.2012.07.011_b0035","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1172\/JCI106273","article-title":"Abnormal rheology of oxygenated blood in sickle cell anemia","volume":"49","author":"Chien","year":"1970","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.actbio.2012.07.011_b0040","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1182\/blood.V69.1.316.316","article-title":"Ektacytometric measurement of sickle cell deformability as a continuous function of oxygen tension","volume":"69","author":"Sorette","year":"1987","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.actbio.2012.07.011_b0045","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1172\/JCI111234","article-title":"Static and dynamic rigidities of normal and sickle erythrocytes. Major influence of cell hemoglobin concentration","volume":"73","author":"Evans","year":"1984","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.actbio.2012.07.011_b0050","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1182\/blood.V63.1.73.73","article-title":"Mechanical properties of oxygenated red blood cells in sickle cell (HbSS) disease","volume":"63","author":"Nash","year":"1984","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.actbio.2012.07.011_b0055","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1182\/blood.V70.1.152.152","article-title":"Endothelial cell interactions with sickle cell, sickle trait, mechanically injured, and normal erythrocytes under controlled flow","volume":"70","author":"Barabino","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.actbio.2012.07.011_b0060","unstructured":"Maciaszek JL, Andemariam B, Lykotrafitis G. Microelasticity of red blood cells in sickle cell disease. J Strain Anal Eng Des [accepted]."},{"issue":"15","key":"10.1016\/j.actbio.2012.07.011_b0065","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1073\/pnas.0909533107","article-title":"Measurement of red blood cell mechanics during morphological changes","volume":"107","author":"Park","year":"2010","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.actbio.2012.07.011_b0070","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1073\/pnas.0910785107","article-title":"Metabolic remodeling of the human red blood cell membran","volume":"107","author":"Park","year":"2010","journal-title":"Proc Natl Acad Sci"},{"issue":"37","key":"10.1016\/j.actbio.2012.07.011_b0075","doi-asserted-by":"crossref","first-page":"13730","DOI":"10.1073\/pnas.0806100105","article-title":"Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum","volume":"105","author":"Park","year":"2008","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"10.1016\/j.actbio.2012.07.011_b0080","doi-asserted-by":"crossref","first-page":"031921","DOI":"10.1103\/PhysRevE.77.031921","article-title":"Nanorheology of viscoelastic shells: applications to viral capsids","volume":"77","author":"Kuriabova","year":"2008","journal-title":"Phys Rev E"},{"issue":"5","key":"10.1016\/j.actbio.2012.07.011_b0085","doi-asserted-by":"crossref","first-page":"051925","DOI":"10.1103\/PhysRevE.83.051925","article-title":"Measurement of the nonlinear elasticity of red blood cell membranes","volume":"83","author":"Park","year":"2011","journal-title":"Phys Rev E"},{"issue":"3","key":"10.1016\/j.actbio.2012.07.011_b0090","first-page":"593","article-title":"New insights into red cell network structure, elasticity, and spectrin unfolding \u2013 a current review","volume":"6","author":"Discher","year":"2001","journal-title":"Cell Mol Biol Lett"},{"issue":"1","key":"10.1016\/j.actbio.2012.07.011_b0095","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0006-3495(80)85124-1","article-title":"Temperature dependence of the viscoelastic recovery of red cell membrane","volume":"29","author":"Hochmuth","year":"1980","journal-title":"Biophys J"},{"issue":"2","key":"10.1016\/j.actbio.2012.07.011_b0100","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1152\/jappl.1969.27.2.213","article-title":"Red cell deformation and fluidity of concentrated cell suspensions","volume":"27","author":"Wells","year":"1969","journal-title":"J Appl Physiol"},{"issue":"9","key":"10.1016\/j.actbio.2012.07.011_b0105","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0006-3495(73)86036-9","article-title":"New membrane concept applied to the analysis of fluid shear- and micropipette-deformed red blood cells","volume":"13","author":"Evans","year":"1973","journal-title":"Biophys J"},{"issue":"36","key":"10.1016\/j.actbio.2012.07.011_b0110","doi-asserted-by":"crossref","first-page":"15312","DOI":"10.1073\/pnas.0904614106","article-title":"ATP-dependent mechanics of red blood cells","volume":"106","author":"Betz","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"issue":"22","key":"10.1016\/j.actbio.2012.07.011_b0115","doi-asserted-by":"crossref","first-page":"228101","DOI":"10.1103\/PhysRevLett.90.228101","article-title":"Cytoskeleton confinement and tension of red blood cell membranes","volume":"90","author":"Gov","year":"2003","journal-title":"Phys Rev Lett"},{"key":"10.1016\/j.actbio.2012.07.011_b0120","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.ph.49.030187.001233","article-title":"Erythrocyte membrane elasticity and viscocity","volume":"49","author":"Hochmuth","year":"1987","journal-title":"Ann Rev Physiol"},{"key":"10.1016\/j.actbio.2012.07.011_b0125","first-page":"1689","article-title":"Blood cell biomechanics evaluated by the single-cell micromanipulation","volume":"5","author":"Leli\u00e8vre","year":"1995","journal-title":"J Phys III France"},{"issue":"1","key":"10.1016\/j.actbio.2012.07.011_b0130","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0006-3495(00)76295-3","article-title":"Effect of chain length and unsaturation on elasticity of lipid bilayers","volume":"79","author":"Rawicz","year":"2000","journal-title":"Biophys J"},{"issue":"1","key":"10.1016\/j.actbio.2012.07.011_b0135","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0006-3495(01)75678-0","article-title":"Direct measurement of the area expansion and shear moduli of the human red blood cell membrane skeleton","volume":"81","author":"Lenormand","year":"2001","journal-title":"Biophys J"},{"issue":"8","key":"10.1016\/j.actbio.2012.07.011_b0140","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.msec.2005.08.020","article-title":"Molecularly based analysis of deformation of spectrin network and human erythrocyte","volume":"26","author":"Dao","year":"2006","journal-title":"Mater Sci Eng C"},{"issue":"3","key":"10.1016\/j.actbio.2012.07.011_b0145","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0006-3495(77)85551-3","article-title":"Osmotic correction to elastic area compressibility measurements on red-cell membrane","volume":"20","author":"Evans","year":"1977","journal-title":"Biophys J"},{"issue":"6","key":"10.1016\/j.actbio.2012.07.011_b0150","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0006-3495(76)85713-X","article-title":"Elastic area compressibility modulus of red-cell membrane","volume":"16","author":"Evans","year":"1976","journal-title":"Biophys J"},{"issue":"3","key":"10.1016\/j.actbio.2012.07.011_b0155","doi-asserted-by":"crossref","first-page":"031904","DOI":"10.1103\/PhysRevE.81.031904","article-title":"Multiscale simulation of erythrocyte membranes","volume":"81","author":"Peng","year":"2010","journal-title":"Phys Rev E"},{"issue":"2","key":"10.1016\/j.actbio.2012.07.011_b0160","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0006-3495(78)85395-8","article-title":"Theoretical and experimental studies on viscoelastic properties of erythrocyte membrane","volume":"24","author":"Chien","year":"1978","journal-title":"Biophys J"},{"issue":"11\u20131","key":"10.1016\/j.actbio.2012.07.011_b0165","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1515\/znc-1973-11-1209","article-title":"Elastic properties of lipid bilayers: theory and possible experiments","volume":"28","author":"Helfrich","year":"1973","journal-title":"Z naturforsch C"},{"issue":"6","key":"10.1016\/j.actbio.2012.07.011_b0170","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/bip.1978.360170615","article-title":"Photon correlation spectroscopy of hemoglobin: diffusion of Oxy HbA and Oxy HbS","volume":"17","author":"Jones","year":"1978","journal-title":"Biopolymers"},{"issue":"19","key":"10.1016\/j.actbio.2012.07.011_b0175","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1021\/j150619a029","article-title":"Translational diffusion coefficient of macroparticles in solvents of high viscosity","volume":"85","author":"Phillies","year":"1981","journal-title":"J Phys Chem"},{"issue":"6","key":"10.1016\/j.actbio.2012.07.011_b0180","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1364\/OL.31.000775","article-title":"Diffraction phase microscopy for quantifying cell structure and dynamics","volume":"31","author":"Popescu","year":"2006","journal-title":"Opt Lett"},{"issue":"18","key":"10.1016\/j.actbio.2012.07.011_b0185","doi-asserted-by":"crossref","first-page":"8263","DOI":"10.1364\/OE.14.008263","article-title":"Diffraction phase and fluorescence microscopy","volume":"14","author":"Park","year":"2006","journal-title":"Opt Exp"},{"issue":"1","key":"10.1016\/j.actbio.2012.07.011_b0190","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bcmd.2008.01.010","article-title":"Imaging red blood cell dynamics by quantitative phase microscopy","volume":"41","author":"Popescu","year":"2008","journal-title":"Blood Cells, Molecules, and Diseases"},{"issue":"23","key":"10.1016\/j.actbio.2012.07.011_b0195","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1364\/OL.36.004677","article-title":"Real-time quantitative phase imaging by spatial phase shifting algorithm","volume":"36","author":"Debnath","year":"2011","journal-title":"Opt Lett"},{"issue":"1","key":"10.1016\/j.actbio.2012.07.011_b0200","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1532\/LH96.04075","article-title":"The ADVIA 2120 hematology system: flow cytometry-based analysis of blood and body fluids in the routine hematology laboratory","volume":"11","author":"Harris","year":"2005","journal-title":"Lab Hematol"},{"issue":"2","key":"10.1016\/j.actbio.2012.07.011_b0205","doi-asserted-by":"crossref","first-page":"C538","DOI":"10.1152\/ajpcell.00121.2008","article-title":"Optical imaging of cell mass and growth dynamics","volume":"295","author":"Popescu","year":"2008","journal-title":"Am J Physiol: Cell Physiol"},{"issue":"6","key":"10.1016\/j.actbio.2012.07.011_b0210","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1182\/blood.V88.6.1960.bloodjournal8861960","article-title":"Hydroxyurea for treatment of severe sickle cell anemia: a pediatric clinical trial","volume":"88","author":"Ferster","year":"1996","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.actbio.2012.07.011_b0215","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1172\/JCI110960","article-title":"Erythrocytes in sickle cell anemia are heterogeneous in their rheological and hemodynamic characteristics","volume":"72","author":"Kaul","year":"1983","journal-title":"J Clin Invest"},{"issue":"4389","key":"10.1016\/j.actbio.2012.07.011_b0220","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/1721097a0","article-title":"Determination of dry mass, thickness, solid and water concentration in living cells","volume":"172","author":"Barer","year":"1953","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.actbio.2012.07.011_b0225","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1056\/NEJM199004123221504","article-title":"Hematologic responses of patients with sickle cell disease to treatment with hydroxyurea","volume":"322","author":"Rodgers","year":"1990","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.actbio.2012.07.011_b0230","doi-asserted-by":"crossref","first-page":"e1002270","DOI":"10.1371\/journal.pcbi.1002270","article-title":"Multiscale modeling of red blood cell mechanics and blood flow in malaria","volume":"7","author":"Fedosov","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.actbio.2012.07.011_b0235","doi-asserted-by":"crossref","first-page":"030506","DOI":"10.1117\/1.3556717","article-title":"Quantitative microscopy and nanoscopy of sickle red blood cells performed by wide field digital interferometry","volume":"16","author":"Shaked","year":"2011","journal-title":"J Biomed Opt"},{"issue":"1","key":"10.1016\/j.actbio.2012.07.011_b0240","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/ajh.2830480105","article-title":"Sickle cell rheology is determined by polymer fraction-not cell morphology","volume":"48","author":"Hiruma","year":"1995","journal-title":"Am J Hematol"},{"issue":"5","key":"10.1016\/j.actbio.2012.07.011_b0245","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1172\/JCI110695","article-title":"Hydration of sickle cells using the sodium ionophore monensin. A model for therapy","volume":"70","author":"Clark","year":"1982","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.actbio.2012.07.011_b0250","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/ajh.2830130403","article-title":"The effect of cell hydration on the deformability of normal and sickle erythrocytes","volume":"13","author":"Gulley","year":"1982","journal-title":"Am J Hematol"},{"key":"10.1016\/j.actbio.2012.07.011_b0255","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1182\/blood.V60.3.659.659","article-title":"A simple laboratory alternative to irreversibly sickled cell (ISC) counts","volume":"60","author":"Clark","year":"1982","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.actbio.2012.07.011_b0260","first-page":"537","article-title":"Filtration characteristics of sickle cells: rates of alteration of filterability after deoxygenation and reoxygenation, and correlations with sickling and unsickling","volume":"76","author":"Messer","year":"1970","journal-title":"J Lab Clin Med"},{"issue":"4","key":"10.1016\/j.actbio.2012.07.011_b0265","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1172\/JCI30920","article-title":"Sickle cell disease: old discoveries, new concepts, and future promise","volume":"117","author":"Frenette","year":"2007","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.actbio.2012.07.011_b0270","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1172\/JCI111672","article-title":"Uncoupling of the membrane skeleton from the lipid bilayer. The cause of accelerated phospholipid flip-flop leading to an enhanced procoagulant activity of sickled cells","volume":"75","author":"Franck","year":"1985","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.actbio.2012.07.011_b0275","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1182\/blood.V77.2.214.214","article-title":"Beyond hemoglobin polymerization: the red blood cell membrane and sickle disease pathophysiology","volume":"77","author":"Hebbel","year":"1991","journal-title":"Blood"},{"issue":"51","key":"10.1016\/j.actbio.2012.07.011_b0280","doi-asserted-by":"crossref","first-page":"20496","DOI":"10.1073\/pnas.0707122105","article-title":"Sickle cell vasoocclusion and rescue in a microfluidic device","volume":"104","author":"Higgins","year":"2007","journal-title":"Proc Natl Acad Sci"},{"issue":"11","key":"10.1016\/j.actbio.2012.07.011_b0285","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1172\/JCI119442","article-title":"Perspectives series: cell adhesion in vascular biology. Adhesive interactions of sickle erythrocytes with endothelium","volume":"99","author":"Hebbel","year":"1997","journal-title":"J Clin Invest"},{"issue":"23","key":"10.1016\/j.actbio.2012.07.011_b0290","doi-asserted-by":"crossref","first-page":"238103","DOI":"10.1103\/PhysRevLett.106.238103","article-title":"Effective temperature of red-blood-cell membrane fluctuations","volume":"106","author":"Ben-Isaac","year":"2011","journal-title":"Phys Rev Lett"},{"issue":"2","key":"10.1016\/j.actbio.2012.07.011_b0295","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1182\/blood.V72.2.539.539","article-title":"Rheologic impairment of sickle RBCs induced by repetitive cycles of deoxygenation\u2013reoxygenation","volume":"72","author":"Nash","year":"1988","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.actbio.2012.07.011_b0300","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.tibtech.2011.08.004","article-title":"Optical imaging techniques for the study of malaria","volume":"30","author":"Cho","year":"2011","journal-title":"Trends Biotechnol"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706112003121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706112003121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:36:19Z","timestamp":1761669379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706112003121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":60,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S1742706112003121"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2012.07.011","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2012.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}