{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:58:13Z","timestamp":1791161893136,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"12","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.actbio.2013.07.032","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T08:16:23Z","timestamp":1375431383000},"page":"9292-9302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Nanoparticles for localized delivery of hyaluronan oligomers towards regenerative repair of elastic matrix"],"prefix":"10.1016","volume":"9","author":[{"given":"Andrew","family":"Sylvester","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balakrishnan","family":"Sivaraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha","family":"Deb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Ramamurthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2013.07.032_b0005","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1089\/ten.tea.2008.0593","article-title":"Utility of hyaluronan oligomers and transforming growth factor-beta1 factors for elastic matrix regeneration by aneurysmal rat aortic smooth muscle cells","volume":"15","author":"Kothapalli","year":"2009","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2013.07.032_b0010","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1136\/bmj.b2307","article-title":"Screening men for abdominal aortic aneurysm: 10year mortality and cost effectiveness results from the randomised multicentre aneurysm screening study","volume":"338","author":"Thompson","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.actbio.2013.07.032_b0015","first-page":"1198","article-title":"Abdominal aortic aneurysm","volume":"73","author":"Upchurch","year":"2006","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.actbio.2013.07.032_b0020","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/01.sla.0000234893.88045.dc","article-title":"Long-term outcomes after endovascular abdominal aortic aneurysm repair: the first decade","volume":"244","author":"Brewster","year":"2006","journal-title":"Ann Surg"},{"key":"10.1016\/j.actbio.2013.07.032_b0025","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1089\/ten.tea.2007.0390","article-title":"Biomimetic regeneration of elastin matrices using hyaluronan and copper ion cues","volume":"1","author":"Kothapalli","year":"2009","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2013.07.032_b0030","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1016\/j.biomaterials.2006.01.020","article-title":"Fragment size- and dose-specific effects of hyaluronan on matrix synthesis by vascular smooth muscle cells","volume":"27","author":"Joddar","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2013.07.032_b0035","doi-asserted-by":"crossref","first-page":"5698","DOI":"10.1016\/j.biomaterials.2006.07.020","article-title":"Elastogenic effects of exogenous hyaluronan oligosaccharides on vascular smooth muscle cells","volume":"27","author":"Joddar","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2013.07.032_b0040","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1089\/ten.tea.2010.0526","article-title":"Elastogenic inductability of smooth muscle cells from a rat model of late stage abdominal aortic aneurysms","volume":"17","author":"Gacchina","year":"2011","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2013.07.032_b0045","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1016\/j.actbio.2013.01.023","article-title":"Multifunctional nanoparticles for doxycycline delivery towards localized elastic matrix stabilization and regenerative repair","volume":"9","author":"Sivaraman","year":"2013","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2013.07.032_b0050","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1161\/01.CIR.94.6.1441","article-title":"Local intraluminal infusion of biodegradable polymeric nanoparticles. A novel approach for prolonged drug delivery after balloon angioplasty","volume":"94","author":"Guzman","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2013.07.032_b0055","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1021\/js980021f","article-title":"Arterial uptake of biodegradable nanoparticles: effect of surface modifications","volume":"87","author":"Labhasetwar","year":"1998","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.actbio.2013.07.032_b0060","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0168-3659(96)01484-8","article-title":"Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery","volume":"43","author":"Song","year":"1997","journal-title":"J Control Release"},{"key":"10.1016\/j.actbio.2013.07.032_b0065","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1161\/01.CIR.82.3.973","article-title":"Elastase-induced experimental aneurysms in rats","volume":"82","author":"Anidjar","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2013.07.032_b0070","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1083\/jcb.133.5.1041","article-title":"Role of Ced-3\/ICE-family proteases in staurosporine-induced programmed cell death","volume":"133","author":"Jacobsen","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/j.actbio.2013.07.032_b0075","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1083\/jcb.133.5.1053","article-title":"Constitutive expression of the machinery for programmed cell death","volume":"133","author":"Weil","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/j.actbio.2013.07.032_b0080","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0022-1759(94)90147-3","article-title":"An improved fluorescence assay for the determination of lymphocyte-mediated cytotoxicity using flow cytometry","volume":"177","author":"Papadopoulos","year":"1994","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.actbio.2013.07.032_b0085","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/0198-8859(93)90510-8","article-title":"A new microcellular cytotoxicity test based on calcein AM release","volume":"37","author":"Wang","year":"1993","journal-title":"Hum Immunol"},{"key":"10.1016\/j.actbio.2013.07.032_b0090","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jconrel.2004.08.020","article-title":"Controlled release of hyaluronan oligomers from biodegradable polymeric microparticle carriers","volume":"100","author":"Hedberg","year":"2004","journal-title":"J Control Release"},{"key":"10.1016\/j.actbio.2013.07.032_b0095","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0003-2697(80)90165-7","article-title":"A simple, rapid, and sensitive DNA assay procedure","volume":"102","author":"Labarca","year":"1980","journal-title":"Anal Biochem"},{"key":"10.1016\/j.actbio.2013.07.032_b0100","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/term.286","article-title":"Impact of pre-existing elastic matrix on TGF\u03b21 and HA oligomer-induced regenerative elastin repair by rat aortic smooth muscle cells","volume":"5","author":"Gacchina","year":"2011","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.actbio.2013.07.032_b0105","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.actbio.2009.06.006","article-title":"Induced elastin regeneration by chronically activated smooth muscle cells for targeted aneurysm repair","volume":"6","author":"Kothapalli","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2013.07.032_b0110","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1089\/ten.tea.2008.0593","article-title":"Utility of hyaluronan oligomers and transforming growth factor-beta1 factors for elastic matrix regeneration by aneurysmal rat aortic smooth muscle cells","volume":"15","author":"Kothapalli","year":"2009","journal-title":"Tissue Eng"},{"key":"10.1016\/j.actbio.2013.07.032_b0115","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/term.70","article-title":"Benefits of concurrent delivery of hyaluronan and IGF-1 cues to regeneration of crosslinked elastin matrices by adult rat vascular cells","volume":"2","author":"Kothapalli","year":"2008","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.actbio.2013.07.032_b0120","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1089\/ten.tea.2008.0040","article-title":"Transforming growth factor beta 1 and hyaluronan oligomers synergistically enhance elastin matrix regeneration by vascular smooth muscle cells","volume":"15","author":"Kothapalli","year":"2009","journal-title":"Tissue Eng"},{"key":"10.1016\/j.actbio.2013.07.032_b0125","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0008-6363(98)00321-6","article-title":"Collagen synthesis in atherosclerosis: too much and not enough","volume":"41","author":"Rekhter","year":"1999","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.actbio.2013.07.032_b0130","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s13346-012-0070-6","article-title":"Advances in biomimetic regeneration of elastic matrix structures","volume":"2","author":"Sivaraman","year":"2012","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.actbio.2013.07.032_b0135","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1089\/ten.tea.2010.0526","article-title":"Elastogenic inductability of smooth muscle cells from a rat model of late stage abdominal aortic aneurysms","volume":"17","author":"Gacchina","year":"2011","journal-title":"Tissue Eng"},{"key":"10.1016\/j.actbio.2013.07.032_b0140","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.bbadis.2011.03.012","article-title":"Systemic administration of high-molecular weight hyaluronan stimulates wound healing in genetically diabetic mice","volume":"1812","author":"Galeano","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.actbio.2013.07.032_b0145","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2144\/000113628","article-title":"High transfection efficiency of neural stem cells with magnetofection","volume":"50","author":"Sapet","year":"2011","journal-title":"Biotechniques"},{"key":"10.1016\/j.actbio.2013.07.032_b0150","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1208\/s12249-009-9222-5","article-title":"Intratumoral delivery of paclitaxel in solid tumor from biodegradable hyaluronan nanoparticle formulations","volume":"10","author":"Al-Ghananeem","year":"2009","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.actbio.2013.07.032_b0155","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2147\/IJN.S18905","article-title":"Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents","volume":"6","author":"Dinarvand","year":"2011","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.actbio.2013.07.032_b0160","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/(SICI)1097-4636(1999)48:3<342::AID-JBM20>3.0.CO;2-7","article-title":"Hydrolytic degradation characteristics of aliphatic polyesters derived from lactic and glycolic acids","volume":"48","author":"Li","year":"1999","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2013.07.032_b0165","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nnano.2007.223","article-title":"Immunological properties of engineered nanomaterials","volume":"2","author":"Dobrovolskaia","year":"2007","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.actbio.2013.07.032_b0170","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2217\/17435889.3.3.343","article-title":"Design opportunities for actively targeted nanoparticle vaccines","volume":"3","author":"Fahmy","year":"2008","journal-title":"Nanomedicine"},{"key":"10.1016\/j.actbio.2013.07.032_b0175","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00118-6","article-title":"Nanosuspensions as particulate drug formulations in therapy: rationale for development and what we can expect for the future","volume":"47","author":"M\u00fcller","year":"2001","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.actbio.2013.07.032_b0180","first-page":"561","article-title":"Nanoparticles \u2013 a review","volume":"5","author":"Mohanraj","year":"2006","journal-title":"Trop J Pharm Res"},{"key":"10.1016\/j.actbio.2013.07.032_b0185","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.2147\/IJN.S36111","article-title":"The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles","volume":"7","author":"Frohlich","year":"2012","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.actbio.2013.07.032_b0190","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3844\/ajassp.2012.1091.1100","article-title":"Properties of chitosan nanoparticles formed using sulfate anions as crosslinking bridges","volume":"9","author":"Al-Remawi","year":"2012","journal-title":"Am J Appl Sci"},{"key":"10.1016\/j.actbio.2013.07.032_b0195","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0168-3659(02)00127-X","article-title":"Residual polyvinyl alcohol associated with poly (d,l-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake","volume":"82","author":"Sahoo","year":"2002","journal-title":"J Control Release"},{"key":"10.1016\/j.actbio.2013.07.032_b0200","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1089\/ten.tea.2008.0040","article-title":"Transforming growth factor beta 1 and hyaluronan oligomers synergistically enhance elastin matrix regeneration by vascular smooth muscle cells","volume":"15","author":"Kothapalli","year":"2009","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2013.07.032_b0205","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0955-0674(02)00375-7","article-title":"Versican: a versatile extracellular matrix proteoglycan in cell biology","volume":"14","author":"Wight","year":"2002","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.actbio.2013.07.032_b0210","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1016\/j.biomaterials.2007.05.019","article-title":"Impact of delivery mode of hyaluronan oligomers on elastogenic responses of adult vascular smooth muscle cells","volume":"28","author":"Joddar","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2013.07.032_b0215","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1440-1681.1984.tb00235.x","article-title":"Elimination of hyaluronic acid from the blood stream in the human","volume":"11","author":"Fraser","year":"1984","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.actbio.2013.07.032_b0220","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.atherosclerosis.2009.07.036","article-title":"Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm","volume":"208","author":"Onoda","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.actbio.2013.07.032_b0225","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/nm1335","article-title":"Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase","volume":"11","author":"Yoshimura","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.actbio.2013.07.032_b0230","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1067\/msy.2000.107379","article-title":"Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms","volume":"128","author":"Huffman","year":"2000","journal-title":"Surgery"},{"key":"10.1016\/j.actbio.2013.07.032_b0235","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000109819","article-title":"Granulocyte macrophage colony-stimulating factor deficiency affects vascular elastin production and integrity of elastic lamellae","volume":"45","author":"Weissen-Plenz","year":"2008","journal-title":"J Vasc Res"},{"key":"10.1016\/j.actbio.2013.07.032_b0240","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/jcb.10413","article-title":"Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell","volume":"88","author":"Kagan","year":"2003","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.actbio.2013.07.032_b0245","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1006\/cbir.2001.0759","article-title":"Effect of hyaluronan on MMP expression and activation","volume":"25","author":"Isnard","year":"2001","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.actbio.2013.07.032_b0250","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1065-6995(03)00167-7","article-title":"Effect of sulfated GAGs on the expression and activation of MMP-2 and MMP-9 in corneal and dermal explant cultures","volume":"27","author":"Isnard","year":"2003","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.actbio.2013.07.032_b0255","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1083\/jcb.30.1.59","article-title":"Fine structure of elastic fibers","volume":"30","author":"Greenlee","year":"1966","journal-title":"J Cell Biol"},{"key":"10.1016\/j.actbio.2013.07.032_b0260","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1083\/jcb.105.3.1463","article-title":"Lysyl oxidase activity and elastin\/glycosaminoglycan interactions in growing chick and rat aortas","volume":"105","author":"Fornieri","year":"1987","journal-title":"J Cell Biol"},{"key":"10.1016\/j.actbio.2013.07.032_b0265","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(05)66459-8","article-title":"Abdominal aortic aneurysm","volume":"365","author":"Sakalihasan","year":"2005","journal-title":"Lancet"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706113003802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706113003802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T21:01:08Z","timestamp":1646254868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706113003802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S1742706113003802"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2013.07.032","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanoparticles for localized delivery of hyaluronan oligomers towards regenerative repair of elastic matrix","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2013.07.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}