{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:34:20Z","timestamp":1791117260844,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"12","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.actbio.2013.08.017","type":"journal-article","created":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T03:47:37Z","timestamp":1376711257000},"page":"9474-9484","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Micropatterned dermal\u2013epidermal regeneration matrices create functional niches that enhance epidermal morphogenesis"],"prefix":"10.1016","volume":"9","author":[{"given":"Amanda L.","family":"Clement","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Thomas J.","family":"Moutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Pins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2013.08.017_b0015","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000178867","article-title":"Tissue engineering for cutaneous wounds: selecting the proper time and space for growth factors, cells and the extracellular matrix","volume":"22","author":"Macri","year":"2009","journal-title":"Skin Pharmacol Physiol"},{"key":"10.1016\/j.actbio.2013.08.017_b0020","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1098\/rsif.2009.0403","article-title":"A review of tissue-engineered skin bioconstructs available for skin reconstruction","volume":"7","author":"Shevchenko","year":"2010","journal-title":"J R Soc Interface"},{"key":"10.1016\/j.actbio.2013.08.017_b0025","article-title":"Biomarket trends: phalanx of treatments propels burn market: recombinant growth factor therapies are predicted to be up-and-coming players","author":"Carlson","year":"2008","journal-title":"Genet Eng Biotechnol News"},{"key":"10.1016\/j.actbio.2013.08.017_b0030","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0305-4179(01)00019-5","article-title":"Design principles for composition and performance of cultured skin substitutes","volume":"27","author":"Boyce","year":"2001","journal-title":"Burns"},{"key":"10.1016\/j.actbio.2013.08.017_b0035","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0305-4179(98)00176-4","article-title":"Skin substitutes in burns","volume":"25","author":"Sheridan","year":"1999","journal-title":"Burns"},{"key":"10.1016\/j.actbio.2013.08.017_b0040","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.clindermatol.2004.07.023","article-title":"Engineered skin substitutes: practices and potentials","volume":"23","author":"Supp","year":"2005","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.actbio.2013.08.017_b0045","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000178868","article-title":"Skin substitutes and wound healing","volume":"22","author":"Auger","year":"2009","journal-title":"Skin Pharmacol Physiol"},{"key":"10.1016\/j.actbio.2013.08.017_b0050","series-title":"Rook\u2019s textbook of dermatology","author":"Rook","year":"2010"},{"key":"10.1016\/j.actbio.2013.08.017_b0055","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.1016\/j.biomaterials.2012.04.009","article-title":"Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis","volume":"33","author":"Gautrot","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2013.08.017_b0060","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1089\/ten.tea.2009.0542","article-title":"Uniaxial strain regulates morphogenesis, gene expression, and tissue strength in engineered skin","volume":"16","author":"Powell","year":"2010","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2013.08.017_b0065","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/mabi.201200262","article-title":"In vitro 3D full-thickness skin-equivalent tissue model using silk and collagen biomaterials","volume":"12","author":"Bellas","year":"2012","journal-title":"Macromol Biosci"},{"key":"10.1016\/j.actbio.2013.08.017_b0070","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0092-8674(95)90453-0","article-title":"Stem cell patterning and fate in human epidermis","volume":"80","author":"Jones","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2013.08.017_b0075","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1126\/science.7058342","article-title":"Heterogeneity in epidermal basal keratinocytes: morphological and functional correlations","volume":"215","author":"Lavker","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.actbio.2013.08.017_b0080","doi-asserted-by":"crossref","first-page":"121s","DOI":"10.1111\/1523-1747.ep12540880","article-title":"Epidermal stem cells","volume":"81","author":"Lavker","year":"1983","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.actbio.2013.08.017_b0085","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/ar.1091080305","article-title":"The morphology of the attachment between the dermis and the epidermis","volume":"108","author":"Odland","year":"1950","journal-title":"Anat Rec"},{"key":"10.1016\/j.actbio.2013.08.017_b0090","series-title":"Concise histology","author":"Fawcet","year":"1997"},{"key":"10.1016\/j.actbio.2013.08.017_b0095","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1098\/rstb.1998.0247","article-title":"Epidermal stem cells: markers, patterning and the control of stem cell fate","volume":"353","author":"Watt","year":"1998","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.actbio.2013.08.017_b0100","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0923-1811(02)00003-8","article-title":"The stem cell compartment in human interfollicular epidermis","volume":"28","author":"Watt","year":"2002","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.actbio.2013.08.017_b0105","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0959-437X(00)00211-2","article-title":"Stem cell fate and patterning in mammalian epidermis","volume":"11","author":"Watt","year":"2001","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.actbio.2013.08.017_b0110","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.clindermatol.2007.08.005","article-title":"The histopathologic spectrum of psoriasis","volume":"25","author":"Murphy","year":"2007","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.actbio.2013.08.017_b0115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/1523-1747.ep12532761","article-title":"Structural changes in aging human skin","volume":"73","author":"Montagna","year":"1979","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.actbio.2013.08.017_b0120","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/jid.2008.265","article-title":"Cadherin-mediated cell\u2013cell contact regulates keratinocyte differentiation","volume":"129","author":"Charest","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.actbio.2013.08.017_b0125","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nmat3339","article-title":"Extracellular-matrix tethering regulates stem-cell fate","volume":"11","author":"Trappmann","year":"2012","journal-title":"Nat Mater"},{"key":"10.1016\/j.actbio.2013.08.017_b0130","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nmeth.1732","article-title":"Artificial niche microarrays for probing single stem cell fate in high throughput","volume":"8","author":"Gobaa","year":"2011","journal-title":"Nat Methods"},{"key":"10.1016\/j.actbio.2013.08.017_b0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/scrt44","article-title":"Engineering a stem cell house into a home","volume":"2","author":"Gilbert","year":"2011","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.actbio.2013.08.017_b0140","series-title":"Regenerative medicine and cell therapy","first-page":"57","article-title":"Keratinocyte stem cells: biology and clinical applications","author":"Pincelli","year":"2013"},{"key":"10.1016\/j.actbio.2013.08.017_b0145","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/mabi.201100443","article-title":"Construction of a microstructured collagen membrane mimicking the papillary dermis architecture and guiding keratinocyte morphology and gene expression","volume":"12","author":"Lammers","year":"2012","journal-title":"Macromol Biosci"},{"key":"10.1016\/j.actbio.2013.08.017_b0150","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1089\/ten.tea.2011.0479","article-title":"Development of microfabricated dermal epidermal regenerative matrices to evaluate the role of cellular microenvironments on epidermal morphogenesis","volume":"18","author":"Bush","year":"2012","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2013.08.017_b0155","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/jbm.a.30210","article-title":"The influence of microtextured basal lamina analog topography on keratinocyte function and epidermal organization","volume":"72","author":"Downing","year":"2005","journal-title":"J Biomed Mater Res Part A"},{"key":"10.1016\/j.actbio.2013.08.017_b0160","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1083\/jcb.54.3.626","article-title":"Collagen substrata for studies on cell behavior","volume":"54","author":"Elsdale","year":"1972","journal-title":"J Cell Biol"},{"key":"10.1016\/j.actbio.2013.08.017_b0165","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jbm.a.30132","article-title":"Characterizing fibroblast migration on discrete collagen threads for applications in tissue regeneration","volume":"71","author":"Cornwell","year":"2004","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.actbio.2013.08.017_b0170","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1023\/A:1016350316926","article-title":"Immunohistochemical distribution of laminin-5 gamma2 chain and its developmental change in human embryonic and foetal tissues","volume":"33","author":"Lu","year":"2001","journal-title":"Histochem J"},{"key":"10.1016\/j.actbio.2013.08.017_b0175","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/sj.onc.1209918","article-title":"Basement membrane component laminin-5 is a target of the tumor suppressor Smad4","volume":"26","author":"Zapatka","year":"2007","journal-title":"Oncogene"},{"issue":"Pt 12","key":"10.1016\/j.actbio.2013.08.017_b0180","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1242\/jcs.112.12.1843","article-title":"Keratinocyte growth regulation in fibroblast cocultures via a double paracrine mechanism","volume":"112","author":"Maas-Szabowski","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1016\/j.actbio.2013.08.017_b0185","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0092-8674(00)00178-1","article-title":"C-Jun and JunB antagonistically control cytokine-regulated mesenchymal\u2013epidermal interaction in skin","volume":"103","author":"Szabowski","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2013.08.017_b0190","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0962-8924(01)01955-9","article-title":"Paracrine regulation of keratinocyte proliferation and differentiation","volume":"11","author":"Werner","year":"2001","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.actbio.2013.08.017_b0195","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/labinvest.3700014","article-title":"Fibroblasts facilitate re-epithelialization in wounded human skin equivalents","volume":"84","author":"El Ghalbzouri","year":"2004","journal-title":"Lab Invest"},{"key":"10.1016\/j.actbio.2013.08.017_b0200","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/1523-1747.ep12491522","article-title":"In vitro reconstitution of skin: fibroblasts facilitate keratinocyte growth and differentiation on acellular reticular dermis","volume":"97","author":"Krejci","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.actbio.2013.08.017_b0205","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.burns.2003.12.007","article-title":"Fibroblasts improve performance of cultured composite skin substitutes on athymic mice","volume":"30","author":"Erdag","year":"2004","journal-title":"Burns"},{"key":"10.1016\/j.actbio.2013.08.017_b0210","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00441-002-0621-0","article-title":"Crucial role of fibroblasts in regulating epidermal morphogenesis","volume":"310","author":"El Ghalbzouri","year":"2002","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.actbio.2013.08.017_b0215","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1046\/j.1365-2133.2002.04871.x","article-title":"Effect of fibroblasts on epidermal regeneration","volume":"147","author":"el-Ghalbzouri","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.actbio.2013.08.017_b0220","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1083\/jcb.122.2.417","article-title":"Mutual induction of growth factor gene expression by epidermal\u2013dermal cell interaction","volume":"122","author":"Smola","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/j.actbio.2013.08.017_b0225","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.0022-202X.2004.23549.x","article-title":"Basement membrane reconstruction in human skin equivalents is regulated by fibroblasts and\/or exogenously activated keratinocytes","volume":"124","author":"El Ghalbzouri","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.actbio.2013.08.017_b0230","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/sj.jid.5700230","article-title":"Interactions between fibroblasts and keratinocytes in morphogenesis of dermal epidermal junction in a model of reconstructed skin","volume":"126","author":"Marionnet","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.actbio.2013.08.017_b0235","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.matbio.2005.05.006","article-title":"A simplified laminin nomenclature","volume":"24","author":"Aumailley","year":"2005","journal-title":"Matrix Biol"},{"key":"10.1016\/j.actbio.2013.08.017_b0240","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0955-0674(97)80118-4","article-title":"The dermal\u2013epidermal junction","volume":"9","author":"Burgeson","year":"1997","journal-title":"Curr Opin Cell Biol"},{"issue":"Pt 10","key":"10.1016\/j.actbio.2013.08.017_b0245","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1242\/jcs.109.10.2509","article-title":"Laminin-5 and hemidesmosomes: role of the alpha 3 chain subunit in hemidesmosome stability and assembly","volume":"109","author":"Baker","year":"1996","journal-title":"J Cell Sci"},{"key":"10.1016\/j.actbio.2013.08.017_b0250","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1349-7006.2006.00150.x","article-title":"Laminin-5 (laminin-332): unique biological activity and role in tumor growth and invasion","volume":"97","author":"Miyazaki","year":"2006","journal-title":"Cancer Sci"},{"key":"10.1016\/j.actbio.2013.08.017_b0255","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1067\/mjd.2000.106369","article-title":"Revised classification system for inherited epidermolysis bullosa: report of the second international consensus meeting on diagnosis and classification of epidermolysis bullosa","volume":"42","author":"Fine","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.actbio.2013.08.017_b0260","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1046\/j.1523-1747.2003.12515.x","article-title":"Targeted inactivation of murine laminin gamma2-chain gene recapitulates human junctional epidermolysis bullosa","volume":"121","author":"Meng","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.actbio.2013.08.017_b0265","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0955-0674(00)00131-9","article-title":"Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion","volume":"12","author":"Nguyen","year":"2000","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.actbio.2013.08.017_b0270","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1365-2133.2004.06175.x","article-title":"Increase of laminin 5 synthesis in human keratinocytes by acute wound fluid, inflammatory cytokines and growth factors, and lysophospholipids","volume":"151","author":"Amano","year":"2004","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.actbio.2013.08.017_b0275","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.yexcr.2004.10.033","article-title":"Cellular and molecular facets of keratinocyte reepithelization during wound healing","volume":"304","author":"Santoro","year":"2005","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.actbio.2013.08.017_b0280","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1038\/sj.jid.5700874","article-title":"Upregulation of hypoxia-inducible factors in normal and psoriatic skin","volume":"127","author":"Rosenberger","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.actbio.2013.08.017_b0285","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1172\/JCI119837","article-title":"Hypoxia increases human keratinocyte motility on connective tissue","volume":"100","author":"O\u2019Toole","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.actbio.2013.08.017_b0290","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1098\/rsif.2008.0064","article-title":"The effect of geometry on three-dimensional tissue growth","volume":"5","author":"Rumpler","year":"2008","journal-title":"J R Soc Interface"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706113004091?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706113004091?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T01:43:00Z","timestamp":1646358180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706113004091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":56,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S1742706113004091"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2013.08.017","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Micropatterned dermal\u2013epidermal regeneration matrices create functional niches that enhance epidermal morphogenesis","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2013.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}