{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:11:53Z","timestamp":1791313913036,"version":"4.3.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011929","name":"Programa Operacional Tem\u00e1tico Factores de Competitividade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PEst-C\/EQB\/UI0102\/2011"],"award-info":[{"award-number":["PEst-C\/EQB\/UI0102\/2011"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PEst-C\/SAU\/LA0001\/2013-2014"],"award-info":[{"award-number":["PEst-C\/SAU\/LA0001\/2013-2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU FAR\/121109\/2010"],"award-info":[{"award-number":["PTDC\/SAU FAR\/121109\/2010"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU-MII\/098567\/2008"],"award-info":[{"award-number":["PTDC\/SAU-MII\/098567\/2008"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.actbio.2013.09.040","type":"journal-article","created":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T09:13:01Z","timestamp":1381396381000},"page":"843-857","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":148,"title":["Chitosan-based dressings loaded with neurotensin\u2014an efficient strategy to improve early diabetic wound healing"],"prefix":"10.1016","volume":"10","author":[{"given":"Liane I.F.","family":"Moura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.A.","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermelindo C.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herm\u00ednio C.","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eug\u00e9nia","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2013.09.040_b0005","doi-asserted-by":"crossref","first-page":"7093","DOI":"10.1016\/j.actbio.2013.03.033","article-title":"Recent advances on the development of wound dressings for diabetic foot ulcer treatment \u2013 a review","volume":"9","author":"Moura","year":"2013","journal-title":"Acta Biomaterialia"},{"key":"10.1016\/j.actbio.2013.09.040_b0010","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/1877382601003020043","article-title":"Inflammatory and angiogenic abnormalities in diabetic wound healing: role of neuropeptides and therapeutic perspectives","volume":"3","author":"Tellechea","year":"2010","journal-title":"Open Circ Vasc J"},{"key":"10.1016\/j.actbio.2013.09.040_b0015","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1517\/14712598.2010.515207","article-title":"Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing","volume":"10","author":"Silva","year":"2010","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.actbio.2013.09.040_b0020","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1017\/S1462399409000945","article-title":"Inflammation and neuropeptides: the connection in diabetic wound healing","volume":"11","author":"Pradhan","year":"2009","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.actbio.2013.09.040_b0025","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0028-3908(77)90033-8","article-title":"Distribution, localization and characteristics of neurotensin binding sites in the rat brain","volume":"16","author":"Lazarus","year":"1977","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.actbio.2013.09.040_b0030","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF00218696","article-title":"Immunohistochemical localization of neurotensin in endocrine cells of the gut","volume":"178","author":"Sundler","year":"1977","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.actbio.2013.09.040_b0035","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0162-3109(97)00055-6","article-title":"Sensory neuropeptides: their role in inflammation and wound healing","volume":"37","author":"Brain","year":"1997","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.actbio.2013.09.040_b0040","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.regpep.2011.04.005","article-title":"Contribution of neurotensin in the immune and neuroendocrine modulation of normal and abnormal enteric function","volume":"170","author":"Kalafatakis","year":"2011","journal-title":"Regul Pept"},{"key":"10.1016\/j.actbio.2013.09.040_b0045","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1524-475X.2008.00400.x","article-title":"Topical substance P increases inflammatory cell density in genetically diabetic murine wounds","volume":"16","author":"Scott","year":"2008","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.actbio.2013.09.040_b0050","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jss.2009.09.012","article-title":"Gene expression of pro-inflammatory cytokines and neuropeptides in diabetic wound healing","volume":"167","author":"Pradhan","year":"2011","journal-title":"J Surg Res"},{"key":"10.1016\/j.actbio.2013.09.040_b0055","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/0145721706286897","article-title":"What is the future of diabetic wound care?","volume":"32","author":"Sweitzer","year":"2006","journal-title":"Diabetes Educ"},{"key":"10.1016\/j.actbio.2013.09.040_b0060","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.addr.2007.03.012","article-title":"Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications","volume":"59","author":"Malafaya","year":"2007","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.actbio.2013.09.040_b0065","first-page":"522","article-title":"The use of natural polymers in tissue engineering: a focus on electrospun extracellular matrix analogues","volume":"2","author":"Sell","year":"2010","journal-title":"Polym Adv Technol"},{"key":"10.1016\/j.actbio.2013.09.040_b0070","first-page":"603","article-title":"Chitin and chitosan: properties and applications","volume":"31","author":"Rinaudo","year":"2006","journal-title":"Polym Adv Technol"},{"key":"10.1016\/j.actbio.2013.09.040_b0075","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/j.actbio.2009.03.002","article-title":"Accelerated wound closure of pressure ulcers in aged mice by chitosan scaffolds with and without bFGF","volume":"5","author":"Park","year":"2009","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2013.09.040_b0080","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jconrel.2009.10.018","article-title":"Naturally derived materials-based cell and drug delivery systems in skin regeneration","volume":"142","author":"Huang","year":"2010","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.actbio.2013.09.040_b0085","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1586\/eri.11.59","article-title":"Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects","volume":"9","author":"Dai","year":"2011","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.actbio.2013.09.040_b0090","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.actbio.2011.10.005","article-title":"Synthesis of a chitosan derivative soluble at neutral pH and gellable by freeze-thawing, and its application in wound care","volume":"8","author":"Takei","year":"2012","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2013.09.040_b0095","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0142-9612(94)90209-7","article-title":"Incorporation of basic fibroblast growth factor into methylpyrrolidinone chitosan fleeces and determination of the in vitro release characteristics","volume":"15","author":"Berscht","year":"1994","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2013.09.040_b0100","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/bdd.590","article-title":"A novel pH sensitive N-succinyl chitosan\/alginate hydrogel bead for nifedipine delivery","volume":"29","author":"Dai","year":"2008","journal-title":"Biopharm Drug Dispos"},{"key":"10.1016\/j.actbio.2013.09.040_b0105","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.carbpol.2011.01.036","article-title":"Carboxymethyl chitosan prevents formation of broad-spectrum biofilm","volume":"84","author":"Tan","year":"2011","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.actbio.2013.09.040_b0110","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1016\/S0142-9612(02)00207-7","article-title":"The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts","volume":"23","author":"Chen","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2013.09.040_b0115","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/0885328208091562","article-title":"Review paper: chitosan derivatives as promising materials for controlled drug delivery","volume":"23","author":"Prabaharan","year":"2008","journal-title":"J Biomater Appl"},{"key":"10.1016\/j.actbio.2013.09.040_b0120","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0144-8617(93)90084-H","article-title":"Preparation and characteristic properties of 5-methyl pyrrolidinone chitosan","volume":"20","author":"Muzzarelli","year":"1993","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.actbio.2013.09.040_b0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.carbpol.2004.08.020","article-title":"32Factorial design and response surface analysis optimization of N-carboxybutylchitosan synthesis","volume":"59","author":"Santos","year":"2005","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.actbio.2013.09.040_b0130","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.supflu.2012.12.007","article-title":"Wound dressings loaded with an anti-inflammatory juc\u00e1 (Libidibia ferrea) extract using supercritical carbon dioxide technology","volume":"74","author":"Dias","year":"2013","journal-title":"J Supercrit Fluids"},{"key":"10.1016\/j.actbio.2013.09.040_b0135","doi-asserted-by":"crossref","first-page":"G621","DOI":"10.1152\/ajpgi.00140.2004","article-title":"Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation","volume":"288","author":"Brun","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.actbio.2013.09.040_b0140","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/j.bbamcr.2011.06.018","article-title":"Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression","volume":"1813","author":"da Silva","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.actbio.2013.09.040_b0145","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1067-1927.2005.130406.x","article-title":"Acceleration of wound healing in healing-impaired db\/db mice with a photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2","volume":"13","author":"Obara","year":"2005","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.actbio.2013.09.040_b0150","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/10837450701366903","article-title":"Wound dressings based on chitosans and hyaluronic acid for the release of chlorhexidine diacetate in skin ulcer therapy","volume":"12","author":"Rossi","year":"2007","journal-title":"Pharm Dev Technol"},{"key":"10.1016\/j.actbio.2013.09.040_b0155","first-page":"25","article-title":"Preparation and biocompatibility of N-carboxymethyl chitosan","volume":"7","author":"Huang","year":"2009","journal-title":"J Funct Mater"},{"key":"10.1016\/j.actbio.2013.09.040_b0160","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1006\/bbrc.2000.2602","article-title":"Chitinous materials inhibit nitric oxide production by activated RAW 264.7 macrophages","volume":"271","author":"Hwang","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.actbio.2013.09.040_b0165","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.carbpol.2010.07.013","article-title":"A green fabrication approach of gelatin\/CM-chitosan hybrid hydrogel for wound healing","volume":"82","author":"Yang","year":"2010","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.actbio.2013.09.040_b0170","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1021\/bm050754b","article-title":"Development of a new N-O-(carboxymethyl)\/chitosan\/collagen matrixes as a wound dressing","volume":"7","author":"Chen","year":"2006","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2013.09.040_b0175","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0144-8617(92)90051-Q","article-title":"Depolymerization of methyl pyrrolidinone chitosan by lysozyme","volume":"19","author":"Muzzarelli","year":"1992","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.actbio.2013.09.040_b0180","first-page":"31","article-title":"Basic science of wound healing","volume":"26","author":"Enoch","year":"2008","journal-title":"Surgery"},{"issue":"Suppl.","key":"10.1016\/j.actbio.2013.09.040_b0185","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1007\/PL00007448","article-title":"Animal models for wound repair","volume":"290","author":"Davidson","year":"1998","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.actbio.2013.09.040_b0190","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0378-5173(92)90353-4","article-title":"In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers","volume":"78","author":"Lehr","year":"1992","journal-title":"Int J Pharm"},{"key":"10.1016\/j.actbio.2013.09.040_b0195","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/(SICI)1097-4636(1999)48:5<621::AID-JBM5>3.0.CO;2-1","article-title":"Effect of a collagen matrix containing basic fibroblast growth factor on wound contraction","volume":"48","author":"Ono","year":"1999","journal-title":"J Biomed Mater Res Appl Biomater"},{"key":"10.1016\/j.actbio.2013.09.040_b0200","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1046\/j.1524-475x.2001.00513.x","article-title":"Acceleration of wound contraction and healing with a photocrosslinkable chitosan hydrogel","volume":"9","author":"Ishihara","year":"2001","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.actbio.2013.09.040_b0205","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1743-6109.2006.00155.x","article-title":"Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers","volume":"14","author":"Galkowska","year":"2006","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.actbio.2013.09.040_b0210","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/S0002-9440(10)63597-3","article-title":"HoxD3 accelerates wound healing in diabetic mice","volume":"163","author":"Hansen","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.actbio.2013.09.040_b0215","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00403-008-0893-7","article-title":"TNF-alpha production in the skin","volume":"301","author":"Bashir","year":"2009","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.actbio.2013.09.040_b0220","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1189\/jlb.0802397","article-title":"Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6 deficient mice","volume":"73","author":"Lin","year":"2003","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.actbio.2013.09.040_b0225","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/path.1427","article-title":"The myofibroblast in wound healing and fibrocontractive diseases","volume":"200","author":"Gabbiani","year":"2003","journal-title":"J Pathol"},{"key":"10.1016\/j.actbio.2013.09.040_b0230","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2741\/1184","article-title":"Wound healing: an overview of acute, fibrotic and delayed healing","volume":"9","author":"Diegelmann","year":"2004","journal-title":"Front Biosci"},{"key":"10.1016\/j.actbio.2013.09.040_b0235","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM199909023411006","article-title":"Cutaneous wound healing","volume":"341","author":"Singer","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.actbio.2013.09.040_b0240","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/1534734609337151","article-title":"Altered molecular mechanisms of diabetic foot ulcers","volume":"8","author":"Blakytny","year":"2009","journal-title":"Int J Low Extrem Wounds"},{"key":"10.1016\/j.actbio.2013.09.040_b0245","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1524-475X.2010.00597.x","article-title":"Monitoring the healing of combat wounds using Raman spectroscopic mapping","volume":"18","author":"Crane","year":"2010","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.actbio.2013.09.040_b0250","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cellsig.2004.02.007","article-title":"TGF-beta and TNF-alpha: antagonistic cytokines controlling type I collagen gene expression","volume":"16","author":"Verrecchia","year":"2004","journal-title":"Cell Signal"},{"key":"10.1016\/j.actbio.2013.09.040_b0255","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1001\/archsurg.138.1.34","article-title":"Decrease of collagen deposition in wound repair in type 1 diabetes independent of glycemic control","volume":"138","author":"Black","year":"2003","journal-title":"Arch Surg"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706113005047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706113005047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:39:57Z","timestamp":1761669597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706113005047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S1742706113005047"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2013.09.040","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chitosan-based dressings loaded with neurotensin\u2014an efficient strategy to improve early diabetic wound healing","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2013.09.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}