{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:36:36Z","timestamp":1790015796627,"version":"4.0.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.actbio.2013.10.030","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T21:33:31Z","timestamp":1383687211000},"page":"996-1004","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Biodegradation of metallic magnesium elicits an inflammatory response in primary nasal epithelial cells"],"prefix":"10.1016","volume":"10","author":[{"given":"S.","family":"Schumacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"B\u00e4umer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kietzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2013.10.030_b0005","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.biomaterials.2008.10.021","article-title":"In vitro corrosion and biocompatibility of binary magnesium alloys","volume":"30","author":"Gu","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2013.10.030_b0010","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.biomaterials.2005.10.003","article-title":"Magnesium and its alloys as orthopedic biomaterials: a review","volume":"27","author":"Staiger","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2013.10.030_b0015","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1016\/j.biomaterials.2004.09.049","article-title":"In vivo corrosion of four magnesium alloys and the associated bone response","volume":"26","author":"Witte","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2013.10.030_b0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10853-012-6572-2","article-title":"Biodegradable magnesium implants for orthopedic applications","volume":"48","author":"Waizy","year":"2013","journal-title":"J Mater Sci"},{"key":"10.1016\/j.actbio.2013.10.030_b0025","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.actbio.2010.02.027","article-title":"Assessing the biocompatibility of degradable metallic materials: state-of-the-art and focus on the potential of genetic regulation","volume":"6","author":"Purnama","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2013.10.030_b0030","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.actbio.2009.06.028","article-title":"Research on an Mg\u2013n alloy as a degradable biomaterial","volume":"6","author":"Zhang","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2013.10.030_b0035","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.corsci.2007.01.001","article-title":"Control of biodegradation of biocompatable magnesium alloys","volume":"49","author":"Song","year":"2007","journal-title":"Corros Sci"},{"key":"10.1016\/j.actbio.2013.10.030_b0040","doi-asserted-by":"crossref","first-page":"8548","DOI":"10.1016\/j.actbio.2012.08.028","article-title":"Long-term in vivo degradation behaviour and biocompatibility of the magnesium alloy ZEK100 for use as a biodegradable bone implant","volume":"9","author":"Dziuba","year":"2013","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2013.10.030_b0045","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1016\/j.actbio.2012.05.024","article-title":"Characterization of MgNd2 alloy for potential applications in bioresorbable implantable devices","volume":"8","author":"Seitz","year":"2012","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2013.10.030_b0050","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/026119291103900312","article-title":"The use of an in vitro-cultured porcine nasal mucosa model for the biocompatibility assessment of biodegradable magnesium","volume":"39","author":"Schumacher","year":"2011","journal-title":"Altern Lab Anim"},{"key":"10.1016\/j.actbio.2013.10.030_b0055","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1017\/S0022215110001052","article-title":"Long-term stenting for chronic frontal sinus disease: case series and literature review","volume":"124","author":"Hunter","year":"2010","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.actbio.2013.10.030_b0060","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/194589240401800607","article-title":"Evidence of bacterial biofilms on frontal recess stents in patients with chronic rhinosinusitis","volume":"18","author":"Perloff","year":"2004","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.actbio.2013.10.030_b0065","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00106-008-1752-8","article-title":"Endonasal frontal sinus surgery. Part 2: frontal sinus drainage type III (median drainage), tips and tricks, postoperative care","volume":"57","author":"Weber","year":"2009","journal-title":"HNO"},{"key":"10.1016\/j.actbio.2013.10.030_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0009-8981(99)00258-2","article-title":"Magnesium. An update on physiological, clinical and analytical aspects","volume":"294","author":"Saris","year":"2000","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.actbio.2013.10.030_b0075","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/bies.20183","article-title":"Magnesium: the missing element in molecular views of cell proliferation control","volume":"27","author":"Rubin","year":"2005","journal-title":"BioEssays"},{"key":"10.1016\/j.actbio.2013.10.030_b0080","doi-asserted-by":"crossref","first-page":"34","DOI":"10.5301\/IJAO.2011.6332","article-title":"Ex vivo examination of the biocompatibility of biodegradable magnesium via microdialysis in the isolated perfused bovine udder model","volume":"34","author":"Schumacher","year":"2011","journal-title":"Int J Artif Organs"},{"key":"10.1016\/j.actbio.2013.10.030_b0085","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cryobiol.2009.07.012","article-title":"Ciliogenesis in cryopreserved mammalian tracheal epithelial cells cultured at the air\u2013liquid interface","volume":"59","author":"Mao","year":"2009","journal-title":"Cryobiology"},{"key":"10.1016\/j.actbio.2013.10.030_b0090","series-title":"Methods of enzymatic analysis","first-page":"774","article-title":"Pyruvate kinase","author":"Gutmann","year":"1974"},{"key":"10.1016\/j.actbio.2013.10.030_b0095","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1242\/jcs.74.1.283","article-title":"Morphological changes in rat tracheal cells during the adaptive and early growth phase in primary cell culture","volume":"74","author":"Chang","year":"1985","journal-title":"J Cell Sci"},{"key":"10.1016\/j.actbio.2013.10.030_b0100","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/019021401300317125","article-title":"Cellular and molecular characteristics of basal cells in airway epithelium","volume":"27","author":"Evans","year":"2001","journal-title":"Exp Lung Res"},{"key":"10.1016\/j.actbio.2013.10.030_b0105","first-page":"706","article-title":"The differentiation potential of tracheal basal cells","volume":"58","author":"Inayama","year":"1988","journal-title":"Lab Invest"},{"key":"10.1016\/j.actbio.2013.10.030_b0110","first-page":"9","article-title":"New interests in magnesium","volume":"17","author":"Williams","year":"2006","journal-title":"Med Device Technol"},{"key":"10.1016\/j.actbio.2013.10.030_b0115","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.surfcoat.2004.01.004","article-title":"Evaluation of cyto-toxicity and corrosion behavior of alkali-heat-treated magnesium in simulated body fluid","volume":"185","author":"Li","year":"2004","journal-title":"Surf Coat Technol"},{"key":"10.1016\/j.actbio.2013.10.030_b0120","doi-asserted-by":"crossref","first-page":"045005","DOI":"10.1088\/1748-6041\/5\/4\/045005","article-title":"Effects of magnesium alloys extracts on adult human bone marrow-derived stromal cell viability and osteogenic differentiation","volume":"5","author":"Yang","year":"2010","journal-title":"Biomed Mater"},{"key":"10.1016\/j.actbio.2013.10.030_b0125","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s10856-008-3669-x","article-title":"The preparation, cytocompatibility, and in vitro biodegradation study of pure beta-TCP on magnesium","volume":"20","author":"Geng","year":"2009","journal-title":"J Mater Sci - Mater Med"},{"key":"10.1016\/j.actbio.2013.10.030_b0130","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/j.actbio.2009.04.018","article-title":"Effect of surface pre-treatments on biocompatibility of magnesium","volume":"5","author":"Lorenz","year":"2009","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2013.10.030_b0135","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.actbio.2009.10.020","article-title":"Interference of magnesium corrosion with tetrazolium based cytotoxicity assays","volume":"6","author":"Fischer","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2013.10.030_b0140","doi-asserted-by":"crossref","first-page":"e10202","DOI":"10.1371\/journal.pone.0010202","article-title":"Limitations of MTT and MTS-based assays for measurement of antiproliferative activity of green tea polyphenols","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2013.10.030_b0145","unstructured":"Lodish H, Berk A, Kaiser CA, Krieger M, Bretscher A, Ploegh H, Amon A et al. Cellular energetics. In: Molecular cell biology \u2013 international edition, 7th ed. Basingstoke: Macmillan Higher Education; 2012. p. 517\u201376."},{"key":"10.1016\/j.actbio.2013.10.030_b0150","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1006\/abbi.1993.1311","article-title":"Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction","volume":"303","author":"Berridge","year":"1993","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.actbio.2013.10.030_b0155","doi-asserted-by":"crossref","first-page":"12849","DOI":"10.1021\/bi960139f","article-title":"Mg2+ control of respiration in isolated rat liver mitochondria","volume":"35","author":"Panov","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.actbio.2013.10.030_b0160","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.mseb.2011.04.008","article-title":"Improved cytotoxicity testing of magnesium materials","volume":"176","author":"Fischer","year":"2011","journal-title":"Mater Sci Eng B: Adv Funct Solid-State Mater"},{"key":"10.1016\/j.actbio.2013.10.030_b0165","doi-asserted-by":"crossref","first-page":"e241","DOI":"10.1111\/j.1600-0625.2010.01071.x","article-title":"K16 is a further new candidate for homotypic intermediate filament protein interactions","volume":"19","author":"Trost","year":"2010","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.actbio.2013.10.030_b0170","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0092-8674(82)90234-3","article-title":"Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies","volume":"30","author":"Tseng","year":"1982","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2013.10.030_b0175","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/jbm.a.32235","article-title":"Rare earth metals used in biodegradable magnesium-based stents do not interfere with proliferation of smooth muscle cells but do induce the upregulation of inflammatory genes","volume":"91","author":"Drynda","year":"2009","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.actbio.2013.10.030_b0180","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/jbm.10106","article-title":"Concentration- and composition-dependent effects of metal ions on human MG-63 osteoblasts","volume":"60","author":"Hallab","year":"2002","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2013.10.030_b0185","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/sj.ejcn.1601689","article-title":"Possible roles of magnesium on the immune system","volume":"57","author":"Tam","year":"2003","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.actbio.2013.10.030_b0190","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1684\/mrh.2009.0168","article-title":"High-magnesium concentration and cytokine production in human whole blood model","volume":"22","author":"Nowacki","year":"2009","journal-title":"Magnes Res"},{"key":"10.1016\/j.actbio.2013.10.030_b0195","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jri.2006.06.004","article-title":"Magnesium sulfate suppresses inflammatory responses by human umbilical vein endothelial cells (HuVECs) through the NFkappaB pathway","volume":"73","author":"Rochelson","year":"2007","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.actbio.2013.10.030_b0200","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.exer.2012.12.001","article-title":"Betaine stabilizes cell volume and protects against apoptosis in human corneal epithelial cells under hyperosmotic stress","volume":"108","author":"Garrett","year":"2013","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.actbio.2013.10.030_b0205","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.biochi.2004.07.009","article-title":"Osmotic stress, a proinflammatory signal in Caco-2 cells","volume":"86","author":"Hubert","year":"2004","journal-title":"Biochimie"},{"key":"10.1016\/j.actbio.2013.10.030_b0210","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.it.2009.12.009","article-title":"The immunobiology of aluminium adjuvants: how do they really work?","volume":"31","author":"Exley","year":"2010","journal-title":"Trends Immunol"},{"key":"10.1016\/j.actbio.2013.10.030_b0215","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1006\/bbrc.2001.5465","article-title":"Isolation of normal epithelial cells adapted to grow at nonphysiological concentration of magnesium","volume":"286","author":"Sgambato","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.actbio.2013.10.030_b0220","doi-asserted-by":"crossref","first-page":"15998","DOI":"10.1074\/jbc.M110.205724","article-title":"Down-regulation of cytokine-induced interleukin-8 requires inhibition of p38 mitogen-activated protein kinase (MAPK) via MAPK phosphatase 1-dependent and -independent mechanisms","volume":"286","author":"Dauletbaev","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.actbio.2013.10.030_b0225","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1136\/thx.53.4.260","article-title":"Induction of IL-8 production in human alveolar macrophages and human bronchial epithelial cells in vitro by swine dust","volume":"53","author":"Palmberg","year":"1998","journal-title":"Thorax"},{"key":"10.1016\/j.actbio.2013.10.030_b0230","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1475-925X-9-63","article-title":"Evaluation of the soft tissue biocompatibility of MgCa0.8 and surgical steel 316L in vivo: a comparative study in rabbits","volume":"9","author":"Erdmann","year":"2010","journal-title":"Biomed Eng Online"},{"key":"10.1016\/j.actbio.2013.10.030_b0235","doi-asserted-by":"crossref","unstructured":"Freshney RI. Biology of cultured cells. In: Freshney RI, editor. Culture of Animal Cells. Hoboken, NJ: John Wiley & Sons; 2010. p. 11\u201323.","DOI":"10.1002\/9780470649367"},{"key":"10.1016\/j.actbio.2013.10.030_b0240","doi-asserted-by":"crossref","first-page":"G736","DOI":"10.1152\/ajpgi.00453.2003","article-title":"Dual role of MEK\/ERK signaling in senescence and transformation of intestinal epithelial cells","volume":"286","author":"Boucher","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.actbio.2013.10.030_b0245","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","article-title":"Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation","volume":"80","author":"Marshall","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2013.10.030_b0250","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1023\/A:1016022730880","article-title":"Structural and catalytic chemistry of magnesium-dependent enzymes","volume":"15","author":"Cowan","year":"2002","journal-title":"Biometals"},{"key":"10.1016\/j.actbio.2013.10.030_b0255","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1042\/CS20070129","article-title":"Cell (patho)physiology of magnesium","volume":"114","author":"Wolf","year":"2008","journal-title":"Clin Sci"},{"key":"10.1016\/j.actbio.2013.10.030_b0260","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.biomaterials.2007.12.021","article-title":"The development of binary Mg\u2013Ca alloys for use as biodegradable materials within bone","volume":"29","author":"Li","year":"2008","journal-title":"Biomaterials"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706113005473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706113005473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T16:28:38Z","timestamp":1647016118000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706113005473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S1742706113005473"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2013.10.030","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biodegradation of metallic magnesium elicits an inflammatory response in primary nasal epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2013.10.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}