{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:59:59Z","timestamp":1791190799157,"version":"4.1.0"},"reference-count":166,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.actbio.2014.01.004","type":"journal-article","created":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T04:01:46Z","timestamp":1389412906000},"page":"1793-1805","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":131,"title":["The relevance of biomaterials to the prevention and treatment of osteoporosis"],"prefix":"10.1016","volume":"10","author":[{"given":"D.","family":"Arcos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.R.","family":"Boccaccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bohner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"D\u00edez-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Epple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"G\u00f3mez-Barrena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Planell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Rodr\u00edguez-Ma\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vallet-Reg\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2014.01.004_b0005","series-title":"Bone repair biomaterials","article-title":"Challenges of bone repair","author":"Planell","year":"2009"},{"key":"10.1016\/j.actbio.2014.01.004_b0010","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1007\/s11999-010-1530-2","article-title":"Mortality after distal femur fractures in elderly patients","volume":"469","author":"Streubel","year":"2011","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0015","unstructured":"National Osteoporosis Foundation. http:\/\/www.nof.org."},{"key":"10.1016\/j.actbio.2014.01.004_b0020","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1089\/jwh.1.1999.8.1077","article-title":"Healthcare use among U.S. women aged 45 and older: total costs and costs for selected postmenopausal health risks","volume":"8","author":"Hoerger","year":"2007","journal-title":"J Womens Health Gend Based Med"},{"key":"10.1016\/j.actbio.2014.01.004_b0025","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1017\/S0266462300010059","article-title":"Costs and cost-effectiveness in hip and knee replacements: a prospective study","volume":"13","author":"Rissanen","year":"1997","journal-title":"Int J Technol Assess Health Care"},{"key":"10.1016\/j.actbio.2014.01.004_b0030","unstructured":"Day JC. Population projections of the United States by age, sex, race and Hispanic origin: 1995 to 2050. Washington, DC: US Government Printing Office; 1996."},{"key":"10.1016\/j.actbio.2014.01.004_b0035","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1359\/jbmr.1997.12.1.24","article-title":"Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation","volume":"12","author":"Ray","year":"1997","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0040","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/8756-3282(94)90813-3","article-title":"Costs and health effects of osteoporotic fractures","volume":"15","author":"Chrischilles","year":"1994","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2014.01.004_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/8756-3282(93)90341-7","article-title":"Hip fractures: a worldwide problem today and tomorrow","volume":"14","author":"Melton","year":"1993","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2014.01.004_b0050","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00198-004-1811-2","article-title":"Requirements for DXA for the management of osteoporosis in Europe","volume":"16","author":"Kanis","year":"2005","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2014.01.004_b0055","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.1073\/pnas.111152298","article-title":"Changes in the prevalence of chronic disability in the United States black and nonblack population above age 65 from 1982 to 1999","volume":"98","author":"Manton","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.actbio.2014.01.004_b0060","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1111\/j.1532-5415.2008.02023.x","article-title":"Recovery of activities of daily living in older adults after hospitalization for acute medical illness","volume":"56","author":"Boyd","year":"2008","journal-title":"J Am Geriatr Soc."},{"key":"10.1016\/j.actbio.2014.01.004_b0065","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly people","volume":"381","author":"Clegg","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.actbio.2014.01.004_b0070","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.actbio.2014.01.004_b0075","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/gerona\/gls119","article-title":"Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition-consensus conference project","volume":"68","author":"Rodr\u00edguez-Ma\u00f1as","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.actbio.2014.01.004_b0080","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/gerona\/62.11.1237","article-title":"Designing clinical trials of interventions for mobility disability: results from the lifestyle interventions and independence for elders pilot (LIFE-P) trial","volume":"62","author":"Espeland","year":"2007","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.actbio.2014.01.004_b0085","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1359\/jbmr.2002.17.4.716","article-title":"Incidence of vertebral fracture in europe: results from the European Prospective Osteoporosis Study (EPOS)","volume":"17","author":"Felsenberg","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0090","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11657-011-0063-y","article-title":"Epidemiological burden of postmenopausal osteoporosis in the UK from 2010 to 2021: estimations from a disease model","volume":"6","author":"Gauthier","year":"2011","journal-title":"Arch Osteoporos"},{"key":"10.1016\/j.actbio.2014.01.004_b0095","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1056\/NEJMra053077","article-title":"Bone quality\u2014the material and structural basis of bone strength and fragility","volume":"354","author":"Seeman","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.actbio.2014.01.004_b0100","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1001\/jama.252.6.799","article-title":"Consensus conference. Osteoporosis","volume":"252","year":"1984","journal-title":"JAMA"},{"key":"10.1016\/j.actbio.2014.01.004_b0105","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s001980050138","article-title":"Number and type of vertebral deformities: epidemiological characteristics and relation to back pain and height loss. European Vertebral Osteoporosis Study Group","volume":"9","author":"Ismail","year":"1999","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2014.01.004_b0110","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1001\/jama.282.7.637","article-title":"Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators","volume":"282","author":"Ettinger","year":"1999","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.actbio.2014.01.004_b0115","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jocd.2011.05.017","article-title":"Official positions for FRAX(R) bone mineral density and FRAX(R) simplification from Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX(R)","volume":"14","author":"Lewiecki","year":"2011","journal-title":"J Clin Densitom"},{"key":"10.1016\/j.actbio.2014.01.004_b0120","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.bone.2011.11.006","article-title":"Probability of fractures predicted by FRAX(R) and observed incidence in the Spanish ECOSAP Study cohort","volume":"50","author":"Gonzalez-Macias","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2014.01.004_b0125","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.bone.2012.02.639","article-title":"Effect of co-morbidities on fracture risk: findings from the Global Longitudinal Study of Osteoporosis in Women (GLOW)","volume":"50","author":"Dennison","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2014.01.004_b0130","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jocd.2011.05.007","article-title":"Joint official positions of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX\u00ae. Executive summary of the 2010 Position Development Conference on Interpretation and use of FRAX\u00ae in clinical practice","volume":"14","author":"Hans","year":"2011","journal-title":"J Clin Densitom"},{"key":"10.1016\/j.actbio.2014.01.004_b0135","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1016\/j.jbiomech.2008.07.025","article-title":"Microcracking damage and the fracture process in relation to strain rate in human cortical bone tensile failure","volume":"41","author":"Zioupos","year":"2008","journal-title":"J Biomech"},{"key":"10.1016\/j.actbio.2014.01.004_b0140","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/jbmr.73","article-title":"Microindentation for in vivo measurement of bone tissue mechanical properties in humans","volume":"25","author":"Diez-Perez","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0145","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/jbmr.1731","article-title":"Microindentation for in vivo measurement of bone tissue material properties in atypical femoral fracture patients and controls","volume":"28","author":"Guerri-Fernandez","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0150","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1359\/jbmr.2000.15.8.1526","article-title":"Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study","volume":"15","author":"Garnero","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0155","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00198-010-1501-1","article-title":"Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards","volume":"22","author":"Vasikaran","year":"2011","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2014.01.004_b0160","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00198-012-2074-y","article-title":"European guidance for the diagnosis and management of osteoporosis in postmenopausal women","volume":"24","author":"Kanis","year":"2013","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2014.01.004_b0165","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1007\/s00198-012-1958-1","article-title":"A framework for the development of guidelines for the management of glucocorticoid-induced osteoporosis","volume":"23","author":"Lekamwasam","year":"2012","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2014.01.004_b0170","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00223-012-9630-5","article-title":"Management of glucocorticoid-induced osteoporosis","volume":"91","author":"Rizzoli","year":"2012","journal-title":"Calcif Tiss Int"},{"key":"10.1016\/j.actbio.2014.01.004_b0175","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bone.2012.11.018","article-title":"Treatment of osteoporosis in men","volume":"53","author":"Kaufman","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2014.01.004_b0180","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bone.2011.05.007","article-title":"Regional differences in treatment for osteoporosis. The Global Longitudinal Study of Osteoporosis in Women (GLOW)","volume":"49","author":"Diez-Perez","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2014.01.004_b0185","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/jbmr.1496","article-title":"Risk factors for prediction of inadequate response to antiresorptives","volume":"27","author":"Diez-Perez","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0190","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1007\/s00198-012-2093-8","article-title":"Treatment failure in osteoporosis","volume":"23","author":"Diez-Perez","year":"2012","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2014.01.004_b0195","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00223-011-9499-8","article-title":"Adverse reactions and drug\u2013drug interactions in the management of women with postmenopausal osteoporosis","volume":"89","author":"Rizzoli","year":"2011","journal-title":"Calcif Tiss Int"},{"key":"10.1016\/j.actbio.2014.01.004_b0200","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1007\/s00198-012-1902-4","article-title":"Reduced colon cancer incidence and mortality in postmenopausal women treated with an oral bisphosphonate\u2014Danish National Register Based Cohort Study","volume":"23","author":"Pazianas","year":"2012","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2014.01.004_b0205","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1056\/NEJMoa074941","article-title":"Zoledronic acid and clinical fractures and mortality after hip fracture","volume":"357","author":"Lyles","year":"2007","journal-title":"N Eng J Med"},{"key":"10.1016\/j.actbio.2014.01.004_b0210","doi-asserted-by":"crossref","first-page":"619","DOI":"10.5435\/00124635-200811000-00001","article-title":"Recent developments in the biology of fracture repair","volume":"16","author":"Kwong","year":"2008","journal-title":"J Am Acad Orthop Surg"},{"issue":"5","key":"10.1016\/j.actbio.2014.01.004_b0215","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jhsa.2011.02.005","article-title":"A systematic review of outcomes and complications of treating unstable distal radius fractures in the elderly","volume":"36","author":"Diaz-Garcia","year":"2011","journal-title":"J Hand Surg Am"},{"key":"10.1016\/j.actbio.2014.01.004_b0220","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1007\/s00586-012-2314-z","article-title":"Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies","volume":"21","author":"Papanastassiou","year":"2012","journal-title":"Eur Spine J"},{"key":"10.1016\/j.actbio.2014.01.004_b0225","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/jbmr.353","article-title":"Mortality risk for operated and nonoperated vertebral fracture patients in the Medicare population","volume":"26","author":"Edidin","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0230","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1007\/s11999-012-2250-6","article-title":"Which is the best alternative for displaced femoral neck fractures in the elderly? A meta-analysis","volume":"470","author":"Gao","year":"2012","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0235","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2106\/JBJS.E.00215","article-title":"Randomized comparison of reduction and fixation, bipolar hemiarthroplasty, and total hip arthroplasty. Treatment of displaced intracapsular hip fractures in healthy older patients","volume":"88","author":"Keating","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.actbio.2014.01.004_b0240","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/17453670710013861","article-title":"Comparison of cemented and uncemented fixation in total hip replacement: a meta-analysis","volume":"78","author":"Morshed","year":"2007","journal-title":"Acta Orthop"},{"key":"10.1016\/j.actbio.2014.01.004_b0245","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00776-008-1317-4","article-title":"Cementless total hip replacement: past, present, and future","volume":"14","author":"Yamada","year":"2009","journal-title":"J Orthop Sci"},{"key":"10.1016\/j.actbio.2014.01.004_b0250","first-page":"CD001706","article-title":"Arthroplasties (with and without bone cement) for proximal femoral fractures in adults","volume":"16","author":"Parker","year":"2010","journal-title":"Cochrane Database Syst Rev."},{"key":"10.1016\/j.actbio.2014.01.004_b0255","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.4081\/or.2013.e8","article-title":"Cemented versus uncemented fixation in total hip replacement: a systematic review and meta-analysis of randomized controlled trials","volume":"5","author":"Abdulkarim","year":"2013","journal-title":"Orthop Rev (Pavia)"},{"key":"10.1016\/j.actbio.2014.01.004_b0260","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2106\/00004623-200402000-00028","article-title":"Osteoporotic pertrochanteric hip fractures. Management and current controversies","volume":"86","author":"Lorich","year":"2004","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.actbio.2014.01.004_b0265","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1302\/0301-620X.83B1.10162","article-title":"Biocompatibility and osteointergration in osteoporotic bone","volume":"83","author":"Fini","year":"2001","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.actbio.2014.01.004_b0270","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s005860000204","article-title":"Augmentation of mechanical properties in osteoporotic vertebral bones \u2013 a biomechanical investigation of vertebroplasty efficacy with different bone cements","volume":"10","author":"Heini","year":"2001","journal-title":"Eur Spine J"},{"key":"10.1016\/j.actbio.2014.01.004_b0275","article-title":"A novel injectable calcium phosphate cement-bioactive glass composite for boneregeneration","author":"Yu","year":"2013","journal-title":"PLOS One"},{"key":"10.1016\/j.actbio.2014.01.004_b0280","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/jbm.a.34677","article-title":"Tantalum oxide and barium sulfate as radiopacifiers in injectable calcium phosphate-poly(lactic-co-glycolic acid) cements for monitoring in vivo degradation","volume":"A102","author":"Hoekstra","year":"2014","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0285","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1089\/ten.tea.2012.0172","article-title":"Human embryonic stem cell-derived mesenchymal stem cell seeding on calcium phosphate cement-chitosan-RGD scaffold for bone repair","volume":"19","author":"Chen","year":"2013","journal-title":"Tiss Eng A"},{"key":"10.1016\/j.actbio.2014.01.004_b0290","doi-asserted-by":"crossref","first-page":"9558","DOI":"10.1016\/j.actbio.2013.08.009","article-title":"Ready-to-use injectable calcium phosphate bone cement paste as drug carrier","volume":"9","author":"Vorndran","year":"2013","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2014.01.004_b0295","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.micron.2005.07.008","article-title":"Peri-implant osteogenesis in health and osteoporosis","volume":"36","author":"Franchi","year":"2005","journal-title":"Micron"},{"key":"10.1016\/j.actbio.2014.01.004_b0300","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.biopha.2004.08.016","article-title":"Osteoporosis and biomaterial osteointegration","volume":"58","author":"Fini","year":"2004","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.actbio.2014.01.004_b0305","doi-asserted-by":"crossref","first-page":"7776","DOI":"10.1016\/j.biomaterials.2010.06.047","article-title":"In vivo bone augmentation in an osteoporotic environment using bisphosphonate-loaded calcium deficient apatite","volume":"31","author":"Verron","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0310","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1016\/j.actbio.2011.06.004","article-title":"Comparison of the osteoblastic activity conferred to si-doped hydroxyapatite scaffolds by different osteostatin coating","volume":"7","author":"Manzano","year":"2011","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2014.01.004_b0315","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.actamat.2012.10.039","article-title":"Bioceramics for drug delivery","volume":"61","author":"Arcos","year":"2013","journal-title":"Acta Mater"},{"key":"10.1016\/j.actbio.2014.01.004_b0320","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1016\/j.actbio.2012.06.022","article-title":"Controlling the biological function of calcium phosphate bone substitutes with drugs","volume":"8","author":"Verron","year":"2012","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2014.01.004_b0325","doi-asserted-by":"crossref","first-page":"8564","DOI":"10.1016\/j.biomaterials.2010.07.103","article-title":"The osteoinductive properties of mesoporous silicate coated with osteostatin in a rabbit femur cavity defect model","volume":"31","author":"Trejo","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0330","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.progsolidstchem.2012.05.001","article-title":"Revisiting bioceramics: bone regenerative and local drug delivery systems","volume":"40","author":"Manzano","year":"2012","journal-title":"Prog. Solid State Ch"},{"key":"10.1016\/j.actbio.2014.01.004_b0335","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1115\/1.2796022","article-title":"Factors affecting the pullout strength of cancellous bone screws","volume":"118","author":"Chapman","year":"1996","journal-title":"J Biomech Eng"},{"key":"10.1016\/j.actbio.2014.01.004_b0340","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/BTO.0b013e3181501047","article-title":"Biomechanics of plate osteosynthesis","volume":"22","author":"Frigg","year":"2007","journal-title":"Tech Orthop"},{"key":"10.1016\/j.actbio.2014.01.004_b0345","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/(SICI)1097-4636(2000)53:3<216::AID-JBM5>3.0.CO;2-O","article-title":"An injectable cementing screw for fixation in osteoporotic bone","volume":"53","author":"McKoy","year":"2000","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0350","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00586-011-1824-4","article-title":"Polymethylmethacrylate augmentation of the pedicle screw: the cement distribution in the vertebral body","volume":"20","author":"Hu","year":"2011","journal-title":"Eur Spine J"},{"key":"10.1016\/j.actbio.2014.01.004_b0355","doi-asserted-by":"crossref","first-page":"E1628","DOI":"10.1097\/BRS.0b013e3182740e56","article-title":"Pedicle screw design and cement augmentation in osteoporotic vertebrae: effects of fenestrations and cement viscosity on fixation and extraction","volume":"37","author":"Choma","year":"2012","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.actbio.2014.01.004_b0360","doi-asserted-by":"crossref","first-page":"6268","DOI":"10.1016\/j.actbio.2012.12.002","article-title":"The roles of titanium surface micro\/nanotopography and wettability on the differential response of human osteoblast lineage cells","volume":"9","author":"Gittens","year":"2013","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2014.01.004_b0365","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/jbm.820250708","article-title":"Influence of surface characteristics on bone integration of titanium implants \u2013 a histomorphometric study in miniature pigs","volume":"25","author":"Buser","year":"1991","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0370","first-page":"1324","article-title":"A 5-year prospective multicenter study of early loaded titanium implants with a sandblasted and acid-etched surface","volume":"26","author":"Cocharan","year":"2011","journal-title":"Int Oral Maxillofac Implants"},{"key":"10.1016\/j.actbio.2014.01.004_b0375","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1902\/jop.2007.060297","article-title":"Randomized, controlled histologic and histomorphometric evaluation of implants with nanometer-scale calcium phosphate added to the dual acid-etched surace in the human posterior maxilla","volume":"78","author":"Orsini","year":"2007","journal-title":"J Periodontol"},{"key":"10.1016\/j.actbio.2014.01.004_b0380","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1600-0501.2010.02077.x","article-title":"A 2-year prospective study on immediate loading with fluoride-modified implants in the edentulous mandible","volume":"22","author":"Collaert","year":"2011","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0385","doi-asserted-by":"crossref","first-page":"7386","DOI":"10.1016\/j.biomaterials.2012.06.066","article-title":"The responses to surface wettability gradientes induced by chitosan nanofilms on microtextured titanium mediated by specific integrin receptors","volume":"33","author":"Park","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0390","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1902\/jop.2010.090727","article-title":"Early loading at 21 days of non-submerged titanium implants with a chemically modified sandblasted and acid-etched surface. 3-year results of a prospective study in the posterior mandible","volume":"81","author":"Bornstein","year":"2010","journal-title":"J Periodontol"},{"key":"10.1016\/j.actbio.2014.01.004_b0395","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0142-9612(03)00607-0","article-title":"The effect of sol\u2013gel-formed calcium phosphate coatings on bone in growth and osteoconductivity of porous-surfaced Ti alloy implants","volume":"25","author":"Nguyen","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0400","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.biomaterials.2004.02.029","article-title":"A review on calcium phosphate coatings produced using a sputtering process\u2014an alternative to plasma spraying","volume":"26","author":"Yang","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0405","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/j.surfcoat.2011.11.002","article-title":"A review of plasma-assisted methods for calcium phosphate-based coatings fabrication","volume":"206","author":"Surmenev","year":"2012","journal-title":"Surf Coat Technol"},{"key":"10.1016\/j.actbio.2014.01.004_b0410","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1016\/j.surfcoat.2006.04.052","article-title":"Thermal spraying of biomaterials","volume":"201","author":"Heimann","year":"2006","journal-title":"Surface Coatings Technol"},{"key":"10.1016\/j.actbio.2014.01.004_b0415","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.actbio.2013.10.036","article-title":"Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis \u2013 A review","volume":"10","author":"Surmenev","year":"2014","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2014.01.004_b0420","first-page":"455","article-title":"Serum analysis and toxic effects of methylmethacrylate","volume":"23","author":"Bright","year":"1972","journal-title":"Surg Forum"},{"key":"10.1016\/j.actbio.2014.01.004_b0425","first-page":"239","article-title":"Thermal aspects of the use of polymethylmethacrylate in large metaphyseal defects in bone: A clinical review and laboratory study","author":"Leeson","year":"1993","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0430","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/jbm.820240202","article-title":"A fractographic analysis of in vivo poly(methyl methalcrylate) bone cement failure mechanisms","volume":"24","author":"Topoleski","year":"1990","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0435","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1302\/0301-620X.84B5.11841","article-title":"Adjacent vertebral failure after vertebroplasty\u2014a biomechanical investigation","volume":"84B","author":"Berlemann","year":"2002","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.actbio.2014.01.004_b0440","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/jbm.b.30398","article-title":"Injectable bone cements for use in vertebroplasty and kyphoplasty: state-of-the-art review","volume":"76","author":"Lewis","year":"2006","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.actbio.2014.01.004_b0445","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00270-012-0409-x","article-title":"Elastoplasty: first experience in 12 patients","volume":"36","author":"Urlings","year":"2013","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.1016\/j.actbio.2014.01.004_b0450","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/BRS.0b013e31818f8bc1","article-title":"Suitability of a calcium phosphate cement in osteoporotic vertebral body fracture augmentation: a controlled, randomized, clinical trial of balloon kyphoplasty comparing calcium phosphate versus polymethylmethacrylate","volume":"34","author":"Blattert","year":"2009","journal-title":"Spine"},{"key":"10.1016\/j.actbio.2014.01.004_b0455","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12306-011-0130-y","article-title":"Vertebral body recollapse without trauma after kyphoplasty with calcium phosphate cement","volume":"95","author":"Piazzolla","year":"2011","journal-title":"Musculoskelet Surg"},{"key":"10.1016\/j.actbio.2014.01.004_b0460","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00586-006-0277-7","article-title":"Prospective study of standalone balloon kyphoplasty with calcium phosphate cement augmentation in traumatic fractures (G. Maestretti et al.)","volume":"16","author":"Boszczyk","year":"2007","journal-title":"Eur Spine J"},{"key":"10.1016\/j.actbio.2014.01.004_b0465","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00586-006-0258-x","article-title":"Prospective study of standalone balloon kyphoplasty with calcium phosphate cement augmentation in traumatic fractures","volume":"16","author":"Maestretti","year":"2007","journal-title":"Eur Spine J"},{"key":"10.1016\/j.actbio.2014.01.004_b0470","unstructured":"Bernards CM, Chapman JR, Mirza SK. Lethality of embolizednorian bone cement varies with the time between mixing and embolization. In: 50th Annual Meeting of the Orthopaedic Research Society, San Fransisco; 2004. p. 0254."},{"key":"10.1016\/j.actbio.2014.01.004_b0475","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/jbm.b.30758","article-title":"Cardiovascular changes after pulmonary embolism from injecting calcium phosphate cement","volume":"82","author":"Krebs","year":"2007","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.actbio.2014.01.004_b0480","first-page":"209","article-title":"Percutaneous balloon kyphoplasty in osteoporotic vertebral body fracture with a calcium aluminate ceramic (Xeraspine\u00a9)","volume":"7","author":"Dressel","year":"2012","journal-title":"Eur Musculoskelet Rev"},{"key":"10.1016\/j.actbio.2014.01.004_b0485","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00586-010-1279-z","article-title":"Bioceramic vertebral augmentation with a calcium sulphate\/hydroxyapatite composite (Cerament\u2122 SpineSupport) in vertebral compression fractures due to osteoporosis","volume":"19","author":"Rauschmann","year":"2010","journal-title":"Eur Spine J"},{"key":"10.1016\/j.actbio.2014.01.004_b0490","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00234-011-0940-5","article-title":"Osteoporotic vertebral compression fractures augmentation by injectable partly resorbable ceramic bone substitute (Cerament\u2122|SPINE SUPPORT): A prospective nonrandomized study","volume":"54","author":"Masala","year":"2012","journal-title":"Neuroradiology"},{"key":"10.1016\/j.actbio.2014.01.004_b0495","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1097\/00007632-200112150-00009","article-title":"Augmentation of anterior vertebral body screw fixation by an injectable, biodegradable calcium phosphate bone substitute","volume":"26","author":"Bai","year":"2001","journal-title":"Spine"},{"key":"10.1016\/j.actbio.2014.01.004_b0500","first-page":"401","article-title":"Potential use of biodegradable bone cement in bone surgery: holding strength of screws in reinforced osteoporotic bone","volume":"16","author":"Bohner","year":"1992","journal-title":"Orthop Trans"},{"key":"10.1016\/j.actbio.2014.01.004_b0505","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00005131-199601000-00003","article-title":"Crisco Iii JJ. The reinforcement of cancellous bone screws with calcium phosphate cement","volume":"10","author":"Mermelstein","year":"1996","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.actbio.2014.01.004_b0510","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/jor.1100140516","article-title":"Augmentation of femoral neck fracture fixation with an injectable calcium-phosphate bone mineral cement","volume":"14","author":"Stankewich","year":"1996","journal-title":"J Orthop Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0515","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.jbiomech.2012.02.004","article-title":"Injectable calcium phosphate cement for augmentation around cancellous bone screws. In vivo biomechanical studies","volume":"45","author":"Larsson","year":"2012","journal-title":"J Biomech"},{"key":"10.1016\/j.actbio.2014.01.004_b0520","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1016\/j.jbiomech.2010.07.025","article-title":"Calcium phosphate cement augmentation of cancellous bone screws can compensate for the absence of cortical fixation","volume":"43","author":"Stadelmann","year":"2010","journal-title":"J Biomech"},{"key":"10.1016\/j.actbio.2014.01.004_b0525","first-page":"1","article-title":"Bioactive mesoporoussilicas as controlled delivery systems: Application in bonetissue regeneration","volume":"4","author":"Vallet-Reg\u00ed","year":"2008","journal-title":"J Biomed Nanotechnol"},{"key":"10.1016\/j.actbio.2014.01.004_b0530","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/S0142-9612(00)00121-6","article-title":"Scaffolds in tissue engineering bone and cartilage","author":"Hutmacher","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0535","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1126\/science.1106587","article-title":"Exploring and engineering the cell surface interface","volume":"310","author":"Stevens","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.actbio.2014.01.004_b0540","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00068-006-6047-8","article-title":"Biomaterials as scaffolds for bone tissue engineering","volume":"32","author":"Schieker","year":"2006","journal-title":"Eur J Trauma"},{"key":"10.1016\/j.actbio.2014.01.004_b0545","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/107632703764664792","article-title":"Viable osteogenic cells are obligatory for tissue-engineered ectopic bone formation in goats","volume":"9","author":"Kruyt","year":"2003","journal-title":"Tissue Eng"},{"key":"10.1016\/j.actbio.2014.01.004_b0550","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1002\/1521-3773(20020902)41:17<3130::AID-ANIE3130>3.0.CO;2-1","article-title":"Biological and medical significance of calcium phosphates","volume":"41","author":"Dorozhkin","year":"2002","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.actbio.2014.01.004_b0555","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.progsolidstchem.2004.07.001","article-title":"Calcium phosphates as substitution of bone tissues","volume":"32","author":"Vallet-Reg\u00ed","year":"2004","journal-title":"Progr Solid State Chem"},{"key":"10.1016\/j.actbio.2014.01.004_b0560","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S1369-7021(10)70014-6","article-title":"Resorbable biomaterials as bone graft substitutes","volume":"13","author":"Bohner","year":"2010","journal-title":"Mater Today"},{"key":"10.1016\/j.actbio.2014.01.004_b0565","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev.matsci.28.1.271","article-title":"The material bone: structure\u2013mechanical function relations","volume":"28","author":"Weiner","year":"1998","journal-title":"Annu Rev Mater Sci"},{"key":"10.1016\/j.actbio.2014.01.004_b0570","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0142-9612(03)00621-5","article-title":"A thorough physicochemical characterisation of 14 calcium phosphate-based bone substitution materials in comparison to natural bone","volume":"25","author":"Tadic","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0575","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1016\/S0142-9612(03)00335-1","article-title":"Synchrotron X-ray microtomography (on a micron scale) provides three-dimensional imaging representation of bone ingrowth in calcium phosphate biomaterials","volume":"24","author":"Weiss","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0580","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1016\/j.biomaterials.2003.10.079","article-title":"Resorbability of bone substitute biomaterials by human osteoclasts","volume":"25","author":"Schilling","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0585","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1016\/j.actbio.2010.03.003","article-title":"The resorption of nanocrystalline calcium phosphates by osteoclast-like cells","volume":"6","author":"Detsch","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2014.01.004_b0590","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s002230001134","article-title":"Bioglass (R) 45S5 stimulates osteoblast turnover and enhances bone formation in vitro: implications and applications for bone tissue engineering","volume":"67","author":"Xynos","year":"2000","journal-title":"Calcif Tiss Int"},{"key":"10.1016\/j.actbio.2014.01.004_b0595","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1039\/C2BM00108J","article-title":"The effect of silicate ions on proliferation, osteogenic differentiation and cell signaling pathways (WNT and SHH) of bone marrow stromal cells","volume":"1","author":"Han","year":"2013","journal-title":"Biomater Sci"},{"key":"10.1016\/j.actbio.2014.01.004_b0600","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bbrc.2010.01.109","article-title":"Extracellular calcium modulates in vitro bone marrow-derived Flk-1+ CD34+ progenitor cell chemotaxis and differentiation through a calcium-sensing receptor","volume":"393","author":"Aguirre","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.actbio.2014.01.004_b0605","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.jeurceramsoc.2008.08.002","article-title":"Genetic design of bioactive glass","volume":"29","author":"Hench","year":"2009","journal-title":"J. Eur Ceram Soc"},{"key":"10.1016\/j.actbio.2014.01.004_b0610","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.actbio.2011.03.016","article-title":"Bioactive glass in tissue engineering","volume":"7","author":"Rahaman","year":"2011","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2014.01.004_b0615","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/1097-4636(200105)55:2<151::AID-JBM1001>3.0.CO;2-D","article-title":"Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass\u00ae 45S5 dissolution","volume":"55","author":"Xynos","year":"2001","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0620","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1089\/ten.teb.2009.0416","article-title":"Effect of bioactive glasses on angiogenesis: in-vitro and in-vivo evidence. A review","volume":"16","author":"Gorustovich","year":"2010","journal-title":"Tiss Eng B"},{"key":"10.1016\/j.actbio.2014.01.004_b0625","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/jbm.a.20014","article-title":"Cellular response to calcium phosphate glasses with controlled solubility","volume":"67A","author":"Navarro","year":"2003","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0630","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1007\/s10856-008-3390-9","article-title":"A PLA\/calcium phosphate degradable composite material for bone tissue engineering: an in vitro study","volume":"19","author":"Charles-Harris","year":"2008","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.actbio.2014.01.004_b0635","doi-asserted-by":"crossref","first-page":"893","DOI":"10.4028\/www.scientific.net\/KEM.284-286.893","article-title":"In vivo behavior of calcium phosphate glasses with controlled solubility","volume":"284\u2013286","author":"Navarro","year":"2005","journal-title":"Key Eng Mater"},{"key":"10.1016\/j.actbio.2014.01.004_b0640","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1016\/j.biomaterials.2010.01.121","article-title":"The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro","volume":"31","author":"Gentleman","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0645","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.archoralbio.2004.02.013","article-title":"Bone healing in osteoporotic female rats following intra-alveolar grafting of bioactive glass","volume":"49","author":"Teofilo","year":"2004","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.actbio.2014.01.004_b0650","doi-asserted-by":"crossref","first-page":"7548","DOI":"10.1002\/anie.200604488","article-title":"Mesoporous materials for drug delivery","volume":"46","author":"Vallet-Reg\u00ed","year":"2007","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.actbio.2014.01.004_b0655","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.biomaterials.2007.09.019","article-title":"Mandibular bone repair by implantation of rhBMP-2 in a slow release carrier or polylactic acid\u2014an experimental study in rats","volume":"29","author":"Schliephake","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0660","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12306-008-0064-1","article-title":"Growth factors in bone repair","volume":"92","author":"Devescovi","year":"2008","journal-title":"Chir Organi Mov"},{"key":"10.1016\/j.actbio.2014.01.004_b0665","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s00264-011-1301-z","article-title":"Use and efficacy of bone morphogenetic proteins in fracture healing","volume":"35","author":"Lissenberg-Thunnissen","year":"2011","journal-title":"Int Orthop"},{"key":"10.1016\/j.actbio.2014.01.004_b0670","doi-asserted-by":"crossref","first-page":"30","DOI":"10.22203\/eCM.v019a04","article-title":"VEGF incorporated into calcium phosphate ceramics promotes vascularisation and bone formation in vivo","volume":"19","author":"Wernike","year":"2010","journal-title":"Eur Cells Mater"},{"key":"10.1016\/j.actbio.2014.01.004_b0675","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/jbm.a.31024","article-title":"Calcium phosphate bone cements, functionalized with VEGF: release kinetics and biological activity","volume":"81A","author":"Lode","year":"2007","journal-title":"J Biomed Mater Res"},{"issue":"12","key":"10.1016\/j.actbio.2014.01.004_b0680","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1017\/S1462399410001493","article-title":"Gene therapy for bone healing","volume":"23","author":"Evans","year":"2010","journal-title":"Exp Rev Mol Med"},{"key":"10.1016\/j.actbio.2014.01.004_b0685","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1172\/JCI32949","article-title":"Retroviral integration and human gene therapy","volume":"117","author":"Bushman","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.actbio.2014.01.004_b0690","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2174\/1566523052997514","article-title":"Retroviral gene therapy: safety issues and possible solutions","volume":"5","author":"Yi","year":"2005","journal-title":"Curr Gene Ther"},{"key":"10.1016\/j.actbio.2014.01.004_b0695","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1002\/anie.200703039","article-title":"Inorganic nanoparticles as carriers of nucleic acids into cells","volume":"47","author":"Sokolova","year":"2008","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.actbio.2014.01.004_b0700","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1021\/ar200151m","article-title":"Recent advances in nonviral vectors for gene delivery","volume":"45","author":"Guo","year":"2012","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0705","doi-asserted-by":"crossref","first-page":"230","DOI":"10.22203\/eCM.v021a18","article-title":"Osteogenic differentiation as a result of BMP-2 plasmid DNA based gene therapy in vitro and in vivo","volume":"21","author":"Wegman","year":"2011","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.actbio.2014.01.004_b0710","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/aps.2010.67","article-title":"Angiopoiesis and bone regeneration via co-expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivo","volume":"31","author":"Zhang","year":"2010","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.actbio.2014.01.004_b0715","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/jbm.a.32441","article-title":"Calcium phosphate-DNA nanoparticle gene delivery from alginate hydrogels induces in vivo osteogenesis","volume":"92A","author":"Krebs","year":"2010","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.actbio.2014.01.004_b0720","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1016\/j.biomaterials.2009.12.041","article-title":"The ability of a collagen\/calcium phosphate scaffold to act as its own vector for gene delivery and to promote bone formation via transfection with VEGF165","volume":"31","author":"Keeney","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0725","doi-asserted-by":"crossref","first-page":"8050","DOI":"10.1039\/c0jm00852d","article-title":"Calcium carbonate\/CaIP6 nanocomposite particles as gene delivery vehicles for human vascular smooth muscle cells","volume":"20","author":"Cheang","year":"2010","journal-title":"J Mater Chem"},{"key":"10.1016\/j.actbio.2014.01.004_b0730","doi-asserted-by":"crossref","first-page":"11155","DOI":"10.1039\/c3ra23450a","article-title":"A genetically active nano-calcium phosphate paste for bone substitution, encoding the formation of BMP-7 and VEGF-A","volume":"3","author":"Chernousova","year":"2013","journal-title":"RSC Adv"},{"key":"10.1016\/j.actbio.2014.01.004_b0735","first-page":"299","article-title":"Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications","volume":"5","author":"Liu","year":"2010","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.actbio.2014.01.004_b0740","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-matsci-070909-104421","article-title":"Biological composites","volume":"40","author":"Dunlop","year":"2010","journal-title":"Ann Rev Mater Res"},{"key":"10.1016\/j.actbio.2014.01.004_b0745","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev.matsci.28.1.271","article-title":"The material bone: structure-mechanical function relations","volume":"28","author":"Weiner","year":"1998","journal-title":"Annu Rev Mater Sci"},{"key":"10.1016\/j.actbio.2014.01.004_b0750","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/adma.200902019","article-title":"Revealing the design principles of high-performance biological composites using ab initio and multiscale simulations: The example of lobster cuticle","volume":"22","author":"Nikolov","year":"2010","journal-title":"Adv Mater"},{"key":"10.1016\/j.actbio.2014.01.004_b0755","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/anie.200802092","article-title":"RNA Interference: from basic research to therapeutic applications","volume":"48","author":"Kurreck","year":"2009","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.actbio.2014.01.004_b0760","doi-asserted-by":"crossref","first-page":"7138","DOI":"10.1016\/j.biomaterials.2012.06.068","article-title":"A review of nanocarriers for the delivery of small interfering RNA","volume":"33","author":"Kesharwani","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0765","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.nano.2008.06.001","article-title":"Drug delivery of siRNA therapeutics: potentials and limits of nanosystems","volume":"5","author":"Reischl","year":"2009","journal-title":"Nanomedicine"},{"issue":"2","key":"10.1016\/j.actbio.2014.01.004_b0770","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nrg2504","article-title":"Small silencing RNAs: an expanding universe","volume":"10","author":"Ghildiyal","year":"2009","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.actbio.2014.01.004_b0775","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.biomaterials.2010.09.062","article-title":"Functional TNF-a gene silencing mediated by polyethyleneimine\/TNF-a siRNAnanocomplexes in inflamed colon","volume":"32","author":"Laroui","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0780","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1016\/j.biomaterials.2010.04.024","article-title":"SiRNA-loaded multi-shell nanoparticles incorporated into a multilayered film as a reservoir for gene silencing","volume":"31","author":"Zhang","year":"2010","journal-title":"Biomaterials"},{"issue":"285","key":"10.1016\/j.actbio.2014.01.004_b0785","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1001\/jama.285.6.785","article-title":"Osteoporosis prevention, diagnosis, and therapy","volume":"14","author":"NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.actbio.2014.01.004_b0790","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1582-4934.2010.01224.x","article-title":"Bone regeneration and stem cells","volume":"15","author":"Arvidson","year":"2011","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.actbio.2014.01.004_b0795","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1111\/j.1582-4934.2011.01265.x","article-title":"Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology","volume":"15","author":"G\u00f3mez-Barrena","year":"2011","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.actbio.2014.01.004_b0800","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.2106\/JBJS.D.02215","article-title":"Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells","volume":"87","author":"Hernigou","year":"2005","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.actbio.2014.01.004_b0805","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.maturitas.2013.03.004","article-title":"Bone tissue engineering in osteoporosis","volume":"75","author":"Jakob","year":"2013","journal-title":"Maturitas"},{"key":"10.1016\/j.actbio.2014.01.004_b0810","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1016\/j.biomaterials.2009.01.008","article-title":"Can bioactivity be tested in vitro with SBF solution?","volume":"30","author":"Bohner","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.01.004_b0815","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1016\/j.actbio.2010.05.013","article-title":"Apatite-formation ability \u2013 predictor of \u201cbioactivity\u201d?","volume":"6","author":"Pan","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2014.01.004_b0820","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1056\/NEJMoa0900563","article-title":"A randomized controlled trial of vertebroplasty for osteoporotic spine fractures","volume":"361","author":"Kallmes","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.actbio.2014.01.004_b0825","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMoa0900429","article-title":"A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures","volume":"361","author":"Buchbinder","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.actbio.2014.01.004_b0830","unstructured":"http:\/\/en.wikipedia.org\/wiki\/Contaminated_haemophilia_blood_products."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706114000075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706114000075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:54:06Z","timestamp":1716425646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706114000075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":166,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S1742706114000075"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2014.01.004","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The relevance of biomaterials to the prevention and treatment of osteoporosis","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2014.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}