{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:14:06Z","timestamp":1793031246983,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"7","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.actbio.2014.03.016","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T14:40:09Z","timestamp":1396017609000},"page":"3188-3196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["A temperature-induced and shear-reversible assembly of latanoprost-loaded amphiphilic chitosan colloids: Characterization and in vivo glaucoma treatment"],"prefix":"10.1016","volume":"10","author":[{"given":"Meng-Hsuan","family":"Hsiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hwa","family":"Chiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6755-8418","authenticated-orcid":false,"given":"Mikael","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Hsuan","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine Jui-Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean-Mo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2014.03.016_b0005","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nrd3745","article-title":"Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma","volume":"11","author":"Zhang","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.actbio.2014.03.016_b0010","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.actbio.2014.03.016_b0015","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jcrs.2007.11.029","article-title":"Circumferential viscodilation and tensioning of schlemm canal (canaloplasty) with temporal clear corneal phacoemulsification cataract surgery for open-angle glaucoma and visually significant cataract: one-year results","volume":"34","author":"Shingleton","year":"2008","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.actbio.2014.03.016_b0020","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/S0161-6420(96)30407-7","article-title":"Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Latanoprost study groups","volume":"103","author":"Camras","year":"1996","journal-title":"Ophthalmology"},{"key":"10.1016\/j.actbio.2014.03.016_b0025","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ophtha.2003.09.025","article-title":"The advanced glaucoma intervention study (agis). 13. Comparison of treatment outcomes within race: 10-year results","volume":"111","author":"Ederer","year":"2004","journal-title":"Ophthalmology"},{"key":"10.1016\/j.actbio.2014.03.016_b0030","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/S0161-6420(01)00873-9","article-title":"Interim clinical outcomes in the collaborative initial glaucoma treatment study comparing initial treatment randomized to medications or surgery","volume":"108","author":"Lichter","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.actbio.2014.03.016_b0035","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0002-9394(14)72725-4","article-title":"The glaucoma laser trial (GLT) and glaucoma laser trial follow-up study. 7. Results. Glaucoma laser trial research group","volume":"120","year":"1995","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.actbio.2014.03.016_b0040","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(10)61423-7","article-title":"Glaucoma","volume":"377","author":"Quigley","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.actbio.2014.03.016_b0045","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2415-10-4","article-title":"First-line latanoprost therapy in ocular hypertension or open-angle glaucoma patients: a 3-month efficacy analysis stratified by initial intraocular pressure","volume":"10","author":"Denis","year":"2010","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.actbio.2014.03.016_b0050","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.otohns.2003.07.005","article-title":"Safety review of benzalkonium chloride used as a preservative in intranasal solutions: an overview of conflicting data and opinions","volume":"130","author":"Marple","year":"2004","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.actbio.2014.03.016_b0055","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1007\/s00347-012-2638-4","article-title":"Preservatives in ophthalmology","volume":"109","author":"Messmer","year":"2012","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.actbio.2014.03.016_b0060","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.preteyeres.2010.03.001","article-title":"Preservatives in eyedrops: the good, the bad and the ugly","volume":"29","author":"Baudouin","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.actbio.2014.03.016_b0065","first-page":"123","article-title":"Nanomedicine for glaucoma: liposomes provide sustained release of latanoprost in the eye","volume":"7","author":"Natarajan","year":"2012","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.actbio.2014.03.016_b0070","doi-asserted-by":"crossref","first-page":"e24513","DOI":"10.1371\/journal.pone.0024513","article-title":"Sustained release of an anti-glaucoma drug: demonstration of efficacy of a liposomal formulation in the rabbit eye","volume":"6","author":"Natarajan","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2014.03.016_b0075","doi-asserted-by":"crossref","first-page":"11800","DOI":"10.1021\/jp902103p","article-title":"Self-assembly behavior and doxorubicin-loading capacity of acylated carboxymethyl chitosans","volume":"113","author":"Liu","year":"2009","journal-title":"J Phys Chem B"},{"key":"10.1016\/j.actbio.2014.03.016_b0080","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1021\/ma8002399","article-title":"Self-assembled hollow nanocapsule from amphiphatic carboxymethyl-hexanoyl chitosan as drug carrier","volume":"41","author":"Liu","year":"2008","journal-title":"Macromolecules"},{"key":"10.1016\/j.actbio.2014.03.016_b0085","doi-asserted-by":"crossref","first-page":"9740","DOI":"10.1021\/la061471n","article-title":"Synthesis and characterization of amphiphatic carboxymethyl-hexanoyl chitosan hydrogel: water-retention ability and drug encapsulation","volume":"22","author":"Liu","year":"2006","journal-title":"Langmuir"},{"key":"10.1016\/j.actbio.2014.03.016_b0090","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.5772\/56768","article-title":"Evaluation of carboxymethyl-hexanoyl chitosan as a protein nanocarrier","volume":"3","author":"Larsson","year":"2013","journal-title":"Nanomater Nanotechnol"},{"key":"10.1016\/j.actbio.2014.03.016_b0095","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.progpolymsci.2013.06.009","article-title":"Biomedical applications and colloidal properties of amphiphilically modified chitosan hybrids","volume":"38","author":"Larsson","year":"2013","journal-title":"Prog Polym Sci"},{"key":"10.1016\/j.actbio.2014.03.016_b0100","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jconrel.2012.05.038","article-title":"Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivo release of the hydrophilic anti-epilepsy drug ethosuximide","volume":"161","author":"Hsiao","year":"2012","journal-title":"J Control Release"},{"key":"10.1016\/j.actbio.2014.03.016_b0105","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.1016\/j.biomaterials.2012.07.029","article-title":"Corneal repair by human corneal keratocyte-reprogrammed iPSCs and amphiphatic carboxymethyl-hexanoyl chitosan hydrogel","volume":"33","author":"Chien","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.03.016_b0110","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1002\/jps.10157","article-title":"Physical characterization of a chitosan-based hydrogel delivery system","volume":"91","author":"Li","year":"2002","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.actbio.2014.03.016_b0115","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jconrel.2004.12.019","article-title":"PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release","volume":"103","author":"Bhattarai","year":"2005","journal-title":"J Control Release"},{"key":"10.1016\/j.actbio.2014.03.016_b0120","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1016\/j.biomaterials.2008.12.080","article-title":"Injectable in situ forming biodegradable chitosan\u2013hyaluronic acid based hydrogels for cartilage tissue engineering","volume":"30","author":"Tan","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.03.016_b0125","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jconrel.2007.12.008","article-title":"Thermo-sensitive and biodegradable hydrogels based on stereocomplexed pluronic multi-block copolymers for controlled protein delivery","volume":"127","author":"Chung","year":"2008","journal-title":"J Control Release"},{"key":"10.1016\/j.actbio.2014.03.016_b0130","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nmat3248","article-title":"Mesoporous organohydrogels from thermogelling photocrosslinkable nanoemulsions","volume":"11","author":"Helgeson","year":"2012","journal-title":"Nat Mater"},{"key":"10.1016\/j.actbio.2014.03.016_b0135","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/IAE.0b013e31816079e8","article-title":"Secondary ocular hypertension after intravitreal injection of 4 mg of triamcinolone acetonide \u2013 incidence and risk factors","volume":"28","author":"Vasconcelos-Santos","year":"2008","journal-title":"Retina"},{"key":"10.1016\/j.actbio.2014.03.016_b0140","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/S0142-9612(00)00116-2","article-title":"Novel injectable neutral solutions of chitosan form biodegradable gels in situ","volume":"21","author":"Chenite","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.03.016_b0145","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/app.29954","article-title":"Preparation and characterization of a novel thermosensitive hydrogel based on chitosan and gelatin blends","volume":"113","author":"Chang","year":"2009","journal-title":"J Appl Polym Sci"},{"key":"10.1016\/j.actbio.2014.03.016_b0150","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jconrel.2007.11.018","article-title":"Injectable chitosan hydrogels for localised cancer therapy","volume":"126","author":"Ta","year":"2008","journal-title":"J Control Release"},{"key":"10.1016\/j.actbio.2014.03.016_b0155","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10971-006-9007-1","article-title":"Gelation time and degradation rate of chitosan-based injectable hydrogel","volume":"42","author":"Ganji","year":"2007","journal-title":"J Sol Gel Sci Technol"},{"key":"10.1016\/j.actbio.2014.03.016_b0160","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0144-8617(00)00281-2","article-title":"Rheological characterisation of thermogelling chitosan\/glycerol-phosphate solutions","volume":"46","author":"Chenite","year":"2001","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.actbio.2014.03.016_b0165","first-page":"298","article-title":"Effects of latanoprost and pilocarpine combination on the intraocular pressure and pupil size of normal rabbits","volume":"12","author":"Sarchahi","year":"2011","journal-title":"Iran J Vet Res"},{"key":"10.1016\/j.actbio.2014.03.016_b0170","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1001\/archopht.122.10.1492","article-title":"Steroid-induced ocular hypertension in normal cattle","volume":"122","author":"Gerometta","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.actbio.2014.03.016_b0175","first-page":"77","article-title":"Oculohypotensive effects of foeniculum vulgare in experimental models of glaucoma","volume":"52","author":"Agarwal","year":"2008","journal-title":"Ind J Physiol Pharmacol"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706114001275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706114001275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T21:04:59Z","timestamp":1565298299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706114001275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S1742706114001275"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2014.03.016","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A temperature-induced and shear-reversible assembly of latanoprost-loaded amphiphilic chitosan colloids: Characterization and in vivo glaucoma treatment","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2014.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}