{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:46:37Z","timestamp":1791182797107,"version":"4.1.0"},"reference-count":79,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002956","name":"Defence Research and Development Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.actbio.2014.04.033","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T15:46:10Z","timestamp":1399391170000},"page":"3563-3570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Progress in developing a living human tissue-engineered tri-leaflet heart valve assembled from tissue produced by the self-assembly approach"],"prefix":"10.1016","volume":"10","author":[{"given":"Jean","family":"Dub\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Bourget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gauvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Lafrance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Roberge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois A.","family":"Auger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Germain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2014.04.033_b0005","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1067\/mtc.2002.119696","article-title":"Aortic valve cusp vessel density: relationship with tissue thickness","volume":"123","author":"Weind","year":"2002","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0010","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0021-9290(02)00042-8","article-title":"A precise radiographic technique for the measurement of dimensional changes in heart valve biomaterials following fixation","volume":"35","author":"Weind","year":"2002","journal-title":"J Biomech"},{"key":"10.1016\/j.actbio.2014.04.033_b0015","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.addr.2011.01.008","article-title":"Aortic valve disease and treatment: the need for naturally engineered solutions","volume":"63","author":"Butcher","year":"2011","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.actbio.2014.04.033_b0020","doi-asserted-by":"crossref","first-page":"e48843","DOI":"10.1371\/journal.pone.0048843","article-title":"Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease","volume":"7","author":"Sun","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.actbio.2014.04.033_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carpath.2012.06.005","article-title":"The progression of calcific aortic valve disease through injury, cell dysfunction, and disruptive biologic and physical force feedback loops","volume":"22","author":"Li","year":"2013","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.actbio.2014.04.033_b0030","first-page":"e6","article-title":"Heart disease and stroke statistics-2013 update: a report from the American Heart Association","volume":"127","author":"Go","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2014.04.033_b0035","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.carpath.2006.04.007","article-title":"Pathology of inflammatory native valvular heart disease","volume":"15","author":"Veinot","year":"2006","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.actbio.2014.04.033_b0040","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0167-5273(94)90199-6","article-title":"Incidence of rheumatic fever and prevalence of rheumatic heart disease in India","volume":"43","author":"Vijaykumar","year":"1994","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.actbio.2014.04.033_b0045","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1161\/01.ATV.0000255952.47980.c2","article-title":"Aortic valve calcification: determinants and progression in the population","volume":"27","author":"Messika-Zeitoun","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.actbio.2014.04.033_b0050","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/01.RES.0000185326.04010.9f","article-title":"Heart valve tissue engineering","volume":"97","author":"Vesely","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.actbio.2014.04.033_b0055","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.actbio.2014.04.033_b0060","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nrcardio.2010.164","article-title":"Prosthetic valve selection for middle-aged patients with aortic stenosis","volume":"7","author":"Chikwe","year":"2010","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.actbio.2014.04.033_b0065","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jtcvs.2005.03.044","article-title":"Aortic root replacement with a novel decellularized cryopreserved aortic homograft: postoperative immunoreactivity and early results","volume":"130","author":"Zehr","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0070","doi-asserted-by":"crossref","first-page":"II101","DOI":"10.1161\/01.CIR.92.9.101","article-title":"Influence of coronary artery bypass and age on clinical performance after aortic and mitral valve replacement with biological and mechanical prostheses","volume":"92","author":"Jamieson","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2014.04.033_b0075","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0022-5223(94)70298-5","article-title":"Actuarial versus actual risk of porcine structural valve deterioration","volume":"108","author":"Grunkemeier","year":"1994","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0080","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1056\/NEJM199608083350607","article-title":"Prosthetic heart valves","volume":"335","author":"Vongpatanasin","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.actbio.2014.04.033_b0085","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ejcts.2006.11.001","article-title":"Aortic valve surgery: time to be open-minded and to rethink","volume":"31","author":"Walther","year":"2007","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0090","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1161\/CIRCULATIONAHA.105.587022","article-title":"Impact of prosthesis-patient mismatch on cardiac events and midterm mortality after aortic valve replacement in patients with pure aortic stenosis","volume":"113","author":"Tasca","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2014.04.033_b0095","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1136\/hrt.2005.067363","article-title":"Prosthesis-patient mismatch: definition, clinical impact, and prevention","volume":"92","author":"Pibarot","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.actbio.2014.04.033_b0100","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0140-6736(10)60828-8","article-title":"Long-term outcomes after autograft versus homograft aortic root replacement in adults with aortic valve disease: a randomised controlled trial","volume":"376","author":"El-Hamamsy","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.actbio.2014.04.033_b0105","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.acvd.2012.02.013","article-title":"Valve replacement in children: a challenge for a whole life","volume":"105","author":"Henaine","year":"2012","journal-title":"Arch Cardiovasc Dis"},{"key":"10.1016\/j.actbio.2014.04.033_b0110","first-page":"166","article-title":"Mechanical aortic valve replacement: long-term outcomes in children","volume":"14","author":"Shanmugam","year":"2005","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.actbio.2014.04.033_b0115","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.trim.2003.12.010","article-title":"Heart valve tissue engineering","volume":"12","author":"Neuenschwander","year":"2004","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.actbio.2014.04.033_b0120","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.athoracsur.2010.01.046","article-title":"Late outcomes for aortic valve replacement with the Carpentier-Edwards pericardial bioprosthesis: up to 17-year follow-up in 1000 patients","volume":"89","author":"McClure","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0125","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0022-5223(95)70096-X","article-title":"The Carpentier-Edwards pericardial aortic valve. Ten-year results","volume":"110","author":"Cosgrove","year":"1995","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0130","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.athoracsur.2004.06.033","article-title":"Calcification of tissue heart valve substitutes: progress toward understanding and prevention","volume":"79","author":"Schoen","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0135","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0003-4975(00)01255-8","article-title":"Tissue engineering of heart valves: in vitro experiences","volume":"70","author":"Sodian","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0140","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0002-9149(62)90047-4","article-title":"Aortic valve replacement with a caged ball valve","volume":"9","author":"Harken","year":"1962","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.actbio.2014.04.033_b0145","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/0003-4975(89)90623-1","article-title":"Heart valves: ten commandments and still counting","volume":"48","author":"Harken","year":"1989","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0150","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0022-5223(19)41999-5","article-title":"Collagen-derived heart valves; concept and experimental results","volume":"62","author":"Carpentier","year":"1971","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0155","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev-bioeng-061008-124903","article-title":"Bioengineering challenges for heart valve tissue engineering","volume":"11","author":"Sacks","year":"2009","journal-title":"Annu Rev Biomed Eng"},{"key":"10.1016\/j.actbio.2014.04.033_b0160","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ejcts.2010.07.030","article-title":"Cells, scaffolds and bioreactors for tissue-engineered heart valves: a journey from basic concepts to contemporary developmental innovations","volume":"39","author":"Gandaglia","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0165","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S1010-7940(03)00094-0","article-title":"Early failure of the tissue engineered porcine heart valve SYNERGRAFT in pediatric patients","volume":"23","author":"Simon","year":"2003","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0170","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1089\/ten.2006.12.2059","article-title":"Decellularized xenogenic heart valves reveal remodeling and growth potential in vivo","volume":"12","author":"Erdbrugger","year":"2006","journal-title":"Tissue Eng"},{"key":"10.1016\/j.actbio.2014.04.033_b0175","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1016\/j.biomaterials.2013.04.059","article-title":"Off-the-shelf human decellularized tissue-engineered heart valves in a non-human primate model","volume":"34","author":"Weber","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.04.033_b0180","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.1016\/j.biomaterials.2012.03.015","article-title":"Decellularized homologous tissue-engineered heart valves as off-the-shelf alternatives to xeno- and homografts","volume":"33","author":"Dijkman","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.04.033_b0185","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.jacc.2013.09.082","article-title":"Transcatheter implantation of homologous \u201coff-the-shelf\u201d tissue engineered heart valves with self-repair capacity: long term functionality and rapid in vivo remodeling in sheep","volume":"63","author":"Driessen-Mol","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.actbio.2014.04.033_b0190","doi-asserted-by":"crossref","first-page":"I132","DOI":"10.1161\/CIRCULATIONAHA.105.001065","article-title":"Clinical application of tissue engineered human heart valves using autologous progenitor cells","volume":"114","author":"Cebotari","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2014.04.033_b0195","doi-asserted-by":"crossref","first-page":"I152","DOI":"10.1161\/CIRCULATIONAHA.105.001123","article-title":"Autologous human tissue-engineered heart valves: prospects for systemic application","volume":"114","author":"Mol","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2014.04.033_b0200","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1161\/CIRCULATIONAHA.104.498378","article-title":"From stem cells to viable autologous semilunar heart valve","volume":"111","author":"Sutherland","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2014.04.033_b0205","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jtcvs.2009.11.006","article-title":"In vivo monitoring of function of autologous engineered pulmonary valve","volume":"139","author":"Gottlieb","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0210","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.biomaterials.2009.10.019","article-title":"The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells","volume":"31","author":"Ramaswamy","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.04.033_b0215","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/jbm.a.34305","article-title":"Laser microfabricated poly(glycerol sebacate) scaffolds for heart valve tissue engineering","volume":"101","author":"Masoumi","year":"2013","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.actbio.2014.04.033_b0220","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.1016\/j.actbio.2013.01.001","article-title":"Valvular interstitial cell seeded poly(glycerol sebacate) scaffolds: toward a biomimetic in vitro model for heart valve tissue engineering","volume":"9","author":"Masoumi","year":"2013","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2014.04.033_b0225","doi-asserted-by":"crossref","first-page":"III44","DOI":"10.1161\/circ.102.suppl_3.III-44","article-title":"Functional living trileaflet heart valves grown in vitro","volume":"102","author":"Hoerstrup","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2014.04.033_b0230","doi-asserted-by":"crossref","first-page":"III22","DOI":"10.1161\/circ.102.suppl_3.III-22","article-title":"Early in vivo experience with tissue-engineered trileaflet heart valves","volume":"102","author":"Sodian","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2014.04.033_b0235","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.athoracsur.2009.11.058","article-title":"Use of human umbilical cord blood-derived progenitor cells for tissue-engineered heart valves","volume":"89","author":"Sodian","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0240","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1089\/ten.tea.2009.0018","article-title":"In vivo remodeling and structural characterization of fibrin-based tissue-engineered heart valves in the adult sheep model","volume":"15","author":"Flanagan","year":"2009","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2014.04.033_b0245","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1089\/ten.tea.2009.0708","article-title":"Fibrin degradation enhances vascular smooth muscle cell proliferation and matrix deposition in fibrin-based tissue constructs fabricated in vitro","volume":"16","author":"Ahmann","year":"2010","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2014.04.033_b0250","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/ten.a.2007.0148","article-title":"Functional tissue-engineered valves from cell-remodeled fibrin with commissural alignment of cell-produced collagen","volume":"14","author":"Robinson","year":"2008","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2014.04.033_b0255","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1016\/j.actbio.2013.04.050","article-title":"Stiffness and adhesivity control aortic valve interstitial cell behavior within hyaluronic acid based hydrogels","volume":"9","author":"Duan","year":"2013","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2014.04.033_b0260","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jtcvs.2007.01.087","article-title":"Development of an in vivo tissue-engineered, autologous heart valve (the biovalve): preparation of a prototype model","volume":"134","author":"Hayashida","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0265","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s10047-010-0491-2","article-title":"Preparation of in-vivo tissue-engineered valved conduit with the sinus of Valsalva (type IV biovalve)","volume":"13","author":"Yamanami","year":"2010","journal-title":"J Artif Organs"},{"key":"10.1016\/j.actbio.2014.04.033_b0270","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1016\/j.athoracsur.2004.03.106","article-title":"Biomatrix\/polymer composite material for heart valve tissue engineering","volume":"78","author":"Stamm","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0275","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1089\/ten.2006.12.1325","article-title":"Direct freeform fabrication of seeded hydrogels in arbitrary geometries","volume":"12","author":"Cohen","year":"2006","journal-title":"Tissue Eng"},{"key":"10.1016\/j.actbio.2014.04.033_b0280","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1089\/ten.tec.2009.0441","article-title":"An optical method for evaluation of geometric fidelity for anatomically shaped tissue-engineered constructs","volume":"16","author":"Ballyns","year":"2010","journal-title":"Tissue Eng Part C Methods"},{"key":"10.1016\/j.actbio.2014.04.033_b0285","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/jbm.a.34420","article-title":"3D bioprinting of heterogeneous aortic valve conduits with alginate\/gelatin hydrogels","volume":"101","author":"Duan","year":"2013","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.actbio.2014.04.033_b0290","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1016\/j.actbio.2013.12.005","article-title":"Three-dimensional printed trileaflet valve conduits using biological hydrogels and human valve interstitial cells","volume":"10","author":"Duan","year":"2014","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2014.04.033_b0295","doi-asserted-by":"crossref","unstructured":"McAllister T, Dusserre N, Chronos N, L\u2019Heureux N. A completely biological, tissue engineered valve leaflet suitable for TAVI. In: 5th Biannual Conference on Heart Valve Biology and Tissue Engineering, Myconos Island, Greece; 2012.","DOI":"10.5339\/qproc.2012.heartvalve.4.83"},{"key":"10.1016\/j.actbio.2014.04.033_b0300","first-page":"47","article-title":"A completely biological tissue-engineered human blood vessel","volume":"12","author":"L\u2019Heureux","year":"1998","journal-title":"FASEB J"},{"key":"10.1016\/j.actbio.2014.04.033_b0305","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-1-59745-060-7_15","article-title":"Regeneration of skin and cornea by tissue engineering","volume":"482","author":"Larouche","year":"2009","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.actbio.2014.04.033_b0310","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s11626-999-0081-x","article-title":"Characterization of a new tissue-engineered human skin equivalent with hair","volume":"35","author":"Michel","year":"1999","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"10.1016\/j.actbio.2014.04.033_b0315","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jpurol.2005.11.019","article-title":"In vitro reconstruction of a tissue-engineered endothelialized bladder from a single porcine biopsy","volume":"2","author":"Magnan","year":"2006","journal-title":"J Pediatr Urol"},{"key":"10.1016\/j.actbio.2014.04.033_b0320","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0305-4179(93)90028-7","article-title":"Improvement of human keratinocyte isolation and culture using thermolysin","volume":"19","author":"Germain","year":"1993","journal-title":"Burns"},{"key":"10.1016\/j.actbio.2014.04.033_b0325","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1074\/jbc.272.1.345","article-title":"Ascorbate differentially regulates elastin and collagen biosynthesis in vascular smooth muscle cells and skin fibroblasts by pretranslational mechanisms","volume":"272","author":"Davidson","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.actbio.2014.04.033_b0330","series-title":"Manual of histologic staining methods of the armed forces institute of pathology","author":"Luna","year":"1968"},{"key":"10.1016\/j.actbio.2014.04.033_b0335","article-title":"Some histological methods: trichrome staining and their preliminary technique","volume":"12","author":"Masson","year":"1929","journal-title":"J Tech Methods"},{"key":"10.1016\/j.actbio.2014.04.033_b0340","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0305-4179(95)80004-8","article-title":"Early basement membrane formation following the grafting of cultured epidermal sheets detached with thermolysin or Dispase","volume":"21","author":"Germain","year":"1995","journal-title":"Burns"},{"key":"10.1016\/j.actbio.2014.04.033_b0345","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1177\/0885328212465482","article-title":"A comparative study of bovine and porcine pericardium to highlight their potential advantages to manufacture percutaneous cardiovascular implants","volume":"28","author":"Gauvin","year":"2013","journal-title":"J Biomater Appl"},{"key":"10.1016\/j.actbio.2014.04.033_b0350","unstructured":"Germain L, Dub\u00e9 J, Lafrance H, Yin F, Roberge C, Auger F. On the production of a living human tissue-engineered tri-leaflet heart valve. In: 10th Annual Hilton head Workshop and 2nd Bienial Heart Valve Meeting, Hilton Head; 2006."},{"key":"10.1016\/j.actbio.2014.04.033_b0355","doi-asserted-by":"crossref","first-page":"S513","DOI":"10.1016\/S0003-4975(21)01185-1","article-title":"Tissue engineering heart valves: valve leaflet replacement study in a lamb model","volume":"60","author":"Shinoka","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0360","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/S0003-4975(02)03445-8","article-title":"Hemodynamic stability during 17 years of the Carpentier-Edwards aortic pericardial bioprosthesis","volume":"73","author":"Banbury","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0365","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1089\/ten.tea.2009.0090","article-title":"Normal human epithelial cells regulate the size and morphology of tissue-engineered capillaries","volume":"16","author":"Rochon","year":"2010","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2014.04.033_b0370","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s10439-009-9646-9","article-title":"A new bioreactor for the development of tissue-engineered heart valves","volume":"37","author":"Ruel","year":"2009","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.actbio.2014.04.033_b0375","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1016\/j.biomaterials.2013.10.080","article-title":"Engineering of a bio-functionalized hybrid off-the-shelf heart valve","volume":"35","author":"Hinderer","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2014.04.033_b0380","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1089\/ten.2006.12.3223","article-title":"Engineering of biologically active living heart valve leaflets using human umbilical cord-derived progenitor cells","volume":"12","author":"Schmidt","year":"2006","journal-title":"Tissue Eng"},{"key":"10.1016\/j.actbio.2014.04.033_b0385","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0021-9290(91)90351-M","article-title":"An approach to the optimization of preparation of bioprosthetic heart valves","volume":"24","author":"Mavrilas","year":"1991","journal-title":"J Biomech"},{"key":"10.1016\/j.actbio.2014.04.033_b0390","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.ejcts.2004.05.043","article-title":"Comparison of biomechanical and structural properties between human aortic and pulmonary valve","volume":"26","author":"Stradins","year":"2004","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.actbio.2014.04.033_b0395","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1525-1594.2012.01549.x","article-title":"Donkey pericardium as an alternative bioprosthetic heart valve material","volume":"37","author":"Chen","year":"2013","journal-title":"Artif Organs"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706114002025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706114002025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:42:26Z","timestamp":1761669746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706114002025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":79,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S1742706114002025"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2014.04.033","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progress in developing a living human tissue-engineered tri-leaflet heart valve assembled from tissue produced by the self-assembly approach","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2014.04.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}