{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:01:57Z","timestamp":1790431317994,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001588","name":"Enterprise Ireland","doi-asserted-by":"publisher","award":["IP\/2011\/0096"],"award-info":[{"award-number":["IP\/2011\/0096"]}],"id":[{"id":"10.13039\/501100001588","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.actbio.2015.02.030","type":"journal-article","created":{"date-parts":[[2015,4,5]],"date-time":"2015-04-05T15:48:45Z","timestamp":1428248925000},"page":"66-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"special_numbering":"C","title":["Hyaluronic acid decreases IL-6 and IL-8 secretion and permeability in an inflammatory model of interstitial cystitis"],"prefix":"10.1016","volume":"19","author":[{"given":"Peadar","family":"Rooney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo R.","family":"Quinlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay","family":"Pandit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2015.02.030_b0005","first-page":"81","article-title":"A Multidisciplinary consensus meeting on ic\/pbs: outcome of the consensus meeting on interstitial cystitis\/painful bladder syndrome, February 10, 2007, Washington, DC","volume":"9","author":"Chancellor","year":"2007","journal-title":"Rev Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0010","series-title":"Epidemiology of interstitial cystitis: 2. Interstitial cystitis","author":"Held","year":"1990"},{"key":"10.1016\/j.actbio.2015.02.030_b0015","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.juro.2011.03.064","article-title":"AUA guideline for the diagnosis and treatment of interstitial cystitis\/bladder pain syndrome","volume":"185","author":"Hanno","year":"2011","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0020","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1097\/01.ju.0000181203.82693.95","article-title":"Prevalence of interstitial cystitis symptoms in women: a population based study in the primary care office","volume":"174","author":"Rosenberg","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0025","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0090-4295(96)00322-6","article-title":"A deficit of chondroitin on the bladder urothelium","volume":"4295","author":"Hurst","year":"1996","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0030","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0022-5347(05)67682-3","article-title":"The association of elevated urinary total to sulfated glycosaminoglycan ratio and high molecular mass hyaluronic acid with interstitial cystitis","volume":"163","author":"Wei","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0035","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/S0022-5347(01)62516-3","article-title":"Increased urinary hyaluronic acid and interstitial cystitis","volume":"160","author":"Erickson","year":"1998","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0040","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/01.ju.0000161599.69942.2e","article-title":"Urinary uronate and sulfated glycosaminoglycan levels: markers for interstitial cystitis severity","volume":"174","author":"Lokeshwar","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0022-5347(17)35990-6","article-title":"Urinary glycosaminoglycan excretion as a laboratory marker in the diagnosis of interstitial cystitis","volume":"149","author":"Hurst","year":"1993","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0050","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.urology.2010.03.016","article-title":"A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with interstitial cystitis\/painful bladder syndrome","volume":"76","author":"Nickel","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.actbio.2015.02.030_b0055","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.urology.2006.08.1105","article-title":"Rational approaches to the treatment of patients with interstitial cystitis","volume":"69","author":"Moldwin","year":"2007","journal-title":"Urology"},{"key":"10.1016\/j.actbio.2015.02.030_b0060","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/00365590410015876-1","article-title":"Treatment of interstitial cystitis with Cystistat\u00ae, a hyaluronic acid product","volume":"39","author":"Kallestrup","year":"2005","journal-title":"Scand J Urol Nephrol"},{"key":"10.1016\/j.actbio.2015.02.030_b0065","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0022-5347(17)38437-9","article-title":"Epithelial dysfunction in nonbacterial cystitis (interstitial cystitis)","volume":"145","author":"Parsons","year":"1991","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0070","first-page":"945","article-title":"Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis","volume":"171","author":"Slobodov","year":"2007","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0075","doi-asserted-by":"crossref","first-page":"e48351","DOI":"10.1371\/journal.pone.0048351","article-title":"Hyaluronan fragments improve wound healing on in vitro cutaneous model through P2X7 purinoreceptor basal activation: role of molecular weight","volume":"7","author":"Ghazi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2015.02.030_b0080","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1747-0285.2011.01108.x","article-title":"Normalization of proliferation and tight junction formation in bladder epithelial cells from patients with interstitial cystitis\/painful bladder syndrome by d-proline and d-pipecolic acid derivatives of antiproliferative factor","volume":"77","author":"Keay","year":"2011","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.actbio.2015.02.030_b0085","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/jid.2010.390","article-title":"CD44 regulates tight-junction assembly and barrier function","volume":"131","author":"Kirschner","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.actbio.2015.02.030_b0090","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/S0022-5347(05)68345-0","article-title":"Antiproliferative activity is present in bladder but not renal pelvic urine from interstitial cystitis patients","volume":"162","author":"Keay","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0095","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1097\/01.ju.0000180417.11976.99","article-title":"Regulation of tight junction proteins and bladder epithelial paracellular permeability by an antiproliferative factor from patients with interstitial cystitis","volume":"174","author":"Zhang","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0100","doi-asserted-by":"crossref","first-page":"G367","DOI":"10.1152\/ajpgi.00173.2003","article-title":"TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation","volume":"286","author":"Ma","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.actbio.2015.02.030_b0105","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1136\/gut.2004.047092","article-title":"Increased gut permeability in Crohn\u2019s disease: is TNF the link?","volume":"53","author":"Gibson","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.actbio.2015.02.030_b0110","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10","article-title":"Tumor necrosis factor-\u03b1 signaling in macrophages","volume":"20","author":"Parameswaran","year":"2010","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"10.1016\/j.actbio.2015.02.030_b0115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.cdd.4401189","article-title":"Tumor necrosis factor signaling","volume":"10","author":"Wajant","year":"2003","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.actbio.2015.02.030_b0120","doi-asserted-by":"crossref","first-page":"e44687","DOI":"10.1371\/journal.pone.0044687","article-title":"Increased urine and serum nerve growth factor levels in interstitial cystitis suggest chronic inflammation is involved in the pathogenesis of disease","volume":"7","author":"Kuo","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.actbio.2015.02.030_b0125","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0022-5347(17)32594-6","article-title":"Interleukin-6 and interstitial cystitis","volume":"152","author":"Lotz","year":"1994","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0130","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.juro.2008.03.184","article-title":"Localization and expression of inducible nitric oxide synthase in biopsies from patients with interstitial cystitis","volume":"180","author":"Koskela","year":"2008","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0135","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1016\/j.juro.2008.01.047","article-title":"Urine markers do not predict biopsy findings or presence of bladder ulcers in interstitial cystitis\/painful bladder syndrome","volume":"179","author":"Erickson","year":"2008","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0140","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.urology.2006.04.033","article-title":"Interleukin-6, histamine, and methylhistamine as diagnostic markers for interstitial cystitis","volume":"68","author":"Lamale","year":"2006","journal-title":"Urology"},{"key":"10.1016\/j.actbio.2015.02.030_b0145","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.urology.2003.11.022","article-title":"Expression of intercellular adhesion molecules in the bladder of patients with interstitial cystitis","volume":"63","author":"Green","year":"2004","journal-title":"Urology"},{"key":"10.1016\/j.actbio.2015.02.030_b0150","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0022-5347(17)35212-6","article-title":"Interleukin-1B: a clinically relevant urinary marker","volume":"151","author":"Martins","year":"1994","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0155","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/S0022-5347(05)65005-7","article-title":"A comparison of multiple urine markers for interstitial cystitis","volume":"167","author":"Erickson","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0160","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/j.juro.2012.01.034","article-title":"Urinary chemokines as noninvasive predictors of ulcerative interstitial cystitis","volume":"187","author":"Tyagi","year":"2012","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0165","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/iju.12090","article-title":"Interleukin-6 levels in female rats with protamine sulfate-induced chronic cystitis treated with hyaluronic acid","volume":"20","author":"Lv","year":"2013","journal-title":"Int J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0170","doi-asserted-by":"crossref","first-page":"F816","DOI":"10.1152\/ajprenal.90733.2008","article-title":"Interleukin-8 is essential for normal urothelial cell survival","volume":"297","author":"Tseng-Rogenski","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.actbio.2015.02.030_b0175","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0090-4295(99)00162-4","article-title":"Preliminary study on urinary cytokine levels in interstitial cystitis: does intravesical bacille Calmette\u2013Gu\u00e9rin treat interstitial cystitis by altering the immune profile in the bladder?","volume":"54","author":"Peters","year":"1999","journal-title":"Urology"},{"key":"10.1016\/j.actbio.2015.02.030_b0180","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1590\/S1677-55382008000400013","article-title":"Urinary glycosaminoglycans excretion and the effect of dimethyl sulfoxide in an experimental model of non-bacterial cystitis","volume":"34","author":"Soler","year":"2008","journal-title":"Int Braz J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0185","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/S0022-5347(01)66201-3","article-title":"Decreased urine glycosaminoglycan excretion in cats with interstitial cystitis","volume":"155","author":"Buffington","year":"1996","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0190","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0022-5347(01)65280-7","article-title":"Urinary chondroitin sulfates, heparan sulfate and total sulfated glycosaminoglycans in interstitial cystitis","volume":"157","author":"Erickson","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.actbio.2015.02.030_b0195","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1023\/A:1007198708404","article-title":"Glycosaminoglycans excretion in interstitial cystitis","volume":"31","author":"Ak\u00e7ay","year":"1999","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.actbio.2015.02.030_b0200","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.juro.2012.09.022","article-title":"The distribution and function of chondroitin sulfate and other sulfated glycosaminoglycans in the human bladder and their contribution to the protective bladder barrier","volume":"189","author":"Janssen","year":"2013","journal-title":"J Urol"},{"issue":"Pt 24","key":"10.1016\/j.actbio.2015.02.030_b0205","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1242\/jcs.113.24.4435","article-title":"Human zonulin, a potential modulator of intestinal tight junctions","volume":"113","author":"Wang","year":"2000","journal-title":"J Cell Sci"},{"key":"10.1016\/j.actbio.2015.02.030_b0210","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1749-6632.2000.tb05244.x","article-title":"Regulation of intercellular tight junctions by zonula occludens toxin and its eukaryotic analogue zonulin","volume":"915","author":"Fasano","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.actbio.2015.02.030_b0215","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1007\/s00192-012-1711-5","article-title":"Diagnosis of interstitial cystitis\/bladder pain syndrome in women with chronic pelvic pain: a prospective observational study","volume":"23","author":"Cheng","year":"2012","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.actbio.2015.02.030_b0220","doi-asserted-by":"crossref","first-page":"E136","DOI":"10.1111\/j.1464-410X.2010.09911.x","article-title":"Higher levels of cell apoptosis and abnormal E-cadherin expression in the urothelium are associated with inflammation in patients with interstitial cystitis\/painful bladder syndrome","volume":"108","author":"Shie","year":"2011","journal-title":"BJU Int"},{"key":"10.1016\/j.actbio.2015.02.030_b0225","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1524-475X.2012.00777.x","article-title":"Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: a systematic review and meta-analysis of randomized controlled trials","volume":"20","author":"Voigt","year":"2012","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.actbio.2015.02.030_b0230","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s00068-003-1284-6","article-title":"In vivo effect of tumor necrosis factor alpha on wound angiogenesis and epithelialization","volume":"29","author":"Frank","year":"2003","journal-title":"Eur J Trauma"},{"key":"10.1016\/j.actbio.2015.02.030_b0235","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.jaad.2006.01.038","article-title":"Resolution of endothelial activation and down-regulation of Tie2 receptor in psoriatic skin after infliximab therapy","volume":"54","author":"Markham","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.actbio.2015.02.030_b0240","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1136\/ard.2006.061143","article-title":"Microscopic measurement of inflammation in synovial tissue: inter-observer agreement for manual quantitative, semiquantitative and computerised digital image analysis","volume":"66","author":"Rooney","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.actbio.2015.02.030_b0245","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.biomaterials.2006.08.037","article-title":"Stereological methods to assess tissue response for tissue-engineered scaffolds","volume":"28","author":"Garcia","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2015.02.030_b0250","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1600-0625.1995.tb00254.x","article-title":"Cytokines involved in growth and differentiation of human basophils andmast cells","volume":"4","author":"Valent","year":"1995","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.actbio.2015.02.030_b0255","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.urology.2008.07.031","article-title":"Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis","volume":"73","author":"Smaldone","year":"2009","journal-title":"Urology"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706115001130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706115001130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:41:48Z","timestamp":1761669708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706115001130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":51,"alternative-id":["S1742706115001130"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2015.02.030","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyaluronic acid decreases IL-6 and IL-8 secretion and permeability in an inflammatory model of interstitial cystitis","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2015.02.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}