{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:17:31Z","timestamp":1778822251877,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC 100-2314-B-195-001"],"award-info":[{"award-number":["NSC 100-2314-B-195-001"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC 101-2314-B-195-001"],"award-info":[{"award-number":["NSC 101-2314-B-195-001"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004866","name":"National Research Program for Biopharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.actbio.2015.03.034","type":"journal-article","created":{"date-parts":[[2015,4,5]],"date-time":"2015-04-05T14:58:06Z","timestamp":1428245886000},"page":"147-154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["The potential role of strontium ranelate in treating particle-induced osteolysis"],"prefix":"10.1016","volume":"20","author":[{"given":"Yung-Chang","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Kuo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Ting","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsu-Wei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Yen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-I","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Hsiung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Hung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2015.03.034_b0005","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.2106\/00004623-200208000-00038","article-title":"What\u2019s new in orthopaedic research","volume":"84","author":"Silva","year":"2002","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.actbio.2015.03.034_b0010","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.biomaterials.2004.04.035","article-title":"The role of macrophages in osteolysis of total joint replacement","volume":"26","author":"Ingham","year":"2005","journal-title":"Biomaterials"},{"issue":"Suppl. 1","key":"10.1016\/j.actbio.2015.03.034_b0015","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/ar2170","article-title":"Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies","volume":"9","author":"Abu-Amer","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.actbio.2015.03.034_b0020","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/01.blo.0000238813.95035.1b","article-title":"The cellular and molecular biology of periprosthetic osteolysis","volume":"454","author":"Purdue","year":"2007","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.actbio.2015.03.034_b0025","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJMoa030897","article-title":"Ten years\u2019 experience with alendronate for osteoporosis in postmenopausal women","volume":"350","author":"Bone","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.actbio.2015.03.034_b0030","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/jor.20620","article-title":"Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT","volume":"26","author":"Tsutsumi","year":"2008","journal-title":"J Orthop Res"},{"key":"10.1016\/j.actbio.2015.03.034_b0035","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s00011-010-0229-x","article-title":"Efficacy of periprosthetic erythromycin delivery for wear debris-induced inflammation and osteolysis","volume":"59","author":"Ren","year":"2010","journal-title":"Inflamm Res"},{"key":"10.1016\/j.actbio.2015.03.034_b0040","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/jor.21062","article-title":"The effects of local and systemic alendronate delivery on wear debris-induced osteolysis in vivo","volume":"28","author":"Zhu","year":"2010","journal-title":"J Orthop Res"},{"key":"10.1016\/j.actbio.2015.03.034_b0045","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.bone.2012.08.115","article-title":"Risk of osteomyelitis of the jaw induced by oral bisphosphonates in patients taking medications for osteoporosis: a hospital-based cohort study in Japan","volume":"51","author":"Yamazaki","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2015.03.034_b0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.amjmed.2012.06.023","article-title":"Bisphosphonate therapy for osteoporosis: benefits, risks, and drug holiday","volume":"126","author":"McClung","year":"2013","journal-title":"Am J Med"},{"key":"10.1016\/j.actbio.2015.03.034_b0055","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s002230010055","article-title":"Mechanisms of action and therapeutic potential of strontium in bone","volume":"69","author":"Marie","year":"2001","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.actbio.2015.03.034_b0060","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1007\/s00198-008-0815-8","article-title":"Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants","volume":"20","author":"Bain","year":"2009","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2015.03.034_b0065","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10439-011-0406-2","article-title":"Strontium ranelate prevents bone loss in a rat model of localized muscle paralysis","volume":"40","author":"Sheng","year":"2012","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.actbio.2015.03.034_b0070","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00198-010-1193-6","article-title":"Strontium ranelate decreases the incidence of new caudal vertebral fractures in a growing mouse model with spontaneous fractures by improving bone microarchitecture","volume":"22","author":"Geoffroy","year":"2010","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2015.03.034_b0075","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.bone.2010.01.379","article-title":"Strontium ranelate improves implant osseointegration","volume":"46","author":"Maimoun","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2015.03.034_b0080","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/230949900401200121","article-title":"Cross-linked polyethylene and bisphosphonate therapy for osteolysis in total hip arthroplasty: a case report","volume":"12","author":"O\u2019Hara","year":"2004","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"10.1016\/j.actbio.2015.03.034_b0085","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1016\/j.biomaterials.2004.09.043","article-title":"The effect of simvastatin on polyethylene particle-induced osteolysis","volume":"26","author":"von Knoch","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2015.03.034_b0090","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/jbm.b.10067","article-title":"Generation of narrowly distributed ultra-high-molecular-weight polyethylene particles by surface texturing techniques","volume":"67","author":"Fang","year":"2003","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.actbio.2015.03.034_b0095","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/(SICI)1097-4636(199607)31:3<355::AID-JBM9>3.0.CO;2-L","article-title":"Characterization of submicron polyethylene wear debris from synovial-fluid samples of revised knee replacements using a light-scattering technique","volume":"31","author":"Hahn","year":"1996","journal-title":"J Biomed Mater"},{"key":"10.1016\/j.actbio.2015.03.034_b0100","unstructured":"Documents FG. Endotoxin Testing Recommendations for Single-Use Intraocular Ophthalmic Devices \u2013 Draft Guidance for Industry and Food and Drug Administration Staff. 2014, <http:\/\/wwwfdagov\/medicaldevices\/deviceregulationandguidance\/guidancedocuments\/ucm393374htm2014>."},{"key":"10.1016\/j.actbio.2015.03.034_b0105","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/jor.20987","article-title":"Decrease in particle-induced osteolysis in ovariectomized mice","volume":"28","author":"Nich","year":"2010","journal-title":"J Orthop Res"},{"key":"10.1016\/j.actbio.2015.03.034_b0110","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/jor.21002","article-title":"Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model","volume":"28","author":"Zhou","year":"2010","journal-title":"J Orthop Res"},{"key":"10.1016\/j.actbio.2015.03.034_b0115","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1016\/j.actbio.2011.02.013","article-title":"A new insight into the dissociating effect of strontium on bone resorption and formation","volume":"7","author":"Braux","year":"2011","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2015.03.034_b0120","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1016\/j.actbio.2014.07.025","article-title":"Strontium ranelate inhibits titanium-particle-induced osteolysis by restraining inflammatory osteoclastogenesis in vivo","volume":"10","author":"Liu","year":"2014","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2015.03.034_b0125","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1007\/s00198-014-2791-5","article-title":"Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures","volume":"25","author":"Wornham","year":"2014","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2015.03.034_b0130","doi-asserted-by":"crossref","first-page":"e3211","DOI":"10.1136\/bmj.e3211","article-title":"Bisphosphonates in the treatment of osteoporosis","volume":"344","author":"Poole","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.actbio.2015.03.034_b0135","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1210\/jc.2004-1774","article-title":"Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: treatment of peripheral osteoporosis (TROPOS) study","volume":"90","author":"Reginster","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.actbio.2015.03.034_b0140","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.biomaterials.2004.06.010","article-title":"The decrease of particle-induced osteolysis after a single dose of bisphosphonate","volume":"26","author":"von Knoch","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2015.03.034_b0145","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2106\/00004623-200202000-00011","article-title":"Effects of alendronate on particle-induced osteolysis in a rat model","volume":"84","author":"Millett","year":"2002","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.actbio.2015.03.034_b0150","first-page":"33","article-title":"The John Charnley award. Inhibition of wear debris mediated osteolysis in a canine total hip arthroplasty model","author":"Shanbhag","year":"1997","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.actbio.2015.03.034_b0155","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1359\/jbmr.2001.16.11.2126","article-title":"Alendronate reduces periprosthetic bone loss after uncemented primary total hip arthroplasty: a prospective randomized study","volume":"16","author":"Venesmaa","year":"2001","journal-title":"J Bone Miner Res"},{"issue":"Suppl 1","key":"10.1016\/j.actbio.2015.03.034_b0160","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1007\/s00198-004-1753-8","article-title":"Strontium ranelate: a novel mode of action optimizing bone formation and resorption","volume":"16","author":"Marie","year":"2005","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2015.03.034_b0165","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1359\/jbmr.2001.16.2.299","article-title":"Strontium ranelate increases cartilage matrix formation","volume":"16","author":"Henrotin","year":"2001","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.actbio.2015.03.034_b0170","doi-asserted-by":"crossref","first-page":"733","DOI":"10.2165\/10481900-000000000-00000","article-title":"Strontium ranelate: a review of its use in the treatment of postmenopausal osteoporosis","volume":"70","author":"Deeks","year":"2010","journal-title":"Drugs"},{"key":"10.1016\/j.actbio.2015.03.034_b0175","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1056\/NEJMoa022436","article-title":"The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis","volume":"350","author":"Meunier","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.actbio.2015.03.034_b0180","first-page":"137","article-title":"Inhibiting wear particles-induced osteolysis with naringin","volume":"37","author":"Yu","year":"2013","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2015.03.034_b0185","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1016\/j.jss.2010.12.006","article-title":"N-acetyl-L-cysteine inhibits wear particle-induced prosthesis loosening","volume":"168","author":"Fang","year":"2011","journal-title":"J Surg Res"},{"key":"10.1016\/j.actbio.2015.03.034_b0190","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1016\/j.fct.2008.08.016","article-title":"Baicalein inhibits osteoclast differentiation and induces mature osteoclast apoptosis","volume":"46","author":"Kim","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.actbio.2015.03.034_b0195","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1016\/j.actbio.2012.05.002","article-title":"Inhibitory effects of luteolin on titanium particle-induced osteolysis in a mouse model","volume":"8","author":"Shin","year":"2012","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2015.03.034_b0200","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jss.2011.08.011","article-title":"The aqueous extract of Angelica sinensis, a popular Chinese herb, inhibits wear debris-induced inflammatory osteolysis in mice","volume":"176","author":"Yang","year":"2012","journal-title":"J Surg Res"},{"key":"10.1016\/j.actbio.2015.03.034_b0205","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1053\/meta.2002.33360","article-title":"Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice","volume":"51","author":"Delannoy","year":"2002","journal-title":"Metabolism"},{"key":"10.1016\/j.actbio.2015.03.034_b0210","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00198-010-1193-6","article-title":"Strontium ranelate decreases the incidence of new caudal vertebral fractures in a growing mouse model with spontaneous fractures by improving bone microarchitecture","volume":"22","author":"Geoffroy","year":"2011","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.actbio.2015.03.034_b0215","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/S0142-9612(98)00140-9","article-title":"Polyethylene particles of a \u2018critical size\u2019 are necessary for the induction of cytokines by macrophages in vitro","volume":"19","author":"Green","year":"1998","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2015.03.034_b0220","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.2106\/00004623-200212000-00015","article-title":"Osteolysis in failed total knee arthroplasty: a comparison of mobile-bearing and fixed-bearing knees","volume":"84","author":"Huang","year":"2002","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.actbio.2015.03.034_b0225","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/S0736-0266(02)00015-3","article-title":"Particle size and morphology of UHMWPE wear debris in failed total knee arthroplasties \u2013 a comparison between mobile bearing and fixed bearing knees","volume":"20","author":"Huang","year":"2002","journal-title":"J Orthop Res"},{"key":"10.1016\/j.actbio.2015.03.034_b0230","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1302\/0301-620X.92B4.22560","article-title":"Wear-pattern analysis in retrieved tibial inserts of mobile-bearing and fixed-bearing total knee prostheses","volume":"92","author":"Lu","year":"2010","journal-title":"J Bone Joint Surg Br"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706115001440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706115001440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T13:11:55Z","timestamp":1598879515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706115001440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":46,"alternative-id":["S1742706115001440"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2015.03.034","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The potential role of strontium ranelate in treating particle-induced osteolysis","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2015.03.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}