{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:26:13Z","timestamp":1786983973300,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.actbio.2015.04.001","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T23:56:02Z","timestamp":1428623762000},"page":"39-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Delineation of in vitro chondrogenesis of human synovial stem cells following preconditioning using decellularized matrix"],"prefix":"10.1016","volume":"20","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2015.04.001_b0005","series-title":"Gene and cell therapy: Therapeutic mechanisms and strategies","first-page":"1123","article-title":"Cell therapy for the creation of cartilage and related clinical trials","author":"Karnes","year":"2014"},{"key":"10.1016\/j.actbio.2015.04.001_b0010","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1089\/ten.teb.2012.0002","article-title":"Synovium-derived stem cells: a tissue-specific stem cell for cartilage tissue engineering and regeneration","volume":"18","author":"Jones","year":"2012","journal-title":"Tissue Eng Part B Rev"},{"key":"10.1016\/j.actbio.2015.04.001_b0015","article-title":"Impact of tissue-specific stem cells on lineage specific differentiation: a focus on musculoskeletal system","author":"Pizzute","year":"2014","journal-title":"Stem Cell Rev Rep"},{"key":"10.1016\/j.actbio.2015.04.001_b0020","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1089\/ten.teb.2011.0583","article-title":"Cell senescence: A challenge in cartilage engineering and regeneration","volume":"18","author":"Li","year":"2012","journal-title":"Tissue Eng Part B"},{"key":"10.1016\/j.actbio.2015.04.001_b0025","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1089\/ten.tea.2009.0188","article-title":"Reconstruction of an in vitro tissue-specific microenvironment to rejuvenate synovium-derived stem cells for cartilage tissue engineering","volume":"15","author":"He","year":"2009","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2015.04.001_b0030","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/term.505","article-title":"Extracellular matrix enhances differentiation of adipose stem cells from infrapatellar fat pad toward chondrogenesis","volume":"7","author":"He","year":"2013","journal-title":"J Tissue Eng Regener Med"},{"key":"10.1016\/j.actbio.2015.04.001_b0035","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00441-011-1212-8","article-title":"Creation of an in vitro microenvironment to enhance human fetal synovium-derived stem cell chondrogenesis","volume":"345","author":"Li","year":"2011","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.actbio.2015.04.001_b0040","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ten.tea.2010.0339","article-title":"Optimization of an in vitro three-dimensional microenvironment to reprogram synovium-derived stem cells for cartilage tissue engineering","volume":"17","author":"Li","year":"2011","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2015.04.001_b0045","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1089\/ten.tea.2011.0158","article-title":"Expansion on extracellular matrix deposited by human bone marrow stromal cells facilitates stem cell proliferation and tissue-specific lineage potential","volume":"17","author":"Pei","year":"2011","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2015.04.001_b0050","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4172\/2157-7552.1000104","article-title":"Three dimensional cell expansion substrate for cartilage tissue engineering and regeneration: a comparison in decellularized matrix deposited by synovium-derived stem cells and chondrocytes","volume":"2","author":"Pei","year":"2011","journal-title":"J Tissue Sci Eng"},{"key":"10.1016\/j.actbio.2015.04.001_b0055","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00441-014-1801-4","article-title":"Expansion on matrix deposited by nonchondrogenic urine stem cells strengthens repeated passage bone marrow stromal cells\u2019 chondrogenic capacity","volume":"356","author":"Pei","year":"2014","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.actbio.2015.04.001_b0060","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/BRS.0b013e31821fcc64","article-title":"Rejuvenation of nucleus pulposus cells using extracellular matrix deposited by synovium-derived stem cells","volume":"37","author":"He","year":"2012","journal-title":"Spine"},{"key":"10.1016\/j.actbio.2015.04.001_b0065","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1002\/jcp.22950","article-title":"Extracellular matrix deposited by synovium-derived stem cells delays chondrocyte dedifferentiation and enhances redifferentiation","volume":"227","author":"Pei","year":"2012","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.actbio.2015.04.001_b0070","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1097\/BRS.0b013e31825150bf","article-title":"Modulation of in vitro microenvironment facilitates synovium-derived stem cell-based nucleus pulposus tissue regeneration","volume":"37","author":"Pei","year":"2012","journal-title":"Spine"},{"key":"10.1016\/j.actbio.2015.04.001_b0075","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1089\/ten.tea.2012.0351","article-title":"Repair of large animal partial-thickness cartilage defects using matrix rejuvenated synovium-derived stem cells","volume":"19","author":"Pei","year":"2013","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2015.04.001_b0080","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.biomaterials.2013.09.099","article-title":"Rejuvenation of chondrogenic potential by young stem cell microenvironment","volume":"35","author":"Li","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2015.04.001_b0085","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1089\/scd.2012.0495","article-title":"Antioxidation of decellularized stem cell matrix promotes human synovium-derived stem cell-based chondrogenesis","volume":"22","author":"Pei","year":"2013","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.actbio.2015.04.001_b0090","series-title":"Stem cells and cancer stem cells: Therapeutic applications in disease and injury","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-94-017-8032-2_10","article-title":"Decellularized stem cell matrix: A novel approach for autologous chondrocyte-based cartilage repair","author":"Li","year":"2014"},{"key":"10.1016\/j.actbio.2015.04.001_b0095","doi-asserted-by":"crossref","first-page":"333","DOI":"10.22203\/eCM.v022a25","article-title":"A review of decellularized stem cell matrix: a novel cell expansion system for cartilage tissue engineering","volume":"22","author":"Pei","year":"2011","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.actbio.2015.04.001_b0100","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00441-014-2010-x","article-title":"A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration","volume":"358","author":"Zhang","year":"2014","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.actbio.2015.04.001_b0105","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/S0006-3495(98)77868-3","article-title":"Relative microelastic mapping of living cells by atomic force microscopy","volume":"74","author":"A-Hassan","year":"1998","journal-title":"Biophys J"},{"key":"10.1016\/j.actbio.2015.04.001_b0110","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1159\/000016367","article-title":"Cell volume in the regulation of cell proliferation and apoptotic cell death","volume":"10","author":"Lang","year":"2000","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.actbio.2015.04.001_b0115","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2015.04.001_b0120","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1089\/ten.tea.2013.0369","article-title":"Matrix dimensions, stiffness, and structural properties modulate spontaneous chondrogenic commitment of mouse embryonic fibroblasts","volume":"20","author":"Fern\u00e1ndez-Mui\u00f1os","year":"2014","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.actbio.2015.04.001_b0125","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/adhm.201200430","article-title":"Exposure to carbon nanotubes leads to changes in the cellular biomechanics","volume":"2","author":"Dong","year":"2013","journal-title":"Adv Healthcare Mater"},{"key":"10.1016\/j.actbio.2015.04.001_b0130","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1021\/la103275y","article-title":"Comparison of scanning ion conductance microscopy with atomic force microscopy for cell imaging","volume":"27","author":"Rheinlaender","year":"2011","journal-title":"Langmuir"},{"key":"10.1016\/j.actbio.2015.04.001_b0135","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1073\/pnas.0813200106","article-title":"Stem cell fate dictated solely by altered nanotube dimension","volume":"106","author":"Oh","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.actbio.2015.04.001_b0140","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1021\/nl070678d","article-title":"Nanosize and vitality: TiO2 nanotube diameter directs cell fate","volume":"7","author":"Park","year":"2007","journal-title":"Nano Lett"},{"key":"10.1016\/j.actbio.2015.04.001_b0145","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1242\/dev.129.16.3783","article-title":"The IIIc alternative of Fgfr2 is a positive regulator of bone formation","volume":"129","author":"Eswarakumar","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.actbio.2015.04.001_b0150","doi-asserted-by":"crossref","first-page":"26450","DOI":"10.1074\/jbc.M703282200","article-title":"Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation","volume":"282","author":"Wan","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.actbio.2015.04.001_b0155","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1101\/gad.965602","article-title":"Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18","volume":"16","author":"Liu","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.actbio.2015.04.001_b0160","doi-asserted-by":"crossref","first-page":"31055","DOI":"10.1074\/jbc.M109.079962","article-title":"Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis","volume":"285","author":"Teixeira","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.actbio.2015.04.001_b0165","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1210\/endo.142.2.7922","article-title":"Bone anabolic effects of sonic\/indian hedgehog are mediated by bmp-2\/4-dependent pathways in the neonatal rat metatarsal model","volume":"142","author":"Krishnan","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.actbio.2015.04.001_b0170","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1172\/JCI20427","article-title":"A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells","volume":"114","author":"Miura","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.actbio.2015.04.001_b0175","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1083\/jcb.200409182","article-title":"Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation","volume":"168","author":"Mansukhani","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1016\/j.actbio.2015.04.001_b0180","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1101\/gad.1185804","article-title":"Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates","volume":"18","author":"Chen","year":"2004","journal-title":"Genes Dev"},{"key":"10.1016\/j.actbio.2015.04.001_b0185","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1749-6632.2003.tb03217.x","article-title":"Role of collagen type II and perlecan in skeletal development","volume":"995","author":"Gustafsson","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.actbio.2015.04.001_b0190","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ydbio.2012.01.005","article-title":"Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning","volume":"363","author":"Wilson","year":"2012","journal-title":"Dev Biol"},{"key":"10.1016\/j.actbio.2015.04.001_b0195","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/nm1655","article-title":"Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human","volume":"13","author":"Hiraoka","year":"2007","journal-title":"Nat Med"},{"issue":"part 24","key":"10.1016\/j.actbio.2015.04.001_b0200","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1242\/jcs.00152","article-title":"Wnt regulation of chondrocyte differentiation","volume":"115","author":"Church","year":"2002","journal-title":"J Cell Sci"},{"key":"10.1016\/j.actbio.2015.04.001_b0205","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/jcb.20284","article-title":"Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells","volume":"93","author":"Boland","year":"2004","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.actbio.2015.04.001_b0210","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1111\/j.1745-7254.2007.00671.x","article-title":"Wnt3a signaling promotes proliferation, myogenic differentiation, and migration of rat bone marrow mesenchymal stem cells","volume":"28","author":"Shang","year":"2007","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.actbio.2015.04.001_b0215","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1091\/mbc.e06-04-0320","article-title":"Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2","volume":"17","author":"Masckauch\u00e1n","year":"2006","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.actbio.2015.04.001_b0220","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11010-014-1963-0","article-title":"Overexpression of Wnt11 promotes chondrogenic differentiation of bone marrow-derived mesenchymal stem cells in synergism with TGF-\u03b2","volume":"390","author":"Liu","year":"2014","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.actbio.2015.04.001_b0225","doi-asserted-by":"crossref","first-page":"22039","DOI":"10.1074\/jbc.M601804200","article-title":"Opposing roles of WNT-5A and WNT-11 in interleukin-1beta regulation of type II collagen expression in articular chondrocytes","volume":"281","author":"Ryu","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.actbio.2015.04.001_b0230","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1242\/dev.00324","article-title":"Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation","volume":"130","author":"Yang","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.actbio.2015.04.001_b0235","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.matbio.2013.02.005","article-title":"Dual functions for WNT5A during cartilage development and in disease","volume":"32","author":"Hosseini-Farahabadi","year":"2013","journal-title":"Matrix Biol"},{"key":"10.1016\/j.actbio.2015.04.001_b0240","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1242\/dev.127.14.3141","article-title":"Dual roles of Wnt signaling during chondrogenesis in the chicken limb","volume":"127","author":"Hartmann","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.actbio.2015.04.001_b0245","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.modgep.2006.04.008","article-title":"Characterization and expression patterns of the MAPK family in zebrafish","volume":"6","author":"Krens","year":"2006","journal-title":"Gene Expr Patterns"},{"issue":"Pt 2","key":"10.1016\/j.actbio.2015.04.001_b0250","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1242\/jcs.01601","article-title":"Both ERK and Wnt\/beta-catenin pathways are involved in Wnt3a-induced proliferation","volume":"118","author":"Yun","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.actbio.2015.04.001_b0255","doi-asserted-by":"crossref","first-page":"41342","DOI":"10.1074\/jbc.M502168200","article-title":"Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src\/ERK and phosphatidylinositol 3-kinase\/AKT","volume":"280","author":"Almeida","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.actbio.2015.04.001_b0260","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1242\/dev.00669","article-title":"Spatial and temporal patterns of ERK signaling during mouse embryogenesis","volume":"130","author":"Corson","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.actbio.2015.04.001_b0265","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ydbio.2006.10.014","article-title":"A spatial and temporal map of FGF\/Erk1\/2 activity and response repertoires in the early chick embryo","volume":"302","author":"Lunn","year":"2007","journal-title":"Dev Biol"},{"key":"10.1016\/j.actbio.2015.04.001_b0270","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1074\/jbc.275.8.5613","article-title":"Opposing role of mitogen-activated protein kinase subtypes, erk-1\/2 and p38, in the regulation of chondrogenesis of mesenchymes","volume":"275","author":"Oh","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.actbio.2015.04.001_b0275","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/excr.1999.4535","article-title":"P38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth\/differentiation factor-5 in ATDC5 cells","volume":"250","author":"Nakamura","year":"1999","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.actbio.2015.04.001_b0280","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0012-1606(03)00321-X","article-title":"MAP kinases in chondrocyte differentiation","volume":"263","author":"Stanton","year":"2003","journal-title":"Dev Biol"},{"key":"10.1016\/j.actbio.2015.04.001_b0285","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1089\/scd.2014.0002","article-title":"Significance of epigenetic landscape in cartilage regeneration from the cartilage development and pathology perspective","volume":"23","author":"Li","year":"2014","journal-title":"Stem Cells Dev"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706115001622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706115001622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T16:04:49Z","timestamp":1651680289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706115001622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":57,"alternative-id":["S1742706115001622"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2015.04.001","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Delineation of in vitro chondrogenesis of human synovial stem cells following preconditioning using decellularized matrix","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2015.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}