{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:36:13Z","timestamp":1785209773492,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.actbio.2015.06.002","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T20:53:49Z","timestamp":1433624029000},"page":"295-308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"special_numbering":"C","title":["Novel therapeutic core\u2013shell hydrogel scaffolds with sequential delivery of cobalt and bone morphogenetic protein-2 for synergistic bone regeneration"],"prefix":"10.1016","volume":"23","author":[{"given":"Roman A.","family":"Perez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer O.","family":"Buitrago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan B.","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2015.06.002_b0005","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.addr.2012.03.009","article-title":"Naturally and synthetic smart composite biomaterials for tissue regeneration","volume":"65","author":"Perez","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2015.06.002_b0010","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/00003086-199810001-00003","article-title":"The cell and molecular biology of fracture healing","volume":"355","author":"Einhorn","year":"1998","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.actbio.2015.06.002_b0015","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2217\/rme.12.1","article-title":"Administration of growth factors for bone regeneration","volume":"7","author":"Yun","year":"2012","journal-title":"Regen. Med."},{"key":"10.1016\/j.actbio.2015.06.002_b0020","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/j.biomaterials.2010.11.038","article-title":"The enhancement of VEGF-mediated angiogenesis by polycaprolactone scaffolds with surface cross-linked heparin","volume":"32","author":"Singh","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2015.06.002_b0025","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.bone.2008.06.019","article-title":"Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model","volume":"43","author":"Patel","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2015.06.002_b0030","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1016\/j.biomaterials.2009.01.031","article-title":"Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthopic bone regeneration","volume":"30","author":"Kempen","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2015.06.002_b0035","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1016\/j.biomaterials.2011.04.036","article-title":"Tunable dual growth factor delivery from polyelectrolyte multilayer films","volume":"32","author":"Shah","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2015.06.002_b0040","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/jbm.a.34406","article-title":"Core-shell deigned scaffolds of alginate\/alpha-tricalcium phosphate for the loading and delivery of biological proteins","volume":"101","author":"Perez","year":"2013","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2015.06.002_b0045","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1089\/ten.tea.2013.0198","article-title":"Utilizing core-shell fibrous collagen-alginate hydrogel cell delivery system for bone tissue engineering","volume":"20","author":"Perez","year":"2014","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.actbio.2015.06.002_b0050","doi-asserted-by":"crossref","first-page":"15911","DOI":"10.1074\/jbc.M300463200","article-title":"Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel\u2013Lindau protein by direct binding to hypoxia-inducible factor-alpha","volume":"278","author":"Yuan","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2015.06.002_b0055","doi-asserted-by":"crossref","first-page":"31189","DOI":"10.1074\/jbc.270.52.31189","article-title":"Hypoxia Induces vascular endothelial growth factor in cultured human endothelial cells","volume":"270","author":"Namiki","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2015.06.002_b0060","doi-asserted-by":"crossref","first-page":"21686","DOI":"10.1039\/c2jm34395a","article-title":"Preparation, characterization and in vitro angiogenic capacity of cobalt substituted \u03b2-tricalcium phosphate ceramics","volume":"22","author":"Zhang","year":"2012","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.actbio.2015.06.002_b0065","doi-asserted-by":"crossref","first-page":"025008","DOI":"10.1088\/1748-6041\/4\/2\/025008","article-title":"In vitro adhesion of human dermal fibroblasts on iron crosslinked alginate films","volume":"4","author":"Machida-Sano","year":"2009","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.actbio.2015.06.002_b0070","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/820513","article-title":"Effects of composition of iron-cross-linked alginate hydrogels for cultivation of human dermal fibroblasts","author":"Machida-Sano","year":"2012","journal-title":"Int. J. Biomat."},{"key":"10.1016\/j.actbio.2015.06.002_b0075","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1016\/j.biomaterials.2010.01.083","article-title":"Enhancing in vivo vascularized bone formation by cobalt chloride-treated bone marrow stromal cells in a tissue engineered periosteum model","volume":"31","author":"Fan","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2015.06.002_b0080","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2121-12-32","article-title":"Hypoxia-mimetic agents inhibit proliferation and alter the morphology of human umbilical cord derived mesenchymal stem cells","volume":"12","author":"Zeng","year":"2011","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.actbio.2015.06.002_b0085","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/jbm.b.31798","article-title":"Porous hydroxyapatite and gelatin\/hydroxyapatite microspheres obtained by calcium phosphate cement emulsion","volume":"97","author":"Perez","year":"2011","journal-title":"J. Biomed. Mater. Res. B"},{"key":"10.1016\/j.actbio.2015.06.002_b0090","doi-asserted-by":"crossref","DOI":"10.1177\/2041731414543965","article-title":"Dynamic cell culture on calcium phosphate microcarriers for bone tissue engineering applications","volume":"5","author":"Perez","year":"2014","journal-title":"J. Tissue Eng."},{"key":"10.1016\/j.actbio.2015.06.002_b0095","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1023\/A:1020617904251","article-title":"Enhanced fibronectin-mediated cell adhesion of human osteoblast by fibroblast growth factor, FGF-2","volume":"24","author":"Jang","year":"2002","journal-title":"Biotechno. Lett."},{"key":"10.1016\/j.actbio.2015.06.002_b0100","article-title":"Initial immune reaction and angiogenesis in bone healing","author":"Schmidt-Bleek","year":"2012","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.actbio.2015.06.002_b0105","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1089\/ten.tea.2008.0510","article-title":"Dose effect of dual delivery of vascular endothelial growth factor and bone morphogenetic protein-2 on bone regeneration in a rat critical-size defect model","volume":"15","author":"Young","year":"2009","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.actbio.2015.06.002_b0110","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.biomaterials.2009.10.059","article-title":"The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation","volume":"31","author":"Kanczler","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2015.06.002_b0115","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.actbio.2015.03.013","article-title":"Core-shell designed scaffolds for drug delivery and tissue engineering","volume":"21","author":"Perez","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2015.06.002_b0120","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1016\/j.biomaterials.2010.01.083","article-title":"Enhancing in vivo vascularized bone formation by cobalt chloride-treated bone marrow stromal cells in a tissue engineered periosteum model","volume":"31","author":"Fan","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2015.06.002_b0125","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.biomaterials.2011.11.042","article-title":"Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering","volume":"33","author":"Wu","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2015.06.002_b0130","article-title":"Engineering and application of collagen-binding fibroblast growth factor 2 for sustained release","author":"Jeon","year":"2013","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2015.06.002_b0135","doi-asserted-by":"crossref","first-page":"24202","DOI":"10.1039\/c3ra43534b","article-title":"Collagen gel combined with mesoporous nanoparticles loading growth factor as a feasible therapeutic three-dimensional depot for neural tissue engineering","volume":"3","author":"Lee","year":"2013","journal-title":"RSC Adv."},{"key":"10.1016\/j.actbio.2015.06.002_b0140","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bbrc.2006.05.169","article-title":"Proliferation and differentiation of bone marrow stromal cells under hypoxic conditions","volume":"347","author":"Ren","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.actbio.2015.06.002_b0145","doi-asserted-by":"crossref","first-page":"C853","DOI":"10.1152\/ajpcell.2000.278.4.C853","article-title":"VEGF expression in an osteoblast-like cell line is regulated by a hypoxia response mechanism","volume":"278","author":"Steinbrech","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.actbio.2015.06.002_b0150","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1124\/pr.56.4.3","article-title":"Vascular endothelial growth factor and angiogenesis","volume":"56","author":"Hoeben","year":"2004","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.actbio.2015.06.002_b0155","doi-asserted-by":"crossref","first-page":"e46842","DOI":"10.1371\/journal.pone.0046842","article-title":"Endothelial differentiation of mesenchymal stromal cells","volume":"7","author":"Janeczek Portalska","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.actbio.2015.06.002_b0160","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1089\/biores.2012.9905","article-title":"HIF-1\u03b1 Overexpression induces angiogenesis in mesenchymal stem cells","volume":"1","author":"Razban","year":"2012","journal-title":"Biores. Open Access."},{"key":"10.1016\/j.actbio.2015.06.002_b0165","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.cardiores.2005.02.006","article-title":"Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hind limb ischemia","volume":"66","author":"Iwasea","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.actbio.2015.06.002_b0170","doi-asserted-by":"crossref","first-page":"e35579","DOI":"10.1371\/journal.pone.0035579","article-title":"Differentiation-dependent secretion of proangiogenic factors by mesenchymal stem cells","volume":"7","author":"Al","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2015.06.002_b0175","doi-asserted-by":"crossref","DOI":"10.1177\/2041731413509646","article-title":"Application of stem-cell media to explant culture of human periosteum: An optimal approach for preparing osteogenic cell material","volume":"4","author":"Uematsu","year":"2013","journal-title":"J. Tissue Eng."},{"key":"10.1016\/j.actbio.2015.06.002_b0180","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bbrc.2011.11.105","article-title":"Oxygen tension regulates the osteogenic, chondrogenic and endochondral phenotype of bone marrow derived mesenchymal stem cells","volume":"417","author":"Sheehy","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.actbio.2015.06.002_b0185","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/jcp.1081","article-title":"Cultivation of rat marrowderived mesenchymal stem cells in reduced oxygen tension: effects on in vitro and in vivo osteochondrogenesis","volume":"187","author":"Lennon","year":"2001","journal-title":"J. Cell Physiol."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706115002676?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706115002676?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:45:13Z","timestamp":1761669913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706115002676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":37,"alternative-id":["S1742706115002676"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2015.06.002","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel therapeutic core\u2013shell hydrogel scaffolds with sequential delivery of cobalt and bone morphogenetic protein-2 for synergistic bone regeneration","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2015.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}