{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:15:28Z","timestamp":1783152928404,"version":"3.54.6"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01DK101536"],"award-info":[{"award-number":["R01DK101536"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["R01DK079184"],"award-info":[{"award-number":["R01DK079184"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000183","name":"U.S. Army Research Office","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000183","id-type":"DOI","asserted-by":"crossref"}]},{"name":"U.S. Army Medical Research and Material Command"},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.actbio.2016.01.014","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T23:28:25Z","timestamp":1452814105000},"page":"89-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Sonic hedgehog delivery from self-assembled nanofiber hydrogels reduces the fibrotic response in models of erectile dysfunction"],"prefix":"10.1016","volume":"32","author":[{"given":"Shawn","family":"Choe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorina","family":"Veliceasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Bond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel I.","family":"Stupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin T.","family":"McVary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Podlasek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2016.01.014_b0005","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1046\/j.0105-6263.2003.00447.x","article-title":"Expression of cavernous transforming growth factor-\u03b21 and its Type II receptor in patients with erectile dysfunction","volume":"27","author":"Ryu","year":"2004","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.actbio.2016.01.014_b0010","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1097\/01.ju.0000154356.76027.4f","article-title":"Histological alterations in cavernous tissue after radical prostatectomy","volume":"173","author":"Iacono","year":"2005","journal-title":"J. Urol."},{"key":"10.1016\/j.actbio.2016.01.014_b0015","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1464-410X.2004.04969.x","article-title":"Expression of transforming growth factor-\u03b21 in penile tissue from rats with bilateral cavernosal nerve ablation","volume":"94","author":"Hu","year":"2004","journal-title":"BJU Int."},{"key":"10.1016\/j.actbio.2016.01.014_b0020","first-page":"970363","article-title":"The effects of trimetazidine and sildenafil on bilateral cavernosal nerve injury induced oxidative damage and cavernosal fibrosis in rats","author":"Atilgan","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.actbio.2016.01.014_b0025","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1111\/j.1743-6109.2009.01508.x","article-title":"Age-related morphological changes in smooth muscle and collagen content in human corpus cavernosum","volume":"7","author":"Ferrer","year":"2010","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.actbio.2016.01.014_b0030","first-page":"42","article-title":"Age changes of the connective tissue structures of human penis","volume":"140","author":"Klimachev","year":"2011","journal-title":"Morfologiia"},{"issue":"Suppl. 1","key":"10.1016\/j.actbio.2016.01.014_b0035","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1590\/S0102-86502014001300008","article-title":"Lard and\/or canola oil-rich diets induce penile morphological alterations in a rat model","volume":"29","author":"Junior","year":"2014","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.actbio.2016.01.014_b0040","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0022-5347(01)67730-9","article-title":"PGE1 suppresses the induction of collagen synthesis by transforming growth factor-\u03b21 in human corpus cavernosum smooth muscle","volume":"153","author":"Moreland","year":"1995","journal-title":"J. Urol."},{"key":"10.1016\/j.actbio.2016.01.014_b0045","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/j.1939-4640.2003.tb02668.x","article-title":"Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernous","volume":"24","author":"Leungwattanakij","year":"2003","journal-title":"J. Androl."},{"key":"10.1016\/j.actbio.2016.01.014_b0050","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/sj.ijir.3900323","article-title":"Cyclic AMP modulates TGF-beta 1-induced fibrillar collagen synthesis in cultured human corpus cavernosum smooth muscle cells","volume":"10","author":"Moreland","year":"1998","journal-title":"Int. J. Impot. Res."},{"key":"10.1016\/j.actbio.2016.01.014_b0055","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1096\/fj.09-144147","article-title":"Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling","volume":"24","author":"Wen","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.actbio.2016.01.014_b0060","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/carcin\/bgm281","article-title":"Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway","volume":"29","author":"Yoo","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.actbio.2016.01.014_b0065","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/jnci\/djq257","article-title":"GLI2-mediated melanoma invasion and metastasis","volume":"102","author":"Alexaki","year":"2010","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.actbio.2016.01.014_b0070","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1016\/j.ajpath.2012.08.019","article-title":"The hedgehog system machinery controls transforming growth factor-beta-dependent myofibroblastic differentiation in humans: involvement in idiopathic pulmonary fibrosis","volume":"181","author":"Cigna","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.actbio.2016.01.014_b0075","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1165\/rcmb.2014-0108OC","article-title":"Reemergence of hedgehog mediates epithelial\u2013mesenchymal crosstalk in pulmonary fibrosis","volume":"52","author":"Hu","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.actbio.2016.01.014_b0080","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1095\/biolreprod.102.006643","article-title":"Sonic hedgehog cascade is required for penile postnatal morphogenesis, differentiation and adult homeostasis","volume":"68","author":"Podlasek","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.actbio.2016.01.014_b0085","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1095\/biolreprod.102.013508","article-title":"Altered sonic hedgehog signaling is associated with morphological abnormalities in the penis of the BB\/WOR diabetic rat","volume":"69","author":"Podlasek","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.actbio.2016.01.014_b0090","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1095\/biolreprod.106.053926","article-title":"Regulation of cavernous nerve injury-induced apoptosis by sonic hedgehog","volume":"76","author":"Podlasek","year":"2007","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.actbio.2016.01.014_b0095","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1095\/biolreprod.107.064766","article-title":"Neural influences on sonic hedgehog and apoptosis in the penis","volume":"78","author":"Bond","year":"2008","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.actbio.2016.01.014_b0100","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1743-6109.2010.02001.x","article-title":"Peptide amphiphile nanofiber delivery of sonic hedgehog protein to reduce smooth muscle apoptosis in the penis after cavernous nerve resection","volume":"8","author":"Bond","year":"2011","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.actbio.2016.01.014_b0105","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.biomaterials.2010.10.003","article-title":"Regeneration of the cavernous nerve by sonic hedgehog using aligned peptide amphiphile nanofibers","volume":"32","author":"Angeloni","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2016.01.014_b0110","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1111\/j.1743-6109.2012.02930.x","article-title":"Sonic hedgehog is neuroprotective in the cavernous nerve with crush injury","volume":"10","author":"Angeloni","year":"2013","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.actbio.2016.01.014_b0115","doi-asserted-by":"crossref","first-page":"e70985","DOI":"10.1371\/journal.pone.0070985","article-title":"Sonic hedgehog protein is decreased and penile morphology is altered in prostatectomy and diabetic patients","volume":"8","author":"Angeloni","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2016.01.014_b0120","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1681\/ASN.2011060614","article-title":"Sonic hedgehog signaling mediates epithelial\u2013mesenchymal communication and promotes renal fibrosis","volume":"23","author":"Ding","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.actbio.2016.01.014_b0125","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1002\/art.34444","article-title":"Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis","volume":"64","author":"Horn","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.actbio.2016.01.014_b0130","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1365-2613.2010.00743.x","article-title":"Oxidative damage and TGF-beta differentially induce lung epithelial cell sonic hedgehog and tenascin-C expression: implications for the regulation of lung remodeling in idiopathic interstitial lung disease","volume":"92","author":"Fitch","year":"2011","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.actbio.2016.01.014_b0135","doi-asserted-by":"crossref","first-page":"10299","DOI":"10.1523\/JNEUROSCI.2500-09.2009","article-title":"Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation","volume":"29","author":"Amankulor","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.actbio.2016.01.014_b0140","doi-asserted-by":"crossref","first-page":"L978","DOI":"10.1152\/ajplung.00184.2012","article-title":"Role of sonic hedgehog in idiopathic pulmonary fibrosis","volume":"303","author":"Bolanos","year":"2012","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.actbio.2016.01.014_b0145","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1242\/dev.128.9.1573","article-title":"Induced repatterning of type XVIII collagen expression in ureter bud from kidney to lung type: association with sonic hedgehog and ectopic surfactant protein C","volume":"128","author":"Lin","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.actbio.2016.01.014_b0150","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1165\/rcmb.2012-0347OC","article-title":"Hedgehog signaling in neonatal and adult lung","volume":"48","author":"Liu","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.actbio.2016.01.014_b0155","doi-asserted-by":"crossref","first-page":"e82201","DOI":"10.1371\/journal.pone.0082201","article-title":"Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis","volume":"8","author":"Tsang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2016.01.014_b0160","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nmat2778","article-title":"A self-assembly pathway to aligned monodomain gels","volume":"9","author":"Zhang","year":"2010","journal-title":"Nat. Mater."},{"key":"10.1016\/j.actbio.2016.01.014_b0165","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.biomaterials.2013.09.077","article-title":"Aligned neurite outgrowth and directed cell migration in self-assembled monodomain gels","volume":"35","author":"Berns","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2016.01.014_b0170","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0021-9290(00)00122-6","article-title":"A biomechanical model of Peyronie\u2019s disease","volume":"33","author":"Gefen","year":"2000","journal-title":"J. Biomech."},{"key":"10.1016\/j.actbio.2016.01.014_b0175","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0009-9120(96)00003-6","article-title":"A simplified method for the analysis of hydroxyproline in biological tissues","volume":"29","author":"Reddy","year":"1996","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.actbio.2016.01.014_b0180","series-title":"Theory and Practice of Histotechnology","author":"Sheehan","year":"1980"},{"key":"10.1016\/j.actbio.2016.01.014_b0185","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1743-6109.2005.00158.x","article-title":"Functional sequelae of cavernous nerve injury in the rat: is there model dependency","volume":"3","author":"Mullerad","year":"2006","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.actbio.2016.01.014_b0190","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.expneurol.2007.05.011","article-title":"Reduced efficacy of nitrergic neurotransmission exacerbates erectile dysfunction after penile nerve injury despite axonal regeneration","volume":"207","author":"Nangle","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.actbio.2016.01.014_b0195","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.2174\/138161205774913408","article-title":"Sonic hedgehog, the penis and erectile dysfunction: a review of sonic hedgehog signaling in the penis","volume":"11","author":"Podlasek","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.actbio.2016.01.014_b0200","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/bies.10230","article-title":"Fibrillar collagen: the key to vertebrate evolution? A tale of molecular incest","volume":"25","author":"Boot-Handford","year":"2003","journal-title":"BioEssays"},{"key":"10.1016\/j.actbio.2016.01.014_b0205","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/S0022-5347(05)67110-8","article-title":"Organization and relative content of smooth muscle cells, collagen and elastic fibers in the corpus cavernosum of rat penis","volume":"164","author":"Pinheiro","year":"2000","journal-title":"J. Urol."},{"key":"10.1016\/j.actbio.2016.01.014_b0210","first-page":"121","article-title":"Hypoxia induces fibrosis of corpus cavernosum smooth muscle in SD rats","volume":"17","author":"Lu","year":"2011","journal-title":"Zhonghua Nan. Ke. Xue."},{"key":"10.1016\/j.actbio.2016.01.014_b0215","first-page":"986","article-title":"Survey on spontaneous peripheral neuropathy in aging rats","volume":"42","author":"Majeed","year":"1992","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.actbio.2016.01.014_b0220","first-page":"11","article-title":"Development of the os penis in genital tubercle cultured beneath the renal capsule of adult rats","volume":"149","author":"Murakami","year":"1986","journal-title":"J. Anat."},{"key":"10.1016\/j.actbio.2016.01.014_b0225","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1159\/000142803","article-title":"Penile cavernous tissue: an electron microscopic study of its development in the rat","volume":"63","author":"Leeson","year":"1966","journal-title":"Acta Anat."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706116300149?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706116300149?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:48:53Z","timestamp":1761670133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706116300149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":45,"alternative-id":["S1742706116300149"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2016.01.014","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sonic hedgehog delivery from self-assembled nanofiber hydrogels reduces the fibrotic response in models of erectile dysfunction","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2016.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}