{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:26:00Z","timestamp":1783153560709,"version":"3.54.6"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005053","name":"CIBER-BBN","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Acci\u00f3n Estrat\u00e9gica en Salud"},{"DOI":"10.13039\/100012818","name":"Comunidad Aut\u00f3noma de Madrid","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MMA Foundation"},{"name":"Neurosciences and Aging Foundation"},{"name":"Francisco Soria Melguizo Foundation"},{"name":"Octopharma and Parkinson Madrid"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.actbio.2016.01.017","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T11:46:38Z","timestamp":1453117598000},"page":"275-282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors"],"prefix":"10.1016","volume":"33","author":[{"given":"Juan L.","family":"Paris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paz de la","family":"Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Manzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Victoria","family":"Caba\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Vallet-Reg\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2016.01.017_b0005","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1021\/nn900002m","article-title":"Impact of nanotechnology on drug delivery","volume":"3","author":"Farokhzad","year":"2009","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2016.01.017_b0010","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1002\/smll.201000523","article-title":"Engineering nanocomposite materials for cancer therapy","volume":"6","author":"Minelli","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.actbio.2016.01.017_b0015","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ejps.2012.12.006","article-title":"A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics","volume":"48","author":"Steichen","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.actbio.2016.01.017_b0020","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/cm402592t","article-title":"Multifunctional mesoporous silica nanoparticles as a universal platform for drug delivery","volume":"26","author":"Argyo","year":"2014","journal-title":"Chem. Mater."},{"key":"10.1016\/j.actbio.2016.01.017_b0025","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1517\/17425240903304024","article-title":"Drug delivery from ordered mesoporous matrices","volume":"6","author":"Manzano","year":"2009","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.actbio.2016.01.017_b0030","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1039\/b922651f","article-title":"New developments in ordered mesoporous materials for drug delivery","volume":"20","author":"Manzano","year":"2010","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.actbio.2016.01.017_b0035","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1002\/smll.200700005","article-title":"Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs","volume":"3","author":"Lu","year":"2007","journal-title":"Small"},{"key":"10.1016\/j.actbio.2016.01.017_b0040","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1039\/c1cs15246g","article-title":"Mesoporous silica nanoparticles in biomedical applications","volume":"41","author":"Li","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.actbio.2016.01.017_b0045","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/smll.201000538","article-title":"Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals","volume":"6","author":"Lu","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.actbio.2016.01.017_b0050","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.addr.2010.04.009","article-title":"The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect","volume":"63","author":"Fang","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2016.01.017_b0055","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.addr.2012.10.002","article-title":"The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo","volume":"65","author":"Maeda","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2016.01.017_b0060","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.addr.2013.11.009","article-title":"Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology","volume":"66","author":"Bertrand","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2016.01.017_b0065","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jconrel.2012.07.010","article-title":"Analysis on the current status of targeted drug delivery to tumors","volume":"164","author":"Kwon","year":"2012","journal-title":"J. Control Rel."},{"key":"10.1016\/j.actbio.2016.01.017_b0070","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.addr.2012.09.038","article-title":"Cancer nanomedicines: so many papers and so few drugs!","volume":"65","author":"Venditto","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2016.01.017_b0075","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.actbio.2016.01.017_b0080","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jconrel.2010.05.015","article-title":"Mesenchymal stem cells: a promising targeted-delivery vehicle in cancer gene therapy","volume":"147","author":"Hu","year":"2010","journal-title":"J. Control Rel."},{"key":"10.1016\/j.actbio.2016.01.017_b0085","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.nano.2012.06.003","article-title":"Mesenchymal stem cells: a potential targeted-delivery vehicle for anti-cancer drug, loaded nanoparticles","volume":"9","author":"Gao","year":"2013","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.actbio.2016.01.017_b0090","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/cgt.2012.71","article-title":"Decidua mesenchymal stem cells migrated toward mammary tumors in vitro and in vivo affecting tumor growth and tumor development","volume":"20","author":"Vegh","year":"2013","journal-title":"Cancer Gene Therapy"},{"key":"10.1016\/j.actbio.2016.01.017_b0095","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1002\/stem.187","article-title":"Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging","volume":"27","author":"Kidd","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.actbio.2016.01.017_b0100","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/gt.2008.39","article-title":"Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells","volume":"15","author":"Spaeth","year":"2008","journal-title":"Gene Therapy"},{"key":"10.1016\/j.actbio.2016.01.017_b0105","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/mt.2010.58","article-title":"Toward brain tumor gene therapy using multipotent mesenchymal stromal cell vectors","volume":"18","author":"Bexell","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.actbio.2016.01.017_b0110","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.biomaterials.2012.11.032","article-title":"Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery","volume":"34","author":"Huang","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2016.01.017_b0115","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1002\/adfm.201400729","article-title":"Hybrid enzyme-polymeric capsules\/mesoporous silica nanodevice for in situ cytotoxic agent generation","volume":"24","author":"Baeza","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2016.01.017_b0120","doi-asserted-by":"crossref","first-page":"495.e9","DOI":"10.1016\/j.ajog.2010.06.045","article-title":"Isolation and characterization of true mesenchymal stem cells derived from human term decidua capable of multilineage differentiation into all 3 embryonic layers","volume":"203","author":"Macias","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.actbio.2016.01.017_b0125","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1477-3163-6-18","article-title":"Prolactin, TNF alpha and nitric oxide expression in nitroso-N-methylurea-induced-mammary tumours","volume":"6","author":"Vegh","year":"2007","journal-title":"J. Carcinog."},{"key":"10.1016\/j.actbio.2016.01.017_b0130","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1002\/smll.200901789","article-title":"Mesoporous silica nanoparticles for intracellular controlled drug delivery","volume":"6","author":"Vivero-Escoto","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.actbio.2016.01.017_b0135","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1002\/anie.200503075","article-title":"Silica-based mesoporous organic\u2013inorganic hybrid materials","volume":"45","author":"Hoffmann","year":"2006","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.actbio.2016.01.017_b0140","doi-asserted-by":"crossref","unstructured":"T. Yu, A. Malugin, H. Ghandehari, Impact of silica nanoparticle design on cellular toxicity and hemolytic activity, in: ACS Nano, 2011: pp. 5717\u20135728.","DOI":"10.1021\/nn2013904"},{"key":"10.1016\/j.actbio.2016.01.017_b0145","doi-asserted-by":"crossref","first-page":"12690","DOI":"10.1021\/ja104501a","article-title":"Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves","volume":"132","author":"Meng","year":"2010","journal-title":"J. Am. Chem. Soc."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706116300162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706116300162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:45:34Z","timestamp":1761669934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706116300162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":29,"alternative-id":["S1742706116300162"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2016.01.017","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2016.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}