{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:32:32Z","timestamp":1788982352410,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"am","delay-in-days":335,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008615","name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","award":["1F32AI102535"],"award-info":[{"award-number":["1F32AI102535"]}],"id":[{"id":"10.13039\/100008615","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008615","name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","award":["U19AI096398"],"award-info":[{"award-number":["U19AI096398"]}],"id":[{"id":"10.13039\/100008615","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008615","name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","award":["R21EB017938"],"award-info":[{"award-number":["R21EB017938"]}],"id":[{"id":"10.13039\/100008615","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008615","name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","award":["2013-39274"],"award-info":[{"award-number":["2013-39274"]}],"id":[{"id":"10.13039\/100008615","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008615","name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","award":["DMR-1151477"],"award-info":[{"award-number":["DMR-1151477"]}],"id":[{"id":"10.13039\/100008615","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1F32AI102535"],"award-info":[{"award-number":["1F32AI102535"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI096398"],"award-info":[{"award-number":["U19AI096398"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21EB017938"],"award-info":[{"award-number":["R21EB017938"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2013-39274"],"award-info":[{"award-number":["2013-39274"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DMR-1151477"],"award-info":[{"award-number":["DMR-1151477"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000008","name":"David and Lucile Packard Foundation","doi-asserted-by":"publisher","award":["1F32AI102535"],"award-info":[{"award-number":["1F32AI102535"]}],"id":[{"id":"10.13039\/100000008","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000008","name":"David and Lucile Packard Foundation","doi-asserted-by":"publisher","award":["U19AI096398"],"award-info":[{"award-number":["U19AI096398"]}],"id":[{"id":"10.13039\/100000008","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000008","name":"David and Lucile Packard Foundation","doi-asserted-by":"publisher","award":["R21EB017938"],"award-info":[{"award-number":["R21EB017938"]}],"id":[{"id":"10.13039\/100000008","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000008","name":"David and Lucile Packard Foundation","doi-asserted-by":"publisher","award":["2013-39274"],"award-info":[{"award-number":["2013-39274"]}],"id":[{"id":"10.13039\/100000008","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000008","name":"David and Lucile Packard Foundation","doi-asserted-by":"publisher","award":["DMR-1151477"],"award-info":[{"award-number":["DMR-1151477"]}],"id":[{"id":"10.13039\/100000008","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1F32AI102535"],"award-info":[{"award-number":["1F32AI102535"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["U19AI096398"],"award-info":[{"award-number":["U19AI096398"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["R21EB017938"],"award-info":[{"award-number":["R21EB017938"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2013-39274"],"award-info":[{"award-number":["2013-39274"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMR-1151477"],"award-info":[{"award-number":["DMR-1151477"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001797","name":"Pharmaceutical Research and Manufacturers of America Foundation","doi-asserted-by":"publisher","award":["1F32AI102535"],"award-info":[{"award-number":["1F32AI102535"]}],"id":[{"id":"10.13039\/100001797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001797","name":"Pharmaceutical Research and Manufacturers of America Foundation","doi-asserted-by":"publisher","award":["U19AI096398"],"award-info":[{"award-number":["U19AI096398"]}],"id":[{"id":"10.13039\/100001797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001797","name":"Pharmaceutical Research and Manufacturers of America Foundation","doi-asserted-by":"publisher","award":["R21EB017938"],"award-info":[{"award-number":["R21EB017938"]}],"id":[{"id":"10.13039\/100001797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001797","name":"Pharmaceutical Research and Manufacturers of America Foundation","doi-asserted-by":"publisher","award":["2013-39274"],"award-info":[{"award-number":["2013-39274"]}],"id":[{"id":"10.13039\/100001797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001797","name":"Pharmaceutical Research and Manufacturers of America Foundation","doi-asserted-by":"publisher","award":["DMR-1151477"],"award-info":[{"award-number":["DMR-1151477"]}],"id":[{"id":"10.13039\/100001797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013056","name":"UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","award":["1F32AI102535"],"award-info":[{"award-number":["1F32AI102535"]}],"id":[{"id":"10.13039\/100013056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013056","name":"UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","award":["U19AI096398"],"award-info":[{"award-number":["U19AI096398"]}],"id":[{"id":"10.13039\/100013056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013056","name":"UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","award":["R21EB017938"],"award-info":[{"award-number":["R21EB017938"]}],"id":[{"id":"10.13039\/100013056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013056","name":"UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","award":["2013-39274"],"award-info":[{"award-number":["2013-39274"]}],"id":[{"id":"10.13039\/100013056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013056","name":"UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","award":["DMR-1151477"],"award-info":[{"award-number":["DMR-1151477"]}],"id":[{"id":"10.13039\/100013056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.actbio.2016.07.019","type":"journal-article","created":{"date-parts":[[2016,7,16]],"date-time":"2016-07-16T09:50:15Z","timestamp":1468662615000},"page":"61-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus"],"prefix":"10.1016","volume":"43","author":[{"given":"Christine E.","family":"Henry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumon","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Hoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Ensign","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenetta L.","family":"Nunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"McCallen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Moench","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Cone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve R.","family":"Roffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel K.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2016.07.019_b0005","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.addr.2008.09.012","article-title":"Micro- and macrorheology of mucus","volume":"61","author":"Lai","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2016.07.019_b0010","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.addr.2008.11.002","article-title":"Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues","author":"Lai","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2016.07.019_b0015","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1021\/mp8001254","article-title":"Controlled surface modification with poly(ethylene)glycol enhances diffusion of PLGA nanoparticles in human cervical mucus","volume":"6","author":"Cu","year":"2009","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2016.07.019_b0020","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1073\/pnas.0608611104","article-title":"Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus","volume":"104","author":"Lai","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.actbio.2016.07.019_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2015.01.023","article-title":"Nanoparticle diffusion within intestinal mucus: three-dimensional response analysis dissecting the impact of particle surface charge, size and heterogeneity across polyelectrolyte, pegylated and viral particles","author":"Abdulkarim","year":"2015","journal-title":"Eur. J. Pharmaceutics Biopharm."},{"key":"10.1016\/j.actbio.2016.07.019_b0030","doi-asserted-by":"crossref","first-page":"8077","DOI":"10.1039\/c1sm05888f","article-title":"Adsorption of bile salts to particles allows penetration of intestinal mucus","volume":"7","author":"Macierzanka","year":"2011","journal-title":"Soft Matter"},{"key":"10.1016\/j.actbio.2016.07.019_b0035","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1073\/pnas.0911748107","article-title":"Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses","volume":"107","author":"Lai","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.actbio.2016.07.019_b0040","doi-asserted-by":"crossref","first-page":"6922","DOI":"10.1016\/j.biomaterials.2013.05.039","article-title":"Enhanced vaginal drug delivery through the use of hypotonic formulations that induce fluid uptake","volume":"34","author":"Ensign","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2016.07.019_b0045","doi-asserted-by":"crossref","first-page":"9726","DOI":"10.1002\/anie.200803526","article-title":"Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that \u201cslip\u201d through the human mucus barrier","volume":"47","author":"Wang","year":"2008","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.actbio.2016.07.019_b0050","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/adhm.201300519","article-title":"Vaginal delivery of paclitaxel via nanoparticles with non-mucoadhesive surfaces suppresses cervical tumor growth","volume":"3","author":"Yang","year":"2014","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.actbio.2016.07.019_b0055","doi-asserted-by":"crossref","first-page":"138ra79","DOI":"10.1126\/scitranslmed.3003453","article-title":"Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus","volume":"4","author":"Ensign","year":"2012","journal-title":"Sci. Trans. Med."},{"key":"10.1016\/j.actbio.2016.07.019_b0060","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jconrel.2014.01.007","article-title":"Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier","volume":"178","author":"Suk","year":"2014","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.actbio.2016.07.019_b0065","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0005-2736(91)90246-5","article-title":"Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo","volume":"1066","author":"Allen","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.actbio.2016.07.019_b0070","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nrd1033","article-title":"Effect of pegylation on pharmaceuticals","volume":"2","author":"Harris","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.actbio.2016.07.019_b0075","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0014-5793(90)81016-H","article-title":"Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes","volume":"268","author":"Klibanov","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/j.actbio.2016.07.019_b0080","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2217\/nnm.11.19","article-title":"Nanoparticle PEGylation for imaging and therapy","volume":"6","author":"Jokerst","year":"2011","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.actbio.2016.07.019_b0085","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0022-3565(24)35391-1","article-title":"Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes","volume":"292","author":"Dams","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.actbio.2016.07.019_b0090","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0378-5173(03)00085-1","article-title":"Accelerated clearance of a second injection of PEGylated liposomes in mice","volume":"255","author":"Ishida","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2016.07.019_b0095","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ymthe.2005.09.014","article-title":"Hypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomes","volume":"13","author":"Judge","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.actbio.2016.07.019_b0100","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1124\/jpet.104.078113","article-title":"Immunogenicity and rapid blood clearance of liposomes containing polyethylene glycol-lipid conjugates and nucleic acid","volume":"312","author":"Semple","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.actbio.2016.07.019_b0105","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jconrel.2007.02.010","article-title":"Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes","volume":"119","author":"Wang","year":"2007","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.actbio.2016.07.019_b0110","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s11095-013-1067-7","article-title":"The immunogenicity of polyethylene glycol: facts and fiction","volume":"30","author":"Schellekens","year":"2013","journal-title":"Pharm. Res."},{"key":"10.1016\/j.actbio.2016.07.019_b0115","first-page":"556","article-title":"Occurrence of an antibody to poly(ethylene glycol) in normal donors","volume":"102","author":"Armstrong","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.actbio.2016.07.019_b0120","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/wnan.1339","article-title":"Anti-PEG immunity: emergence, characteristics, and unaddressed questions","volume":"7","author":"Yang","year":"2015","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2016.07.019_b0125","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/mi.2013.120","article-title":"IgG in cervicovaginal mucus traps HSV and prevents vaginal herpes infections","volume":"7","author":"Wang","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.actbio.2016.07.019_b0130","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/S0006-3495(01)75844-4","article-title":"Diffusion of macromolecules and virus-like particles in human cervical mucus","volume":"81","author":"Olmsted","year":"2001","journal-title":"Biophys. J."},{"key":"10.1016\/j.actbio.2016.07.019_b0135","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/j.bpj.2014.02.038","article-title":"Transient antibody-mucin interactions produce a dynamic molecular shield against viral invasion","volume":"106","author":"Chen","year":"2014","journal-title":"Biophys. J."},{"key":"10.1016\/j.actbio.2016.07.019_b0140","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1021\/mp400703d","article-title":"Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation","volume":"11","author":"Yang","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2016.07.019_b0145","unstructured":"Academia Sinica. <http:\/\/www.ibms.sinica.edu.tw\/~sroff\/anti-PEG\/anti-PEG_antibody_order.html>. Accessed February 22, 2016."},{"key":"10.1016\/j.actbio.2016.07.019_b0150","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1021\/bc100067t","article-title":"Sensitive quantification of PEGylated compounds by second-generation anti-poly(ethylene glycol) monoclonal antibodies","volume":"21","author":"Su","year":"2010","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.actbio.2016.07.019_b0155","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.4161\/mabs.29124","article-title":"Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies","volume":"6","author":"Su","year":"2014","journal-title":"mAbs"},{"key":"10.1016\/j.actbio.2016.07.019_b0160","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jmr.920","article-title":"Affinity purification and characterization of an anti-PEG IgM","volume":"22","author":"Ehrlich","year":"2009","journal-title":"J. Mol. Recogn. JMR"},{"key":"10.1016\/j.actbio.2016.07.019_b0165","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0006-3495(00)76363-6","article-title":"Multiple-particle tracking measurements of heterogeneities in solutions of actin filaments and actin bundles","volume":"79","author":"Apgar","year":"2000","journal-title":"Biophys. J."},{"key":"10.1016\/j.actbio.2016.07.019_b0170","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jconrel.2015.10.021","article-title":"Minimizing biases associated with tracking analysis of submicron particles in heterogeneous biological fluids","volume":"220","author":"Wang","year":"2015","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.actbio.2016.07.019_b0175","doi-asserted-by":"crossref","first-page":"50393","DOI":"10.1074\/jbc.M309026200","article-title":"Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport","volume":"278","author":"Dawson","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2016.07.019_b0180","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.addr.2004.06.001","article-title":"Real-time multiple-particle tracking: applications to drug and gene delivery","volume":"57","author":"Suh","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2016.07.019_b0185","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1073\/pnas.0608611104","article-title":"Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus","volume":"104","author":"Lai","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.actbio.2016.07.019_b0190","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1073\/pnas.1012861108","article-title":"Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection","volume":"108","author":"Li","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.actbio.2016.07.019_b0195","first-page":"292","article-title":"IgG and IgA content of vaginal fluid during the menstrual cycle","volume":"34","author":"Usala","year":"1989","journal-title":"J. Reprod. Med."},{"key":"10.1016\/j.actbio.2016.07.019_b0200","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1021\/mp400087y","article-title":"Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues","volume":"10","author":"Ensign","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2016.07.019_b0205","article-title":"Antibody blocks acquisition of bacterial colonization through agglutination","author":"Roche","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.actbio.2016.07.019_b0210","series-title":"Handbook of Mucosal Immunology","first-page":"43","article-title":"Mucus","author":"Cone","year":"1999"},{"key":"10.1016\/j.actbio.2016.07.019_b0215","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jconrel.2006.01.005","article-title":"Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes","volume":"112","author":"Ishida","year":"2006","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.actbio.2016.07.019_b0220","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1021\/acs.molpharmaceut.5b00144","article-title":"Anti-PEG IgM Is a major contributor to the accelerated blood clearance of polyethylene glycol-conjugated protein","volume":"12","author":"Mima","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2016.07.019_b0225","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ijpharm.2012.07.049","article-title":"Accelerated blood clearance of PEGylated liposomes containing doxorubicin upon repeated administration to dogs","volume":"436","author":"Suzuki","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2016.07.019_b0230","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ijpharm.2014.09.047","article-title":"Influence of dose and animal species on accelerated blood clearance of PEGylated liposomal doxorubicin","volume":"476","author":"Suzuki","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2016.07.019_b0235","doi-asserted-by":"crossref","first-page":"R12","DOI":"10.1186\/ar1861","article-title":"Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase","volume":"8","author":"Ganson","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.actbio.2016.07.019_b0240","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/art.22403","article-title":"Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout","volume":"56","author":"Sundy","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.actbio.2016.07.019_b0245","doi-asserted-by":"crossref","first-page":"892","DOI":"10.7326\/0003-4819-106-6-892","article-title":"Intravascular and mucosal immunoglobulin A: two separate but related systems of immune defense?","volume":"106","author":"Conley","year":"1987","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.actbio.2016.07.019_b0250","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0090-1229(86)90073-5","article-title":"The human IgA system: a reassessment","volume":"40","author":"Mestecky","year":"1986","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.actbio.2016.07.019_b0255","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1136\/gut.44.1.2","article-title":"Intestinal IgA: novel views on its function in the defence of the largest mucosal surface","volume":"44","author":"Mestecky","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.actbio.2016.07.019_b0260","doi-asserted-by":"crossref","first-page":"e4294","DOI":"10.1371\/journal.pone.0004294","article-title":"Altering mucus rheology to \u201csolidify\u201d human mucus at the nanoscale","volume":"4","author":"Lai","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2016.07.019_b0265","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1248\/bpb.b14-00653","article-title":"Relationship between the concentration of anti-polyethylene glycol (PEG) immunoglobulin M (IgM) and the intensity of the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes in mice","volume":"38","author":"Hashimoto","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.actbio.2016.07.019_b0270","doi-asserted-by":"crossref","DOI":"10.1038\/mi.2013.120","article-title":"IgG in cervicovaginal mucus traps HSV and prevents vaginal Herpes infections","author":"Wang","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.actbio.2016.07.019_b0275","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0006-3495(94)80802-1","article-title":"Antibody diffusion in human cervical mucus","volume":"66","author":"Saltzman","year":"1994","journal-title":"Biophys. J."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706116303440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706116303440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:51:02Z","timestamp":1761670262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706116303440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":55,"alternative-id":["S1742706116303440"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2016.07.019","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2016.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}