{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:14:59Z","timestamp":1791926099815,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,11]],"date-time":"2017-11-11T00:00:00Z","timestamp":1510358400000},"content-version":"am","delay-in-days":314,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["21635007"],"award-info":[{"award-number":["21635007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["21303178"],"award-info":[{"award-number":["21303178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Program of China","award":["2016YFA0203200"],"award-info":[{"award-number":["2016YFA0203200"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.actbio.2016.10.010","type":"journal-article","created":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T06:32:30Z","timestamp":1476081150000},"page":"124-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":247,"special_numbering":"C","title":["Targeted polydopamine nanoparticles enable photoacoustic imaging guided chemo-photothermal synergistic therapy of tumor"],"prefix":"10.1016","volume":"47","author":[{"given":"Yuanyuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelong","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lehui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2016.10.010_b0005","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1039\/C2CS15261D","article-title":"Multifunctional nanoparticles for multimodal imaging and theragnosis","volume":"41","author":"Lee","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.actbio.2016.10.010_b0010","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.addr.2010.07.009","article-title":"Nanoparticle-based theranostic agents","volume":"62","author":"Xie","year":"2010","journal-title":"Adv. Drug Deliver. Rev."},{"key":"10.1016\/j.actbio.2016.10.010_b0015","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1021\/ar200019c","article-title":"Theranostic nanomedicine","volume":"44","author":"Lammers","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.actbio.2016.10.010_b0020","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1038\/ncomms5712","article-title":"A smart and versatile theranostic nanomedicine platform based on nanoporphyrin","volume":"5","author":"Li","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2016.10.010_b0025","doi-asserted-by":"crossref","first-page":"10059","DOI":"10.1038\/ncomms10059","article-title":"An endoscope with integrated transparent bioelectronics and theranostic nanoparticles for colon cancer treatment","volume":"6","author":"Lee","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2016.10.010_b0030","doi-asserted-by":"crossref","first-page":"6110","DOI":"10.1002\/adma.201503006","article-title":"Core-shell MnSe@Bi2Se3 fabricated via a cation exchange method as novel nanotheranostics for multimodal imaging and synergistic thermoradiotherapy","volume":"27","author":"Song","year":"2015","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2016.10.010_b0035","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.addr.2010.09.002","article-title":"Development and applications of photo-triggered theranostic agents","volume":"62","author":"Rai","year":"2010","journal-title":"Adv. Drug Deliver. Rev."},{"key":"10.1016\/j.actbio.2016.10.010_b0040","doi-asserted-by":"crossref","first-page":"6254","DOI":"10.1039\/C4CS00011K","article-title":"Near-infrared light-responsive nanomaterials in cancer therapeutics","volume":"43","author":"Shanmugam","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.actbio.2016.10.010_b0045","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1021\/ar200022e","article-title":"Cancer theranostics with near-infrared light-activatable multimodal nanoparticles","volume":"44","author":"Melancon","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.actbio.2016.10.010_b0050","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1021\/acsnano.5b00059","article-title":"Joining time-resolved thermometry and magnetic-induced heating in a single nanoparticle unveils intriguing thermal properties","volume":"9","author":"Pinol","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2016.10.010_b0055","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1021\/nn304373q","article-title":"Subtissue thermal sensing based on neodymium-doped LaF3 nanoparticles","volume":"7","author":"Rocha","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2016.10.010_b0060","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1126\/science.1216210","article-title":"Photoacoustic tomography: in vivo imaging from organelles to organs","volume":"335","author":"Wang","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.actbio.2016.10.010_b0065","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nm.2721","article-title":"A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle","volume":"18","author":"Kircher","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.actbio.2016.10.010_b0070","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nbt1220","article-title":"Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging","volume":"24","author":"Zhang","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.actbio.2016.10.010_b0075","doi-asserted-by":"crossref","first-page":"28325","DOI":"10.1038\/srep28325","article-title":"Multifunctional Fe3O4@Au core\/shell nanostars: a unique platform for multimode imaging and photothermal therapy of tumors","volume":"6","author":"Hu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2016.10.010_b0080","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2217\/nnm.14.169","article-title":"Gold nanoparticles for photoacoustic imaging","volume":"10","author":"Li","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.actbio.2016.10.010_b0085","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1039\/C4CS00394B","article-title":"Imaging agents based on lanthanide doped nanoparticles","volume":"44","author":"Prodi","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.actbio.2016.10.010_b0090","doi-asserted-by":"crossref","first-page":"7132","DOI":"10.1039\/C4CS00086B","article-title":"Structural and functional photoacoustic molecular tomography aided by emerging contrast agents","volume":"43","author":"Nie","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.actbio.2016.10.010_b0095","doi-asserted-by":"crossref","first-page":"6621","DOI":"10.1002\/adfm.201401560","article-title":"Photoacoustic imaging guided near-infrared photothermal therapy using highly water-dispersible single-walled carbon nanohorns as theranostic agents","volume":"24","author":"Chen","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2016.10.010_b0100","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1063\/1.3141939","article-title":"Photoacoustics for molecular imaging and therapy","volume":"62","author":"Emelianov","year":"2009","journal-title":"Phys. Today"},{"key":"10.1016\/j.actbio.2016.10.010_b0105","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1021\/nl100996u","article-title":"Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy","volume":"10","author":"Yang","year":"2010","journal-title":"Nano Lett."},{"key":"10.1016\/j.actbio.2016.10.010_b0110","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1021\/ar800150g","article-title":"Nanoshell-enabled photothermal cancer therapy: impending clinical impact","volume":"41","author":"Lal","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.actbio.2016.10.010_b0115","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1021\/ar7002804","article-title":"Noble metals on the nanoscale: optical and photothermal properties and some applications in imaging, sensing, biology, and medicine","volume":"41","author":"Jain","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.actbio.2016.10.010_b0120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11434-014-0700-0","article-title":"Nanosurface chemistry and dose govern the bioaccumulation and toxicity of carbon nanotubes, metal nanomaterials and quantum dots in vivo","volume":"60","author":"Zhao","year":"2015","journal-title":"Sci. Bull."},{"key":"10.1016\/j.actbio.2016.10.010_b0125","doi-asserted-by":"crossref","first-page":"15145","DOI":"10.1021\/jacs.5b07973","article-title":"Post-synthesis incorporation of 64Cu in CuS nanocrystals to radiolabel photothermal probes: a feasible approach for clinics","volume":"137","author":"Riedinger","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.actbio.2016.10.010_b0130","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1002\/adma.201500323","article-title":"Red-emissive carbon dots for fluorescent, photoacoustic, and thermal theranostics in living mice","volume":"27","author":"Ge","year":"2015","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2016.10.010_b0135","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1002\/adma.201405634","article-title":"Co9Se8 nanoplates as a new theranostic platform for photoacoustic\/magnetic resonance dual-modal-imaging-guided chemo-photothermal combination therapy","volume":"27","author":"Song","year":"2015","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2016.10.010_b0140","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1002\/adma.201502486","article-title":"Ultrasmall gold nanorod vesicles with enhanced tumor accumulation and fast excretion from the body for cancer therapy","volume":"27","author":"Song","year":"2015","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2016.10.010_b0145","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.2217\/nnm.10.95","article-title":"Carbon nanotubes in cancer theragnosis","volume":"5","author":"Thakare","year":"2010","journal-title":"Nanomedicine"},{"key":"10.1016\/j.actbio.2016.10.010_b0150","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biomaterials.2015.10.048","article-title":"One-pot synthesis of PEGylated plasmonic MoO3-x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer","volume":"76","author":"Bao","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2016.10.010_b0155","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1016\/j.biomaterials.2013.03.090","article-title":"Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy","volume":"34","author":"Sheng","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2016.10.010_b0160","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1021\/cr400407a","article-title":"Polydopamine and its derivative materials: synthesis and promising applications in energy, environmental, and biomedical fields","volume":"114","author":"Liu","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.actbio.2016.10.010_b0165","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/adma.201203923","article-title":"Sp2 C-dominant N-doped carbon sub-micrometer spheres with a tunable size: a versatile platform for highly efficient oxygen-reduction catalysts","volume":"25","author":"Ai","year":"2013","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2016.10.010_b0170","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/adma.201204683","article-title":"Dopamine-melanin colloidal nanospheres: an efficient near-infrared photothermal therapeutic agent for in vivo cancer therapy","volume":"25","author":"Liu","year":"2013","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2016.10.010_b0175","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1021\/ar970250t","article-title":"Spectroscopic and dynamic studies of the epidermal chromophores trans-urocanic acid and eumelanin","volume":"33","author":"Simon","year":"2000","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.actbio.2016.10.010_b0180","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.3109\/03602538409033561","article-title":"The melanin binding of drugs and its implications","volume":"15","author":"Ings","year":"1984","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.actbio.2016.10.010_b0185","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1039\/C6TB00773B","article-title":"X, Shi, Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy","volume":"4","author":"Li","year":"2016","journal-title":"J. Mater. Chem. B."},{"key":"10.1016\/j.actbio.2016.10.010_b0190","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1021\/nn500722y","article-title":"Multifunctional Fe3O4@polydopamine core-shell nanocomposites for intracellular mRNA detection and imaging-guided photothermal therapy","volume":"8","author":"Lin","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2016.10.010_b0195","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.biomaterials.2015.11.037","article-title":"Multi-responsive photothermal-chemotherapy with drug-loaded melanin-like nanoparticles for synergetic tumor ablation","volume":"81","author":"Wang","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2016.10.010_b0200","doi-asserted-by":"crossref","first-page":"7327","DOI":"10.1002\/adfm.201503587","article-title":"Polydopamine as a biocompatible multifunctional nanocarrier for combined radioisotope therapy and chemotherapy of cancer","volume":"25","author":"Zhong","year":"2015","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2016.10.010_b0205","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1002\/adma.201502201","article-title":"Engineering melanin nanoparticles as an efficient drug-delivery system for imaging-guided chemotherapy","volume":"27","author":"Zhang","year":"2015","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2016.10.010_b0210","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/adhm.201400676","article-title":"Facile preparation of doxorubicin-loaded upconversion@polydopamine nanoplatforms for simultaneous in vivo multimodality imaging and chemophotothermal synergistic therapy","volume":"4","author":"Liu","year":"2015","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.actbio.2016.10.010_b0215","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1016\/S0142-9612(03)00343-0","article-title":"RGD modified polymers: biomaterials for stimulated cell adhesion and beyond","volume":"24","author":"Hersel","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2016.10.010_b0220","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1039\/C4RA09735A","article-title":"Comprehensive studies of pharmacokinetics and biodistribution of indocyanine green and liposomal indocyanine green by multispectral optoacoustic tomography","volume":"5","author":"Song","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.actbio.2016.10.010_b0225","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1021\/mp800070s","article-title":"Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking","volume":"5","author":"Oba","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2016.10.010_b0230","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1021\/nl052405t","article-title":"Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects","volume":"6","author":"Cai","year":"2006","journal-title":"Nano Lett."},{"key":"10.1016\/j.actbio.2016.10.010_b0235","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.biomaterials.2015.11.010","article-title":"Polydopamine-based coordination nanocomplex for T1\/T2 dual mode magnetic resonance imaging-guided chemo-photothermal synergistic therapy","volume":"77","author":"Chen","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2016.10.010_b0240","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jconrel.2010.01.036","article-title":"Endocytosis of nanomedicines","volume":"145","author":"Sahay","year":"2010","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.actbio.2016.10.010_b0245","series-title":"The Tumor Microenvironment 5","first-page":"29","article-title":"Hyperthermia, the tumor microenvironment and immunity, Tumor Ablation","author":"Calderwood","year":"2013"},{"key":"10.1016\/j.actbio.2016.10.010_b0250","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1002\/adma.201405084","article-title":"Interfacing materials science and biology for drug carrier design","volume":"27","author":"Such","year":"2015","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2016.10.010_b0255","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nnano.2008.231","article-title":"Carbon nanotubes as photoacoustic molecular imaging agents in living mice","volume":"3","author":"De La Zerda","year":"2008","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.actbio.2016.10.010_b0260","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nmat2986","article-title":"Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents","volume":"10","author":"Lovell","year":"2011","journal-title":"Nat. Mat."},{"key":"10.1016\/j.actbio.2016.10.010_b0265","doi-asserted-by":"crossref","first-page":"9494","DOI":"10.1039\/C4NR00708E","article-title":"Nanoparticles for photothermal therapies","volume":"6","author":"Jaque","year":"2014","journal-title":"Nanoscale"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706116305281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706116305281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T01:54:25Z","timestamp":1619402065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706116305281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":53,"alternative-id":["S1742706116305281"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2016.10.010","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted polydopamine nanoparticles enable photoacoustic imaging guided chemo-photothermal synergistic therapy of tumor","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2016.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}