{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:31:49Z","timestamp":1790145109589,"version":"4.0.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:00:00Z","timestamp":1481846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["PIIF-GA-2013-624904"],"award-info":[{"award-number":["PIIF-GA-2013-624904"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["NH\/11\/1\/28922"],"award-info":[{"award-number":["NH\/11\/1\/28922"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/09\/003\/27122"],"award-info":[{"award-number":["RG\/09\/003\/27122"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/15\/4\/31268"],"award-info":[{"award-number":["RG\/15\/4\/31268"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["SP\/15\/7\/31561"],"award-info":[{"award-number":["SP\/15\/7\/31561"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["320598 3D-E"],"award-info":[{"award-number":["320598 3D-E"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.actbio.2016.11.059","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T04:18:57Z","timestamp":1480479537000},"page":"218-234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":166,"special_numbering":"C","title":["Fundamental insight into the effect of carbodiimide crosslinking on cellular recognition of collagen-based scaffolds"],"prefix":"10.1016","volume":"49","author":[{"given":"Daniel V.","family":"Bax","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Davidenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Gullberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir W.","family":"Hamaia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Farndale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena M.","family":"Best","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth E.","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2016.11.059_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(01)00691-3","article-title":"Biomedical applications of collagen","volume":"221","author":"Lee","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2016.11.059_b0010","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1242\/jcs.03453","article-title":"Collagens at a glance","volume":"120","author":"Kadler","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.actbio.2016.11.059_b0015","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1203\/PDR.0b013e31816c5bc3","article-title":"Collagen tissue engineering: development of novel biomaterials and applications","volume":"63","author":"Cen","year":"2008","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.actbio.2016.11.059_b0020","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-94-017-9153-3_9","article-title":"Integrin recognition motifs in the human collagens","volume":"819","author":"Hamaia","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.actbio.2016.11.059_b0025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1183\/09059180.00010909","article-title":"The role of integrins in pulmonary fibrosis","volume":"17","author":"Sheppard","year":"2008","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.actbio.2016.11.059_b0030","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1242\/jcs.03098","article-title":"Integrin ligands at a glance","volume":"119","author":"Humphries","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.actbio.2016.11.059_b0035","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00441-009-0834-6","article-title":"Integrins","volume":"339","author":"Barczyk","year":"2010","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.actbio.2016.11.059_b0040","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/BST0360241","article-title":"Cell-collagen interactions: the use of peptide Toolkits to investigate collagen-receptor interactions","volume":"36","author":"Farndale","year":"2008","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.actbio.2016.11.059_b0045","doi-asserted-by":"crossref","first-page":"47763","DOI":"10.1074\/jbc.M404685200","article-title":"Integrin activation state determines selectivity for novel recognition sites in fibrillar collagens","volume":"279","author":"Siljander","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2016.11.059_b0050","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0092-8674(00)80622-4","article-title":"Structural basis of collagen recognition by integrin alpha2beta1","volume":"101","author":"Emsley","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2016.11.059_b0055","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.actbio.2015.07.034","article-title":"Control of crosslinking for tailoring collagen-based scaffolds stability and mechanics","volume":"25","author":"Davidenko","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2016.11.059_b0060","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jmbbm.2012.02.028","article-title":"Investigating the morphological, mechanical and degradation properties of scaffolds comprising collagen, gelatin and elastin for use in soft tissue engineering","volume":"10","author":"Grover","year":"2012","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2016.11.059_b0065","doi-asserted-by":"crossref","first-page":"20130958","DOI":"10.1098\/rsif.2013.0958","article-title":"A design protocol for tailoring ice-templated scaffold structure","volume":"11","author":"Pawelec","year":"2013","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.actbio.2016.11.059_b0070","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1007\/s10853-015-9343-z","article-title":"Altering crystal growth and annealing in ice-templated scaffolds","volume":"50","author":"Pawelec","year":"2015","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.actbio.2016.11.059_b0075","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1089\/ten.tec.2015.0483","article-title":"Parameterizing the transport pathways for cell invasion in complex Scaffold architectures","volume":"22","author":"Ashworth","year":"2016","journal-title":"Tissue Eng. Part C Methods"},{"key":"10.1016\/j.actbio.2016.11.059_b0080","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/adhm.201500197","article-title":"Cell invasion in collagen Scaffold architectures characterized by percolation theory","volume":"4","author":"Ashworth","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2016.11.059_b0085","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1006\/dbio.2001.0363","article-title":"Alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells","volume":"237","author":"Tiger","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.actbio.2016.11.059_b0090","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1385\/MB:18:1:57","article-title":"Cell adhesion assays","volume":"18","author":"Humphries","year":"2001","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.actbio.2016.11.059_b0095","doi-asserted-by":"crossref","first-page":"26019","DOI":"10.1074\/jbc.M112.353144","article-title":"Mapping of potent and specific binding motifs, GLOGEN and GVOGEA, for integrin alpha1beta1 using collagen toolkits II and III","volume":"287","author":"Hamaia","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 1","key":"10.1016\/j.actbio.2016.11.059_b0100","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1538-7836.2007.02521.x","article-title":"Platelet receptor recognition and cross-talk in collagen-induced activation of platelets","volume":"5","author":"Farndale","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.actbio.2016.11.059_b0105","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1074\/jbc.M509818200","article-title":"Use of synthetic peptides to locate novel integrin alpha2beta1-binding motifs in human collagen III","volume":"281","author":"Raynal","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2016.11.059_b0110","doi-asserted-by":"crossref","first-page":"29873","DOI":"10.1074\/jbc.M304073200","article-title":"Prolyl hydroxylation of collagen type I is required for efficient binding to integrin alpha 1 beta 1 and platelet glycoprotein VI but not to alpha 2 beta 1","volume":"278","author":"Perret","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2016.11.059_b0115","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1074\/jbc.275.1.35","article-title":"The collagen-binding A-domains of integrins alpha(1)beta(1) and alpha(2)beta(1) recognize the same specific amino acid sequence, GFOGER, in native (triple-helical) collagens","volume":"275","author":"Knight","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2016.11.059_b0120","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1016\/j.biomaterials.2009.07.050","article-title":"A molecularly defined array based on native fibrillar collagen for the assessment of skin tissue engineering biomaterials","volume":"30","author":"Lammers","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2016.11.059_b0125","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1002\/jbm.a.34187","article-title":"The interplay between physical and chemical properties of protein films affects their bioactivity","volume":"100","author":"Grover","year":"2012","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2016.11.059_b0130","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1016\/j.actbio.2012.05.006","article-title":"Crosslinking and composition influence the surface properties, mechanical stiffness and cell reactivity of collagen-based films","volume":"8","author":"Grover","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2016.11.059_b0135","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.biomaterials.2016.01.044","article-title":"The synthesis and coupling of photoreactive collagen-based peptides to restore integrin reactivity to an inert substrate, chemically-crosslinked collagen","volume":"85","author":"Malcor","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2016.11.059_b0140","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s10856-011-4336-1","article-title":"Extruded collagen fibres for tissue engineering applications: effect of crosslinking method on mechanical and biological properties","volume":"22","author":"Enea","year":"2011","journal-title":"J. Mater. Sci. \u2013 Mater. Med."},{"key":"10.1016\/j.actbio.2016.11.059_b0145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/rb\/rbv005","article-title":"Effect of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide concentrations on the mechanical and biological characteristics of cross-linked collagen fibres for tendon repair","volume":"2","author":"Ahmad","year":"2015","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.actbio.2016.11.059_b0150","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1089\/ten.tea.2010.0590","article-title":"Crosslinking and mechanical properties significantly influence cell attachment, proliferation, and migration within collagen glycosaminoglycan scaffolds","volume":"17","author":"Haugh","year":"2011","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.actbio.2016.11.059_b0155","first-page":"4406","article-title":"Crosslinking of micropatterned collagen-based nerve guides to modulate the expected half-life","volume":"102","author":"Salvatore","year":"2014","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2016.11.059_b0160","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.actbio.2009.06.022","article-title":"Preparation of a collagen\/polymer hybrid gel for tissue membranes. Part II: in vitro and in vivo biological properties of the collagen gels","volume":"6","author":"Nam","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2016.11.059_b0165","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/jbm.b.30444","article-title":"First steps towards tissue engineering of small-diameter blood vessels: preparation of flat scaffolds of collagen and elastin by means of freeze drying","volume":"77","author":"Buttafoco","year":"2006","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.actbio.2016.11.059_b0170","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1055\/s-0037-1614015","article-title":"Endothelial cell seeding on crosslinked collagen: effects of crosslinking on endothelial cell proliferation and functional parameters","volume":"84","author":"Wissink","year":"2000","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.actbio.2016.11.059_b0175","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/jbm.a.35222","article-title":"An investigation of common crosslinking agents on the stability of electrospun collagen scaffolds","volume":"103","author":"Huang","year":"2015","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2016.11.059_b0180","doi-asserted-by":"crossref","first-page":"11752","DOI":"10.1021\/la801913c","article-title":"Enhancing amine terminals in an amine-deprived collagen matrix","volume":"24","author":"Tiong","year":"2008","journal-title":"Langmuir"},{"key":"10.1016\/j.actbio.2016.11.059_b0185","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijbiomac.2013.06.038","article-title":"Carbodiimide crosslinked collagen from porcine dermal matrix for high-strength tissue engineering scaffold","volume":"61","author":"Li","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.actbio.2016.11.059_b0190","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1242\/jcs.00059","article-title":"Fibronectin at a glance","volume":"115","author":"Pankov","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.actbio.2016.11.059_b0195","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1357-2725(96)00155-0","article-title":"The alpha v beta 3 integrin \u201cvitronectin receptor\u201d","volume":"29","author":"Horton","year":"1997","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.actbio.2016.11.059_b0200","doi-asserted-by":"crossref","first-page":"17441","DOI":"10.1074\/jbc.M113.469841","article-title":"Structural analysis of collagen type I interactions with human fibronectin reveals a cooperative binding mode","volume":"288","author":"Erat","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2016.11.059_b0205","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/glycob\/cwm031","article-title":"Changes in glycosylation of vitronectin modulate multimerization and collagen binding during liver regeneration","volume":"17","author":"Sano","year":"2007","journal-title":"Glycobiology"},{"key":"10.1016\/j.actbio.2016.11.059_b0210","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1016\/j.actbio.2012.10.012","article-title":"Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages","volume":"9","author":"Her","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2016.11.059_b0215","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s10856-016-5763-9","article-title":"Evaluation of cell binding to collagen and gelatin: a study of the effect of 2D and 3D architecture and surface chemistry","volume":"27","author":"Davidenko","year":"2016","journal-title":"J. Mater. Sci. \u2013 Mater. Med."},{"key":"10.1016\/j.actbio.2016.11.059_b0220","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nature05063","article-title":"Cells on chips","volume":"442","author":"El-Ali","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2016.11.059_b0225","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0257-8972(99)00150-4","article-title":"Plasma-induced chemical micropatterning for cell culturing applications: a brief review","volume":"119","author":"Ohl","year":"1999","journal-title":"Surf. Coat Tech."},{"key":"10.1016\/j.actbio.2016.11.059_b0230","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1089\/107632703764664729","article-title":"Microfluidic patterning of cells in extracellular matrix biopolymers: effects of channel size, cell type, and matrix composition on pattern integrity","volume":"9","author":"Tan","year":"2003","journal-title":"Tissue Eng."},{"key":"10.1016\/j.actbio.2016.11.059_b0235","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nmat2109","article-title":"Patterning surfaces with functional polymers","volume":"7","author":"Nie","year":"2008","journal-title":"Nat. Mater."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706116306559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706116306559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:55:27Z","timestamp":1761670527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706116306559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":47,"alternative-id":["S1742706116306559"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2016.11.059","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fundamental insight into the effect of carbodiimide crosslinking on cellular recognition of collagen-based scaffolds","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2016.11.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}