{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:48:44Z","timestamp":1791395324412,"version":"4.3.3"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"NSF CAREER","award":["1253453"],"award-info":[{"award-number":["1253453"]}]},{"name":"Public Health Service Research","award":["EY021500"],"award-info":[{"award-number":["EY021500"]}]},{"name":"Public Health Service Research","award":["EY02120"],"award-info":[{"award-number":["EY02120"]}]},{"name":"Public Health Service Research","award":["EY01765"],"award-info":[{"award-number":["EY01765"]}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["G2015132"],"award-info":[{"award-number":["G2015132"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.actbio.2016.12.054","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T16:54:29Z","timestamp":1484672069000},"page":"123-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations"],"prefix":"10.1016","volume":"53","author":[{"given":"Dan E.","family":"Midgett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Pease","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan L.","family":"Jefferys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohak","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Franck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry A.","family":"Quigley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thao D.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2016.12.054_b0005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1350-9462(98)00014-7","article-title":"Neuronal death in glaucoma","volume":"18","author":"Quigley","year":"1999","journal-title":"Prog. Ret. Eye Res."},{"key":"10.1016\/j.actbio.2016.12.054_b0010","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/bjo.56.3.186","article-title":"The glaucomatous visual field","volume":"56","author":"Drance","year":"1972","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0015","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1001\/archopht.1981.03930010139020","article-title":"Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage","volume":"99","author":"Quigley","year":"1981","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0020","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0161-6420(13)31694-7","article-title":"Pattern of glaucomatous neuroretinal rim loss","volume":"100","author":"Jonas","year":"1993","journal-title":"Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0025","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0039-6257(98)00049-6","article-title":"Ophthalmoscopic evaluation of the optic nerve head","volume":"43","author":"Jonas","year":"1999","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0030","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1001\/archopht.1982.01030030137016","article-title":"Optic nerve damage in human glaucoma III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy","volume":"100","author":"Quigley","year":"1982","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1001\/archopht.1981.03930010139020","article-title":"Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage","volume":"99","author":"Quigley","year":"1981","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0040","first-page":"484","article-title":"Retinal ganglion cell loss is size dependent in experimental glaucoma","volume":"32","author":"Glovinsky","year":"1991","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0045","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0002-9394(89)90488-1","article-title":"Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma","volume":"107","author":"Quigley","year":"1989","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0050","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/09286580701501931","article-title":"Open-angle glaucoma - An epidemiologic overview","volume":"14","author":"Leske","year":"2007","journal-title":"Ophthalmic Epidemiol."},{"key":"10.1016\/j.actbio.2016.12.054_b0055","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/IJG.0b013e31806540a1","article-title":"Risk factors and open-angle glaucoma: classification and application","volume":"16","author":"Boland","year":"2007","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.actbio.2016.12.054_b0060","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.ophtha.2004.02.017","article-title":"Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study","volume":"111","author":"Nouri-Mahdavi","year":"2004","journal-title":"Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0065","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00417-004-1103-8","article-title":"Diurnal IOP fluctuation: not an independent risk factor for glaucomatous visual field loss in high-risk ocular hypertension","volume":"243","author":"Bengtsson","year":"2005","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0070","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.ophtha.2007.10.031","article-title":"Intraocular pressure fluctuation. A risk factor for visual field progression at low intraocular pressures in the advanced glaucoma intervention study","volume":"115","author":"Caprioli","year":"2008","journal-title":"Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0075","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0002-9394(00)00538-9","article-title":"The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration","volume":"130","author":"Gaasterland","year":"2000","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0080","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","article-title":"Reduction of intraocular pressure and glaucoma progression","volume":"120","author":"Heijl","year":"2002","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0085","first-page":"640","article-title":"Distribution of axonal transport blockade by acute intraocular pressure elevation in the primate optic nerve head","volume":"16","author":"Quigley","year":"1977","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0090","first-page":"429","article-title":"Correlations between anatomic features and axonal transport in primate optic nerve head","volume":"84","author":"Minckler","year":"1986","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.actbio.2016.12.054_b0095","first-page":"1593","article-title":"Selective effects of experimental glaucoma on axonal transport by retinal ganglion cells to the dorsal lateral geniculate nucleus","volume":"32","author":"Dandona","year":"1991","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0100","first-page":"3460","article-title":"Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats","volume":"41","author":"Quigley","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0105","first-page":"764","article-title":"Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma","volume":"41","author":"Pease","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0110","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.exer.2005.11.025","article-title":"Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucoma","volume":"83","author":"Martin","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.actbio.2016.12.054_b0115","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/00061198-199400330-00006","article-title":"Activation of elastin mRNA expression in human optic nerve heads with primary open-angle glaucoma","volume":"3","author":"Hernandez","year":"1994","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.actbio.2016.12.054_b0120","series-title":"Opt. Nerve Glaucoma","first-page":"79","article-title":"Cell biology of the human lamina cribrosa","author":"Clark","year":"1995"},{"key":"10.1016\/j.actbio.2016.12.054_b0125","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/sj.eye.6701746","article-title":"New paradigms in the mechanisms and management of glaucoma","volume":"19","author":"Quigley","year":"2005","journal-title":"Eye"},{"key":"10.1016\/j.actbio.2016.12.054_b0130","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1001\/archopht.1991.01080080050026","article-title":"Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans: the Baltimore Eye Survey","volume":"109","author":"Sommer","year":"1991","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0135","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/archopht.120.6.701","article-title":"The ocular hypertension treatment study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma","volume":"120","author":"Kass","year":"2002","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0140","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0008-4182(06)80060-8","article-title":"Scleral biomechanics and glaucoma\u2013a connection?","volume":"41","author":"Ethier","year":"2006","journal-title":"Can. J. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.preteyeres.2004.06.001","article-title":"The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage","volume":"24","author":"Burgoyne","year":"2005","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.actbio.2016.12.054_b0150","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s10237-012-0455-y","article-title":"Scleral anisotropy and its effects on the mechanical response of the optic nerve head","volume":"12","author":"Coudrillier","year":"2013","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.actbio.2016.12.054_b0155","doi-asserted-by":"crossref","first-page":"9023","DOI":"10.1167\/iovs.11-8183","article-title":"IOP-induced lamina cribrosa deformation and scleral canal expansion: independent or related?","volume":"52","author":"Sigal","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0160","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1167\/iovs.05-0541","article-title":"Factors influencing optic nerve head biomechanics","volume":"46","author":"Sigal","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0165","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1001\/archopht.1981.03930021042012","article-title":"Displacement of the optic nerve head. Response to acute intraocular pressure elevation in primate eyes","volume":"99","author":"Levy","year":"1981","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0170","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/archopht.1984.01040030630037","article-title":"Displacement of optic nerve head in response to short-term intraocular pressure elevation in human eyes","volume":"102","author":"Levy","year":"1984","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0175","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1001\/archopht.1989.01070020298042","article-title":"The relation between glaucomatous damage and optic nerve head mechanical compliance","volume":"107","author":"Zeimer","year":"1989","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0180","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0161-6420(91)32345-5","article-title":"Displacement of the optic nerve head by acute changes in intraocular pressure in monkey eyes","volume":"98","author":"Coleman","year":"1991","journal-title":"Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0185","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/bjo.78.8.643","article-title":"Deformation of the lamina cribrosa by elevated intraocular pressure","volume":"78","author":"Yan","year":"1994","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0190","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/bjo.84.3.318","article-title":"Age related compliance of the lamina cribrosa in human eyes","volume":"84","author":"Albon","year":"2000","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0195","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1167\/iovs.01-1282","article-title":"Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma","volume":"44","author":"Bellezza","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0200","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1167\/iovs.09-3410","article-title":"Deformation of the normal monkey optic nerve head connective tissue after acute IOP elevation within 3-D histomorphometric reconstructions","volume":"50","author":"Yang","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0205","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ophtha.2010.05.016","article-title":"Laminar and prelaminar tissue displacement during intraocular pressure elevation in glaucoma patients and healthy controls","volume":"118","author":"Agoumi","year":"2011","journal-title":"Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0210","doi-asserted-by":"crossref","first-page":"6192","DOI":"10.1167\/iovs.10-7137","article-title":"The impact of acutely elevated intraocular pressure on the porcine optic nerve head","volume":"52","author":"Fatehee","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0215","doi-asserted-by":"crossref","first-page":"9431","DOI":"10.1167\/iovs.11-7922","article-title":"Effect of acute intraocular pressure elevation on the monkey optic nerve head as detected by spectral domain optical coherence tomography","volume":"52","author":"Strouthidis","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/iovs.13-12724","article-title":"Eye-specific IOP-induced displacements and deformations of human lamina cribrosa","volume":"55","author":"Sigal","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0225","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2013.0459","article-title":"In vivo optic nerve head biomechanics: performance testing of a three-dimensional tracking algorithm","volume":"10","author":"Girard","year":"2013","journal-title":"J.R. Soc Interface"},{"key":"10.1016\/j.actbio.2016.12.054_b0230","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.ophtha.2016.02.008","article-title":"In Vivo 3-dimensional strain mapping of the optic nerve head following intraocular pressure lowering by trabeculectomy","volume":"123","author":"Girard","year":"2016","journal-title":"Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0235","first-page":"988","article-title":"Phase-contrast micro-computed tomography measurements of the intraocular pressure-induced deformation of the porcine lamina cribrosa","volume":"35","author":"Coudrillier","year":"2016","journal-title":"IEEE"},{"key":"10.1016\/j.actbio.2016.12.054_b0240","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11340-014-9874-2","article-title":"A fast iterative digital volume correlation algorithm for large deformations","volume":"55","author":"Bar-Kochba","year":"2015","journal-title":"Exp. Mech."},{"key":"10.1016\/j.actbio.2016.12.054_b0245","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/BF02321649","article-title":"Submicron deformation field measurements: part 2. Improved digital image correlation","volume":"38","author":"Vendroux","year":"1998","journal-title":"Exp. Mech."},{"key":"10.1016\/j.actbio.2016.12.054_b0250","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0262-8856(86)90057-0","article-title":"Application of an optimized digital correlation method to planar deformation analysis","volume":"4","author":"Sutton","year":"1986","journal-title":"Image Vis. Comput."},{"key":"10.1016\/j.actbio.2016.12.054_b0255","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF02323555","article-title":"Digital volume correlation: three-dimensional strain mapping using x-ray tomography","volume":"39","author":"Bay","year":"1999","journal-title":"Exp. Mech."},{"key":"10.1016\/j.actbio.2016.12.054_b0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1115\/1.2146001","article-title":"Comparison of the linear finite element prediction of deformation and strain of human cancellous bone to 3d digital volume correlation measurements","volume":"128","author":"Zauel","year":"2006","journal-title":"J. Biomech. Eng. Trans. ASME"},{"key":"10.1016\/j.actbio.2016.12.054_b0265","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jsb.2008.08.004","article-title":"3d micro-scale deformations of wood in bending: synchrotron radiation \u03bcct data analyzed with digital volume correlation","volume":"164","author":"Forsberg","year":"2008","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.actbio.2016.12.054_b0270","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1115\/1.1824127","article-title":"Local, three dimensional strain measurements within largely deformed extracellular matrix constructs","volume":"126","author":"Roeder","year":"2005","journal-title":"J. Biomech. Eng. Trans. ASME"},{"key":"10.1016\/j.actbio.2016.12.054_b0275","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1073\/pnas.1510935113","article-title":"Mean deformation metrics for quantifying 3D cell-matrix interactions in the absence of material properties","volume":"113","author":"Stout","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0280","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1142\/S1758825111001019","article-title":"A digital volume correlation technique for 3-d deformation measurements of soft gels","volume":"3","author":"Huang","year":"2011","journal-title":"Int. J. App. Mech."},{"key":"10.1016\/j.actbio.2016.12.054_b0285","doi-asserted-by":"crossref","DOI":"10.1115\/1.4004921","article-title":"A gimbal-mounted pressurization chamber for macroscopic and microscopic assessment of ocular tissues","volume":"133","author":"Keyes","year":"2011","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2016.12.054_b0290","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1047-8477(02)00576-2","article-title":"3-dimensional imaging of collagen using second harmonic generation","volume":"141","author":"Cox","year":"2003","journal-title":"J. Struc. Biol."},{"key":"10.1016\/j.actbio.2016.12.054_b0295","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.actbio.2016.12.054_b0300","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.optlaseng.2008.05.005","article-title":"The effect of out-of-plane motion on 2D and 3D digital image correlation measurements","volume":"46","author":"Sutton","year":"2008","journal-title":"Opt. Lasers Eng."},{"key":"10.1016\/j.actbio.2016.12.054_b0305","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1136\/bjo.59.12.721","article-title":"Vertical ovalness of glaucomatous cupping","volume":"59","author":"Gloster","year":"1975","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0310","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/00061198-199912000-00002","article-title":"The relationship between optic disc area and open-angle glaucoma: the Baltimore Eye Survey","volume":"8","author":"Quigley","year":"1999","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.actbio.2016.12.054_b0315","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/00061198-200004000-00015","article-title":"The relationship between optic disc area and open-angle glaucoma","volume":"9","author":"Healey","year":"2000","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.actbio.2016.12.054_b0320","doi-asserted-by":"crossref","first-page":"5258","DOI":"10.1167\/iovs.12-9705","article-title":"Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae","volume":"53","author":"Pijanka","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0325","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1001\/archopht.1980.01020040482019","article-title":"The organization of nerve fiber bundles in the primate optic nerve head","volume":"98","author":"Minkler","year":"1980","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.actbio.2016.12.054_b0330","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1167\/iovs.11-8009","article-title":"Biomechanics of the human posterior sclera: age- and glaucoma-related changes measured using inflation testing","volume":"53","author":"Coudrillier","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0335","doi-asserted-by":"crossref","DOI":"10.1115\/1.4029430","article-title":"Collagen structure and mechanical properties of the human sclera: analysis for the effects of age","volume":"137","author":"Coudrillier","year":"2015","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2016.12.054_b0340","doi-asserted-by":"crossref","DOI":"10.1115\/1.4029986","article-title":"Effects of age and diabetes on scleral stiffness","volume":"137","author":"Coudrillier","year":"2015","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2016.12.054_b0345","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s10237-013-0517-9","article-title":"Age-related changes in human peripapillary scleral strain","volume":"13","author":"Fazio","year":"2014","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.actbio.2016.12.054_b0350","doi-asserted-by":"crossref","first-page":"8163","DOI":"10.1167\/iovs.14-14029","article-title":"Age- and race-related differences in human scleral material properties","volume":"55","author":"Grytz","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0355","article-title":"Measuring deformation in the mouse optic nerve head and peripapillary scleraInvest","author":"Nguyen","year":"2017","journal-title":"Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2016.12.054_b0360","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0021-9290(93)90610-Q","article-title":"Nonhomogeneous analysis of epicardial strain distributions during acute myocardial ischemia in the dog","volume":"26","author":"Hashima","year":"1993","journal-title":"J. Biomech."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706116307358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706116307358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:53:50Z","timestamp":1761670430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706116307358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":72,"alternative-id":["S1742706116307358"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2016.12.054","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2016.12.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}