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Biol."},{"key":"10.1016\/j.actbio.2017.01.023_b0555","doi-asserted-by":"crossref","first-page":"e66170","DOI":"10.1371\/journal.pone.0066170","article-title":"Substrate topography determines neuronal polarization and growth in vitro","volume":"8","author":"Micholt","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.actbio.2017.01.023_b0560","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1038\/emboj.2012.41","article-title":"N-cadherin specifies first asymmetry in developing neurons","volume":"31","author":"Gartner","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.actbio.2017.01.023_b0565","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4161\/chan.22213","article-title":"Touch sense: functional organization and molecular determinants of mechanosensitive receptors","volume":"6","author":"Roudaut","year":"2012","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.actbio.2017.01.023_b0570","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.biomaterials.2005.08.007","article-title":"Neuro tissue engineering of glial nerve guides and the impact of different cell types","volume":"27","author":"Lietz","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.01.023_b0575","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/bit.20634","article-title":"Oriented Schwann cell growth on microgrooved surfaces","volume":"92","author":"Hsu","year":"2005","journal-title":"Biotechnol. 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