{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:22:56Z","timestamp":1790248976165,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National High Technology Research and Development Program of China","award":["2015AA020316"],"award-info":[{"award-number":["2015AA020316"]}]},{"name":"Jiangsu Province's Key Medical center"},{"name":"Jiangsu Provincial Special Program of Medical Science","award":["BL2012004"],"award-info":[{"award-number":["BL2012004"]}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81672238"],"award-info":[{"award-number":["81672238"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81472077"],"award-info":[{"award-number":["81472077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81372018"],"award-info":[{"award-number":["81372018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81272018"],"award-info":[{"award-number":["81272018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81101399"],"award-info":[{"award-number":["81101399"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.actbio.2017.01.034","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T05:01:05Z","timestamp":1484110865000},"page":"513-525","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"special_numbering":"C","title":["Melatonin attenuates titanium particle-induced osteolysis via activation of Wnt\/\u03b2-catenin signaling pathway"],"prefix":"10.1016","volume":"51","author":[{"given":"Zichuan","family":"Ping","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanyang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiexing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dechun","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2017.01.034_b0005","first-page":"182","article-title":"Biologic effects of implant debris","volume":"67","author":"Hallab","year":"2009","journal-title":"Bull. Hosp. Joint Dis."},{"key":"10.1016\/j.actbio.2017.01.034_b0010","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1016\/j.biomaterials.2007.06.035","article-title":"Wear particles, periprosthetic osteolysis and the immune system","volume":"28","author":"Goodman","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.01.034_b0015","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1016\/j.biomaterials.2006.05.054","article-title":"The correlation of RANK, RANKL and TNFalpha expression with bone loss volume and polyethylene wear debris around hip implants","volume":"27","author":"Holding","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.01.034_b0020","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/j.biomaterials.2009.11.069","article-title":"Protection against titanium particle induced osteolysis by cannabinoid receptor 2 selective antagonist","volume":"31","author":"Geng","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.01.034_b0025","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1016\/j.actbio.2011.05.007","article-title":"Protective effects of COX-2 inhibitor on titanium-particle-induced inflammatory osteolysis via the down-regulation of RANK\/RANKL","volume":"7","author":"Geng","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2017.01.034_b0030","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0736-0266(03)00156-6","article-title":"NF-kB signaling blockade abolishes implant particle-induced osteoclastogenesis","volume":"22","author":"Clohisy","year":"2004","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0035","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00264-014-2596-3","article-title":"Inhibitory effects of triptolide on titanium particle-induced osteolysis and receptor activator of nuclear factor-kappaB ligand-mediated osteoclast differentiation","volume":"39","author":"Kim","year":"2015","journal-title":"Int. Orthop."},{"key":"10.1016\/j.actbio.2017.01.034_b0040","doi-asserted-by":"crossref","first-page":"8937","DOI":"10.1016\/j.biomaterials.2014.06.055","article-title":"The prevention of titanium-particle-induced osteolysis by OA-14 through the suppression of the p38 signaling pathway and inhibition of osteoclastogenesis","volume":"35","author":"Tian","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.01.034_b0045","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/S0142-9612(01)00312-X","article-title":"Ceramic and PMMA particles differentially affect osteoblast phenotype","volume":"23","author":"Lohmann","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.01.034_b0050","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biomaterials.2015.04.048","article-title":"Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model","volume":"60","author":"Shao","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.01.034_b0055","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/jpi.12267","article-title":"Melatonin: an ancient molecule that makes oxygen metabolically tolerable","volume":"59","author":"Manchester","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0060","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.sleep.2012.06.015","article-title":"Melatonin profile and its relation to circadian rhythm sleep disorders in angelman syndrome patients","volume":"13","author":"Takaesu","year":"2012","journal-title":"Sleep Med."},{"key":"10.1016\/j.actbio.2017.01.034_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.2012.01014.x","article-title":"A review of the molecular aspects of melatonin's anti-inflammatory actions: recent insights and new perspectives","volume":"54","author":"Mauriz","year":"2013","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0070","article-title":"Melatonin as a potential anticarcinogen for non-small-cell lung cancer","author":"Ma","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.actbio.2017.01.034_b0075","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1600-079X.2010.00784.x","article-title":"Determination of the minimal melatonin exposure required to induce osteoblast differentiation from human mesenchymal stem cells and these effects on downstream signaling pathways","volume":"49","author":"Sethi","year":"2010","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0080","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/clr.12364","article-title":"New bone formation in bone defects after melatonin and porcine bone grafts: experimental study in rabbits","volume":"26","author":"Calvo-Guirado","year":"2015","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0085","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1089\/rej.2013.1542","article-title":"Melatonin dietary supplement as an anti-aging therapy for age-related bone loss","volume":"17","author":"Tresguerres","year":"2014","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0090","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/jpi.12252","article-title":"Melatonin improves bone mineral density at the femoral neck in postmenopausal women with osteopenia: a randomized controlled trial","volume":"59","author":"Amstrup","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0095","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/jpi.12116","article-title":"Melatonin effects on bone: potential use for the prevention and treatment for osteopenia, osteoporosis, and periodontal disease and for use in bone-grafting procedures","volume":"56","author":"Maria","year":"2014","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0100","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1600-079X.2012.00989.x","article-title":"A novel calcium aluminate-melatonin scaffold enhances bone regeneration within a calvarial defect","volume":"53","author":"Clafshenkel","year":"2012","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0105","doi-asserted-by":"crossref","DOI":"10.1111\/clr.12596","article-title":"Osteoinductive elements around immediate implants for better osseointegration: a pilot study in foxhound dogs","author":"Salomo-Coll","year":"2016","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0110","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1600-079X.2009.00743.x","article-title":"Actions of melatonin mixed with collagenized porcine bone versus porcine bone only on osteointegration of dental implants","volume":"48","author":"Calvo-Guirado","year":"2010","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0115","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1600-079X.2011.00875.x","article-title":"Melatonin promotes osteoblastic differentiation through the BMP\/ERK\/Wnt signaling pathways","volume":"51","author":"Park","year":"2011","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0120","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1359\/jbmr.2002.17.7.1219","article-title":"Melatonin at pharmacologic doses increases bone mass by suppressing resorption through down-regulation of the RANKL-mediated osteoclast formation and activation","volume":"17","author":"Koyama","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0125","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1902\/jop.2007.060396","article-title":"Melatonin: potential functions in the oral cavity","volume":"78","author":"Cutando","year":"2007","journal-title":"J. Periodontol."},{"key":"10.1016\/j.actbio.2017.01.034_b0130","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/jor.1100180321","article-title":"Tumor necrosis factor-alpha\/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis","volume":"18","author":"Schwarz","year":"2000","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0135","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.orthres.2003.08.013","article-title":"The effectiveness of polyethylene versus titanium particles in inducing osteolysis in vivo","volume":"22","author":"von Knoch","year":"2004","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0140","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1600-079X.2006.00410.x","article-title":"Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo","volume":"42","author":"Satomura","year":"2007","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0145","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1016\/j.biomaterials.2013.01.034","article-title":"RANKL-associated suppression of particle-induced osteolysis in an aged model of calcitonin and alpha-CGRP deficiency","volume":"34","author":"Kauther","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.01.034_b0150","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s00223-007-9077-2","article-title":"Particle-induced osteolysis in three-dimensional micro-computed tomography","volume":"81","author":"Wedemeyer","year":"2007","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.actbio.2017.01.034_b0155","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee","volume":"2","author":"Parfitt","year":"1987","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0160","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.biomaterials.2012.10.030","article-title":"Role of direct estrogen receptor signaling in wear particle-induced osteolysis","volume":"34","author":"Nich","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.01.034_b0165","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/10520290310001646668","article-title":"Quantification of tartrate resistant acid phosphatase distribution in mouse tibiae using image analysis","volume":"78","author":"Sawyer","year":"2003","journal-title":"Biotech. Histochem."},{"key":"10.1016\/j.actbio.2017.01.034_b0170","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0898-6568(02)00118-3","article-title":"Roles of Rac and cytosolic phospholipase A2 in the intracellular signalling in response to titanium particles","volume":"15","author":"Lee","year":"2003","journal-title":"Cell. Signal."},{"key":"10.1016\/j.actbio.2017.01.034_b0175","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1002\/jor.20275","article-title":"Involvement of complement receptor 3 (CR3) and scavenger receptor in macrophage responses to wear debris","volume":"24","author":"Rakshit","year":"2006","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0180","doi-asserted-by":"crossref","first-page":"23827","DOI":"10.1038\/srep23827","article-title":"Icariin attenuates titanium-particle inhibition of bone formation by activating the Wnt\/beta-catenin signaling pathway in vivo and in vitro","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2017.01.034_b0185","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.3892\/ijmm.2012.1145","article-title":"MMP-9 inhibition suppresses wear debris-induced inflammatory osteolysis through downregulation of RANK\/RANKL in a murine osteolysis model","volume":"30","author":"Chen","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.actbio.2017.01.034_b0190","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jmbbm.2014.01.001","article-title":"A new technique to improve the mechanical and biological performance of ultra high molecular weight polyethylene using a nylon coating","volume":"32","author":"Firouzi","year":"2014","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2017.01.034_b0195","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1007\/s11999-013-3144-y","article-title":"Do monoblock cups improve survivorship, decrease wear, or reduce osteolysis in uncemented total hip arthroplasty?","volume":"471","author":"Halma","year":"2013","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0200","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/j.actbio.2012.03.029","article-title":"What's next? Alternative materials for articulation in total joint replacement","volume":"8","author":"Sonntag","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2017.01.034_b0205","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1302\/0301-620X.94B1.28047","article-title":"Current concepts in osteolysis","volume":"94","author":"Ollivere","year":"2012","journal-title":"J. Bone Joint Surg. Br."},{"key":"10.1016\/j.actbio.2017.01.034_b0210","doi-asserted-by":"crossref","first-page":"830231","DOI":"10.4061\/2010\/830231","article-title":"Scientific basis for the potential use of melatonin in bone diseases: osteoporosis and adolescent idiopathic scoliosis","volume":"2010","author":"Sanchez-Barcelo","year":"2010","journal-title":"J. Osteoporosis"},{"key":"10.1016\/j.actbio.2017.01.034_b0215","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jss.2010.08.036","article-title":"Melatonin impairs fracture healing by suppressing RANKL-mediated bone remodeling","volume":"173","author":"Histing","year":"2012","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0220","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.biomaterials.2015.07.061","article-title":"Pharmaceutical inhibition of glycogen synthetase kinase 3 beta suppresses wear debris-induced osteolysis","volume":"69","author":"Geng","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.01.034_b0225","doi-asserted-by":"crossref","first-page":"6096","DOI":"10.1016\/j.biomaterials.2006.08.023","article-title":"Effects of orthopaedic wear particles on osteoprogenitor cells","volume":"27","author":"Goodman","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.01.034_b0230","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/jor.1100140318","article-title":"Bone formation and bone resorption in failed total joint arthroplasties: histomorphometric analysis with histochemical and immunohistochemical technique","volume":"14","author":"Kadoya","year":"1996","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0235","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/jor.20620","article-title":"Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT","volume":"26","author":"Tsutsumi","year":"2008","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0240","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/joim.12368","article-title":"The WNT system: background and its role in bone","volume":"277","author":"Lerner","year":"2015","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.actbio.2017.01.034_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2016.06.007","article-title":"WNT\/beta-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression","author":"Cai","year":"2016","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.actbio.2017.01.034_b0250","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2017.01.034_b0255","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.devcel.2005.02.017","article-title":"Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation","volume":"8","author":"Glass","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.actbio.2017.01.034_b0260","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.devcel.2005.10.009","article-title":"EBF2 regulates osteoblast-dependent differentiation of osteoclasts","volume":"9","author":"Kieslinger","year":"2005","journal-title":"Dev. Cell"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174270611730034X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174270611730034X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:56:18Z","timestamp":1761670578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S174270611730034X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":52,"alternative-id":["S174270611730034X"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2017.01.034","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin attenuates titanium particle-induced osteolysis via activation of Wnt\/\u03b2-catenin signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2017.01.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}