{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:38:24Z","timestamp":1787164704700,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502203"],"award-info":[{"award-number":["81502203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572519"],"award-info":[{"award-number":["81572519"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602221"],"award-info":[{"award-number":["81602221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20160117"],"award-info":[{"award-number":["BK20160117"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.actbio.2017.02.021","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T12:02:56Z","timestamp":1487160176000},"page":"427-438","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"special_numbering":"C","title":["Self-assembled tumor-targeting hyaluronic acid nanoparticles for photothermal ablation in orthotopic bladder cancer"],"prefix":"10.1016","volume":"53","author":[{"given":"Tingsheng","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huibo","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlong","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenmin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2017.02.021_b0005","first-page":"7","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.actbio.2017.02.021_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000052386","article-title":"Treatment of superficial bladder tumors: achievements and needs","volume":"37","author":"Kurth","year":"2000","journal-title":"Eur. Urol."},{"key":"10.1016\/j.actbio.2017.02.021_b0015","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.eururo.2013.06.003","article-title":"EAU guidelines on non\u2013muscle-invasive urothelial carcinoma of the bladder: update 2013","volume":"64","author":"Babjuk","year":"2013","journal-title":"Eur. Urol."},{"key":"10.1016\/j.actbio.2017.02.021_b0020","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1097\/01.ju.0000181799.81119.fc","article-title":"Restaging transurethral resection of high risk superficial bladder cancer improves the initial response to bacillus Calmette-Guerin therapy","volume":"174","author":"Herr","year":"2005","journal-title":"J. Urol."},{"key":"10.1016\/j.actbio.2017.02.021_b0025","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.eururo.2009.06.028","article-title":"Recurrence and progression of disease in non\u2013muscle-invasive bladder cancer: from epidemiology to treatment strategy","volume":"56","author":"Van Rhijn","year":"2009","journal-title":"Eur. Urol."},{"key":"10.1016\/j.actbio.2017.02.021_b0030","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.eururo.2014.10.040","article-title":"Diagnosis and management of urothelial carcinoma in situ of the lower urinary tract: a systematic review","volume":"67","author":"Casey","year":"2015","journal-title":"Eur. Urol."},{"key":"10.1016\/j.actbio.2017.02.021_b0035","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.eururo.2009.05.008","article-title":"Complications following radical cystectomy for bladder cancer in the elderly","volume":"56","author":"Froehner","year":"2009","journal-title":"Eur. Urol."},{"key":"10.1016\/j.actbio.2017.02.021_b0040","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.eururo.2012.02.028","article-title":"Radical cystectomy for urothelial carcinoma of the bladder without neoadjuvant or adjuvant therapy: long-term results in 1100 patients","volume":"61","author":"Hautmann","year":"2012","journal-title":"Eur. Urol."},{"key":"10.1016\/j.actbio.2017.02.021_b0045","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.eururo.2012.07.033","article-title":"Epidemiology and risk factors of urothelial bladder cancer","volume":"63","author":"Burger","year":"2013","journal-title":"Eur. Urol."},{"key":"10.1016\/j.actbio.2017.02.021_b0050","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1056\/NEJMoa1106106","article-title":"Radiotherapy with or without chemotherapy in muscle-invasive bladder cancer","volume":"366","author":"James","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.actbio.2017.02.021_b0055","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.juro.2013.01.046","article-title":"How to avoid local side effects of bladder photodynamic therapy: impact of the fluence rate","volume":"190","author":"Fran\u00e7ois","year":"2013","journal-title":"J. Urol."},{"key":"10.1016\/j.actbio.2017.02.021_b0060","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1021\/acsnano.5b00021","article-title":"Elucidating the fundamental mechanisms of cell death triggered by photothermal therapy","volume":"9","author":"Melamed","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2017.02.021_b0065","doi-asserted-by":"crossref","first-page":"948","DOI":"10.7150\/thno.15217","article-title":"Recent progress in light-triggered nanotheranostics for cancer treatment","volume":"6","author":"Zhang","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2017.02.021_b0070","first-page":"128","article-title":"Emergence of functionalized nanomedicines in cancer chemotherapy: Recent advancements, current challenges and toxicity considerations","volume":"3","author":"Rahman","year":"2013","journal-title":"Rec. Pat. Nanomed."},{"key":"10.1016\/j.actbio.2017.02.021_b0075","doi-asserted-by":"crossref","first-page":"755","DOI":"10.7150\/thno.10804","article-title":"Coating solid lipid nanoparticles with hyaluronic acid enhances antitumor activity against melanoma stem-like cells","volume":"5","author":"Shen","year":"2015","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2017.02.021_b0080","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.carbpol.2012.10.028","article-title":"Hyaluronic acid based scaffolds for tissue engineering\u2014A review","volume":"92","author":"Collins","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.actbio.2017.02.021_b0085","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.biomaterials.2016.01.049","article-title":"Hyaluronic acid-shelled acid-activatable paclitaxel prodrug micelles effectively target and treat CD44-overexpressing human breast tumor xenografts in vivo","volume":"84","author":"Zhong","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.02.021_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2490-13-57","article-title":"A modified method for isolation of bladder cancer stem cells from a MB49 murine cell line","volume":"13","author":"Zhu","year":"2013","journal-title":"BMC Urol."},{"key":"10.1016\/j.actbio.2017.02.021_b0095","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.scr.2014.04.006","article-title":"The granulocyte macrophage\u2013colony stimulating factor surface modified MB49 bladder cancer stem cells vaccine against metastatic bladder cancer","volume":"13","author":"Zhu","year":"2014","journal-title":"Stem Cell Research"},{"key":"10.1016\/j.actbio.2017.02.021_b0100","doi-asserted-by":"crossref","first-page":"14016","DOI":"10.1073\/pnas.0906549106","article-title":"Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells","volume":"106","author":"Chan","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.actbio.2017.02.021_b0105","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.clinbiochem.2008.08.085","article-title":"Comparison of CD44 and cytokeratin 20 mRNA in voided urine samples as diagnostic tools for bladder cancer","volume":"41","author":"Eissa","year":"2008","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.actbio.2017.02.021_b0110","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.actbio.2015.05.010","article-title":"Dual-stimuli responsive hyaluronic acid-conjugated mesoporous silica for targeted delivery to CD44-overexpressing cancer cells","volume":"23","author":"Zhao","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2017.02.021_b0115","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/cncr.25565","article-title":"Association of hyaluronic acid family members (HAS1, HAS2, and HYAL-1) with bladder cancer diagnosis and prognosis","volume":"117","author":"Kramer","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.actbio.2017.02.021_b0120","article-title":"Hyaluronan activates Hyal-2\/WWOX\/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed","author":"Hsu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.actbio.2017.02.021_b0125","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1016\/j.biomaterials.2013.05.071","article-title":"IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy","volume":"34","author":"Yue","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.02.021_b0130","doi-asserted-by":"crossref","first-page":"11756","DOI":"10.1002\/anie.201403835","article-title":"A \u201cschizophotonic\u201d all-in-one nanoparticle coating for multiplexed SE(R)RS biomedical imaging","volume":"53","author":"Iacono","year":"2014","journal-title":"Angew. Chem."},{"key":"10.1016\/j.actbio.2017.02.021_b0135","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1111\/j.1464-410X.2010.09424.x","article-title":"Validating bladder cancer xenograft bioluminescence with magnetic resonance imaging: the significance of hypoxia and necrosis","volume":"106","author":"Black","year":"2010","journal-title":"BJU Int."},{"key":"10.1016\/j.actbio.2017.02.021_b0140","doi-asserted-by":"crossref","first-page":"692","DOI":"10.7150\/thno.5922","article-title":"Evaluation of polymethine dyes as potential probes for near infrared fluorescence imaging of tumors: Part - 1","volume":"3","author":"James","year":"2013","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2017.02.021_b0145","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.colsurfb.2011.10.029","article-title":"Hyaluronic acid-based nanocarriers for intracellular targeting: interfacial interactions with proteins in cancer","volume":"99","author":"Choi","year":"2012","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.actbio.2017.02.021_b0150","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.biomaterials.2015.01.069","article-title":"Self-assembled PEG-IR-780-C13 micelle as a targeting, safe and highly-effective photothermal agent for in vivo imaging and cancer therapy","volume":"51","author":"Yuan","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.02.021_b0155","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.biomaterials.2016.07.026","article-title":"Novel theranostic nanoporphyrins for photodynamic diagnosis and trimodal therapy for bladder cancer","volume":"104","author":"Lin","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.02.021_b0160","doi-asserted-by":"crossref","first-page":"37733","DOI":"10.1074\/jbc.M003030200","article-title":"Identification of the hyaluronan receptor for endocytosis (HARE)","volume":"275","author":"Zhou","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2017.02.021_b0165","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1021\/mp800024g","article-title":"Anticancer therapeutics: targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor","volume":"5","author":"Platt","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2017.02.021_b0170","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1002\/smll.200800582","article-title":"Biocompatible polymer-nanoparticle-based bimodal imaging contrast agents for the labeling and tracking of dendritic cells","volume":"4","author":"Lim","year":"2008","journal-title":"Small"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706117301265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706117301265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:53:13Z","timestamp":1761670393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706117301265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":34,"alternative-id":["S1742706117301265"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2017.02.021","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Self-assembled tumor-targeting hyaluronic acid nanoparticles for photothermal ablation in orthotopic bladder cancer","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2017.02.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}