{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:09:32Z","timestamp":1793052572648,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"by Science and Technology Program of Guangzhou, China","award":["2014J2200099"],"award-info":[{"award-number":["2014J2200099"]}]},{"name":"National High Technology Research and Development Program of China","award":["2015AA020942"],"award-info":[{"award-number":["2015AA020942"]}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81400555"],"award-info":[{"award-number":["81400555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Basic Research Plan in Shaanxi Province of China","award":["2015JM8383"],"award-info":[{"award-number":["2015JM8383"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.actbio.2017.08.008","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T16:18:18Z","timestamp":1502209098000},"page":"144-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":109,"special_numbering":"C","title":["Primum non nocere \u2013 The effects of sodium hypochlorite on dentin as used in endodontics"],"prefix":"10.1016","volume":"61","author":[{"given":"Li-sha","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-qing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Bergeron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Pashley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-na","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin R.","family":"Tay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2017.08.008_b0005","series-title":"Advances in Biomaterials for Biomedical Applications","year":"2017"},{"key":"10.1016\/j.actbio.2017.08.008_b0010","first-page":"43","article-title":"Grand challenges in biomaterials","volume":"2","author":"Uluda\u011f","year":"2014","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2017.08.008_b0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.2041-1626.2012.00140.x","article-title":"Biocompatibility of various dental materials in contemporary dentistry: a narrative insight","volume":"4","author":"Mallineni","year":"2013","journal-title":"J. Investig. Clin. Dent."},{"key":"10.1016\/j.actbio.2017.08.008_b0020","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.numecd.2016.05.007","article-title":"Novel antidiabetic drugs and cardiovascular risk: primum non nocere","volume":"26","author":"Bonadonna","year":"2016","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.actbio.2017.08.008_b0025","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.eururo.2016.08.070","article-title":"Primum non nocere: critically assessing the morbidity of prostate biopsy","volume":"71","author":"Gershman","year":"2017","journal-title":"Eur. Urol."},{"key":"10.1016\/j.actbio.2017.08.008_b0030","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jcrc.2015.12.022","article-title":"Noninvasive ventilation in acute respiratory distress syndrome: primum non nocere","volume":"32","author":"Sehgal","year":"2016","journal-title":"J. Crit. Care"},{"key":"10.1016\/j.actbio.2017.08.008_b0035","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/bmj.2.2852.318","article-title":"On the use of certain antiseptic substances in the treatment of infected wounds","volume":"2","author":"Dakin","year":"1915","journal-title":"Br. Med. J."},{"key":"10.1016\/j.actbio.2017.08.008_b0040","doi-asserted-by":"crossref","DOI":"10.1111\/iwj.12728","article-title":"Dakin\u2019s solution: is there a place for it in the 21st century?","author":"Duarte","year":"2017","journal-title":"Int. Wound J."},{"key":"10.1016\/j.actbio.2017.08.008_b0045","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.joen.2005.09.014","article-title":"Root canal irrigants","volume":"32","author":"Zehnder","year":"2006","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0050","series-title":"A Predictable Root Canal Technique","author":"Crane","year":"1920"},{"key":"10.1016\/j.actbio.2017.08.008_b0055","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.joen.2011.08.013","article-title":"Irrigation trends among American Association of Endodontists members: a web-based survey","volume":"38","author":"Dutner","year":"2012","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0060","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.joen.2013.11.026","article-title":"Effect of long-term exposure to endodontic disinfecting solutions on young and old Enterococcus faecalis biofilms in dentin canals","volume":"40","author":"Du","year":"2014","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0065","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.joen.2016.09.013","article-title":"Antibacterial efficacy of octenisept, alexidine, chlorhexidine, and sodium hypochlorite against Enterococcus faecalis biofilms","volume":"43","author":"Bukhary","year":"2017","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0070","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0099-2399(78)80255-6","article-title":"Analysis of the effect of dilution on the necrotic tissue dissolution property of sodium hypochlorite","volume":"4","author":"Hand","year":"1978","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0075","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0099-2399(81)80308-1","article-title":"Solvent effect of various dilutions of sodium hypochlorite on vital and necrotic tissue","volume":"7","author":"Gordon","year":"1981","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0080","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.joen.2011.12.013","article-title":"Physicochemical and pulp tissue dissolution properties of some household bleach brands compared with a dental sodium hypochlorite solution","volume":"38","author":"Jungbluth","year":"2012","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0085","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00004770-200006000-00006","article-title":"Chemomechanical reduction of the bacterial population in the root canal after instrumentation and irrigation with 1%, 2.5%, and 5.25% sodium hypochlorite","volume":"26","author":"Jr","year":"2000","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0090","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0099-2399(06)81170-2","article-title":"An evaluation of the action of different root canal irrigants on facultative aerobic-anaerobic, obligate anaerobic, and microaerophilic bacteria","volume":"25","author":"D'Arcangelo","year":"1999","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0095","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.joen.2009.01.018","article-title":"Enterococcus faecalis biofilms eradication by root canal irrigants","volume":"35","author":"Arias-Moliz","year":"2009","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0100","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.joen.2015.01.028","article-title":"The effect of 8.25% sodium hypochlorite on dental pulp dissolution and dentin flexural strength and modulus","volume":"41","author":"Cullen","year":"2015","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0105","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joen.2016.09.023","article-title":"Sodium hypochlorite accident: a systematic review","volume":"43","author":"Guivarc'h","year":"2017","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0110","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.jdent.2013.08.012","article-title":"Anatomy of sodium hypochlorite accidents involving facial ecchymosis \u2013 a review","volume":"41","author":"Zhu","year":"2013","journal-title":"J. Dent."},{"key":"10.1016\/j.actbio.2017.08.008_b0115","doi-asserted-by":"crossref","first-page":"14","DOI":"10.61872\/sdj-2017-01-233","article-title":"Vertical root fractures of endodontically treated posterior teeth: a histologic analysis with clinical and radiographic correlates","volume":"127","author":"von Arx","year":"2017","journal-title":"Swiss. Dent. J."},{"key":"10.1016\/j.actbio.2017.08.008_b0120","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.joen.2012.05.002","article-title":"Vertical root fractures and dentin defects: effects of root canal preparation, filling, and mechanical cycling","volume":"38","author":"Barreto","year":"2012","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0125","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.joen.2015.04.003","article-title":"The effect of isthmus on vertical root fracture in endodontically treated teeth","volume":"41","author":"Chai","year":"2015","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0130","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/etp.12085","article-title":"Longitudinal tooth cracks and fractures: an update and review","volume":"33","author":"Rivera","year":"2015","journal-title":"Endod. Topics"},{"key":"10.1016\/j.actbio.2017.08.008_b0135","series-title":"Collagen: Structure and Mechanics","first-page":"421","article-title":"Dentin","author":"Zaslansky","year":"2008"},{"key":"10.1016\/j.actbio.2017.08.008_b0140","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0736-0266(01)00047-X","article-title":"The role of collagen in determining bone mechanical properties","volume":"19","author":"Wang","year":"2001","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2017.08.008_b0145","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.dental.2017.03.008","article-title":"Dentin on the nanoscale: hierarchical organization, mechanical behavior and bioinspired engineering","volume":"33","author":"Bertassoni","year":"2017","journal-title":"Dent. Mater."},{"key":"10.1016\/j.actbio.2017.08.008_b0150","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jbm.b.31295","article-title":"Host-derived loss of dentin matrix stiffness associated with solubilization of collagen","volume":"90","author":"Carrilho","year":"2009","journal-title":"J. Biomed. Mater. Res. B. App. Biomater."},{"key":"10.1016\/j.actbio.2017.08.008_b0155","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1046\/j.1365-2591.2001.00357.x","article-title":"Effect of sodium hypochlorite on mechanical properties of dentine and tooth surface strain","volume":"34","author":"Sim","year":"2001","journal-title":"Int. Endod. J."},{"key":"10.1016\/j.actbio.2017.08.008_b0160","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1023\/A:1013894432622","article-title":"Effects of sodium hypochlorite solution on root dentine composition","volume":"13","author":"Driscoll","year":"2002","journal-title":"J. Mater. Sci. - Mater. Med."},{"key":"10.1016\/j.actbio.2017.08.008_b0165","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1365-2591.2007.01287.x","article-title":"Effect of sodium hypochlorite on human root dentine\u2013mechanical, chemical and structural evaluation","volume":"40","author":"Marending","year":"2007","journal-title":"Int. Endod. J."},{"key":"10.1016\/j.actbio.2017.08.008_b0170","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.dental.2010.01.009","article-title":"The effect of initial irrigation with two different sodium hypochlorite concentrations on the erosion of instrumented radicular dentin","volume":"26","author":"Zhang","year":"2010","journal-title":"Dent. Mater."},{"key":"10.1016\/j.actbio.2017.08.008_b0175","article-title":"Final irrigation protocols may affect intraradicular dentin ultrastructure","author":"Wagner","year":"2016","journal-title":"Clin. Oral. Investig."},{"key":"10.1016\/j.actbio.2017.08.008_b0180","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/01.DON.0000128748.05148.1E","article-title":"Effect of sodium hypochlorite on dentin microhardness","volume":"30","author":"Slutzky-Goldberg","year":"2004","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0185","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1016\/j.tripleo.2007.04.019","article-title":"Effects of chlorhexidine and sodium hypochlorite on the microhardness of root canal dentin","volume":"104","author":"Oliveira","year":"2007","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0190","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.joen.2013.10.041","article-title":"Effect of EDTA, sodium hypochlorite, and chlorhexidine gluconate with or without surface modifiers on dentin microhardness","volume":"40","author":"Aslantas","year":"2014","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0195","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.2041-1626.2012.00158.x","article-title":"Effect of sodium hypochlorite under several formulations on root canal dentin microhardness","volume":"4","author":"Garcia","year":"2013","journal-title":"J. Investig. Clin. Dent"},{"key":"10.1016\/j.actbio.2017.08.008_b0200","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.1365-2591.2001.00356.x","article-title":"Effect of exposing dentine to sodium hypochlorite and calcium hydroxide on its flexural strength and elastic modulus","volume":"34","author":"Grigoratos","year":"2001","journal-title":"Int. Endod. J."},{"key":"10.1016\/j.actbio.2017.08.008_b0205","doi-asserted-by":"crossref","first-page":"9522","DOI":"10.1016\/j.actbio.2013.07.037","article-title":"The importance of size-exclusion characteristics of type I collagen in bonding to dentin matrices","volume":"9","author":"Takahashi","year":"2013","journal-title":"Acta. Biomater."},{"key":"10.1016\/j.actbio.2017.08.008_b0210","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0254-0584(02)00466-2","article-title":"Synthesis, charactization and thermal behavior of apatitic tricalcium phosphate","volume":"80","author":"Destainville","year":"2003","journal-title":"Mater. Chem. Phys."},{"key":"10.1016\/j.actbio.2017.08.008_b0215","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.micron.2010.09.010","article-title":"Collagen type I amide I band infrared spectroscopy","volume":"42","author":"Vidal Bde","year":"2011","journal-title":"Micron."},{"key":"10.1016\/j.actbio.2017.08.008_b0220","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.dental.2010.04.001","article-title":"Chlorhexidine binding to mineralized versus demineralized dentin powder","volume":"26","author":"Kim","year":"2010","journal-title":"Dent. Mater."},{"key":"10.1016\/j.actbio.2017.08.008_b0225","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1089\/ten.tec.2017.0018","article-title":"A modified hydroxyproline assay based on hydrochloric acid in Ehrlich\u2019s solution accurately measures tissue collagen content","volume":"23","author":"Cissell","year":"2017","journal-title":"Tissue Eng. Part. C. Methods."},{"key":"10.1016\/j.actbio.2017.08.008_b0230","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/abio.1995.9988","article-title":"Quantification of cysteine residues following oxidation to cysteic acid in the presence of sodium azide","volume":"231","author":"Manneberg","year":"1995","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.actbio.2017.08.008_b0235","first-page":"5","article-title":"Separation and determination of the amino acids by ion exchange column chromatography applying postcolumn derivatization","volume":"1","author":"Csapo","year":"2008","journal-title":"Acta. Univ. Sapientiae-Alimentaria."},{"key":"10.1016\/j.actbio.2017.08.008_b0240","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.biomaterials.2005.10.005","article-title":"Tubule orientation and the fatigue strength of human dentin","volume":"27","author":"Arola","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.08.008_b0245","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1177\/154405910808700704","article-title":"Changes in resin-infiltrated dentin stiffness after water storage","volume":"87","author":"Chiaraputt","year":"2008","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.actbio.2017.08.008_b0250","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00223-007-9053-x","article-title":"Peritubular dentin, a vertebrate apatitic mineralized tissue without collagen: role of a phospholipid-proteolipid complex","volume":"81","author":"Gotliv","year":"2007","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.actbio.2017.08.008_b0255","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1557\/JMR.1993.0087","article-title":"Ultramicrotomy: a unique method for preparation of composite solder for transmission electron microscopy","volume":"8","author":"Jacobs","year":"1993","journal-title":"J. Mater. Res."},{"key":"10.1016\/j.actbio.2017.08.008_b0260","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0003-9969(96)00008-8","article-title":"The density and branching of dentinal tubules in human teeth","volume":"41","author":"Mj\u00f6r","year":"1996","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.actbio.2017.08.008_b0265","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0142-9612(00)00239-8","article-title":"A photoacoustic FTIRS study of the chemical modifications of human dentin surfaces: II deproteination","volume":"22","author":"Di Renzo","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2017.08.008_b0270","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00223-012-9604-7","article-title":"Cathepsin K preferentially solubilizes matured bone matrix","volume":"91","author":"Borel","year":"2012","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.actbio.2017.08.008_b0275","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bone.2014.05.016","article-title":"New developments in biological markers of bone metabolism in osteoporosis","volume":"66","author":"Garnero","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2017.08.008_b0280","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/bip.20958","article-title":"Triple-helical peptides: an approach to collagen conformation, stability, and self-association","volume":"89","author":"Brodsky","year":"2008","journal-title":"Biopolymers"},{"key":"10.1016\/j.actbio.2017.08.008_b0285","doi-asserted-by":"crossref","first-page":"22905","DOI":"10.1074\/jbc.M110.199984","article-title":"Interstrand dipole-dipole interactions can stabilize the collagen triple helix","volume":"286","author":"Shoulders","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2017.08.008_b0290","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/(SICI)1097-4636(19980615)40:4<539::AID-JBM4>3.0.CO;2-G","article-title":"Viscoelastic properties of demineralized human dentin measured in water with atomic force microscope (AFM)-based indentation","volume":"40","author":"Balooch","year":"1998","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.actbio.2017.08.008_b0295","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jmbbm.2007.04.002","article-title":"Fatigue of mineralized tissues: cortical bone and dentin","volume":"1","author":"Kruzic","year":"2008","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2017.08.008_b0300","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jmbbm.2009.01.008","article-title":"Aging and the reduction in fracture toughness of human dentin","volume":"2","author":"Nazari","year":"2009","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2017.08.008_b0305","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.joen.2005.10.062","article-title":"Denaturation temperatures of dentin matrices. I. Effect of demineralization and dehydration","volume":"32","author":"Armstrong","year":"2006","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0310","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/1475-4754.t01-1-00071","article-title":"The survival of organic matter in bone: a review","volume":"44","author":"Collins","year":"2002","journal-title":"Archaeometry"},{"key":"10.1016\/j.actbio.2017.08.008_b0315","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00004770-200201000-00004","article-title":"Time-dependent effects of EDTA on dentin structures","volume":"28","author":"Calt","year":"2002","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0320","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.joen.2011.06.005","article-title":"Quantitative analysis of the effect of irrigant solution sequences on dentin erosion","volume":"37","author":"Qian","year":"2011","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0325","first-page":"99","article-title":"Microleakage in endodontics","volume":"6","author":"Muliyar","year":"2014","journal-title":"J. Int. Oral. Health."},{"key":"10.1016\/j.actbio.2017.08.008_b0330","doi-asserted-by":"crossref","first-page":"22437","DOI":"10.1074\/jbc.M700591200","article-title":"The size exclusion characteristics of type I collagen: implications for the role of noncollagenous bone constituents in mineralization","volume":"282","author":"Toroian","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2017.08.008_b0335","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/j.1365-2591.2011.01911.x","article-title":"Influence of pH changes on chlorine-containing endodontic irrigating solutions","volume":"44","author":"Rossi-Fedele","year":"2011","journal-title":"Int. Endod. J."},{"key":"10.1016\/j.actbio.2017.08.008_b0340","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.joen.2011.02.019","article-title":"Stabilizing sodium hypochlorite at high pH: effects on soft tissue and dentin","volume":"37","author":"Jungbluth","year":"2011","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0345","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1432-1033.1995.672_2.x","article-title":"NMR studies of the action of hypochlorous acid on native pig articular cartilage","volume":"15","author":"Schiller","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.actbio.2017.08.008_b0350","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0891-5849(93)90167-S","article-title":"Potential roles of hypochlorous acid and N-chloroamines in collagen breakdown by phagocytic cells in synovitis","volume":"15","author":"Davies","year":"1993","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.actbio.2017.08.008_b0355","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.joen.2013.12.018","article-title":"Influence of the dentinal wall on the pH of sodium hypochlorite during root canal irrigation","volume":"40","author":"Macedo","year":"2014","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0360","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1042\/bj0300484","article-title":"The oxidation of amino-acids by hypochlorite. I. Glycine","volume":"30","author":"Norman","year":"1936","journal-title":"Biochem. J."},{"key":"10.1016\/j.actbio.2017.08.008_b0365","first-page":"222","article-title":"Action of sodium hypochlorite on \u03b1-Amino Acids","volume":"25","author":"Kantouch","year":"1971","journal-title":"Chem. Zvesti."},{"key":"10.1016\/j.actbio.2017.08.008_b0370","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.joen.2010.02.005","article-title":"Penetration of sodium hypochlorite into dentin","volume":"36","author":"Zou","year":"2010","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0375","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.joen.2009.03.010","article-title":"Review of contemporary irrigant agitation techniques and devices","volume":"35","author":"Gu","year":"2009","journal-title":"J. Endod."},{"key":"10.1016\/j.actbio.2017.08.008_b0380","doi-asserted-by":"crossref","first-page":"788","DOI":"10.2741\/e286","article-title":"Dental pulp and dentin tissue engineering and regeneration: advancement and challenge","volume":"3","author":"Huang","year":"2011","journal-title":"Front. Biosci. (Ellite. Ed.)"},{"key":"10.1016\/j.actbio.2017.08.008_b0385","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.joen.2017.01.022","article-title":"Fracture strength of endodontically treated teeth with different access cavity designs","volume":"43","author":"Plotino","year":"2017","journal-title":"J. Endod."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706117304981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706117304981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:00:05Z","timestamp":1761670805000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706117304981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":77,"alternative-id":["S1742706117304981"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2017.08.008","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Primum non nocere \u2013 The effects of sodium hypochlorite on dentin as used in endodontics","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2017.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}