{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:21:48Z","timestamp":1792668108190,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"am","delay-in-days":337,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000774","name":"Defense Threat Reduction Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.actbio.2018.02.007","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T19:16:38Z","timestamp":1518549398000},"page":"48-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":278,"special_numbering":"C","title":["3D bioprinted functional and contractile cardiac tissue constructs"],"prefix":"10.1016","volume":"70","author":[{"given":"Zhan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng-Jie","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Atala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.actbio.2018.02.007_b0005","first-page":"e6","article-title":"Heart disease and stroke statistics\u20132013 update: a report from the American Heart Association","volume":"127","author":"Go","year":"2013","journal-title":"Circulation"},{"issue":"25","key":"10.1016\/j.actbio.2018.02.007_b0010","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","article-title":"Left ventricular remodeling after myocardial infarction: pathophysiology and therapy","volume":"101","author":"Sutton","year":"2000","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.actbio.2018.02.007_b0015","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nm1394","article-title":"Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts","volume":"12","author":"Zimmermann","year":"2006","journal-title":"Nat. Med."},{"issue":"11 Suppl","key":"10.1016\/j.actbio.2018.02.007_b0020","first-page":"S118","article-title":"Composite cell sheets: a further step toward safe and effective myocardial regeneration by cardiac progenitors derived from embryonic stem cells","volume":"122","author":"Bel","year":"2010","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.actbio.2018.02.007_b0025","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/ten.teb.2009.0352","article-title":"Challenges in cardiac tissue engineering","volume":"16","author":"Vunjak-Novakovic","year":"2010","journal-title":"Tissue Eng. Part B Rev."},{"issue":"4","key":"10.1016\/j.actbio.2018.02.007_b0030","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1089\/ten.teb.2009.0006","article-title":"Micro- and nanoscale control of the cardiac stem cell niche for tissue fabrication","volume":"15","author":"Murtuza","year":"2009","journal-title":"Tissue Eng. Part B Rev."},{"issue":"4","key":"10.1016\/j.actbio.2018.02.007_b0035","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/bdrc.20138","article-title":"Engineered microenvironments for human stem cells","volume":"84","author":"Godier","year":"2008","journal-title":"Birth Defects Res. C Embryo Today"},{"issue":"8","key":"10.1016\/j.actbio.2018.02.007_b0040","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nbt.2958","article-title":"3D bioprinting of tissues and organs","volume":"32","author":"Murphy","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"12","key":"10.1016\/j.actbio.2018.02.007_b0045","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1016\/j.biomaterials.2008.12.084","article-title":"Organ printing: tissue spheroids as building blocks","volume":"30","author":"Mironov","year":"2009","journal-title":"Biomaterials"},{"issue":"7405","key":"10.1016\/j.actbio.2018.02.007_b0050","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/487022a","article-title":"Science in three dimensions: the print revolution","volume":"487","author":"Jones","year":"2012","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.actbio.2018.02.007_b0055","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1007\/s00253-013-4853-6","article-title":"Biofabrication: an overview of the approaches used for printing of living cells","volume":"97","author":"Ferris","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.actbio.2018.02.007_b0060","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.biomaterials.2012.09.035","article-title":"Complex heterogeneous tissue constructs containing multiple cell types prepared by inkjet printing technology","volume":"34","author":"Xu","year":"2013","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.actbio.2018.02.007_b0065","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nmat3665","article-title":"Bioprinting: Functional droplet networks","volume":"12","author":"Durmus","year":"2013","journal-title":"Nat. Mater."},{"issue":"3","key":"10.1016\/j.actbio.2018.02.007_b0070","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nbt.3413","article-title":"A 3D bioprinting system to produce human-scale tissue constructs with structural integrity","volume":"34","author":"Kang","year":"2016","journal-title":"Nat. Biotechnol."},{"issue":"49","key":"10.1016\/j.actbio.2018.02.007_b0075","doi-asserted-by":"crossref","first-page":"E4698","DOI":"10.1073\/pnas.1311120110","article-title":"Design and formulation of functional pluripotent stem cell-derived cardiac microtissues","volume":"110","author":"Thavandiran","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.actbio.2018.02.007_b0080","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/(SICI)1097-0290(20000405)68:1<106::AID-BIT13>3.0.CO;2-3","article-title":"Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes","volume":"68","author":"Zimmermann","year":"2000","journal-title":"Biotechnol. Bioeng."},{"issue":"24","key":"10.1016\/j.actbio.2018.02.007_b0085","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1039\/c1lc20557a","article-title":"Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip","volume":"11","author":"Grosberg","year":"2011","journal-title":"Lab Chip"},{"issue":"25","key":"10.1016\/j.actbio.2018.02.007_b0090","doi-asserted-by":"crossref","first-page":"10097","DOI":"10.1073\/pnas.0900174106","article-title":"Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues","volume":"106","author":"Legant","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"15","key":"10.1016\/j.actbio.2018.02.007_b0095","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1093\/eurheartj\/ehs349","article-title":"Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro","volume":"34","author":"Kensah","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.actbio.2018.02.007_b0100","article-title":"Encapsulation of cardiomyocytes in a fibrin hydrogel for cardiac tissue engineering","volume":"55","author":"Yuan Ye","year":"2011","journal-title":"J. Vis. Exp."},{"issue":"12","key":"10.1016\/j.actbio.2018.02.007_b0105","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1161\/01.RES.0000047530.88338.EB","article-title":"Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscle","volume":"91","author":"Bursac","year":"2002","journal-title":"Circ. Res."},{"issue":"5951","key":"10.1016\/j.actbio.2018.02.007_b0110","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1126\/science.1177350","article-title":"Generation of functional ventricular heart muscle from mouse ventricular progenitor cells","volume":"326","author":"Domian","year":"2009","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.actbio.2018.02.007_b0115","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/nbt.2269","article-title":"A tissue-engineered jellyfish with biomimetic propulsion","volume":"30","author":"Nawroth","year":"2012","journal-title":"Nat. Biotechnol."},{"issue":"35","key":"10.1016\/j.actbio.2018.02.007_b0120","doi-asserted-by":"crossref","first-page":"9180","DOI":"10.1016\/j.biomaterials.2011.08.050","article-title":"Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function","volume":"32","author":"Liau","year":"2011","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.actbio.2018.02.007_b0125","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1161\/CIRCRESAHA.116.310277","article-title":"Myocardial tissue engineering with cells derived from human-induced pluripotent stem cells and a native-like, high-resolution, 3-dimensionally printed scaffold","volume":"120","author":"Gao","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.actbio.2018.02.007_b0130","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.biomaterials.2016.10.026","article-title":"3D printed complex tissue construct using stem cell-laden decellularized extracellular matrix bioinks for cardiac repair","volume":"112","author":"Jang","year":"2017","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.actbio.2018.02.007_b0135","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/nmat4782","article-title":"Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing","volume":"16","author":"Lind","year":"2017","journal-title":"Nat. Mater."},{"issue":"1","key":"10.1016\/j.actbio.2018.02.007_b0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/CIRCRESAHA.110.237206","article-title":"Growth of engineered human myocardium with mechanical loading and vascular coculture","volume":"109","author":"Tulloch","year":"2011","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.actbio.2018.02.007_b0145","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/jcb.23437","article-title":"Characterization and optimization of a simple, repeatable system for the long term in vitro culture of aligned myotubes in 3D","volume":"113","author":"Smith","year":"2012","journal-title":"J. Cell. Biochem."},{"issue":"8","key":"10.1016\/j.actbio.2018.02.007_b0150","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s10237-012-0419-2","article-title":"The contribution of cellular mechanotransduction to cardiomyocyte form and function","volume":"11","author":"Sheehy","year":"2012","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"5","key":"10.1016\/j.actbio.2018.02.007_b0155","doi-asserted-by":"crossref","first-page":"e00078","DOI":"10.1002\/phy2.78","article-title":"Gene expression profiles in engineered cardiac tissues respond to mechanical loading and inhibition of tyrosine kinases","volume":"1","author":"Ye","year":"2013","journal-title":"Physiol. Rep."},{"issue":"2","key":"10.1016\/j.actbio.2018.02.007_b0160","doi-asserted-by":"crossref","first-page":"024109","DOI":"10.1088\/1758-5082\/6\/2\/024109","article-title":"Controlling the structural and functional anisotropy of engineered cardiac tissues","volume":"6","author":"Bian","year":"2014","journal-title":"Biofabrication"},{"issue":"2","key":"10.1016\/j.actbio.2018.02.007_b0165","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s10544-015-9928-y","article-title":"3D printing of soft lithography mold for rapid production of polydimethylsiloxane-based microfluidic devices for cell stimulation with concentration gradients","volume":"17","author":"Kamei","year":"2015","journal-title":"Biomed. Microdevices"},{"issue":"5","key":"10.1016\/j.actbio.2018.02.007_b0170","doi-asserted-by":"crossref","first-page":"052112","DOI":"10.1063\/1.4898632","article-title":"Advances in three-dimensional rapid prototyping of microfluidic devices for biological applications","volume":"8","author":"O'Neill","year":"2014","journal-title":"Biomicrofluidics"},{"key":"10.1016\/j.actbio.2018.02.007_b0175","doi-asserted-by":"crossref","first-page":"7717","DOI":"10.1038\/srep07717","article-title":"3D-printed microfluidic device for the detection of pathogenic bacteria using size-based separation in helical channel with trapezoid cross-section","volume":"5","author":"Lee","year":"2015","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.actbio.2018.02.007_b0180","doi-asserted-by":"crossref","first-page":"e49365","DOI":"10.1371\/journal.pone.0049365","article-title":"A simple, low-cost conductive composite material for 3D printing of electronic sensors","volume":"7","author":"Leigh","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2018.02.007_b0185","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/srep00585","article-title":"Scalable printed electronics: an organic decoder addressing ferroelectric non-volatile memory","volume":"2","author":"Ng","year":"2012","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.actbio.2018.02.007_b0190","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.yjmcc.2011.06.018","article-title":"Adult human heart slices are a multicellular system suitable for electrophysiological and pharmacological studies","volume":"51","author":"Camelliti","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"6A","key":"10.1016\/j.actbio.2018.02.007_b0195","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1111\/j.1582-4934.2008.00439.x","article-title":"Features of cardiomyocyte proliferation and its potential for cardiac regeneration","volume":"12","author":"van Amerongen","year":"2008","journal-title":"J. Cellular Mol. Med."},{"issue":"7337","key":"10.1016\/j.actbio.2018.02.007_b0200","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature09855","article-title":"Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome","volume":"471","author":"Yazawa","year":"2011","journal-title":"Nature"},{"issue":"130","key":"10.1016\/j.actbio.2018.02.007_b0205","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003552","article-title":"Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy","volume":"4","author":"Sun","year":"2012","journal-title":"Sci Transl Med"},{"issue":"2","key":"10.1016\/j.actbio.2018.02.007_b0210","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.devcel.2012.01.014","article-title":"Coordinating tissue interactions: Notch signaling in cardiac development and disease","volume":"22","author":"de la Pompa","year":"2012","journal-title":"Dev. Cell"},{"issue":"4","key":"10.1016\/j.actbio.2018.02.007_b0215","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.yjmcc.2008.02.273","article-title":"Functional role of Notch signaling in the developing and postnatal heart","volume":"45","author":"Nemir","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"6","key":"10.1016\/j.actbio.2018.02.007_b0220","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.yjmcc.2012.03.007","article-title":"Notch signaling and cardiac repair","volume":"52","author":"Gude","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"3","key":"10.1016\/j.actbio.2018.02.007_b0225","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.devcel.2006.12.011","article-title":"Notch signaling is essential for ventricular chamber development","volume":"12","author":"Grego-Bessa","year":"2007","journal-title":"Dev. Cell"},{"issue":"1","key":"10.1016\/j.actbio.2018.02.007_b0230","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/cvr\/cvv209","article-title":"Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart","volume":"108","author":"Metrich","year":"2015","journal-title":"Cardiovasc. Res."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706118300771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706118300771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:05:17Z","timestamp":1761671117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706118300771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":46,"alternative-id":["S1742706118300771"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2018.02.007","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"3D bioprinted functional and contractile cardiac tissue constructs","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2018.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}