{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:56:48Z","timestamp":1791244608134,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.actbio.2018.02.023","type":"journal-article","created":{"date-parts":[[2018,3,17]],"date-time":"2018-03-17T00:21:12Z","timestamp":1521246072000},"page":"215-224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"special_numbering":"C","title":["Long-term in vivo evolution of high-purity Mg screw degradation \u2014 Local and systemic effects of Mg degradation products"],"prefix":"10.1016","volume":"71","author":[{"given":"Yiqiang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2018.02.023_b0005","doi-asserted-by":"crossref","first-page":"8518","DOI":"10.1016\/j.actbio.2013.06.025","article-title":"In vitro and in vivo corrosion, cytocompatibility and mechanical properties of biodegradable Mg-Y-Ca-Zr alloys as implant materials","volume":"9","author":"Chou","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0010","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1016\/j.actbio.2014.07.005","article-title":"Recent advances on the development of magnesium alloys for biodegradable implants","volume":"10","author":"Chen","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0015","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.actbio.2010.02.028","article-title":"The history of biodegradable magnesium implants: a review","volume":"6","author":"Witte","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0020","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biomaterials.2015.06.031","article-title":"In vitro and in vivo studies on the degradation of high-purity Mg (99.99 wt%) screw with femoral intracondylar fractured rabbit model","volume":"64","author":"Han","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2018.02.023_b0025","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jmst.2013.02.005","article-title":"Novel magnesium alloys developed for biomedical application: a review","volume":"29","author":"Li","year":"2013","journal-title":"J. Mater. Sci. Technol."},{"key":"10.1016\/j.actbio.2018.02.023_b0030","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.actbio.2009.06.028","article-title":"Research on an Mg-Zn alloy as a degradable biomaterial","volume":"6","author":"Zhang","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0035","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.envres.2017.07.054","article-title":"The effect of aluminium and sodium impurities on the in vitro toxicity and pro-inflammatory potential of cristobalite","volume":"159","author":"Nattrass","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.actbio.2018.02.023_b0040","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/jbm.a.32235","article-title":"Rare earth metals used in biodegradable magnesium-based stents do not interfere with proliferation of smooth muscle cells but do induce the upregulation of inflammatory genes","volume":"91","author":"Drynda","year":"2009","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2018.02.023_b0045","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.biomaterials.2009.09.065","article-title":"Preparation and properties of high purity Mg-Y biomaterials","volume":"31","author":"Peng","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2018.02.023_b0050","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.corsci.2012.04.030","article-title":"Corrosion behaviour of a nominally high purity Mg ingot produced by permanent mould direct chill casting","volume":"61","author":"Qiao","year":"2012","journal-title":"Corrosion Sci."},{"key":"10.1016\/j.actbio.2018.02.023_b0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.msec.2015.12.002","article-title":"Peri-implant tissue response and biodegradation performance of a Mg-1.0Ca-0.5Sr alloy in rat tibia","volume":"62","author":"Berglund","year":"2016","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.actbio.2018.02.023_b0060","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1475-925X-11-14","article-title":"In vivo assessment of the host reactions to the biodegradation of the two novel magnesium alloys ZEK100 and AX30 in an animal model","volume":"11","author":"Huehnerschulte","year":"2012","journal-title":"Biomed. Eng. Online"},{"key":"10.1016\/j.actbio.2018.02.023_b0065","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.biomaterials.2007.12.021","article-title":"The development of binary Mg-Ca alloys for use as biodegradable materials within bone","volume":"29","author":"Li","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2018.02.023_b0070","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1016\/j.actbio.2014.02.002","article-title":"Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation","volume":"10","author":"Yoshizawa","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0075","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1016\/j.actbio.2009.10.008","article-title":"On the in vitro and in vivo degradation performance and biological response of new biodegradable Mg-Y-Zn alloys","volume":"6","author":"H\u00e4nzi","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0080","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s10856-011-4536-8","article-title":"In vivo behavior of biodegradable Mg-Nd-Y-Zr-Ca alloy","volume":"23","author":"Aghion","year":"2012","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.actbio.2018.02.023_b0085","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1016\/j.actbio.2012.04.028","article-title":"Mg-Zr-Sr alloys as biodegradable implant materials","volume":"8","author":"Li","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0090","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/jbm.a.32132","article-title":"In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation","volume":"90","author":"Zhang","year":"2009","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2018.02.023_b0095","doi-asserted-by":"crossref","first-page":"8548","DOI":"10.1016\/j.actbio.2012.08.028","article-title":"Long-term in vivo degradation behaviour and biocompatibility of the magnesium alloy ZEK100 for use as a biodegradable bone implant","volume":"9","author":"Dziuba","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0100","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/ten.teb.2009.0503","article-title":"Use of fluorochrome labels in in vivo bone tissue engineering research","volume":"16","author":"van Gaalen","year":"2010","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.actbio.2018.02.023_b0105","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1016\/j.biomaterials.2013.01.008","article-title":"The synergistic effect of hierarchical micro\/nano-topography and bioactive ions for enhanced osseointegration","volume":"34","author":"Zhang","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2018.02.023_b0110","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.actbio.2016.11.067","article-title":"Multifunctions of dual Zn\/Mg ion co-implanted titanium on osteogenesis, angiogenesis and bacteria inhibition for dental implants","volume":"49","author":"Yu","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0115","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biomaterials.2017.01.006","article-title":"Blood-brain barrier dysfunction induced by silica NPs in vitro and in vivo: Involvement of oxidative stress and Rho-kinase\/JNK signaling pathways","volume":"121","author":"Liu","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2018.02.023_b0120","doi-asserted-by":"crossref","first-page":"6882","DOI":"10.1016\/j.biomaterials.2014.04.101","article-title":"Stimulation of bone growth following zinc incorporation into biomaterials","volume":"35","author":"Qiao","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2018.02.023_b0125","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.actbio.2016.08.002","article-title":"Biocompatibility and degradation of LAE442-based magnesium alloys after implantation of up to 3.5 years in a rabbit model","volume":"44","author":"Angrisani","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0130","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1016\/j.actbio.2012.02.018","article-title":"In vitro and in vivo studies on a Mg-Sr binary alloy system developed as a new kind of biodegradable metal","volume":"8","author":"Gu","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0135","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/jbm.a.31273","article-title":"In vivo corrosion behavior of Mg-Mn-Zn alloy for bone implant application","volume":"83","author":"Xu","year":"2007","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2018.02.023_b0140","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/ptj\/86.1.77","article-title":"Bone biology and the clinical implications for osteoporosis","volume":"86","author":"Downey","year":"2006","journal-title":"Phys. Ther."},{"key":"10.1016\/j.actbio.2018.02.023_b0145","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.actbio.2010.12.004","article-title":"In vitro studies of biomedical magnesium alloys in a simulated physiological environment: a review","volume":"7","author":"Xin","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0150","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cossms.2014.09.005","article-title":"Corrosion mechanism and hydrogen evolution on Mg","volume":"19","author":"Thomas","year":"2015","journal-title":"Adv. Coatings Thin Film Processes Curr. Opinion Solid State Mater. Sci."},{"key":"10.1016\/j.actbio.2018.02.023_b0155","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1073\/pnas.1518238113","article-title":"Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy","volume":"113","author":"Lee","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.actbio.2018.02.023_b0160","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.msec.2009.01.014","article-title":"Biocorrosion behavior of magnesium alloy in different simulated fluids for biomedical application","volume":"29","author":"Yang","year":"2009","journal-title":"Mater. Sci. Eng.: C"},{"key":"10.1016\/j.actbio.2018.02.023_b0165","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.actbio.2014.11.048","article-title":"Mg and Mg alloys: how comparable are in vitro and in vivo corrosion rates? A review","volume":"13","author":"Martinez","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0170","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.actbio.2017.11.031","article-title":"The influence of biodegradable magnesium implants on the growth plate","volume":"66","author":"Kraus","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0175","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.actbio.2011.11.008","article-title":"Magnesium alloys for temporary implants in osteosynthesis: in vivo studies of their degradation and interaction with bone","volume":"8","author":"Kraus","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0180","doi-asserted-by":"crossref","first-page":"8714","DOI":"10.1016\/j.actbio.2012.10.008","article-title":"Fast escape of hydrogen from gas cavities around corroding magnesium implants","volume":"9","author":"Kuhlmann","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2018.02.023_b0185","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1177\/0885328212472215","article-title":"In vivo study of a biodegradable orthopedic screw (MgYREZr-alloy) in a rabbit model for up to 12 months","volume":"28","author":"Waizy","year":"2014","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.actbio.2018.02.023_b0190","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/jbm.10270","article-title":"Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants","volume":"62","author":"Zreiqat","year":"2002","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.actbio.2018.02.023_b0195","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.msec.2012.12.061","article-title":"Mg ion implantation on SLA-treated titanium surface and its effects on the behavior of mesenchymal stem cell","volume":"33","author":"Kim","year":"2013","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.actbio.2018.02.023_b0200","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/clpt.2012.108","article-title":"Alanine aminotransferase: a clinical and regulatory tool for detecting liver injury-past, present, and future","volume":"92","author":"Senior","year":"2012","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.actbio.2018.02.023_b0205","first-page":"817","article-title":"The past and present of serum aminotransferases and the future of liver injury biomarkers","volume":"15","author":"McGill","year":"2016","journal-title":"Excli. J."},{"key":"10.1016\/j.actbio.2018.02.023_b0210","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000309421","article-title":"Serum and urinary biomarkers of acute kidney injury","volume":"29","author":"Lisowska-Myjak","year":"2010","journal-title":"Blood Purif."},{"key":"10.1016\/j.actbio.2018.02.023_b0215","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1475-2891-11-39","article-title":"Effect of urine pH changed by dietary intervention on uric acid clearance mechanism of pH-dependent excretion of urinary uric acid","volume":"11","author":"Kanbara","year":"2012","journal-title":"Nutr. J."},{"key":"10.1016\/j.actbio.2018.02.023_b0220","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1475-2891-9-45","article-title":"Urine alkalization facilitates uric acid excretion","volume":"9","author":"Kanbara","year":"2010","journal-title":"Nutr. J."},{"key":"10.1016\/j.actbio.2018.02.023_b0225","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.actbio.2017.01.024","article-title":"In vivo characterization of magnesium alloy biodegradation using electrochemical H2 monitoring, ICP-MS, and XPS","volume":"50","author":"Zhao","year":"2017","journal-title":"Acta Biomater."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706118301065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706118301065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:05:09Z","timestamp":1761671109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706118301065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":45,"alternative-id":["S1742706118301065"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2018.02.023","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term in vivo evolution of high-purity Mg screw degradation \u2014 Local and systemic effects of Mg degradation products","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2018.02.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}