{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:40:13Z","timestamp":1790224813808,"version":"4.1.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T00:00:00Z","timestamp":1574467200000},"content-version":"am","delay-in-days":357,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006190","name":"National Key Research and Development Programs","doi-asserted-by":"publisher","award":["2017YFC1104200"],"award-info":[{"award-number":["2017YFC1104200"]}],"id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006190","name":"National Key Research and Development Programs","doi-asserted-by":"publisher","award":["2016YFC1102200"],"award-info":[{"award-number":["2016YFC1102200"]}],"id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]},{"name":"111 Project of Introducing Talents of Discipline to Universities","award":["B16033"],"award-info":[{"award-number":["B16033"]}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31700833"],"award-info":[{"award-number":["31700833"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010574","name":"CAST","doi-asserted-by":"publisher","award":["2017QNRC001"],"award-info":[{"award-number":["2017QNRC001"]}],"id":[{"id":"10.13039\/501100010574","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["YJ201641"],"award-info":[{"award-number":["YJ201641"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.actbio.2018.10.017","type":"journal-article","created":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T21:37:30Z","timestamp":1539466650000},"page":"44-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"special_numbering":"C","title":["Radical polymerization-crosslinking method for improving extracellular matrix stability in bioprosthetic heart valves with reduced potential for calcification and inflammatory response"],"prefix":"10.1016","volume":"82","author":[{"given":"Gaoyang","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhe","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1461-8111","authenticated-orcid":false,"given":"Yang","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunbing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.actbio.2018.10.017_b0005","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S1010-7940(03)00030-7","article-title":"Aortic valve replacement for aortic regurgitation and stenosis, in patients with severe left ventricular dysfunction","volume":"23","author":"Rothenburger","year":"2003","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.actbio.2018.10.017_b0010","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.biomaterials.2014.09.013","article-title":"Polymeric heart valves for surgical implantation, catheter-based technologies and heart assist devices","volume":"36","author":"Bezuidenhout","year":"2015","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2018.10.017_b0015","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/jbm.b.31151","article-title":"Current developments and future prospects for heart valve replacement therapy","volume":"88B","author":"Kidane","year":"2009","journal-title":"J. Biomed. Mater. Res. B"},{"issue":"5","key":"10.1016\/j.actbio.2018.10.017_b0020","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.jtcvs.2015.01.052","article-title":"National trends in utilization and in-hospital outcomes of mechanical versus bioprosthetic aortic valve replacements","volume":"149","author":"Isaacs","year":"2015","journal-title":"J. Thorac. Cardiov. Sur."},{"issue":"24","key":"10.1016\/j.actbio.2018.10.017_b0025","doi-asserted-by":"crossref","DOI":"10.21037\/atm.2016.12.58","article-title":"Anticoagulant independent mechanical heart valves: viable now or still a distant holy grail","volume":"4","author":"Chaux","year":"2016","journal-title":"Ann. Transl. Med."},{"issue":"4","key":"10.1016\/j.actbio.2018.10.017_b0030","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.carpath.2005.03.005","article-title":"Cardiac valves and valvular pathology - Update on function, disease, repair, and replacement","volume":"14","author":"Schoen","year":"2005","journal-title":"Cardiovasc. Pathol."},{"issue":"6","key":"10.1016\/j.actbio.2018.10.017_b0035","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nrcardio.2016.43","article-title":"Durability of prostheses for transcatheter aortic valve implantation","volume":"13","author":"Arsalan","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.actbio.2018.10.017_b0040","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.athoracsur.2011.03.020","article-title":"Crimping may affect the durability of transcatheter valves: an experimental analysis","volume":"92","author":"Kiefer","year":"2011","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.actbio.2018.10.017_b0045","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jmbbm.2015.01.005","article-title":"Mechanical degradation of biological heart valve tissue induced by low diameter crimping: an early assessment","volume":"44","author":"Khoffi","year":"2015","journal-title":"J. Mech. Behav. Biomed."},{"issue":"1","key":"10.1016\/j.actbio.2018.10.017_b0050","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/(SICI)1097-4636(199907)46:1<44::AID-JBM5>3.0.CO;2-D","article-title":"Mechanisms of bioprosthetic heart valve failure: fatigue causes collagen denaturation and glycosaminoglycan loss","volume":"46","author":"Vyavahare","year":"1999","journal-title":"J. Biomed. Mater. Res."},{"issue":"1","key":"10.1016\/j.actbio.2018.10.017_b0055","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/jbm.a.10543","article-title":"Role of elastin in pathologic calcification of xenograft heart valves","volume":"66","author":"Bailey","year":"2003","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"3","key":"10.1016\/j.actbio.2018.10.017_b0060","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1365-2559.2011.03977.x","article-title":"New evidence for a critical role of elastin in calcification of native heart valves: immunohistochemical and ultrastructural study with literature review","volume":"59","author":"Perrotta","year":"2011","journal-title":"Histopathology"},{"issue":"1","key":"10.1016\/j.actbio.2018.10.017_b0065","first-page":"122","article-title":"The role of glutaraldehyde-induced cross-links in calcification of bovine pericardium used in cardiac valve bioprostheses","volume":"127","author":"Golomb","year":"1987","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.actbio.2018.10.017_b0070","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/jbm.a.10066","article-title":"Extracellular matrix degrading enzymes are active in porcine stentless aortic bioprosthetic heart valves","volume":"66","author":"Simionescu","year":"2003","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"1","key":"10.1016\/j.actbio.2018.10.017_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0021-9290(94)90027-2","article-title":"Biomechanical and structural properties of the explanted bioprosthetic valve leaflets","volume":"27","author":"Purinya","year":"1994","journal-title":"J. Biomech."},{"issue":"3","key":"10.1016\/j.actbio.2018.10.017_b0080","first-page":"298","article-title":"Transcatheter aortic valve implantation (TAVI): the hype and the hope","volume":"40","author":"Diez","year":"2013","journal-title":"Tex Heart Inst. J."},{"issue":"5","key":"10.1016\/j.actbio.2018.10.017_b0085","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1054-8807(03)00075-9","article-title":"The evolution of bioprosthetic heart valve design and its impact on durability","volume":"12","author":"Vesely","year":"2003","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.actbio.2018.10.017_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/979351","article-title":"Fine structure of glycosaminoglycans from fresh and decellularized porcine cardiac valves and pericardium","volume":"2012","author":"Cigliano","year":"2012","journal-title":"Biochem. Res. Int."},{"issue":"9","key":"10.1016\/j.actbio.2018.10.017_b0095","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1016\/j.biomaterials.2009.11.088","article-title":"Impact of heart valve decellularization on 3-D ultrastructure, immunogenicity and thrombogenicity","volume":"31","author":"Zhou","year":"2010","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.actbio.2018.10.017_b0100","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.msec.2012.12.062","article-title":"Biomimetic acellular detoxified glutaraldehyde cross-linked bovine pericardium for tissue engineering","volume":"33","author":"Mathapati","year":"2013","journal-title":"Mat. Sci. Eng. C-Mater."},{"issue":"8","key":"10.1016\/j.actbio.2018.10.017_b0105","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.biomaterials.2005.08.003","article-title":"Stability and function of glycosaminoglycans in porcine bioprosthetic heart valves","volume":"27","author":"Lovekamp","year":"2006","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.actbio.2018.10.017_b0110","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s13239-016-0276-8","article-title":"Biomechanical behavior of bioprosthetic heart valve heterograft tissues: characterization, simulation, and performance","volume":"7","author":"Soares","year":"2016","journal-title":"Cardiovasc. Eng. Tech."},{"issue":"5","key":"10.1016\/j.actbio.2018.10.017_b0115","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1177\/0885328213479047","article-title":"Neomycin and pentagalloyl glucose enhanced cross-linking for elastin and glycosaminoglycans preservation in bioprosthetic heart valves","volume":"28","author":"Tripi","year":"2014","journal-title":"J. Biomater. Appl."},{"issue":"1","key":"10.1016\/j.actbio.2018.10.017_b0120","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1016\/j.actbio.2012.09.031","article-title":"On the biomechanical role of glycosaminoglycans in the aortic heart valve leaflet","volume":"9","author":"Eckert","year":"2013","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.actbio.2018.10.017_b0125","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0021-9290(97)00122-X","article-title":"The role of elastin in aortic valve mechanics","volume":"31","author":"Vesely","year":"1998","journal-title":"J. Biomech."},{"issue":"2","key":"10.1016\/j.actbio.2018.10.017_b0130","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0021-9290(00)00187-1","article-title":"The effect of elastin damage on the mechanics of the aortic valve","volume":"34","author":"Lee","year":"2001","journal-title":"J. Biomech."},{"key":"10.1016\/j.actbio.2018.10.017_b0135","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.biomaterials.2015.07.011","article-title":"A novel crosslinking method for improved tear resistance and biocompatibility of tissue based biomaterials","volume":"66","author":"Tam","year":"2015","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.actbio.2018.10.017_b0140","first-page":"490","article-title":"Structural-changes of glutaraldehyde-treated porcine bioprosthetic valves","volume":"106","author":"Camilleri","year":"1982","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"1","key":"10.1016\/j.actbio.2018.10.017_b0145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/rb\/rbu009","article-title":"Crosslinking strategies for preparation of extracellular matrix-derived cardiovascular scaffolds","volume":"1","author":"Ma","year":"2014","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.actbio.2018.10.017_b0150","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.biomaterials.2015.08.045","article-title":"Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels","volume":"73","author":"Yue","year":"2015","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.actbio.2018.10.017_b0155","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.biomaterials.2007.11.007","article-title":"Effects of decellularization on the mechanical and structural properties of the porcine aortic valve leaflet","volume":"29","author":"Liao","year":"2008","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2018.10.017_b0160","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1021\/bm990017d","article-title":"Structural and rheological properties of methacrylamide modified gelatin hydrogels","volume":"1","author":"Van Den Bulcke","year":"2000","journal-title":"Biomacromolecules"},{"issue":"2","key":"10.1016\/j.actbio.2018.10.017_b0165","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.carbpol.2011.09.059","article-title":"Feasibility study of a novel crosslinking reagent (alginate dialdehyde) for biological tissue fixation","volume":"87","author":"Xu","year":"2012","journal-title":"Carbohyd. Polym."},{"issue":"3","key":"10.1016\/j.actbio.2018.10.017_b0170","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-4636(199603)30:3<361::AID-JBM10>3.0.CO;2-N","article-title":"Crosslinking characteristics of porcine tendons: effects of fixation with glutaraldehyde or epoxy","volume":"30","author":"Sung","year":"1996","journal-title":"J. Biomed. Mater. Res."},{"issue":"25","key":"10.1016\/j.actbio.2018.10.017_b0175","doi-asserted-by":"crossref","first-page":"6647","DOI":"10.1016\/j.biomaterials.2010.05.034","article-title":"Carbodiimide cross-linked amniotic membranes for cultivation of limbal epithelial cells","volume":"31","author":"Ma","year":"2010","journal-title":"Biomaterials"},{"issue":"19","key":"10.1016\/j.actbio.2018.10.017_b0180","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1039\/C3TB21832E","article-title":"Synthesis and characterization of protected oligourethanes as crosslinkers of collagen-based scaffolds","volume":"2","author":"Mendoza-Novelo","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2018.10.017_b0185","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.biomaterials.2018.01.054","article-title":"Fucoidan\/VEGF-based surface modification of decellularized pulmonary heart valve improves the antithrombotic and re-endothelialization potential of bioprostheses","volume":"172","author":"Marinval","year":"2018","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.actbio.2018.10.017_b0190","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nbt.2580","article-title":"Zwitterionic hydrogels implanted in mice resist the foreign-body reaction","volume":"31","author":"Zhang","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.actbio.2018.10.017_b0195","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.biomaterials.2017.04.050","article-title":"Structural analysis of photocrosslinkable methacryloyl-modified protein derivatives","volume":"139","author":"Yue","year":"2017","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.actbio.2018.10.017_b0200","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3390\/ma4030543","article-title":"Crosslinked graft copolymer of methacrylic acid and gelatin as a novel hydrogel with ph-responsiveness properties","volume":"4","author":"Sadeghi","year":"2011","journal-title":"Materials"},{"issue":"26","key":"10.1016\/j.actbio.2018.10.017_b0205","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.1016\/S0032-3861(96)00451-X","article-title":"Ultrasonically enhanced persulfate oxidation of polyethylene surfaces","volume":"37","author":"Price","year":"1996","journal-title":"Polymer"},{"issue":"22","key":"10.1016\/j.actbio.2018.10.017_b0210","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/S0142-9612(00)00148-4","article-title":"Acellular vascular tissues: natural biomaterials for tissue repair and tissue engineering","volume":"21","author":"Schmidt","year":"2000","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.actbio.2018.10.017_b0215","doi-asserted-by":"crossref","first-page":"E168","DOI":"10.1111\/j.1525-1594.2009.00978.x","article-title":"Biocompatibility and calcification of bovine pericardium employed for the construction of cardiac bioprostheses treated with different chemical crosslink methods","volume":"34","author":"Jorge-Herrero","year":"2010","journal-title":"Artif. Organs"},{"issue":"1","key":"10.1016\/j.actbio.2018.10.017_b0220","first-page":"71","article-title":"Calcification of subcutaneously implanted type I collagen sponges. Effects of formaldehyde and glutaraldehyde pretreatments","volume":"122","author":"Levy","year":"1986","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.actbio.2018.10.017_b0225","first-page":"122","article-title":"The role of glutaraldehyde-induced cross-links in calcification of bovine pericardium used in cardiac-valve bioprostheses","volume":"127","author":"Golomb","year":"1987","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.actbio.2018.10.017_b0230","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1042\/BA20090101","article-title":"The effects of cross-link density and chemistry on the calcification potential of diamine-extended glutaraldehyde-fixed bioprosthetic heart-valve materials","volume":"54","author":"Bezuidenhout","year":"2009","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"4","key":"10.1016\/j.actbio.2018.10.017_b0235","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jtcvs.2008.12.009","article-title":"Decellularization reduces calcification while improving both durability and 1-year functional results of pulmonary homograft valves in juvenile sheep","volume":"137","author":"Hopkins","year":"2009","journal-title":"J. Thor. a Cardiovasc. Surg."},{"issue":"19","key":"10.1016\/j.actbio.2018.10.017_b0240","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1016\/j.biomaterials.2006.02.014","article-title":"Decellularization of tissues and organs","volume":"27","author":"Gilbert","year":"2006","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.actbio.2018.10.017_b0245","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1016\/j.biomaterials.2011.01.057","article-title":"An overview of tissue and whole organ decellularization processes","volume":"32","author":"Crapo","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2018.10.017_b0250","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ymeth.2015.03.005","article-title":"Methods of tissue decellularization used for preparation of biologic scaffolds and in vivo relevance","volume":"84","author":"Keane","year":"2015","journal-title":"Methods"},{"issue":"3","key":"10.1016\/j.actbio.2018.10.017_b0255","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.actbio.2010.11.017","article-title":"Decellularization of pericardial tissue and its impact on tensile viscoelasticity and glycosaminoglycan content","volume":"7","author":"Mendoza-Novelo","year":"2011","journal-title":"Acta Biomater."},{"issue":"21","key":"10.1016\/j.actbio.2018.10.017_b0260","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1016\/0032-3861(94)90818-4","article-title":"Free-radical aqueous slurry polymerizations of acrylonitrile. 2. End-groups and other minor structures in polyacrylonitriles initiated by potassium persulfate sodium bisulfite","volume":"35","author":"Ebdon","year":"1994","journal-title":"Polymer"},{"issue":"1","key":"10.1016\/j.actbio.2018.10.017_b0265","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.atherosclerosis.2005.11.034","article-title":"Type I and type III collagen synthesis and composition in the valve matrix in aortic valve stenosis","volume":"189","author":"Eriksen","year":"2006","journal-title":"Atherosclerosis"},{"issue":"24","key":"10.1016\/j.actbio.2018.10.017_b0270","doi-asserted-by":"crossref","first-page":"9001","DOI":"10.1073\/pnas.0502718103","article-title":"Microfibrillar structure of type I collagen in situ","volume":"103","author":"Orgel","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.actbio.2018.10.017_b0275","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1749-6632.1996.tb33305.x","article-title":"Biochemistry and molecular regulation of matrix macromolecules in abdominal aortic aneurysms","volume":"800","author":"Ghorpade","year":"1996","journal-title":"Ann. Ny Acad. Sci."},{"issue":"18","key":"10.1016\/j.actbio.2018.10.017_b0280","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1016\/j.biomaterials.2007.02.017","article-title":"Neomycin prevents enzyme-mediated glycosaminoglycan degradation in bioprosthetic heart valves","volume":"28","author":"Raghavan","year":"2007","journal-title":"Biomaterials"},{"issue":"16","key":"10.1016\/j.actbio.2018.10.017_b0285","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1016\/j.biomaterials.2003.10.001","article-title":"Elastin stabilization in cardiovascular implants: improved resistance to enzymatic degradation by treatment with tannic acid","volume":"25","author":"Isenburg","year":"2004","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.actbio.2018.10.017_b0290","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.biomaterials.2007.12.009","article-title":"The effect of glycosaminoglycan stabilization on tissue buckling in bioprosthetic heart valves","volume":"29","author":"Shah","year":"2008","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.actbio.2018.10.017_b0295","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.biomaterials.2004.04.034","article-title":"Tannic acid treatment enhances biostability and reduces calcification of glutaraldehyde fixed aortic wall","volume":"26","author":"Isenburg","year":"2005","journal-title":"Biomaterials"},{"issue":"1\u20132","key":"10.1016\/j.actbio.2018.10.017_b0300","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/03008209809028905","article-title":"Mechanical role of elastin-associated microfibrils in pig aortic elastic tissue","volume":"37","author":"Lillie","year":"1998","journal-title":"Connect Tissue Res."},{"issue":"3","key":"10.1016\/j.actbio.2018.10.017_b0305","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0002-9440(10)65197-8","article-title":"Elastin calcification and its prevention with aluminum chloride pretreatment","volume":"155","author":"Vyavahare","year":"1999","journal-title":"Am. J. Pathol."},{"issue":"19","key":"10.1016\/j.actbio.2018.10.017_b0310","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1016\/j.biomaterials.2006.02.016","article-title":"Structural requirements for stabilization of vascular elastin by polyphenolic tannins","volume":"27","author":"Isenburg","year":"2006","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.actbio.2018.10.017_b0315","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s10856-009-3924-9","article-title":"Crosslinking effect of Nordihydroguaiaretic acid (NDGA) on decellularized heart valve scaffold for tissue engineering","volume":"21","author":"Lu","year":"2010","journal-title":"J. Mater. Sci.-Mater. M"},{"issue":"2","key":"10.1016\/j.actbio.2018.10.017_b0320","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.actbio.2009.07.035","article-title":"Quercetin-crosslinked porcine heart valve matrix: mechanical properties, stability, anticalcification and cytocompatibility","volume":"6","author":"Zhai","year":"2010","journal-title":"Acta Biomater."},{"issue":"19","key":"10.1016\/j.actbio.2018.10.017_b0325","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1016\/j.biomaterials.2006.02.008","article-title":"Crosslinking of decellularized porcine heart valve matrix by procyanidins","volume":"27","author":"Zhai","year":"2006","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.actbio.2018.10.017_b0330","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1021\/acs.biomac.8b00077","article-title":"Optimizing glutaraldehyde-fixed tissue heart valves with chondroitin sulfate hydrogel for endothelialization and shielding against deterioration","volume":"19","author":"Lopez-Moya","year":"2018","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2018.10.017_b0335","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.biomaterials.2017.10.011","article-title":"Heart valve scaffold fabrication: bioinspired control of macro-scale morphology, mechanics and micro-structure","volume":"150","author":"D'Amore","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2018.10.017_b0340","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1042\/BA20030211","article-title":"Bioprosthetic heart valves: the need for a quantum leap","volume":"40","author":"Zilla","year":"2004","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"7","key":"10.1016\/j.actbio.2018.10.017_b0345","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/0002-9149(78)90873-1","article-title":"Structural-changes in glutaraldehyde-treated porcine heterografts used as substitute cardiac valves - transmission and scanning electron-microscopic observations in 12 patients","volume":"41","author":"Ferrans","year":"1978","journal-title":"Am. J. Cardiol."},{"issue":"4","key":"10.1016\/j.actbio.2018.10.017_b0350","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.biomaterials.2007.09.033","article-title":"Prosthetic heart valves: catering for the few","volume":"29","author":"Zilla","year":"2008","journal-title":"Biomaterials"},{"issue":"16","key":"10.1016\/j.actbio.2018.10.017_b0355","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1016\/S0142-9612(02)00054-6","article-title":"Gelatinases in soft tissue biomaterials. Analysis of different crosslinking agents","volume":"23","author":"Calero","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2018.10.017_b0360","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.matsci.31.1.81","article-title":"Biological responses to materials","volume":"31","author":"Anderson","year":"2001","journal-title":"Ann. Rev. Mater. Res."},{"issue":"6","key":"10.1016\/j.actbio.2018.10.017_b0365","doi-asserted-by":"crossref","DOI":"10.1038\/nbt0616-666e","article-title":"Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates (vol 34, pg 345, 2016)","volume":"34","author":"Vegas","year":"2016","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.actbio.2018.10.017_b0370","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"Anderson","year":"2008","journal-title":"Semin. Immunol."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706118306160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706118306160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:09:19Z","timestamp":1761671359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706118306160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":74,"alternative-id":["S1742706118306160"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2018.10.017","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radical polymerization-crosslinking method for improving extracellular matrix stability in bioprosthetic heart valves with reduced potential for calcification and inflammatory response","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2018.10.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}