{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:55:09Z","timestamp":1791590109133,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T00:00:00Z","timestamp":1593820800000},"content-version":"am","delay-in-days":369,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"United States Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health"},{"name":"Northeastern University"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.actbio.2018.12.004","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T13:44:39Z","timestamp":1544103879000},"page":"258-269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":123,"special_numbering":"C","title":["Cartilage penetrating cationic peptide carriers for applications in drug delivery to avascular negatively charged tissues"],"prefix":"10.1016","volume":"93","author":[{"given":"Armin","family":"Vedadghavami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica K.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikhar","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenzhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4750-7207","authenticated-orcid":false,"given":"Ambika G.","family":"Bajpayee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.actbio.2018.12.004_b0005","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrd1693","article-title":"Osteoarthritis\u2014an untreatable disease?","volume":"4","author":"Wieland","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.actbio.2018.12.004_b0010","doi-asserted-by":"crossref","first-page":"528","DOI":"10.2174\/138945010791011893","article-title":"Disease modifying osteoarthritis drugs: facing development challenges and choosing molecular targets","volume":"11","author":"Hellio Le Graverand-Gastineau","year":"2010","journal-title":"Curr. Drug Targets"},{"issue":"1","key":"10.1016\/j.actbio.2018.12.004_b0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrrheum.2010.178","article-title":"Pharmacologic therapy for osteoarthritis\u2014the era of disease modification","volume":"7","author":"Hunter","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"11","key":"10.1016\/j.actbio.2018.12.004_b0020","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.joca.2009.04.009","article-title":"Graverand-Gastineau, OA clinical trials: current targets and trials for OA. Choosing molecular targets: what have we learned and where we are headed?","volume":"17","author":"Hellio Le","year":"2009","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.actbio.2018.12.004_b0025","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrrheum.2016.210","article-title":"Cartilage-targeting drug delivery: can electrostatic interactions help?","volume":"13","author":"Bajpayee","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2018.12.004_b0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrrheum.2013.159","article-title":"Progress in intra-articular therapy","volume":"10","author":"Evans","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"issue":"11","key":"10.1016\/j.actbio.2018.12.004_b0035","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1002\/jps.21346","article-title":"Intra-articular depot formulation principles: Role in the management of postoperative pain and arthritic disorders","volume":"97","author":"Larsen","year":"2008","journal-title":"J. Pharm. Sci."},{"issue":"Pt 2","key":"10.1016\/j.actbio.2018.12.004_b0040","first-page":"335","article-title":"Transport of solutes through cartilage: permeability to large molecules","volume":"122","author":"Maroudas","year":"1976","journal-title":"J. Anat."},{"issue":"3","key":"10.1016\/j.actbio.2018.12.004_b0045","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/0304-4165(76)90204-X","article-title":"The distribution of serum albumin in human normal and degenerate articular cartilage","volume":"428","author":"McK Snowden","year":"1976","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"issue":"1","key":"10.1016\/j.actbio.2018.12.004_b0050","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.abb.2012.12.020","article-title":"Transport of anti-IL-6 antigen binding fragments into cartilage and the effects of injury","volume":"532","author":"Byun","year":"2013","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.actbio.2018.12.004_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2018.07.006","article-title":"How can 50\u202fyears of solute transport data in articular cartilage inform the design of arthritis therapeutics?","author":"DiDomenico","year":"2018","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.actbio.2018.12.004_b0060","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1053\/joca.1998.0161","article-title":"The extracellular matrix, interstitial fluid and ions as a mechanical signal transducer in articular cartilage","volume":"7","author":"Mow","year":"1999","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2018.12.004_b0065","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/260808a0","article-title":"Balance between swelling pressure and collagen tension in normal and degenerate cartilage","volume":"260","author":"Maroudas","year":"1976","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.actbio.2018.12.004_b0070","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/jor.1100030410","article-title":"Influence of cartilage conformation on its equilibrium water partition","volume":"3","author":"Torzilli","year":"1985","journal-title":"J. Orth. Res."},{"issue":"3","key":"10.1016\/j.actbio.2018.12.004_b0075","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/art.24096","article-title":"Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study","volume":"61","author":"Chevalier","year":"2009","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"4","key":"10.1016\/j.actbio.2018.12.004_b0080","doi-asserted-by":"crossref","first-page":"R125","DOI":"10.1186\/ar3430","article-title":"A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee","volume":"13","author":"Cohen","year":"2011","journal-title":"Arthritis Res. Ther."},{"issue":"11","key":"10.1016\/j.actbio.2018.12.004_b0085","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2106\/JBJS.N.00918","article-title":"An intra-articular, extended-release formulation of triamcinolone acetonide prolongs and amplifies analgesic effect in patients with osteoarthritis of the knee: a randomized clinical trial","volume":"97","author":"Bodick","year":"2015","journal-title":"JBJS"},{"issue":"9","key":"10.1016\/j.actbio.2018.12.004_b0090","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.biomaterials.2008.12.017","article-title":"Dexamethasone-containing PLGA superparamagnetic microparticles as carriers for the local treatment of arthritis","volume":"30","author":"Butoescu","year":"2009","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.actbio.2018.12.004_b0095","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.joca.2012.11.011","article-title":"Pharmaceutical nanocarrier association with chondrocytes and cartilage explants: influence of surface modification and extracellular matrix depletion","volume":"21","author":"Elsaid","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2018.12.004_b0100","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.actbio.2016.05.005","article-title":"Thermoresponsive nanospheres with independent dual drug release profiles for the treatment of osteoarthritis","volume":"39","author":"Kang","year":"2016","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.actbio.2018.12.004_b0105","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijpharm.2012.11.031","article-title":"Intra-articular delivery of liposomal celecoxib\u2013hyaluronate combination for the treatment of osteoarthritis in rabbit model","volume":"441","author":"Dong","year":"2013","journal-title":"Int. J. Pharm."},{"issue":"9","key":"10.1016\/j.actbio.2018.12.004_b0110","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.2217\/nnm-2017-0377","article-title":"Hyaluronic acid-conjugated pH-sensitive liposomes for targeted delivery of prednisolone on rheumatoid arthritis therapy","volume":"13","author":"Gouveia","year":"2018","journal-title":"Nanomedicine"},{"issue":"11","key":"10.1016\/j.actbio.2018.12.004_b0115","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1002\/art.22952","article-title":"Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: Sustained release of a local antiinflammatory therapeutic","volume":"56","author":"Shamji","year":"2007","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.actbio.2018.12.004_b0120","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/jbm.a.33020","article-title":"On-demand drug delivery from self-assembled nanofibrous gels: a new approach for treatment of proteolytic disease","volume":"97A","author":"Vemula","year":"2011","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"2","key":"10.1016\/j.actbio.2018.12.004_b0125","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.actbio.2010.09.030","article-title":"Injectable hyaluronic acid\u2013tyramine hydrogels for the treatment of rheumatoid arthritis","volume":"7","author":"Kim","year":"2011","journal-title":"Acta Biomater."},{"issue":"6","key":"10.1016\/j.actbio.2018.12.004_b0130","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/gt.2012.81","article-title":"scAAV-mediated gene transfer of interleukin 1-receptor antagonist to synovium and articular cartilage in large mammalian joints","volume":"20","author":"Watson","year":"2013","journal-title":"Gene Ther."},{"issue":"1","key":"10.1016\/j.actbio.2018.12.004_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joca.2015.08.012","article-title":"Drug delivery to chondrocytes","volume":"24","author":"Evans","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.actbio.2018.12.004_b0140","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.biomaterials.2013.09.091","article-title":"Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis","volume":"35","author":"Bajpayee","year":"2014","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2018.12.004_b0145","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.joca.2015.07.010","article-title":"Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term","volume":"24","author":"Bajpayee","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"8","key":"10.1016\/j.actbio.2018.12.004_b0150","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/jor.22630","article-title":"Electrostatic interactions enable rapid penetration, enhanced uptake and retention of intra-articular injected avidin in rat knee joints","volume":"32","author":"Bajpayee","year":"2014","journal-title":"J. Orthop. Res."},{"issue":"5","key":"10.1016\/j.actbio.2018.12.004_b0155","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/jor.22841","article-title":"A rabbit model demonstrates the influence of cartilage thickness on intra-articular drug delivery and retention within cartilage","volume":"33","author":"Bajpayee","year":"2015","journal-title":"J. Orth. Res."},{"key":"10.1016\/j.actbio.2018.12.004_b0160","doi-asserted-by":"crossref","first-page":"341","DOI":"10.22203\/eCM.v034a21","article-title":"Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis","volume":"34","author":"Bajpayee","year":"2017","journal-title":"Eur. Cell Mater."},{"issue":"6","key":"10.1016\/j.actbio.2018.12.004_b0165","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.bbamem.2013.02.010","article-title":"Different roles of cell surface and exogenous glycosaminoglycans in controlling gene delivery by arginine-rich peptides with varied distribution of arginines","volume":"1828","author":"Naik","year":"2013","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"issue":"4","key":"10.1016\/j.actbio.2018.12.004_b0170","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.bbamem.2015.01.012","article-title":"Exogenous chondroitin sulfate glycosaminoglycan associate with arginine-rich peptide\u2013DNA complexes to alter their intracellular processing and gene delivery efficiency","volume":"1848","author":"Naik","year":"2015","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"issue":"4","key":"10.1016\/j.actbio.2018.12.004_b0175","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/03008208209160269","article-title":"A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures","volume":"9","author":"Farndale","year":"1982","journal-title":"Connect. Tissue Res."},{"issue":"7","key":"10.1016\/j.actbio.2018.12.004_b0180","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"issue":"12","key":"10.1016\/j.actbio.2018.12.004_b0185","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1002\/art.27709","article-title":"Intra-articular injection of HB-IGF-1 sustains delivery of IGF-1 to cartilage through binding to chondroitin sulfate","volume":"62","author":"Miller","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.actbio.2018.12.004_b0190","series-title":"The Mathematics of Diffusion","author":"Crank","year":"1975"},{"issue":"4","key":"10.1016\/j.actbio.2018.12.004_b0195","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF02477854","article-title":"The Donnan equilibrium","volume":"14","author":"Bartlett","year":"1952","journal-title":"Bull. Math. Biophys."},{"issue":"1","key":"10.1016\/j.actbio.2018.12.004_b0200","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1021\/cr60001a003","article-title":"The theory of membrane equilibria","volume":"1","author":"Donnan","year":"1924","journal-title":"Chem. Rev."},{"key":"10.1016\/j.actbio.2018.12.004_b0205","series-title":"Fields, Forces, and Flows in Biological Systems","author":"Grodzinsky","year":"2011"},{"issue":"5","key":"10.1016\/j.actbio.2018.12.004_b0210","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0006-3495(68)86509-9","article-title":"Physicochemical properties of cartilage in the light of ion exchange theory","volume":"8","author":"Maroudas","year":"1968","journal-title":"Biophys. J."},{"issue":"35","key":"10.1016\/j.actbio.2018.12.004_b0215","doi-asserted-by":"crossref","first-page":"9287","DOI":"10.1021\/acs.jpcb.6b05604","article-title":"Polyarginine interacts more strongly and cooperatively than polylysine with phospholipid bilayers","volume":"120","author":"Robison","year":"2016","journal-title":"J. Phys. Chem. B"},{"issue":"11","key":"10.1016\/j.actbio.2018.12.004_b0220","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1016\/j.bbamem.2012.06.006","article-title":"Cell surface binding and uptake of arginine- and lysine-rich penetratin peptides in absence and presence of proteoglycans","volume":"1818","author":"\u00c5mand","year":"2012","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"issue":"2","key":"10.1016\/j.actbio.2018.12.004_b0225","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.joca.2002.12.001","article-title":"The cellular responses of articular cartilage to sharp and blunt trauma1","volume":"12","author":"Redman","year":"2004","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2018.12.004_b0230","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.biomaterials.2018.08.050","article-title":"Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues","volume":"183","author":"Krishnan","year":"2018","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.actbio.2018.12.004_b0235","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.bbamem.2017.06.002","article-title":"Probing the disparate effects of arginine and lysine residues on antimicrobial peptide\/bilayer association","volume":"1859","author":"Rice","year":"2017","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"issue":"11","key":"10.1016\/j.actbio.2018.12.004_b0240","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1016\/j.bbamem.2012.06.006","article-title":"Cell surface binding and uptake of arginine-and lysine-rich penetratin peptides in absence and presence of proteoglycans","volume":"1818","author":"\u00c5mand","year":"2012","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"issue":"6","key":"10.1016\/j.actbio.2018.12.004_b0245","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.bpj.2013.07.050","article-title":"Spatial configuration and composition of charge modulates transport into a mucin hydrogel barrier","volume":"105","author":"Li","year":"2013","journal-title":"Biophys. J."},{"key":"10.1016\/j.actbio.2018.12.004_b0250","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.actbio.2017.09.023","article-title":"Discerning the composition of penetratin for safe penetration from cornea to retina","volume":"63","author":"Jiang","year":"2017","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.actbio.2018.12.004_b0255","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1021\/acs.molpharmaceut.5b00871","article-title":"Charge type, charge spacing, and hydrophobicity of arginine-rich cell-penetrating peptides dictate gene transfection","volume":"13","author":"Alhakamy","year":"2016","journal-title":"Mol. Pharmcol."},{"issue":"31","key":"10.1016\/j.actbio.2018.12.004_b0260","doi-asserted-by":"crossref","first-page":"9506","DOI":"10.1021\/ja0482536","article-title":"Role of membrane potential and hydrogen bonding in the mechanism of translocation of guanidinium-rich peptides into cells","volume":"126","author":"Rothbard","year":"2004","journal-title":"J. Am. Chem. Soc."},{"issue":"6","key":"10.1016\/j.actbio.2018.12.004_b0265","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1021\/acs.accounts.8b00098","article-title":"Arginine \u201cmagic\u201d: guanidinium like-charge ion pairing from aqueous salts to cell penetrating peptides","volume":"51","author":"Vazdar","year":"2018","journal-title":"Acc. Chem. Res."},{"issue":"9","key":"10.1016\/j.actbio.2018.12.004_b0270","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1021\/bi035933x","article-title":"Pathway for polyarginine entry into mammalian cells","volume":"43","author":"Fuchs","year":"2004","journal-title":"Biochemistry"},{"issue":"43","key":"10.1016\/j.actbio.2018.12.004_b0275","doi-asserted-by":"crossref","first-page":"11428","DOI":"10.1073\/pnas.1712078114","article-title":"Self-association of a highly charged arginine-rich cell-penetrating peptide","volume":"114","author":"Tesei","year":"2017","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.actbio.2018.12.004_b0280","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1080\/10717544.2016.1269849","article-title":"Surface density of polyarginine influence the size, zeta potential, cellular uptake and tissue distribution of the nanostructured lipid carrier","volume":"24","author":"Sun","year":"2017","journal-title":"Drug Deliv."},{"issue":"8","key":"10.1016\/j.actbio.2018.12.004_b0285","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1074\/jbc.M007540200","article-title":"Arginine-rich peptides: an abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery","volume":"276","author":"Futaki","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.actbio.2018.12.004_b0290","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/psc.2665","article-title":"Synthesis, characterization, and biological activity of poly (arginine)-derived cancer-targeting peptides in HepG2 liver cancer cells","volume":"20","author":"Joseph","year":"2014","journal-title":"J. Pept. Sci."},{"issue":"5","key":"10.1016\/j.actbio.2018.12.004_b0295","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1034\/j.1399-3011.2000.00723.x","article-title":"Polyarginine enters cells more efficiently than other polycationic homopolymers","volume":"56","author":"Mitchell","year":"2000","journal-title":"J. Pept. Res."},{"key":"10.1016\/j.actbio.2018.12.004_b0300","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jbiomech.2018.06.012","article-title":"Multi-scale imaging techniques to investigate solute transport across articular cartilage","volume":"78","author":"Pouran","year":"2018","journal-title":"J. Biomech."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706118307293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706118307293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:19:10Z","timestamp":1761671950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706118307293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":60,"alternative-id":["S1742706118307293"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2018.12.004","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cartilage penetrating cationic peptide carriers for applications in drug delivery to avascular negatively charged tissues","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2018.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}