{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:08:46Z","timestamp":1790748526102,"version":"4.1.0"},"reference-count":122,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health","doi-asserted-by":"crossref","award":["R01 AR062920"],"award-info":[{"award-number":["R01 AR062920"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.actbio.2019.01.015","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T21:29:15Z","timestamp":1547501355000},"page":"2-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":126,"special_numbering":"C","title":["Implantable antimicrobial biomaterials for local drug delivery in bone infection models"],"prefix":"10.1016","volume":"93","author":[{"given":"Jeremy D.","family":"Caplin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s J.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2019.01.015_b0005","article-title":"Understanding the market for implantable medical devices","volume":"129","author":"Lind","year":"2018","journal-title":"AARP Insight on the Issues"},{"key":"10.1016\/j.actbio.2019.01.015_b0010","series-title":"Biomaterials associated infection: Immunological aspects and antimicrobial strategies","author":"Moriarty","year":"2013"},{"issue":"5","key":"10.1016\/j.actbio.2019.01.015_b0015","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.copbio.2011.02.005","article-title":"Infection and tissue engineering in segmental bone defects\u2013a mini review","volume":"22","author":"Nair","year":"2011","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.actbio.2019.01.015_b0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1590\/S1984-82502013000100003","article-title":"Osteomyelitis: an overview of antimicrobial therapy","volume":"49","author":"Gomes","year":"2013","journal-title":"Braz. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.actbio.2019.01.015_b0025","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.15.2.167-193.2002","article-title":"Biofilms: survival mechanisms of clinically relevant microorganisms","volume":"15","author":"Donlan","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ijos.2014.65","article-title":"Strategies for combating bacterial biofilm infections","volume":"7","author":"Wu","year":"2014","journal-title":"Int. J. Oral Sci."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0035","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1302\/0301-620X.94B1.27026","article-title":"Early antibiotics and debridement independently reduce infection in an open fracture model","volume":"94","author":"Penn-Barwell","year":"2012","journal-title":"J. Bone Joint Surg. Br."},{"key":"10.1016\/j.actbio.2019.01.015_b0040","doi-asserted-by":"crossref","first-page":"20","DOI":"10.7150\/jbji.14075","article-title":"The effectiveness of debridement, antibiotics and irrigation for periprosthetic joint infections after primary hip and knee arthroplasty. A 15 years retrospective study in two community hospitals in the Netherlands","volume":"1","author":"de Vries","year":"2016","journal-title":"J. Bone Joint Infect"},{"issue":"3","key":"10.1016\/j.actbio.2019.01.015_b0045","first-page":"530","article-title":"Debridement, antibiotics and implant retention in early periprosthetic joint infection after primary total hip arthroplasty: 88 percent survival after two years follow-up","volume":"82","author":"Weenders","year":"2016","journal-title":"Acta Orthop. Belg."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0050","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s11999-012-2480-7","article-title":"High infection control rate and function after routine one-stage exchange for chronically infected TKA","volume":"471","author":"Jenny","year":"2013","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0055","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11999-015-4408-5","article-title":"Can good infection control be obtained in one-stage exchange of the infected TKA to a rotating hinge design? 10-year results","volume":"474","author":"Zahar","year":"2016","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"9","key":"10.1016\/j.actbio.2019.01.015_b0060","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1086\/522184","article-title":"Culture-negative prosthetic joint infection","volume":"45","author":"Berbari","year":"2007","journal-title":"Clin. Infect. Dis."},{"issue":"11","key":"10.1016\/j.actbio.2019.01.015_b0065","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1302\/0301-620X.93B11.27319","article-title":"The long-term results of a two-stage protocol for revision of an infected total knee replacement","volume":"93","author":"Macheras","year":"2011","journal-title":"J. Bone Joint Surg. Br."},{"issue":"5","key":"10.1016\/j.actbio.2019.01.015_b0070","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1248\/yakushi.126.327","article-title":"Molecular mechanisms underlying renal accumulation of aminoglycoside antibiotics and mechanism-based approach for developing nonnephrotoxic aminoglycoside therapy","volume":"126","author":"Nagai","year":"2006","journal-title":"Yakugaku Zasshi"},{"issue":"2","key":"10.1016\/j.actbio.2019.01.015_b0075","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/bph.12139","article-title":"Minocycline: far beyond an antibiotic","volume":"169","author":"Garrido-Mesa","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.actbio.2019.01.015_b0080","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.amjmed.2010.07.025","article-title":"Increasing vancomycin serum trough concentrations and incidence of nephrotoxicity","volume":"123","author":"Pritchard","year":"2010","journal-title":"Am. J. Med."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0085","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1752-4571.2008.00066.x","article-title":"Evolutionary biology and the avoidance of antimicrobial resistance","volume":"2","author":"Read","year":"2009","journal-title":"Evol. Appl."},{"key":"10.1016\/j.actbio.2019.01.015_b0090","doi-asserted-by":"crossref","DOI":"10.1186\/s13756-018-0384-3","article-title":"Enumerating the economic cost of antimicrobial resistance per antibiotic consumed to inform the evaluation of interventions affecting their use","volume":"7","author":"Shrestha","year":"2018","journal-title":"Antimicrob. Resist. Infect. Control"},{"issue":"7","key":"10.1016\/j.actbio.2019.01.015_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160187","article-title":"Local intramedullary delivery of vancomycin can prevent the development of long bone staphylococcus aureus infection","volume":"11","author":"Loc-Carrillo","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.actbio.2019.01.015_b0100","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0891-5520(20)30352-4","article-title":"Animal models of osteomyelitis. Knowledge, hypothesis, and speculation","volume":"4","author":"Rissing","year":"1990","journal-title":"Infect. Dis. Clin. North Am."},{"issue":"2","key":"10.1016\/j.actbio.2019.01.015_b0105","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1055\/s-0029-1214167","article-title":"Animal models for the study of osteomyelitis","volume":"23","author":"Patel","year":"2009","journal-title":"Semin. Plast. Surg."},{"issue":"5","key":"10.1016\/j.actbio.2019.01.015_b0110","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/infdis\/122.5.410","article-title":"Experimental osteomyelitis. I. A description of the model","volume":"122","author":"Norden","year":"1970","journal-title":"J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.actbio.2019.01.015_b0115","first-page":"95","article-title":"Bone defect animal models for testing efficacy of bone substitute biomaterials","volume":"3","author":"Li","year":"2015","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.actbio.2019.01.015_b0120","first-page":"118","article-title":"Use of animal models in musculoskeletal research","volume":"18","author":"Neyt","year":"1998","journal-title":"Iowa Orthop. J."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0125","first-page":"1","article-title":"An interspecies comparison of bone fracture properties","volume":"8","author":"Wang","year":"1998","journal-title":"Bio-Med. Mater. Eng."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0130","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4103\/1735-3327.92960","article-title":"Rabbit as an animal model for experimental research","volume":"9","author":"Mapara","year":"2012","journal-title":"Dent. Res. J."},{"key":"10.1016\/j.actbio.2019.01.015_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.22203\/eCM.v013a01","article-title":"Animal models for implant biomaterial research in bone: a review","volume":"13","author":"Pearce","year":"2007","journal-title":"Eur. Cells Mater."},{"issue":"6","key":"10.1016\/j.actbio.2019.01.015_b0140","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s11999-009-1144-8","article-title":"Is sclerotherapy better than intralesional excision for treating aneurysmal bone cysts?","volume":"468","author":"Varshney","year":"2010","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0145","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/jor.20960","article-title":"An animal model for open femur fracture and osteomyelitis: Part I","volume":"28","author":"Lindsey","year":"2010","journal-title":"J. Orthop. Res."},{"issue":"7","key":"10.1016\/j.actbio.2019.01.015_b0150","first-page":"12418","article-title":"Mouse fracture models: a primer","volume":"9","author":"Qi","year":"2016","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"9","key":"10.1016\/j.actbio.2019.01.015_b0155","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1177\/0022034510393967","article-title":"Infection, inflammation, and bone regeneration: a paradoxical relationship","volume":"90","author":"Thomas","year":"2011","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0160","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40001-018-0307-z","article-title":"Whole bone testing in small animals: systematic characterization of the mechanical properties of different rodent bones available for rat fracture models","volume":"23","author":"Prodinger","year":"2018","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.actbio.2019.01.015_b0165","doi-asserted-by":"crossref","first-page":"358","DOI":"10.22203\/eCM.v024a26","article-title":"In vivo tracking of segmental bone defect healing reveals that callus patterning is related to early mechanical stimuli","volume":"24","author":"Mehta","year":"2012","journal-title":"Eur. Cells Mater."},{"issue":"4","key":"10.1016\/j.actbio.2019.01.015_b0170","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.orthres.2005.01.009","article-title":"Characterization of a chronic infection in an internally-stabilized segmental defect in the rat femur","volume":"23","author":"Chen","year":"2005","journal-title":"J. Orthop. Res."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0175","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/jamaoto.2013.5669","article-title":"Defining the critical-sized defect in a rat segmental mandibulectomy model","volume":"140","author":"DeConde","year":"2014","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.actbio.2019.01.015_b0180","first-page":"51558","article-title":"Adjustable stiffness, external fixator for the rat femur osteotomy and segmental bone defect models","volume":"92","author":"Glatt","year":"2014","journal-title":"J. Visualized Exp."},{"issue":"2","key":"10.1016\/j.actbio.2019.01.015_b0185","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jss.2013.02.041","article-title":"A murine femoral segmental defect model for bone tissue engineering using a novel rigid internal fixation system","volume":"183","author":"Liu","year":"2013","journal-title":"J. Surg. Res."},{"issue":"29","key":"10.1016\/j.actbio.2019.01.015_b0190","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1016\/j.biomaterials.2008.06.014","article-title":"The effect of platelet-rich plasma on healing in critical-size long-bone defects","volume":"29","author":"Kasten","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.01.015_b0195","unstructured":"Types of Antibiotics and Synthetic Antimicrobial Agents, Hugo and Russell's Pharmaceutical Microbiology."},{"issue":"7","key":"10.1016\/j.actbio.2019.01.015_b0200","doi-asserted-by":"crossref","first-page":"366","DOI":"10.11622\/smedj.2015105","article-title":"Alexander Fleming (1881\u20131955): discoverer of penicillin","volume":"56","author":"Tan","year":"2015","journal-title":"Singapore Med. J."},{"issue":"11","key":"10.1016\/j.actbio.2019.01.015_b0205","first-page":"511","article-title":"[Depot effects of various antibiotics mixed with Palacos resins]","volume":"41","author":"Buchholz","year":"1970","journal-title":"Chirurg"},{"issue":"14","key":"10.1016\/j.actbio.2019.01.015_b0210","first-page":"934","article-title":"Gentamicin-PMMA-beads in treating bone and soft tissue infections (author's transl)","volume":"104","author":"Klemm","year":"1979","journal-title":"Zentralbl Chir"},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0215","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/phar.1868","article-title":"Past, present, and future of antibacterial economics: increasing bacterial resistance, limited antibiotic pipeline, and societal implications","volume":"37","author":"Luepke","year":"2017","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.actbio.2019.01.015_b0220","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2017.00273","article-title":"Giving drugs a second chance: overcoming regulatory and financial hurdles in repurposing approved drugs as cancer therapeutics","volume":"7","author":"Hernandez","year":"2017","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0225","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s40268-015-0083-y","article-title":"Auranofin: repurposing an old drug for a golden new age","volume":"15","author":"Roder","year":"2015","journal-title":"Drugs R D"},{"key":"10.1016\/j.actbio.2019.01.015_b0230","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2015.00750","article-title":"Repurposing celecoxib as a topical antimicrobial agent","volume":"6","author":"Thangamani","year":"2015","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.actbio.2019.01.015_b0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124595","article-title":"Repurposing salicylanilide anthelmintic drugs to combat drug resistant staphylococcus aureus","volume":"10","author":"Rajamuthiah","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2019.01.015_b0240","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/ja.2017.30","article-title":"The antibiotic resistance crisis, with a focus on the United States","volume":"70","author":"Martens","year":"2017","journal-title":"J. Antibiot."},{"issue":"4","key":"10.1016\/j.actbio.2019.01.015_b0245","first-page":"277","article-title":"The antibiotic resistance crisis: Part 1: Causes and threats","volume":"40","author":"Ventola","year":"2015","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.actbio.2019.01.015_b0250","unstructured":"D. Moore, Antibiotic classification and mechanism, 2013. https:\/\/www.orthobullets.com\/basic-science\/9059\/antibiotic-classification-and-mechanism. (Accessed December 21st, 2018."},{"key":"10.1016\/j.actbio.2019.01.015_b0255","first-page":"25","article-title":"Antibiotics and bacterial resistance in the 21st century","volume":"6","author":"Fair","year":"2014","journal-title":"Perspect. Med. Chem."},{"issue":"8","key":"10.1016\/j.actbio.2019.01.015_b0260","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3390\/ph6081055","article-title":"Characterization of antimicrobial peptides toward the development of novel antibiotics","volume":"6","author":"Aoki","year":"2013","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"issue":"12","key":"10.1016\/j.actbio.2019.01.015_b0265","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.3390\/ph6121543","article-title":"Antimicrobial peptides","volume":"6","author":"Bahar","year":"2013","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"issue":"10","key":"10.1016\/j.actbio.2019.01.015_b0270","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1021\/cb1001558","article-title":"Describing the mechanism of antimicrobial peptide action with the interfacial activity model","volume":"5","author":"Wimley","year":"2010","journal-title":"ACS Chem. Biol."},{"issue":"7","key":"10.1016\/j.actbio.2019.01.015_b0275","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/02713680590968637","article-title":"A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs","volume":"30","author":"Gordon","year":"2005","journal-title":"Curr. Eye Res."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0280","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10989-014-9430-z","article-title":"Cationic antimicrobial peptides cytotoxicity on mammalian cells: an analysis using therapeutic index integrative concept","volume":"21","author":"Bacalum","year":"2015","journal-title":"Int. J. Pept. Res. Ther."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0285","doi-asserted-by":"crossref","DOI":"10.3390\/biom8010004","article-title":"Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo","volume":"8","author":"Kumar","year":"2018","journal-title":"Biomolecules"},{"issue":"21","key":"10.1016\/j.actbio.2019.01.015_b0290","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1046\/j.1432-1033.2001.02494.x","article-title":"Amphipathic alpha helical antimicrobial peptides","volume":"268","author":"Giangaspero","year":"2001","journal-title":"Eur. J. Biochem."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0295","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/ph11010020","article-title":"Antimicrobial peptides for topical treatment of osteomyelitis and implant-related infections: study in the spongy bone","volume":"11","author":"Melicher\u010d\u00edk","year":"2018","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.actbio.2019.01.015_b0300","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/867381","article-title":"Antimicrobial peptides: their role as infection-selective tracers for molecular imaging","volume":"2014","author":"Ebenhan","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"6","key":"10.1016\/j.actbio.2019.01.015_b0305","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/j.1469-7580.2008.00992.x","article-title":"The role of human \u03b2-defensin-2 in bone","volume":"213","author":"Varoga","year":"2008","journal-title":"J. Anat."},{"issue":"2","key":"10.1016\/j.actbio.2019.01.015_b0310","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/path.1974","article-title":"Expression and regulation of human \u03b2-defensin-2 in osteoarthritic cartilage","volume":"209","author":"Varoga","year":"2006","journal-title":"J. Pathol."},{"issue":"11","key":"10.1016\/j.actbio.2019.01.015_b0315","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1002\/art.20605","article-title":"Production of endogenous antibiotics in articular cartilage","volume":"50","author":"Varoga","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0320","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.chembiol.2008.11.006","article-title":"Screening and characterization of surface-tethered cationic peptides for antimicrobial activity","volume":"16","author":"Hilpert","year":"2009","journal-title":"Chem. Biol."},{"issue":"18","key":"10.1016\/j.actbio.2019.01.015_b0325","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1039\/C8PY00012C","article-title":"Biomimetic antimicrobial polymers: recent advances in molecular design","volume":"9","author":"Ergene","year":"2018","journal-title":"Polym. Chem."},{"key":"10.1016\/j.actbio.2019.01.015_b0330","article-title":"Antimicrobial materials, coatings and biomimetic surfaces with modified microtography to control microbial fouling of product contact surfaces within food processing equipment: legislation, requirements, effectiveness and challenges","author":"Moerman","year":"2014","journal-title":"J. Hyg. Eng. Des."},{"key":"10.1016\/j.actbio.2019.01.015_b0335","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.actbio.2014.12.015","article-title":"Development of a catheter functionalized by a polydopamine peptide coating with antimicrobial and antibiofilm properties","volume":"15","author":"Lim","year":"2015","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0340","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/biot.201200313","article-title":"Antimicrobial enzymes: an emerging strategy to fight microbes and microbial biofilms","volume":"8","author":"Thallinger","year":"2013","journal-title":"Biotechnol. J."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0345","first-page":"1","article-title":"Novel alternatives to antibiotics: bacteriophages, bacterial cell wall hydrolases, and antimicrobial peptides","volume":"104","author":"Parisien","year":"2008","journal-title":"J. Appl. Microbiol."},{"issue":"4","key":"10.1016\/j.actbio.2019.01.015_b0350","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3390\/ph3041139","article-title":"Lysostaphin: a staphylococcal bacteriolysin with potential clinical applications","volume":"3","author":"Bastos","year":"2010","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"key":"10.1016\/j.actbio.2019.01.015_b0355","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1801013115","article-title":"Hydrogel delivery of lysostaphin eliminates orthopedic implant infection by Staphylococcus aureus and supports fracture healing","author":"Johnson","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0360","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1743-422X-9-9","article-title":"Bacteriophages and their implications on future biotechnology: a review","volume":"9","author":"Haq","year":"2012","journal-title":"Virol. J."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0365","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4161\/bbug.1.1.9818","article-title":"Recombinant bacteriophage lysins as antibacterials","volume":"1","author":"Fenton","year":"2010","journal-title":"Bioeng. Bugs"},{"issue":"7","key":"10.1016\/j.actbio.2019.01.015_b0370","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1073\/pnas.061038398","article-title":"Prevention and elimination of upper respiratory colonization of mice by group A streptococci by using a bacteriophage lytic enzyme","volume":"98","author":"Nelson","year":"2001","journal-title":"PNAS"},{"issue":"6900","key":"10.1016\/j.actbio.2019.01.015_b0375","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/nature01026","article-title":"A bacteriolytic agent that detects and kills Bacillus anthracis","volume":"418","author":"Schuch","year":"2002","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0380","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1128\/AAC.47.1.375-377.2003","article-title":"Synergistic lethal effect of a combination of phage lytic enzymes with different activities on penicillin-sensitive and -resistant Streptococcus pneumoniae strains","volume":"47","author":"Loeffler","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"issue":"11","key":"10.1016\/j.actbio.2019.01.015_b0385","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1128\/IAI.71.11.6199-6204.2003","article-title":"Phage lytic enzyme Cpl-1 as a novel antimicrobial for pneumococcal bacteremia","volume":"71","author":"Loeffler","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.actbio.2019.01.015_b0390","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1089\/mdr.2012.0025","article-title":"Novel chimerical endolysins with broad antimicrobial activity against methicillin-resistant Staphylococcus aureus","volume":"18","author":"Fernandes","year":"2012","journal-title":"Microbial Drug Resistance (Larchmont, N.Y.)"},{"key":"10.1016\/j.actbio.2019.01.015_b0395","doi-asserted-by":"crossref","first-page":"25063","DOI":"10.1038\/srep25063","article-title":"Triple-acting lytic enzyme treatment of drug-resistant and intracellular Staphylococcus aureus","volume":"6","author":"Becker","year":"2016","journal-title":"Sci. Rep."},{"issue":"25","key":"10.1016\/j.actbio.2019.01.015_b0400","doi-asserted-by":"crossref","first-page":"6363","DOI":"10.1016\/j.biomaterials.2010.05.005","article-title":"Antibiotic-loaded biomaterials and the risks for the spread of antibiotic resistance following their prophylactic and therapeutic clinical use","volume":"31","author":"Campoccia","year":"2010","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.actbio.2019.01.015_b0405","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jcot.2013.11.005","article-title":"Bone cement","volume":"4","author":"Vaishya","year":"2013","journal-title":"J. Clin. Orthop. Trauma"},{"issue":"5","key":"10.1016\/j.actbio.2019.01.015_b0410","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1532-849X.2006.00129.x","article-title":"Calcium phosphate cement: review of mechanical and biological properties","volume":"15","author":"Ambard","year":"2006","journal-title":"J. Prosthodont."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0415","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1186\/s12891-016-1352-9","article-title":"Combination therapy with vancomycin-loaded calcium sulfate and vancomycin-loaded PMMA in the treatment of chronic osteomyelitis","volume":"17","author":"Luo","year":"2016","journal-title":"BMC Musculoskelet. Disord."},{"issue":"4","key":"10.1016\/j.actbio.2019.01.015_b0420","first-page":"209","article-title":"Use of gentamicin-loaded collagen sponge in internal fixation of open fractures","volume":"14","author":"Susheel","year":"2011","journal-title":"Chin. J. Traumatol."},{"issue":"17","key":"10.1016\/j.actbio.2019.01.015_b0425","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/0142-9612(96)87654-X","article-title":"Comparative investigation of drug delivery of collagen implants saturated in antibiotic solutions and a sponge containing gentamicin","volume":"17","author":"Wachol-Drewek","year":"1996","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.actbio.2019.01.015_b0430","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF02588391","article-title":"Treatment of chronic osteomyelitis with a collagen-antibiotic compound\u2013preliminary report","volume":"12","author":"Ascherl","year":"1986","journal-title":"Unfallchirurgie"},{"issue":"5","key":"10.1016\/j.actbio.2019.01.015_b0435","first-page":"259","article-title":"Antibiotic-containing collagen sponge in therapy of osteitis","volume":"95","author":"Wernet","year":"1992","journal-title":"Der Unfallchirurg"},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0440","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/jbm.a.31184","article-title":"Gentamicin-loaded bioresorbable films for prevention of bacterial infections associated with orthopedic implants","volume":"83","author":"Aviv","year":"2007","journal-title":"J. Biomed. Mater. Res. Part A"},{"issue":"3","key":"10.1016\/j.actbio.2019.01.015_b0445","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/(SICI)1097-4636(199603)30:3<281::AID-JBM2>3.0.CO;2-M","article-title":"Controlled release of antibiotics from coated orthopedic implants","volume":"30","author":"Price","year":"1996","journal-title":"J. Biomed. Mater. Res."},{"issue":"11","key":"10.1016\/j.actbio.2019.01.015_b0450","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1039\/C7BM00693D","article-title":"The immobilization of antibiotic-loaded polymeric coatings on osteoarticular Ti implants for the prevention of bone infections","volume":"5","author":"Li","year":"2017","journal-title":"Biomater. Sci."},{"issue":"7","key":"10.1016\/j.actbio.2019.01.015_b0455","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1002\/jbm.b.32747","article-title":"Poly (\u03b5-caprolactone) coating delays vancomycin delivery from porous chitosan\/\u03b2-tricalcium phosphate composites","volume":"100B","author":"Fang","year":"2012","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"issue":"5","key":"10.1016\/j.actbio.2019.01.015_b0460","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3109\/17453670903350040","article-title":"A biodegradable antibiotic delivery system based on poly-(trimethylene carbonate) for the treatment of osteomyelitis","volume":"80","author":"Neut","year":"2009","journal-title":"Acta Orthopaedica"},{"issue":"27","key":"10.1016\/j.actbio.2019.01.015_b0465","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1016\/j.biomaterials.2009.05.012","article-title":"A surface-eroding antibiotic delivery system based on poly-(trimethylene carbonate)","volume":"30","author":"Kluin","year":"2009","journal-title":"Biomaterials"},{"issue":"2 Suppl.","key":"10.1016\/j.actbio.2019.01.015_b0470","first-page":"65","article-title":"Antibiotic-modified hydrogel coatings on titanium dental implants","volume":"26","author":"Cometa","year":"2012","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.actbio.2019.01.015_b0475","doi-asserted-by":"crossref","first-page":"34","DOI":"10.7150\/jbji.15986","article-title":"Does an antibiotic-loaded hydrogel coating reduce early post-surgical infection after joint arthroplasty?","volume":"1","author":"Roman\u00f2","year":"2016","journal-title":"J. Bone Joint Infect."},{"key":"10.1016\/j.actbio.2019.01.015_b0480","first-page":"6317","article-title":"Antimicrobial activity of bone cements embedded with organic nanoparticles","volume":"10","author":"Perni","year":"2015","journal-title":"Int. J. Nanomed."},{"issue":"11","key":"10.1016\/j.actbio.2019.01.015_b0485","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1016\/j.biomaterials.2005.11.036","article-title":"Antibacterial and mechanical properties of bone cement impregnated with chitosan nanoparticles","volume":"27","author":"Shi","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.01.015_b0490","first-page":"104","article-title":"Mechanical properties and elution characteristics of polymethylmethacrylate bone cement impregnated with antibiotics for various surface area and volume constructs","volume":"32","author":"Duey","year":"2012","journal-title":"Iowa Orthop. J."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0495","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftv103","article-title":"Elution of antibiotics from poly(methyl methacrylate) bone cement after extended implantation does not necessarily clear the infection despite susceptibility of the clinical isolates","volume":"74","author":"Swearingen","year":"2016","journal-title":"Pathog. Dis."},{"issue":"8","key":"10.1016\/j.actbio.2019.01.015_b0500","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/bip.22486","article-title":"Review collagen-based biomaterials for wound healing","volume":"101","author":"Chattopadhyay","year":"2014","journal-title":"Biopolymers"},{"issue":"3","key":"10.1016\/j.actbio.2019.01.015_b0505","doi-asserted-by":"crossref","first-page":"129","DOI":"10.14245\/kjs.2016.13.3.129","article-title":"The use of gentamicin-impregnated collagen sponge for reducing surgical site infection after spine surgery","volume":"13","author":"Han","year":"2016","journal-title":"Korean J. Spine"},{"issue":"6","key":"10.1016\/j.actbio.2019.01.015_b0510","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3109\/17453679108994503","article-title":"Gentamicin-collagen sponge for local applications. 10 cases of chronic osteomyelitis followed for 1 year","volume":"62","author":"Ipsen","year":"1991","journal-title":"Acta Orthop. Scand."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0515","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1128\/AAC.00729-05","article-title":"Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines","volume":"51","author":"Duewelhenke","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"issue":"11","key":"10.1016\/j.actbio.2019.01.015_b0520","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1002\/jps.10460","article-title":"Collagen\/PLGA microparticle composites for local controlled delivery of gentamicin","volume":"92","author":"Schlapp","year":"2003","journal-title":"J. Pharm. Sci."},{"issue":"19","key":"10.1016\/j.actbio.2019.01.015_b0525","doi-asserted-by":"crossref","first-page":"9322","DOI":"10.1021\/am402618w","article-title":"Role of size and shape on biofilm eradication for nitric oxide-releasing silica nanoparticles","volume":"5","author":"Slomberg","year":"2013","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2019.01.015_b0530","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2147\/IJN.S121956","article-title":"The antimicrobial activity of nanoparticles: present situation and prospects for the future","volume":"12","author":"Wang","year":"2017","journal-title":"Int. J. Nanomed."},{"issue":"4","key":"10.1016\/j.actbio.2019.01.015_b0535","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/1097-4636(20001215)52:4<662::AID-JBM10>3.0.CO;2-3","article-title":"A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus","volume":"52","author":"Feng","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"issue":"7","key":"10.1016\/j.actbio.2019.01.015_b0540","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/j.nano.2017.05.013","article-title":"Metallic nanoparticles to eradicate bacterial bone infection","volume":"13","author":"Qadri","year":"2017","journal-title":"Nanomed.: Nanotechnol. Biol. Med."},{"key":"10.1016\/j.actbio.2019.01.015_b0545","first-page":"2441","article-title":"Alendronate-coated long-circulating liposomes containing (99m)technetium-ceftizoxime used to identify osteomyelitis","volume":"10","author":"Ferreira","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.actbio.2019.01.015_b0550","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.actbio.2017.10.001","article-title":"Sustained antimicrobial activity and reduced toxicity of oxidative biocides through biodegradable microparticles","volume":"64","author":"Sofokleous","year":"2017","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0555","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/adma.201103574","article-title":"Maleimide cross-linked bioactive peg hydrogel exhibits improved reaction kinetics and cross-linking for cell encapsulation and in situ delivery","volume":"24","author":"Phelps","year":"2012","journal-title":"Adv. Mater."},{"issue":"7","key":"10.1016\/j.actbio.2019.01.015_b0560","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s00264-013-2237-2","article-title":"Efficacy of antibacterial-loaded coating in an in vivo model of acutely highly contaminated implant","volume":"38","author":"Giavaresi","year":"2014","journal-title":"Int. Orthop."},{"issue":"24","key":"10.1016\/j.actbio.2019.01.015_b0565","doi-asserted-by":"crossref","first-page":"20356","DOI":"10.1021\/acsami.8b06262","article-title":"Hydrogel effects rapid biofilm debridement with ex situ contact-kill to eliminate multidrug resistant bacteria in vivo","volume":"10","author":"Yeo","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.actbio.2019.01.015_b0570","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jcis.2007.10.014","article-title":"First successful design of semi-IPN hydrogel-silver nanocomposites: a facile approach for antibacterial application","volume":"318","author":"Murthy","year":"2008","journal-title":"J. Colloid Interface Sci."},{"issue":"5","key":"10.1016\/j.actbio.2019.01.015_b0575","article-title":"Antibacterial hydrogels","volume":"5","author":"Li","year":"2018","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"issue":"47","key":"10.1016\/j.actbio.2019.01.015_b0580","doi-asserted-by":"crossref","first-page":"14793","DOI":"10.1021\/ja076300z","article-title":"Inherent antibacterial activity of a peptide-based beta-hairpin hydrogel","volume":"129","author":"Salick","year":"2007","journal-title":"J. Am. Chem. Soc."},{"issue":"14","key":"10.1016\/j.actbio.2019.01.015_b0585","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1016\/j.biomaterials.2013.01.096","article-title":"Self-assembly of ciprofloxacin and a tripeptide into an antimicrobial nanostructured hydrogel","volume":"34","author":"Marchesan","year":"2013","journal-title":"Biomaterials"},{"issue":"47","key":"10.1016\/j.actbio.2019.01.015_b0590","doi-asserted-by":"crossref","first-page":"25340","DOI":"10.1039\/c3ra44716b","article-title":"Dextrin cross linked with poly(HEMA): a novel hydrogel for colon specific delivery of ornidazole","volume":"3","author":"Das","year":"2013","journal-title":"RSC Adv."},{"issue":"4","key":"10.1016\/j.actbio.2019.01.015_b0595","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/apm.12675","article-title":"Antifouling and antimicrobial biomaterials: an overview","volume":"125","author":"Francolini","year":"2017","journal-title":"APMIS"},{"issue":"4822","key":"10.1016\/j.actbio.2019.01.015_b0600","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1126\/science.3629258","article-title":"Biomaterial-centered infection: microbial adhesion versus tissue integration","volume":"237","author":"Gristina","year":"1987","journal-title":"Science (New York, N.Y.)"},{"issue":"1","key":"10.1016\/j.actbio.2019.01.015_b0605","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3390\/polym4010046","article-title":"Antimicrobial Polymers in Solution and on Surfaces: Overview and Functional Principles","volume":"4","author":"Siedenbiedel","year":"2012","journal-title":"Polymers"},{"issue":"153","key":"10.1016\/j.actbio.2019.01.015_b0610","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004528","article-title":"Biomaterial-associated infection: locating the finish line in the race for the surface","volume":"4","author":"Busscher","year":"2012","journal-title":"Sci. Transl. Med."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706119300352?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706119300352?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:16:57Z","timestamp":1761671817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706119300352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":122,"alternative-id":["S1742706119300352"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2019.01.015","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Implantable antimicrobial biomaterials for local drug delivery in bone infection models","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2019.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}