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Lett."},{"issue":"7","key":"10.1016\/j.actbio.2019.02.053_b0420","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.micron.2005.05.011","article-title":"Ultrastructural examination of dentin using focused ion-beam cross-sectioning and transmission electron microscopy","volume":"36","author":"Nalla","year":"2005","journal-title":"Micron"},{"issue":"6","key":"10.1016\/j.actbio.2019.02.053_b0425","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.bone.2010.02.025","article-title":"On the effect of x-ray irradiation on the deformation and fracture behavior of human cortical bone","volume":"46","author":"Barth","year":"2010","journal-title":"Bone"},{"issue":"34","key":"10.1016\/j.actbio.2019.02.053_b0430","doi-asserted-by":"crossref","first-page":"8892","DOI":"10.1016\/j.biomaterials.2011.08.013","article-title":"Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone","volume":"32","author":"Barth","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.02.053_b0435","series-title":"A Language and Environment for Statistical Computing","author":"Core","year":"2013"},{"key":"10.1016\/j.actbio.2019.02.053_b0440","article-title":"SciPy: open source scientific tools for","author":"Jones","year":"2001","journal-title":"Python"},{"key":"10.1016\/j.actbio.2019.02.053_b0445","unstructured":"T.E. 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Numer. Method Biomed. Eng."},{"issue":"11","key":"10.1016\/j.actbio.2019.02.053_b0755","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1016\/S1359-6454(00)00087-2","article-title":"Neutron diffraction study of the deformation behavior of beryllium\u2013aluminum composites","volume":"48","author":"Carter","year":"2000","journal-title":"Acta Mater."},{"issue":"10","key":"10.1016\/j.actbio.2019.02.053_b0760","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.1073\/pnas.0631609100","article-title":"Materials become insensitive to flaws at nanoscale: lessons from nature","volume":"100","author":"Gao","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.actbio.2019.02.053_b0765","first-page":"163","article-title":"Vi the phenomena of rupture and f low in solids","volume":"221","author":"Griffith","year":"1920","journal-title":"Philos. Trans. R. Soc. 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Biomech."},{"issue":"2","key":"10.1016\/j.actbio.2019.02.053_b0775","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.bone.2009.09.035","article-title":"Rehydration of vertebral trabecular bone: influences on its anisotropy, its stiffness and the indentation work with a view to age, gender and vertebral level","volume":"46","author":"Wolfram","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2019.02.053_b0780","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jmbbm.2015.12.001","article-title":"Effect of water on nanomechanics of bone is different between tension and compression","volume":"57","author":"Samuel","year":"2016","journal-title":"J. Mech. Behav. Biomed. 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