{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:45:58Z","timestamp":1788615958491,"version":"build-2803163510"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Science Foundation"},{"name":"Engineering Research Center for Revolutionizing Metallic Biomaterials","award":["EEC-0812348"],"award-info":[{"award-number":["EEC-0812348"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.actbio.2019.04.061","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T11:46:26Z","timestamp":1556883986000},"page":"215-234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"special_numbering":"C","title":["Embedding magnesium metallic particles in polycaprolactone nanofiber mesh improves applicability for biomedical applications"],"prefix":"10.1016","volume":"98","author":[{"given":"Udhab","family":"Adhikari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxian","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nava","family":"Rijal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalil","family":"Khanal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Chavez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9926-5740","authenticated-orcid":false,"given":"Rigwed","family":"Tatu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagannathan","family":"Sankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Hom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0583-7913","authenticated-orcid":false,"given":"Narayan","family":"Bhattarai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-4263","authenticated-orcid":false,"given":"Sarah K.","family":"Pixley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2019.04.061_b0005","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1002\/anie.200604646","article-title":"Electrospinning: a fascinating method for the preparation of ultrathin fibers","volume":"46","author":"Greiner","year":"2007","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.actbio.2019.04.061_b0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2147\/nano.2006.1.1.15","article-title":"Nanofibers and their applications in tissue engineering","volume":"1","author":"Vasita","year":"2006","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.actbio.2019.04.061_b0015","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5082\/1\/1\/015001","article-title":"Electrospun nanofiber meshes with tailored architectures and patterns as potential tissue-engineering scaffolds","volume":"1","author":"Wang","year":"2009","journal-title":"Biofabrication"},{"key":"10.1016\/j.actbio.2019.04.061_b0020","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.mattod.2013.06.005","article-title":"Biomimetic electrospun nanofibrous structures for tissue engineering","volume":"16","author":"Wang","year":"2013","journal-title":"Mater. Today"},{"key":"10.1016\/j.actbio.2019.04.061_b0025","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1021\/bm0501149","article-title":"Sustained release of proteins from electrospun biodegradable fibers","volume":"6","author":"Chew","year":"2005","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2019.04.061_b0030","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0168-3659(02)00041-X","article-title":"Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend","volume":"81","author":"Kenawy","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2019.04.061_b0035","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jconrel.2008.01.011","article-title":"Electrospun biodegradable nanofiber nonwovens for controlled release of proteins","volume":"127","author":"Maretschek","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2019.04.061_b0040","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jconrel.2007.03.018","article-title":"Fabrication and characterization of PLGA\/HAp composite scaffolds for delivery of BMP-2 plasmid DNA","volume":"120","author":"Nie","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2019.04.061_b0045","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3390\/polym7020186","article-title":"Multifunctional nanofibers towards active biomedical therapeutics","volume":"7","author":"Sharma","year":"2015","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.actbio.2019.04.061_b0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049792","article-title":"Drug-eluting fibers for HIV-1 inhibition and contraception","volume":"7","author":"Ball","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2019.04.061_b0055","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jconrel.2015.09.008","article-title":"Current strategies for sustaining drug release from electrospun nanofibers","volume":"220","author":"Chou","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2019.04.061_b0060","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jconrel.2015.06.042","article-title":"Layered superhydrophobic meshes for controlled drug release","volume":"214","author":"Falde","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2019.04.061_b0065","doi-asserted-by":"crossref","first-page":"e282","DOI":"10.1016\/j.ijpharm.2014.08.039","article-title":"Manufacturing scale-up of electrospun poly(vinyl alcohol) fibers containing tenofovir for vaginal drug delivery","volume":"475","author":"Krogstad","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2019.04.061_b0070","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1163\/156856208784089599","article-title":"Hybrid nanofibrous scaffolds from electrospinning of a synthetic biodegradable elastomer and urinary bladder matrix","volume":"19","author":"Stankus","year":"2008","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.actbio.2019.04.061_b0075","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.apsusc.2016.02.053","article-title":"Tailoring mechanical and antibacterial properties of chitosan\/gelatin nanofiber membranes with Fe3O4 nanoparticles for potential wound dressing application","volume":"369","author":"Cai","year":"2016","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.actbio.2019.04.061_b0080","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cej.2018.10.117","article-title":"Electrospinning tissue engineering and wound dressing scaffolds from polymer-titanium dioxide nanocomposites","volume":"358","author":"Ghosal","year":"2019","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2019.04.061_b0085","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.msec.2018.10.069","article-title":"Reconstructing nanofibers from natural polymers using surface functionalization approaches for applications in tissue engineering, drug delivery and biosensing devices","volume":"94","author":"Sofi","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.actbio.2019.04.061_b0090","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/aa792b","article-title":"Magnesium oxide nanoparticle-loaded polycaprolactone composite electrospun fiber scaffolds for bone-soft tissue engineering applications: in-vitro and in-vivo evaluation","volume":"12","author":"Suryavanshi","year":"2017","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.actbio.2019.04.061_b0095","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.colsurfa.2018.09.012","article-title":"Enhanced drug delivery, mechanical properties and antimicrobial activities in poly(lactic acid) nanofiber with mesoporous Fe3O4-COOH nanoparticles","volume":"559","author":"Han","year":"2018","journal-title":"Colloids Surfaces A Physicochem. Eng. Asp."},{"key":"10.1016\/j.actbio.2019.04.061_b0100","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1684\/mrh.2015.0375","article-title":"Magnesium-based implants: a mini-review","volume":"27","author":"Luthringer","year":"2014","journal-title":"Magnes. Res."},{"key":"10.1016\/j.actbio.2019.04.061_b0105","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.biomaterials.2016.10.017","article-title":"Current status on clinical applications of magnesium-based orthopaedic implants: a review from clinical translational perspective","volume":"112","author":"Zhao","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.04.061_b0110","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1023\/A:1016022730880","article-title":"Structural and catalytic chemistry of magnesium-dependent enzymes","volume":"15","author":"Cowan","year":"2002","journal-title":"Biometals"},{"key":"10.1016\/j.actbio.2019.04.061_b0115","doi-asserted-by":"crossref","first-page":"762","DOI":"10.4236\/pp.2014.57086","article-title":"Magnesium: the neglected electrolyte? a clinical review","volume":"5","author":"Sharma","year":"2014","journal-title":"Pharmacol. Pharmacy, Pharmacol. Pharm."},{"key":"10.1016\/j.actbio.2019.04.061_b0120","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1016\/j.actbio.2014.02.002","article-title":"Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation","volume":"10","author":"Yoshizawa","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2019.04.061_b0125","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/nm.4162","article-title":"Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats","volume":"22","author":"Zhang","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.actbio.2019.04.061_b0130","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1532-5415.2010.03232.x","article-title":"The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial","volume":"59","author":"Rondanelli","year":"2011","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.actbio.2019.04.061_b0135","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/anae.12107","article-title":"A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component","volume":"68","author":"Yousef","year":"2013","journal-title":"Anaesthesia"},{"key":"10.1016\/j.actbio.2019.04.061_b0140","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12026-012-8371-x","article-title":"The role of Mg2+ in immune cells","volume":"55","author":"Brandao","year":"2013","journal-title":"Immunol. Res."},{"key":"10.1016\/j.actbio.2019.04.061_b0145","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.it.2014.05.001","article-title":"Divalent cation signaling in immune cells","volume":"35","author":"Chaigne-Delalande","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/j.actbio.2019.04.061_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00012.2014","article-title":"Magnesium in man: Implications for health and disease","volume":"95","author":"de Baaij","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.actbio.2019.04.061_b0155","first-page":"95","article-title":"Magnesium in the CNS: recent advances and developments","volume":"29","author":"Vink","year":"2016","journal-title":"Magnes. Res."},{"key":"10.1016\/j.actbio.2019.04.061_b0160","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuron.2009.12.026","article-title":"Enhancement of learning and memory by elevating brain magnesium","volume":"65","author":"Slutsky","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.actbio.2019.04.061_b0165","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13041-014-0065-y","article-title":"Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer\u2019s disease mouse model","volume":"7","author":"Li","year":"2014","journal-title":"Mol. Brain."},{"key":"10.1016\/j.actbio.2019.04.061_b0170","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3233\/JAD-150538","article-title":"Efficacy and safety of MMFS-01, a synapse density enhancer, for treating cognitive impairment in older adults: a randomized, double-blind, placebo-controlled trial","volume":"49","author":"Liu","year":"2015","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.actbio.2019.04.061_b0175","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/bs.mie.2014.11.038","article-title":"Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications","volume":"555","author":"Ohta","year":"2015","journal-title":"Methods Enzymol."},{"issue":"9","key":"10.1016\/j.actbio.2019.04.061_b0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007247","article-title":"Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson\u2019s disease","volume":"4","author":"Fujita","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2019.04.061_b0185","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2174\/1567205014666171106145017","article-title":"Effects of molecular hydrogen assessed by an animal model and a randomized clinical study on mild cognitive impairment","volume":"15","author":"Nishimaki","year":"2018","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.actbio.2019.04.061_b0190","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nm1577","article-title":"Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals","volume":"13","author":"Ohsawa","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.actbio.2019.04.061_b0195","doi-asserted-by":"crossref","first-page":"8714","DOI":"10.1016\/j.actbio.2012.10.008","article-title":"Fast escape of hydrogen from gas cavities around corroding magnesium implants","volume":"9","author":"Kuhlmann","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2019.04.061_b0200","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1002\/jbm.a.36176","article-title":"Short and long gap peripheral nerve repair with magnesium metal filaments","volume":"105","author":"Hopkins","year":"2017","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.actbio.2019.04.061_b0205","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1177\/0885328214553135","article-title":"Initial observations on using magnesium metal in peripheral nerve repair","volume":"29","author":"Vennemeyer","year":"2015","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.actbio.2019.04.061_b0210","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/0142-9612(95)93577-Z","article-title":"Monocryl\u00ae suture, a new ultra-pliable absorbable monofilament suture","volume":"16","author":"Bezwada","year":"1995","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.04.061_b0215","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/S0002-9378(89)80015-8","article-title":"Clinical evaluation of the Capronor contraceptive implant: preliminary report","volume":"160","author":"Darney","year":"1989","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.actbio.2019.04.061_b0220","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.progpolymsci.2010.04.002","article-title":"The return of a forgotten polymer \u2013 polycaprolactone in the 21st century","volume":"35","author":"Woodruff","year":"2010","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.actbio.2019.04.061_b0225","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.colsurfa.2012.12.009","article-title":"Influence of electrospinning and dip-coating techniques on the degradation and cytocompatibility of Mg-based alloy","volume":"420","author":"Abdal-hay","year":"2013","journal-title":"Colloids Surfaces A Physicochem. Eng. Asp."},{"key":"10.1016\/j.actbio.2019.04.061_b0230","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.apsusc.2016.10.092","article-title":"Enhanced corrosion resistance and biocompatibility of AZ31 Mg alloy using PCL\/ZnO NPs via electrospinning","volume":"396","author":"Kim","year":"2017","journal-title":"Appl. Surf. Sci."},{"issue":"5","key":"10.1016\/j.actbio.2019.04.061_b0235","first-page":"817","article-title":"Electrospun nanofibrous polymer coated magnesium alloy for biodegradable implant applications","volume":"2014","author":"Soujanya","year":"2014","journal-title":"Int. Conf. Adv. Manuf. Mater. Eng. ICAMME"},{"key":"10.1016\/j.actbio.2019.04.061_b0240","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/jbm.a.35625","article-title":"Incorporation of Mg particles into PDLLA regulates mesenchymal stem cell and macrophage responses","volume":"104","author":"Cifuentes","year":"2016","journal-title":"J. Biomed. Mater. Res. \u2013 Part A"},{"key":"10.1016\/j.actbio.2019.04.061_b0245","article-title":"In vitro and in vivo responses of macrophages to magnesium-doped titanium","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2019.04.061_b0250","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.3390\/ma8074080","article-title":"Fabrication and characterization of electrospun PCL-MgO-keratin-based composite nanofibers for biomedical applications","volume":"8","author":"Boakye","year":"2015","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.actbio.2019.04.061_b0255","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/jbm.b.33172","article-title":"Poly(e-caprolactone)\/keratin-based composite nanofibers for biomedical applications","volume":"103","author":"Edwards","year":"2015","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"10.1016\/j.actbio.2019.04.061_b0260","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.actbio.2007.01.002","article-title":"Evaluation of electrospun PCL\/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution","volume":"3","author":"Chong","year":"2007","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2019.04.061_b0265","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/000456329803500401","article-title":"Magnesium measurement in routine clinical practice","volume":"35","author":"Ryan","year":"1998","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.actbio.2019.04.061_b0270","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1046\/j.1432-1327.2000.01606.x","article-title":"Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity","volume":"267","author":"O\u2019Brien","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.actbio.2019.04.061_b0275","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jneumeth.2015.08.016","article-title":"Combining micro-computed tomography with histology to analyze biomedical implants for peripheral nerve repair","volume":"255","author":"Hopkins","year":"2015","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.actbio.2019.04.061_b0280","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nmat2978","article-title":"Air-stable magnesium nanocomposites provide rapid and high-capacity hydrogen storage without using heavy-metal catalysts","volume":"10","author":"Jeon","year":"2011","journal-title":"Nat. Mater."},{"key":"10.1016\/j.actbio.2019.04.061_b0285","first-page":"10","article-title":"Spectroscopic studies and thermal properties of PCL\/PMMA biopolymer blend","volume":"3","author":"Abdelrazek","year":"2016","journal-title":"Egypt. J. Basic Appl. Sci."},{"key":"10.1016\/j.actbio.2019.04.061_b0290","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1180\/claymin.1993.028.4.03","article-title":"Particle size and shape effects in materials science: examples from polymer and paper systems","volume":"28","author":"Adams","year":"1993","journal-title":"Clay Miner."},{"key":"10.1016\/j.actbio.2019.04.061_b0295","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1007\/BF00552413","article-title":"The fracture of hybrid-particulate composites","volume":"20","author":"Kinloch","year":"1985","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.actbio.2019.04.061_b0300","doi-asserted-by":"crossref","unstructured":"R. Petrucci, L. Torre, 2 \u2013 Filled Polymer Composites, in: C.F. Jasso-Gastinel, J.M. Kenny (Eds.), Modif. Polym. Prop., William Andrew Publishing, 2017: pp. 23\u201346. https:\/\/doi.org\/10.1016\/B978-0-323-44353-1.00002-6.","DOI":"10.1016\/B978-0-323-44353-1.00002-6"},{"key":"10.1016\/j.actbio.2019.04.061_b0305","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0022-3565(24)38087-5","article-title":"Optimization of magnesium therapy after severe diffuse axonal brain injury in rats","volume":"288","author":"Heath","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.actbio.2019.04.061_b0310","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.actbio.2015.04.011","article-title":"Recommendation for modifying current cytotoxicity testing standards for biodegradable magnesium-based materials","volume":"21","author":"Wang","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2019.04.061_b0315","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1177\/0885328210379928","article-title":"Differential adhesiveness and neurite-promoting activity for neural cells of chitosan, gelatin, and poly-l-lysine films","volume":"26","author":"Mart\u00edn-L\u00f3pez","year":"2012","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.actbio.2019.04.061_b0320","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neures.2014.05.001","article-title":"Effects of elevated magnesium and substrate on neuronal numbers and neurite outgrowth of neural stem\/progenitor cells in vitro","volume":"84","author":"Vennemeyer","year":"2014","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.actbio.2019.04.061_b0325","series-title":"Immune Response to Implant. Mater. Devices Impact Immune Syst. Success an Implant","first-page":"15","article-title":"Implications of the acute and chronic inflammatory response and the foreign body reaction to the immune response of implanted biomaterials","author":"Anderson","year":"2016"},{"key":"10.1016\/j.actbio.2019.04.061_b0330","series-title":"Immune Response to Implant. Mater. Devices Impact Immune Syst. Success an Implant","first-page":"1","article-title":"Host response to implanted materials and devices: an overview","author":"Scarritt","year":"2016"},{"key":"10.1016\/j.actbio.2019.04.061_b0335","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tips.2015.03.006","article-title":"Arginase: an old enzyme with new tricks","volume":"36","author":"Caldwell","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.actbio.2019.04.061_b0340","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1038\/jid.2013.164","article-title":"Local arginase 1 activity is required for cutaneous wound healing","volume":"133","author":"Campbell","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.actbio.2019.04.061_b0345","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biomaterials.2016.10.019","article-title":"Shifts in macrophage phenotype at the biomaterial interface via IL-4 eluting coatings are associated with improved implant integration","volume":"112","author":"Hachim","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.04.061_b0350","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1016\/j.polymer.2008.08.022","article-title":"Effect of fiber diameter on tensile properties of electrospun poly(e-caprolactone)","volume":"49","author":"Wong","year":"2008","journal-title":"Polymer (Guildf.)"},{"key":"10.1016\/j.actbio.2019.04.061_b0355","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.biomaterials.2005.09.019","article-title":"The in vivo degradation, absorption and excretion of PCL-based implant","volume":"27","author":"Sun","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.04.061_b0360","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2019.04.061_b0365","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/15438627.2013.852092","article-title":"Hydrogen-rich water affected blood alkalinity in physically active men","volume":"22","author":"Ostojic","year":"2014","journal-title":"Res. Sport. Med."},{"key":"10.1016\/j.actbio.2019.04.061_b0370","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1089\/ten.2006.12.3545","article-title":"Unphysiologically high magnesium concentrations support chondrocyte proliferation and redifferentiation","volume":"12","author":"Feyerabend","year":"2006","journal-title":"Tissue Eng."},{"key":"10.1016\/j.actbio.2019.04.061_b0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159879","article-title":"Effects of corroded and non-corroded biodegradable mg and mg alloys on viability, morphology and differentiation of MC3T3-E1 cells elicited by direct cell\/material interaction","volume":"11","author":"Mostofi","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2019.04.061_b0380","doi-asserted-by":"crossref","first-page":"7016","DOI":"10.1016\/j.biomaterials.2013.05.062","article-title":"Low-modulus Mg\/PCL hybrid bone substitute for osteoporotic fracture fixation","volume":"34","author":"Wong","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.04.061_b0385","series-title":"Biomater. Regen. Med. Immune Syst.","first-page":"17","article-title":"The role of macrophages in the foreign body response to implanted biomaterials","author":"Yu","year":"2015"},{"key":"10.1016\/j.actbio.2019.04.061_b0390","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1189\/jlb.5VMR0415-166R","article-title":"Macrophage responses to implants: prospects for personalized medicine","volume":"98","author":"Kzhyshkowska","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.actbio.2019.04.061_b0395","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.mattod.2015.01.019","article-title":"Biomaterial based modulation of macrophage polarization: a review and suggested design principles","volume":"18","author":"Sridharan","year":"2015","journal-title":"Mater. Today"},{"key":"10.1016\/j.actbio.2019.04.061_b0400","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1016\/j.ajpath.2015.06.001","article-title":"Monocyte and macrophage plasticity in tissue repair and regeneration","volume":"185","author":"Das","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.actbio.2019.04.061_b0405","article-title":"Metabolic reprogramming in macrophage polarization","volume":"5","author":"Galv\u00e1n-Pe\u00f1a","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2019.04.061_b0410","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000371","article-title":"Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis","volume":"5","author":"Pesce","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.actbio.2019.04.061_b0415","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.actbio.2014.09.008","article-title":"Porous magnesium\/PLGA composite scaffolds for enhanced bone regeneration following tooth extraction","volume":"11","author":"Brown","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2019.04.061_b0420","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s10439-013-0941-0","article-title":"A perspective on immunomodulation and tissue repair","volume":"42","author":"Mokarram","year":"2014","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.actbio.2019.04.061_b0425","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2172-11-52","article-title":"Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages","volume":"11","author":"Joshi","year":"2010","journal-title":"BMC Immunol."},{"key":"10.1016\/j.actbio.2019.04.061_b0430","doi-asserted-by":"crossref","DOI":"10.1038\/srep04146","article-title":"Unique macrophages different from M1\/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization","volume":"4","author":"Tatano","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2019.04.061_b0435","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1021\/bm900670n","article-title":"Simple agarose-chitosan gel composite system for enhanced neuronal growth in three dimensions","volume":"10","author":"Cao","year":"2009","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2019.04.061_b0440","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1021\/bm200248h","article-title":"Effect of electrospun fiber diameter and alignment on macrophage activation and secretion of proinflammatory cytokines and chemokines","volume":"12","author":"Saino","year":"2011","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2019.04.061_b0445","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/jbm.a.34104","article-title":"The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)-based hydrogels","volume":"100","author":"Blakney","year":"2012","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2019.04.061_b0450","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201600967","article-title":"Instructing human macrophage polarization by stiffness and glycosaminoglycan functionalization in 3D collagen networks","volume":"6","author":"Friedemann","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2019.04.061_b0455","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.lfs.2017.04.014","article-title":"Biomaterial stiffness determines stem cell fate","volume":"178","author":"Lv","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.actbio.2019.04.061_b0460","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1016\/j.biomaterials.2010.01.074","article-title":"Characterization of topographical effects on macrophage behavior in a foreign body response model","volume":"31","author":"Chen","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.04.061_b0465","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1016\/j.biomaterials.2013.02.065","article-title":"Macrophage functional polarization (M1\/M2) in response to varying fiber and pore dimensions of electrospun scaffolds","volume":"34","author":"Garg","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.04.061_b0470","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1007\/s10439-013-0933-0","article-title":"Porous implants modulate healing and induce shifts in local macrophage polarization in the foreign body reaction","volume":"42","author":"Sussman","year":"2014","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.actbio.2019.04.061_b0475","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/jbm.10285","article-title":"Tissue response to microfibers of different polymers: polyester, polyethylene, polylactic acid, and polyurethane","volume":"62","author":"Sanders","year":"2002","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.actbio.2019.04.061_b0480","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1431927615015597","article-title":"Time-lapse evaluation of interactions between biodegradable Mg particles and cells","volume":"22","author":"Alvarez","year":"2016","journal-title":"Microsc. Microanal."},{"key":"10.1016\/j.actbio.2019.04.061_b0485","doi-asserted-by":"crossref","DOI":"10.1038\/srep46343","article-title":"A promising biodegradable magnesium alloy suitable for clinical vascular stent application","volume":"7","author":"Mao","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706119303150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706119303150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:22:01Z","timestamp":1761672121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706119303150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":97,"alternative-id":["S1742706119303150"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2019.04.061","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Embedding magnesium metallic particles in polycaprolactone nanofiber mesh improves applicability for biomedical applications","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2019.04.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}