{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:12:16Z","timestamp":1792653136526,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.actbio.2019.05.016","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T20:23:14Z","timestamp":1557346994000},"page":"145-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":210,"special_numbering":"C","title":["Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications"],"prefix":"10.1016","volume":"92","author":[{"given":"Idit","family":"Goldfracht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Efraim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Shinnawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Kovalev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irit","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Gepstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Arbel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naim","family":"Shaheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Tiburcy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-4040","authenticated-orcid":false,"given":"Wolfram H.","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelle","family":"Machluf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Gepstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2019.05.016_b0005","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2019.05.016_b0010","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1161\/CIRCRESAHA.108.192237","article-title":"Functional cardiomyocytes derived from human induced pluripotent stem cells","volume":"104","author":"Zhang","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.actbio.2019.05.016_b0015","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1161\/CIRCULATIONAHA.109.868885","article-title":"Cardiomyocyte differentiation of human induced pluripotent stem cells","volume":"120","author":"Zwi","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2019.05.016_b0020","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nature19815","article-title":"Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts","volume":"538","author":"Shiba","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2019.05.016_b0025","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.stem.2014.11.009","article-title":"Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells","volume":"15","author":"Ye","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.actbio.2019.05.016_b0030","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1093\/eurheartj\/ehs096","article-title":"Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients","volume":"34","author":"Zwi-Dantsis","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.actbio.2019.05.016_b0035","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa0908679","article-title":"Patient-specific induced pluripotent stem-cell models for long-QT syndrome","volume":"363","author":"Moretti","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.actbio.2019.05.016_b0040","doi-asserted-by":"crossref","first-page":"130ra47","DOI":"10.1126\/scitranslmed.3003552","article-title":"Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy","volume":"4","author":"Sun","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.actbio.2019.05.016_b0045","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nature09747","article-title":"Modelling the long QT syndrome with induced pluripotent stem cells","volume":"471","author":"Itzhaki","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2019.05.016_b0050","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1161\/CIRCULATIONAHA.113.001883","article-title":"Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity","volume":"127","author":"Liang","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2019.05.016_b0055","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19406","article-title":"Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells","volume":"6","author":"Stillitano","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.actbio.2019.05.016_b0060","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1002\/stem.2403","article-title":"Concise review: measuring physiological responses of human pluripotent stem cell derived cardiomyocytes to drugs and disease","volume":"34","author":"van Meer","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.actbio.2019.05.016_b0065","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.stemcr.2015.08.009","article-title":"Monitoring human-induced pluripotent stem cell-derived cardiomyocytes with genetically encoded calcium and voltage fluorescent reporters","volume":"5","author":"Shinnawi","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.actbio.2019.05.016_b0070","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.116.004725","article-title":"Patient-specific drug screening using a human induced pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia type 2","volume":"10","author":"Maizels","year":"2017","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.actbio.2019.05.016_b0075","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nm.4087","article-title":"Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity","volume":"22","author":"Burridge","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.actbio.2019.05.016_b0080","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.117.310738","article-title":"Engineering cardiac muscle tissue: a maturating field of research","volume":"120","author":"Weinberger","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.actbio.2019.05.016_b0085","doi-asserted-by":"crossref","first-page":"342ps13","DOI":"10.1126\/scitranslmed.aad2304","article-title":"Distilling complexity to advance cardiac tissue engineering","volume":"8","author":"Ogle","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.actbio.2019.05.016_b0090","doi-asserted-by":"crossref","first-page":"363ra148","DOI":"10.1126\/scitranslmed.aaf8781","article-title":"Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells","volume":"8","author":"Weinberger","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.actbio.2019.05.016_b0095","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1161\/CIRCULATIONAHA.117.030785","article-title":"Large cardiac muscle patches engineered from human induced-pluripotent stem cell-derived cardiac cells improve recovery from myocardial infarction in swine","volume":"137","author":"Gao","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2019.05.016_b0100","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/CIRCRESAHA.115.306985","article-title":"Human engineered heart muscles engraft and survive long term in a rodent myocardial infarction model","volume":"117","author":"Riegler","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.actbio.2019.05.016_b0105","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.116.024145","article-title":"Defined engineered human myocardium with advanced maturation for applications in heart failure modeling and repair","volume":"135","author":"Tiburcy","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2019.05.016_b0110","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1161\/01.RES.0000257776.05673.ff","article-title":"Tissue engineering of vascularized cardiac muscle from human embryonic stem cells","volume":"100","author":"Caspi","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.actbio.2019.05.016_b0115","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.addr.2015.05.010","article-title":"Human engineered heart tissue as a model system for drug testing","volume":"96","author":"Eder","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2019.05.016_b0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146697","article-title":"Human engineered cardiac tissues created using induced pluripotent stem cells reveal functional characteristics of BRAF-mediated hypertrophic cardiomyopathy","volume":"11","author":"Cashman","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2019.05.016_b0125","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/CIRCRESAHA.110.237206","article-title":"Growth of engineered human myocardium with mechanical loading and vascular coculture","volume":"109","author":"Tulloch","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.actbio.2019.05.016_b0130","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1038\/s41467-017-01946-x","article-title":"Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues","volume":"8","author":"Shadrin","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2019.05.016_b0135","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/s41551-018-0280-4","article-title":"Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload","volume":"2","author":"Ma","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.actbio.2019.05.016_b0140","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/s41551-018-0271-5","article-title":"A tissue-engineered scale model of the heart ventricle","volume":"2","author":"MacQueen","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.actbio.2019.05.016_b0145","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41586-018-0016-3","article-title":"Advanced maturation of human cardiac tissue grown from pluripotent stem cells","volume":"556","author":"Ronaldson-Bouchard","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2019.05.016_b0150","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1016\/j.biomaterials.2013.04.026","article-title":"Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes","volume":"34","author":"Zhang","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.05.016_b0155","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.biomaterials.2015.07.004","article-title":"Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent stem cell-derived cardiomyocytes","volume":"67","author":"Chun","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.05.016_b0160","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/(SICI)1097-0290(20000405)68:1<106::AID-BIT13>3.0.CO;2-3","article-title":"Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes","volume":"68","author":"Zimmermann","year":"2000","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.actbio.2019.05.016_b0165","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1089\/ten.teb.2007.0435","article-title":"Fibrin: a versatile scaffold for tissue engineering applications","volume":"14","author":"Ahmed","year":"2008","journal-title":"Tissue Eng. Part B: Rev"},{"key":"10.1016\/j.actbio.2019.05.016_b0170","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1161\/CIRCRESAHA.114.302533","article-title":"Myocardial extracellular matrix: an ever-changing and diverse entity","volume":"114","author":"Rienks","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.actbio.2019.05.016_b0175","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1161\/CIRCRESAHA.115.306874","article-title":"Bioengineering human myocardium on native extracellular matrix","volume":"118","author":"Guyette","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.actbio.2019.05.016_b0180","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nm1684","article-title":"Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart","volume":"14","author":"Ott","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.actbio.2019.05.016_b0185","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1038\/ncomms3307","article-title":"Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells","volume":"4","author":"Lu","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2019.05.016_b0190","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.biomaterials.2016.07.035","article-title":"Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction","volume":"105","author":"Wang","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.05.016_b0195","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1089\/ten.tec.2009.0111","article-title":"Acellular cardiac extracellular matrix as a scaffold for tissue engineering: in vitro cell support, remodeling, and biocompatibility","volume":"16","author":"Eitan","year":"2010","journal-title":"Tissue Eng. Part C: Methods"},{"key":"10.1016\/j.actbio.2019.05.016_b0200","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.actbio.2016.12.015","article-title":"Biohybrid cardiac ECM-based hydrogels improve long term cardiac function post myocardial infarction","volume":"50","author":"Efraim","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2019.05.016_b0205","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1089\/biores.2015.0030","article-title":"Porous, ventricular extracellular matrix-derived foams as a platform for cardiac cell culture","volume":"4","author":"Russo","year":"2015","journal-title":"Biores Open Access"},{"key":"10.1016\/j.actbio.2019.05.016_b0210","doi-asserted-by":"crossref","first-page":"H2196","DOI":"10.1152\/ajpheart.01017.2005","article-title":"Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance","volume":"290","author":"Berry","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.actbio.2019.05.016_b0215","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1002\/bit.22647","article-title":"Influence of substrate stiffness on the phenotype of heart cells","volume":"105","author":"Bhana","year":"2010","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.actbio.2019.05.016_b0220","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1242\/jcs.029678","article-title":"Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating","volume":"121","author":"Engler","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.actbio.2019.05.016_b0225","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.07455","article-title":"Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion","volume":"4","author":"Yahalom-Ronen","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.actbio.2019.05.016_b0230","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.yjmcc.2013.04.004","article-title":"Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success","volume":"60","author":"Addis","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.actbio.2019.05.016_b0235","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nmeth.2999","article-title":"Chemically defined generation of human cardiomyocytes","volume":"11","author":"Burridge","year":"2014","journal-title":"Nat. Met."},{"key":"10.1016\/j.actbio.2019.05.016_b0240","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-1-4939-1047-2_15","article-title":"Collagen-based engineered heart muscle","volume":"1181","author":"Tiburcy","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.actbio.2019.05.016_b0245","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1086\/324565","article-title":"A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel","volume":"69","author":"Lahat","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.actbio.2019.05.016_b0250","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ceca.2016.02.004","article-title":"Calcium and voltage mapping in hiPSC-CM monolayers","volume":"59","author":"Herron","year":"2016","journal-title":"Cell Calc."},{"key":"10.1016\/j.actbio.2019.05.016_b0255","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.1038\/s41598-017-05652-y","article-title":"Modeling atrial fibrillation using human embryonic stem cell-derived atrial tissue","volume":"7","author":"Laksman","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2019.05.016_b0260","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/eurheartj\/ehs418","article-title":"Development of a reentrant arrhythmia model in human pluripotent stem cell-derived cardiac cell sheets","volume":"34","author":"Kadota","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.actbio.2019.05.016_b0265","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.yjmcc.2009.08.003","article-title":"Contribution of extracellular matrix to the mechanical properties of the heart","volume":"48","author":"Fomovsky","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.actbio.2019.05.016_b0270","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1196\/annals.1302.025","article-title":"Controlling the cellular organization of tissue-engineered cardiac constructs","volume":"1015","author":"Gonen-Wadmany","year":"2004","journal-title":"Ann. NY. Acad. Sci."},{"key":"10.1016\/j.actbio.2019.05.016_b0275","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s12551-015-0184-4","article-title":"Historical perspective on heart function: the Frank-Starling Law","volume":"7","author":"Sequeira","year":"2015","journal-title":"Biophys. Rev."},{"key":"10.1016\/j.actbio.2019.05.016_b0280","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/S0008-6363(98)00337-X","article-title":"Isometric tension development and its calcium sensitivity in skinned myocyte-sized preparations from different regions of the human heart","volume":"42","author":"van der Velden","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.actbio.2019.05.016_b0285","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.biomaterials.2015.03.055","article-title":"Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation","volume":"60","author":"Godier-Furn\u00e9mont","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.05.016_b0290","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.stemcr.2016.04.011","article-title":"Human engineered heart tissue: analysis of contractile force","volume":"7","author":"Mannhardt","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.actbio.2019.05.016_b0295","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1161\/CIRCULATIONAHA.114.014998","article-title":"Mechanical stress conditioning and electrical stimulation promote contractility and force maturation of induced pluripotent stem cell-derived human cardiac tissue","volume":"134","author":"Ruan","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2019.05.016_b0300","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/CIRCRESAHA.114.300558","article-title":"Engineering adolescencem of human pluripotent stem cell-derived cardiomyocytes","volume":"114","author":"Yang","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.actbio.2019.05.016_b0305","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1161\/CIRCRESAHA.117.311920","article-title":"Thyroid and glucocorticoid hormones promote functional T-tubule development in human-induced pluripotent stem cell-derived cardiomyocytes","volume":"121","author":"Parikh","year":"2017","journal-title":"Circ. Res."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706119303319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706119303319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:18:17Z","timestamp":1761671897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706119303319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":61,"alternative-id":["S1742706119303319"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2019.05.016","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2019.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}