{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:17:16Z","timestamp":1778523436134,"version":"3.51.4"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1846715"],"award-info":[{"award-number":["1846715"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16SDG27770088"],"award-info":[{"award-number":["16SDG27770088"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.actbio.2019.05.074","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T19:30:10Z","timestamp":1561059010000},"page":"524-535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["A computational multi-scale approach to investigate mechanically-induced changes in tricuspid valve anterior leaflet microstructure"],"prefix":"10.1016","volume":"94","author":[{"given":"Vineet S.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rouzbeh","family":"Amini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1484","key":"10.1016\/j.actbio.2019.05.074_b0005","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1098\/rstb.2007.2125","article-title":"Heart valve macro-and microstructure","volume":"362","author":"Misfeld","year":"2007","journal-title":"Philos. Trans. R. Soc. B: Biol. Sci."},{"issue":"3","key":"10.1016\/j.actbio.2019.05.074_b0010","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s10439-017-1961-y","article-title":"Engineering analysis of tricuspid annular dynamics in the beating ovine heart","volume":"46","author":"Rausch","year":"2018","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.actbio.2019.05.074_b0015","first-page":"1","article-title":"The effect of acute pulmonary hypertension on tricuspid annular height, strain, and curvature in sheep","author":"Rausch","year":"2018","journal-title":"Cardiovasc. Eng. Technol."},{"issue":"4","key":"10.1016\/j.actbio.2019.05.074_b0020","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jtcvs.2010.05.039","article-title":"Complete mapping of the tricuspid valve apparatus using three-dimensional sonomicrometry","volume":"141","author":"Fawzy","year":"2011","journal-title":"J. Thoracic Cardiovasc. Surg."},{"key":"10.1016\/j.actbio.2019.05.074_b0025","series-title":"Biomechanics: Mechanical Properties of Living Tissues","author":"Fung","year":"2013"},{"issue":"3","key":"10.1016\/j.actbio.2019.05.074_b0030","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.jtcvs.2003.11.019","article-title":"Tricuspid valve repair: durability and risk factors for failure","volume":"127","author":"McCarthy","year":"2004","journal-title":"J. Thoracic Cardiovasc. Surg."},{"issue":"5","key":"10.1016\/j.actbio.2019.05.074_b0035","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jtcvs.2011.07.004","article-title":"Tricuspid valve surgery: the past 10 years from the nationwide inpatient sample (nis) database","volume":"143","author":"Vassileva","year":"2012","journal-title":"J. Thoracic Cardiovasc. Surg."},{"issue":"5","key":"10.1016\/j.actbio.2019.05.074_b0040","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.athoracsur.2013.06.031","article-title":"Trends and outcomes of tricuspid valve surgery in north america: an analysis of more than 50,000 patients from the society of thoracic surgeons database","volume":"96","author":"Kilic","year":"2013","journal-title":"Ann. Thoracic Surg."},{"issue":"6","key":"10.1016\/j.actbio.2019.05.074_b0045","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0002-9149(98)01064-9","article-title":"Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the framingham heart study)","volume":"83","author":"Singh","year":"1999","journal-title":"Am. J. Cardiol."},{"issue":"6","key":"10.1016\/j.actbio.2019.05.074_b0050","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.jtcvs.2006.08.049","article-title":"Emerging opportunities for cardiac surgeons within structural heart disease","volume":"132","author":"Stuge","year":"2006","journal-title":"J. Thoracic Cardiovasc. Surg."},{"issue":"1","key":"10.1016\/j.actbio.2019.05.074_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2008.09.013","article-title":"Extracellular matrix as a biological scaffold material: structure and function","volume":"5","author":"Badylak","year":"2009","journal-title":"Acta Biomater."},{"issue":"6","key":"10.1016\/j.actbio.2019.05.074_b0060","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s11936-010-0098-1","article-title":"Evolving indications for tricuspid valve surgery","volume":"12","author":"McCarthy","year":"2010","journal-title":"Curr. Treatment Options Cardiovasc. Med."},{"issue":"2","key":"10.1016\/j.actbio.2019.05.074_b0065","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4103\/1995-7645.225027","article-title":"Clinical efficacy of two different tricuspid annuloplasty techniques in left cardiac valve surgery","volume":"11","author":"Ge","year":"2018","journal-title":"Asian Pacific J. Trop. Med."},{"issue":"7","key":"10.1016\/j.actbio.2019.05.074_b0070","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s10439-012-0524-5","article-title":"On the in vivo deformation of the mitral valve anterior leaflet: effects of annular geometry and referential configuration","volume":"40","author":"Amini","year":"2012","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.actbio.2019.05.074_b0075","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201610042","article-title":"Mechanosensing by the nucleus: from pathways to scaling relationships","author":"Cho","year":"2017","journal-title":"J. Cell Biol."},{"issue":"10","key":"10.1016\/j.actbio.2019.05.074_b0080","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.medengphy.2010.08.013","article-title":"Finite element modelling of the tricuspid valve: a preliminary study","volume":"32","author":"Stevanella","year":"2010","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.actbio.2019.05.074_b0085","first-page":"1","article-title":"Finite element analysis of tricuspid valve deformation from multi-slice computed tomography images","author":"Kong","year":"2018","journal-title":"Ann. Biomed. Eng."},{"issue":"8","key":"10.1016\/j.actbio.2019.05.074_b0090","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.jacc.2011.09.069","article-title":"The growing clinical importance of secondary tricuspid regurgitation","volume":"59","author":"Taramasso","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.actbio.2019.05.074_b0095","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0021-9290(77)90053-7","article-title":"Stress analysis of aortic valve leaflets with smoothed geometrical data","volume":"10","author":"Cataloglu","year":"1977","journal-title":"J. Biomech."},{"issue":"5","key":"10.1016\/j.actbio.2019.05.074_b0100","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0013-7944(85)90107-9","article-title":"Large-deformation analysis of aortic valve leaflets during diastole","volume":"22","author":"Hamid","year":"1985","journal-title":"Eng. Fract. Mech."},{"issue":"9","key":"10.1016\/j.actbio.2019.05.074_b0105","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/0021-9290(91)90304-6","article-title":"A three-dimensional analysis of a bioprosthetic heart valve","volume":"24","author":"Black","year":"1991","journal-title":"J. Biomech."},{"issue":"7","key":"10.1016\/j.actbio.2019.05.074_b0110","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.jbiomech.2008.02.026","article-title":"Structural simulations of prosthetic tri-leaflet aortic heart valves","volume":"41","author":"Haj-Ali","year":"2008","journal-title":"J. Biomech."},{"issue":"9","key":"10.1016\/j.actbio.2019.05.074_b0115","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1114\/1.1603749","article-title":"Finite element model of mechanically induced collagen fiber synthesis and degradation in the aortic valve","volume":"31","author":"Boerboom","year":"2003","journal-title":"Ann. Biomed. Eng."},{"issue":"6","key":"10.1016\/j.actbio.2019.05.074_b0120","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/030919099294050","article-title":"Influence of anisotropy on the mechanical behaviour of bioprosthetic heart valves","volume":"23","author":"Burriesci","year":"1999","journal-title":"J. Med. Eng. Technol."},{"issue":"9","key":"10.1016\/j.actbio.2019.05.074_b0125","doi-asserted-by":"crossref","DOI":"10.1115\/1.4040126","article-title":"Quantification of material constants for a phenomenological constitutive model of porcine tricuspid valve leaflets for simulation applications","volume":"140","author":"Khoiy","year":"2018","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2019.05.074_b0130","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jmbbm.2017.11.017","article-title":"Anisotropic and nonlinear biaxial mechanical response of porcine small bowel mesentery","volume":"78","author":"Khoiy","year":"2018","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"7","key":"10.1016\/j.actbio.2019.05.074_b0135","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.jbiomech.2004.07.007","article-title":"Functional analysis of bioprosthetic heart valves","volume":"38","author":"Arcidiacono","year":"2005","journal-title":"J. Biomech."},{"issue":"5","key":"10.1016\/j.actbio.2019.05.074_b0140","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1115\/1.2244578","article-title":"Dynamic simulation pericardial bioprosthetic heart valve function","volume":"128","author":"Kim","year":"2006","journal-title":"J. Biomech. Eng."},{"issue":"1","key":"10.1016\/j.actbio.2019.05.074_b0145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jmbbm.2010.09.009","article-title":"Application of finite element analysis to the design of tissue leaflets for a percutaneous aortic valve","volume":"4","author":"Smuts","year":"2011","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"4","key":"10.1016\/j.actbio.2019.05.074_b0150","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1114\/1.122","article-title":"Stress variations in the human aortic root and valve: the role of anatomic asymmetry","volume":"26","author":"Grande","year":"1998","journal-title":"Ann. Biomed. Eng."},{"issue":"3","key":"10.1016\/j.actbio.2019.05.074_b0155","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1115\/1.1894373","article-title":"A structural constitutive model for collagenous cardiovascular tissues incorporating the angular fiber distribution","volume":"127","author":"Driessen","year":"2005","journal-title":"J. Biomech. Eng."},{"issue":"1","key":"10.1016\/j.actbio.2019.05.074_b0160","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s10439-006-9203-8","article-title":"An experimentally derived stress resultant shell model for heart valve dynamic simulations","volume":"35","author":"Kim","year":"2007","journal-title":"Ann. Biomed. Eng."},{"issue":"2","key":"10.1016\/j.actbio.2019.05.074_b0165","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s10439-007-9409-4","article-title":"Dynamic simulation of bioprosthetic heart valves using a stress resultant shell model","volume":"36","author":"Kim","year":"2008","journal-title":"Ann. Biomed. Eng."},{"issue":"8","key":"10.1016\/j.actbio.2019.05.074_b0170","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1007\/s10439-010-0009-3","article-title":"Simulated thin pericardial bioprosthetic valve leaflet deformation under static pressure-only loading conditions: implications for percutaneous valves","volume":"38","author":"Li","year":"2010","journal-title":"Ann. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.actbio.2019.05.074_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0021-9290(83)90041-6","article-title":"Constitutive equations for fibrous connective tissues","volume":"16","author":"Lanir","year":"1983","journal-title":"J. Biomech."},{"issue":"1\u20133","key":"10.1016\/j.actbio.2019.05.074_b0180","first-page":"1","article-title":"A new constitutive framework for arterial wall mechanics and a comparative study of material models","volume":"61","author":"Holzapfel","year":"2000","journal-title":"J. Elasticity Phys. Sci. Solids"},{"issue":"4","key":"10.1016\/j.actbio.2019.05.074_b0185","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/S0003-4975(01)03588-3","article-title":"Dynamic analysis of the aortic valve using a finite element model","volume":"73","author":"Gnyaneshwar","year":"2002","journal-title":"Ann. Thoracic Surg."},{"issue":"2\u20133","key":"10.1016\/j.actbio.2019.05.074_b0190","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s10237-005-0075-x","article-title":"Finite element implementation of a generalized fung-elastic constitutive model for planar soft tissues","volume":"4","author":"Sun","year":"2005","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"8","key":"10.1016\/j.actbio.2019.05.074_b0195","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.jbiomech.2005.04.020","article-title":"A large-strain finite element formulation for biological tissues with application to mitral valve leaflet tissue mechanics","volume":"39","author":"Weinberg","year":"2006","journal-title":"J. Biomech."},{"issue":"6","key":"10.1016\/j.actbio.2019.05.074_b0200","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jbiomech.2005.02.021","article-title":"Multiscale modelling in biofluidynamics: application to reconstructive paediatric cardiac surgery","volume":"39","author":"Migliavacca","year":"2006","journal-title":"J. Biomech."},{"issue":"1","key":"10.1016\/j.actbio.2019.05.074_b0205","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.medengphy.2012.03.006","article-title":"The important roles of tissue anisotropy and tissue-to-tissue contact on the dynamical behavior of a symmetric tri-leaflet valve during multiple cardiac pressure cycles","volume":"35","author":"Saleeb","year":"2013","journal-title":"Med. Eng. Phys."},{"issue":"19","key":"10.1016\/j.actbio.2019.05.074_b0210","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1016\/j.biomaterials.2006.02.024","article-title":"Design and analysis of tissue engineering scaffolds that mimic soft tissue mechanical anisotropy","volume":"27","author":"Courtney","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.05.074_b0215","series-title":"International Conference on Functional Imaging and Modeling of the Heart","first-page":"416","article-title":"A high-fidelity and micro-anatomically accurate 3d finite element model for simulations of functional mitral valve","author":"Lee","year":"2013"},{"issue":"2","key":"10.1016\/j.actbio.2019.05.074_b0220","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1115\/1.2165699","article-title":"Affine versus non-affine fibril kinematics in collagen networks: theoretical studies of network behavior","volume":"128","author":"Chandran","year":"2006","journal-title":"J. Biomech. Eng."},{"issue":"3","key":"10.1016\/j.actbio.2019.05.074_b0225","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0021-9290(00)00183-4","article-title":"Affine versus non-affine deformation in soft biological tissues, measured by the reorientation and stretching of collagen fibres through the thickness of compressed porcine skin","volume":"34","author":"Hepworth","year":"2001","journal-title":"J. Biomech."},{"issue":"4","key":"10.1016\/j.actbio.2019.05.074_b0230","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1115\/1.2746387","article-title":"Multiscale, structure-based modeling for the elastic mechanical behavior of arterial walls","volume":"129","author":"Stylianopoulos","year":"2007","journal-title":"J. Biomech. Eng."},{"issue":"2","key":"10.1016\/j.actbio.2019.05.074_b0235","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1115\/1.2472369","article-title":"Deterministic material-based averaging theory model of collagen gel micromechanics","volume":"129","author":"Chandran","year":"2007","journal-title":"J. Biomech. Eng."},{"issue":"2","key":"10.1016\/j.actbio.2019.05.074_b0240","doi-asserted-by":"crossref","first-page":"H276","DOI":"10.1152\/ajpheart.00164.2015","article-title":"Load-dependent extracellular matrix organization in atrioventricular heart valves: differences and similarities","volume":"309","author":"Alavi","year":"2015","journal-title":"Am. J. Physiol.-Heart Circulatory Physiol."},{"issue":"4","key":"10.1016\/j.actbio.2019.05.074_b0245","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.athoracsur.2008.12.049","article-title":"Functional collagen fiber architecture of the pulmonary heart valve cusp","volume":"87","author":"Joyce","year":"2009","journal-title":"Ann. Thoracic Surg."},{"key":"10.1016\/j.actbio.2019.05.074_b0250","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.actbio.2017.11.040","article-title":"Pressure-induced microstructural changes in porcine tricuspid valve leaflets","volume":"67","author":"Pant","year":"2018","journal-title":"Acta Biomater."},{"issue":"10","key":"10.1016\/j.actbio.2019.05.074_b0255","article-title":"On the biaxial mechanical response of porcine tricuspid valve leaflets","volume":"138","author":"Khoiy","year":"2016","journal-title":"J. Biomech. Eng."},{"issue":"4","key":"10.1016\/j.actbio.2019.05.074_b0260","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/BF02684845","article-title":"A small angle light scattering device for planar connective tissue microstructural analysis","volume":"25","author":"Sacks","year":"1997","journal-title":"Ann. Biomed. Eng."},{"issue":"8","key":"10.1016\/j.actbio.2019.05.074_b0265","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1122\/1.549945","article-title":"The use of tensors to describe and predict fiber orientation in short fiber composites","volume":"31","author":"Advani","year":"1987","journal-title":"J. Rheol."},{"issue":"2","key":"10.1016\/j.actbio.2019.05.074_b0270","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/jbm.a.31847","article-title":"Comparison of 2D fiber network orientation measurement methods","volume":"88","author":"Sander","year":"2009","journal-title":"J. Biomed. Mater. Res. Part A"},{"issue":"3","key":"10.1016\/j.actbio.2019.05.074_b0275","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1109\/MEMB.2009.932486","article-title":"Image-based biomechanics of collagen-based tissue equivalents","volume":"28","author":"Sander","year":"2009","journal-title":"IEEE Eng. Med. Biol. Mag."},{"key":"10.1016\/j.actbio.2019.05.074_b0280","first-page":"1","article-title":"Multiscale model of fatigue of collagen gels","author":"Dhume","year":"2018","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"31\u201332","key":"10.1016\/j.actbio.2019.05.074_b0285","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1016\/j.cma.2006.06.019","article-title":"Volume-averaging theory for the study of the mechanics of collagen networks","volume":"196","author":"Stylianopoulos","year":"2007","journal-title":"Comput. Methods Appl. Mech. Eng."},{"issue":"9","key":"10.1016\/j.actbio.2019.05.074_b0290","doi-asserted-by":"crossref","DOI":"10.1115\/1.4007097","article-title":"Multiscale model predicts tissue-level failure from collagen fiber-level damage","volume":"134","author":"Hadi","year":"2012","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2019.05.074_b0295","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jbiomech.2018.04.012","article-title":"An anisotropic constitutive model for immersogeometric fluid\u2013structure interaction analysis of bioprosthetic heart valves","volume":"74","author":"Wu","year":"2018","journal-title":"J. Biomech."},{"issue":"1","key":"10.1016\/j.actbio.2019.05.074_b0300","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10237-017-0943-1","article-title":"An integrated inverse model-experimental approach to determine soft tissue three-dimensional constitutive parameters: application to post-infarcted myocardium","volume":"17","author":"Avazmohammadi","year":"2018","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"2","key":"10.1016\/j.actbio.2019.05.074_b0305","doi-asserted-by":"crossref","DOI":"10.1002\/cnm.2921","article-title":"A comprehensive pipeline for multi-resolution modeling of the mitral valve: validation, computational efficiency, and predictive capability","volume":"34","author":"Drach","year":"2018","journal-title":"Int. J. Numer. Methods Biomed. Eng."},{"key":"10.1016\/j.actbio.2019.05.074_b0310","series-title":"Micromechanics: overall properties of heterogeneous materials","volume":"37","author":"Nemat-Nasser","year":"2013"},{"issue":"4","key":"10.1016\/j.actbio.2019.05.074_b0315","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1115\/1.1287158","article-title":"Biaxial mechanical properties of the native and glutaraldehyde-treated aortic valve cusp: Part II: a structural constitutive model","volume":"122","author":"Billiar","year":"2000","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2019.05.074_b0320","series-title":"Nonlinear Continuum Mechanics for Finite Element Analysis","author":"Bonet","year":"1997"},{"issue":"2","key":"10.1016\/j.actbio.2019.05.074_b0325","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/1081286514544258","article-title":"On compressible versions of the incompressible neo-Hookean material","volume":"20","author":"Pence","year":"2015","journal-title":"Math. Mech. Solids"},{"issue":"2","key":"10.1016\/j.actbio.2019.05.074_b0335","doi-asserted-by":"crossref","DOI":"10.1115\/1.4026443","article-title":"Prefailure and failure mechanics of the porcine ascending thoracic aorta: experiments and a multiscale model","volume":"136","author":"Shah","year":"2014","journal-title":"J. Biomech. Eng."},{"issue":"4","key":"10.1016\/j.actbio.2019.05.074_b0340","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1167\/iovs.12-10748","article-title":"Contribution of different anatomical and physiologic factors to iris contour and anterior chamber angle changes during pupil dilation: theoretical analysis","volume":"54","author":"Jouzdani","year":"2013","journal-title":"Invest. Ophthalmol. Visual Sci."},{"issue":"3","key":"10.1016\/j.actbio.2019.05.074_b0345","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1167\/iovs.11-8408","article-title":"The posterior location of the dilator muscle induces anterior iris bowing during dilation, even in the absence of pupillary block","volume":"53","author":"Amini","year":"2012","journal-title":"Invest. Ophthalmol. Visual Sci."},{"issue":"3","key":"10.1016\/j.actbio.2019.05.074_b0350","first-page":"100","article-title":"An imaged-based inverse finite element method to determine in-vivo mechanical properties of the human trabecular meshwork","volume":"1","author":"Pant","year":"2017","journal-title":"J. Model. Ophthalmol."},{"issue":"4","key":"10.1016\/j.actbio.2019.05.074_b0355","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1115\/1.3171862","article-title":"The Poisson function of finite elasticity","volume":"53","author":"Beatty","year":"1986","journal-title":"J. Appl. Mech."},{"issue":"5","key":"10.1016\/j.actbio.2019.05.074_b0360","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1177\/1081286506064719","article-title":"The incremental bulk modulus, Young\u2019s modulus and Poisson\u2019s ratio in nonlinear isotropic elasticity: physically reasonable response","volume":"12","author":"Scott","year":"2007","journal-title":"Math. Mech. Solids"},{"issue":"9","key":"10.1016\/j.actbio.2019.05.074_b0365","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004370","article-title":"Multiscale mechanical model of the pacinian corpuscle shows depth and anisotropy contribute to the receptor\u2019s characteristic response to indentation","volume":"11","author":"Quindlen","year":"2015","journal-title":"PLoS Comput. Biol."},{"issue":"4","key":"10.1016\/j.actbio.2019.05.074_b0370","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jmbbm.2008.01.003","article-title":"Computational predictions of the tensile properties of electrospun fibre meshes: effect of fibre diameter and fibre orientation","volume":"1","author":"Stylianopoulos","year":"2008","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2019.05.074_b0375","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.biomaterials.2017.10.011","article-title":"Heart valve scaffold fabrication: bioinspired control of macro-scale morphology, mechanics and micro-structure","volume":"150","author":"D\u2019Amore","year":"2018","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.actbio.2019.05.074_b0380","doi-asserted-by":"crossref","first-page":"H1565","DOI":"10.1152\/ajpheart.00816.2014","article-title":"Pregnancy-induced remodeling of heart valves","volume":"309","author":"Pierlot","year":"2015","journal-title":"Am. J. Physiol.-Heart Circulatory Physiol."},{"key":"10.1016\/j.actbio.2019.05.074_b0385","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jbiomech.2017.01.039","article-title":"A functionally graded material model for the transmural stress distribution of the aortic valve leaflet","volume":"54","author":"Rego","year":"2017","journal-title":"J. Biomech."},{"key":"10.1016\/j.actbio.2019.05.074_b0390","unstructured":"O.S. Center, Ohio supercomputer center, URL:http:\/\/osc.edu\/ark:\/19495\/f5s1ph73, 1987."},{"key":"10.1016\/j.actbio.2019.05.074_b0395","volume":"vol. 4","author":"Neter","year":"1996"},{"issue":"11","key":"10.1016\/j.actbio.2019.05.074_b0400","article-title":"Surface strains of porcine tricuspid valve septal leaflets measured in ex vivo beating hearts","volume":"138","author":"Khoiy","year":"2016","journal-title":"J. Biomech. Eng."},{"issue":"4","key":"10.1016\/j.actbio.2019.05.074_b0405","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nprot.2012.009","article-title":"Second harmonic generation microscopy for quantitative analysis of collagen fibrillar structure","volume":"7","author":"Chen","year":"2012","journal-title":"Nat. Protoc."},{"issue":"2","key":"10.1016\/j.actbio.2019.05.074_b0410","doi-asserted-by":"crossref","DOI":"10.1115\/1.4023389","article-title":"Regional structural and biomechanical alterations of the ovine main pulmonary artery during postnatal growth","volume":"135","author":"Fata","year":"2013","journal-title":"J. Biomech. Eng."},{"issue":"6","key":"10.1016\/j.actbio.2019.05.074_b0415","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1540-8175.2008.00701.x","article-title":"Traumatic tricuspid papillary muscle and chordae rupture: emerging role of three-dimensional echocardiography","volume":"25","author":"Reddy","year":"2008","journal-title":"Echocardiography"},{"issue":"4","key":"10.1016\/j.actbio.2019.05.074_b0420","first-page":"520","article-title":"De Vega annuloplasty and Carpentier-Edwards ring annuloplasty for secondary tricuspid regurgitation","volume":"10","author":"Matsuyama","year":"2001","journal-title":"J. Heart Valve Disease"},{"issue":"5","key":"10.1016\/j.actbio.2019.05.074_b0425","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.2353\/ajpath.2007.070251","article-title":"The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology","volume":"171","author":"Liu","year":"2007","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.actbio.2019.05.074_b0430","first-page":"875","article-title":"Profile and localization of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in human heart valves","volume":"11","author":"Dreger","year":"2002","journal-title":"J. Heart Valve Disease"},{"issue":"12","key":"10.1016\/j.actbio.2019.05.074_b0435","doi-asserted-by":"crossref","first-page":"9917","DOI":"10.1021\/la100384e","article-title":"Probing collagen\/enzyme mechanochemistry in native tissue with dynamic, enzyme-induced creep","volume":"26","author":"Zareian","year":"2010","journal-title":"Langmuir"},{"issue":"8","key":"10.1016\/j.actbio.2019.05.074_b0440","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012337","article-title":"Mechanical strain stabilizes reconstituted collagen fibrils against enzymatic degradation by mammalian collagenase matrix metalloproteinase 8 (mmp-8)","volume":"5","author":"Flynn","year":"2010","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.actbio.2019.05.074_b0445","article-title":"Material properties of rat middle cerebral arteries at high strain rates","volume":"140","author":"Bell","year":"2018","journal-title":"J. Biomech. Eng."},{"issue":"1","key":"10.1016\/j.actbio.2019.05.074_b0450","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1038\/s41598-018-21786-z","article-title":"Nano-scale mechanisms explain the stiffening and strengthening of ligament tissue with increasing strain rate","volume":"8","author":"Karunaratne","year":"2018","journal-title":"Scientific Rep."},{"issue":"10","key":"10.1016\/j.actbio.2019.05.074_b0455","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.actbio.2019.02.008","article-title":"Rate-dependency of the mechanical behaviour of semilunar heart valves under biaxial deformation","volume":"88","author":"Anssari-Benam","year":"2019","journal-title":"Acta Biomater."},{"issue":"10","key":"10.1016\/j.actbio.2019.05.074_b0460","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s10439-006-9183-8","article-title":"Planar biaxial creep and stress relaxation of the mitral valve anterior leaflet","volume":"34","author":"Grashow","year":"2006","journal-title":"Ann. Biomed. Eng."},{"issue":"2","key":"10.1016\/j.actbio.2019.05.074_b0465","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10439-005-9027-y","article-title":"Biaixal stress\u2013stretch behavior of the mitral valve anterior leaflet at physiologic strain rates","volume":"34","author":"Grashow","year":"2006","journal-title":"Ann. Biomed. Eng."},{"issue":"14 Suppl 1","key":"10.1016\/j.actbio.2019.05.074_b0470","first-page":"S243","article-title":"The effects of mitral regurgitation alone are sufficient for leaflet remodeling","volume":"118","author":"Stephens","year":"2008","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.actbio.2019.05.074_b0475","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/S0735-1097(99)00055-8","article-title":"Range of tricuspid regurgitation velocity at rest and during exercise in normal adult men: implications for the diagnosis of pulmonary hypertension","volume":"33","author":"Bossone","year":"1999","journal-title":"J. Am. Coll. Cardiol."},{"issue":"42","key":"10.1016\/j.actbio.2019.05.074_b0480","doi-asserted-by":"crossref","first-page":"17675","DOI":"10.1073\/pnas.0903716106","article-title":"Image-based multiscale modeling predicts tissue-level and network-level fiber reorganization in stretched cell-compacted collagen gels","volume":"106","author":"Sander","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.actbio.2019.05.074_b0490","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/cvr\/cvr195","article-title":"Mechanical assessment of elastin integrity in fibrillin-1-deficient carotid arteries: implications for Marfan syndrome","volume":"92","author":"Ferruzzi","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.actbio.2019.05.074_b0495","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.actbio.2017.05.042","article-title":"Effects of collagen microstructure and material properties on the deformation of the neural tissues of the lamina cribrosa","volume":"58","author":"Voorhees","year":"2017","journal-title":"Acta Biomater."},{"issue":"7","key":"10.1016\/j.actbio.2019.05.074_b0500","doi-asserted-by":"crossref","DOI":"10.1115\/1.4039679","article-title":"Appropriate objective functions for quantifying iris mechanical properties using inverse finite element modeling","volume":"140","author":"Pant","year":"2018","journal-title":"J. Biomech. Eng."},{"issue":"10","key":"10.1016\/j.actbio.2019.05.074_b0505","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1167\/iovs.18-24327","article-title":"Increased iris stiffness in patients with a history of angle-closure glaucoma: an image-based inverse modeling analysis","volume":"59","author":"Pant","year":"2018","journal-title":"Invest. Ophthalmol. Visual Sci."},{"issue":"12","key":"10.1016\/j.actbio.2019.05.074_b0510","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.jbiomech.2009.05.015","article-title":"On the biomechanics of heart valve function","volume":"42","author":"Sacks","year":"2009","journal-title":"J. Biomech."},{"issue":"6","key":"10.1016\/j.actbio.2019.05.074_b0515","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/jbm.a.34099","article-title":"Biomechanical characterization of aortic valve tissue in humans and common animal models","volume":"100","author":"Martin","year":"2012","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.actbio.2019.05.074_b0520","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.mechmat.2011.07.003","article-title":"Simulated remodeling of loaded collagen networks via strain-dependent enzymatic degradation and constant-rate fiber growth","volume":"44","author":"Hadi","year":"2012","journal-title":"Mech. Mater."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706119304428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706119304428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:01:35Z","timestamp":1778522495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706119304428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":102,"alternative-id":["S1742706119304428"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2019.05.074","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A computational multi-scale approach to investigate mechanically-induced changes in tricuspid valve anterior leaflet microstructure","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2019.05.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}