{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:25:44Z","timestamp":1791840344538,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51573024"],"award-info":[{"award-number":["51573024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800591"],"award-info":[{"award-number":["81800591"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51703078"],"award-info":[{"award-number":["51703078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["17D310612"],"award-info":[{"award-number":["17D310612"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Sailing Program","award":["18YF1412800"],"award-info":[{"award-number":["18YF1412800"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.actbio.2019.11.026","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T19:51:12Z","timestamp":1573761072000},"page":"247-258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"special_numbering":"C","title":["Urethra-inspired biomimetic scaffold: A therapeutic strategy to promote angiogenesis for urethral regeneration in a rabbit model"],"prefix":"10.1016","volume":"102","author":[{"given":"Baoxiu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangguo","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3404-1260","authenticated-orcid":false,"given":"Mujun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4195-3014","authenticated-orcid":false,"given":"Shiyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2019.11.026_bib0001","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1159\/000341138","article-title":"Urethral reconstruction using buccal mucosa or penile skin grafts: systematic review and meta-analysis","volume":"89","author":"Lumen","year":"2012","journal-title":"Urol. Int."},{"key":"10.1016\/j.actbio.2019.11.026_bib0002","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1464-410X.2004.05048.x","article-title":"Oral complications after buccal mucosal graft harvest for urethroplasty","volume":"94","author":"Dublin","year":"2004","journal-title":"BJU Int."},{"key":"10.1016\/j.actbio.2019.11.026_bib0003","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.3390\/ijms20071763","article-title":"From acellular matrices tosmart polymers: degradable scaffolds that are transforming the shape of urethral tissue engineering","volume":"20","author":"Abbas","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2019.11.026_bib0004","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s13770-019-00193-z","article-title":"Overview of urethral reconstruction by tissue engineering: current strategies, clinical status and future direction","volume":"16","author":"Rashidbenam","year":"2019","journal-title":"Tissue Eng. Regen. Med."},{"key":"10.1016\/j.actbio.2019.11.026_bib0005","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1442-2042.2012.03230.x","article-title":"Outcome of small intestinal submucosa graft for repair of anterior urethral strictures","volume":"20","author":"Xu","year":"2013","journal-title":"Int. J. Urol."},{"key":"10.1016\/j.actbio.2019.11.026_bib0006","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1016\/j.transproceed.2013.07.055","article-title":"Urethral reconstruction using bone marrow mesenchymal stem cell- and smooth muscle cell-seeded bladder acellular matrix","volume":"45","author":"Li","year":"2013","journal-title":"Transpl. Proc."},{"key":"10.1016\/j.actbio.2019.11.026_bib0007","doi-asserted-by":"crossref","first-page":"e91592","DOI":"10.1371\/journal.pone.0091592","article-title":"Acellular bi-Layer silk fibroin scaffolds support tissue regeneration in a rabbit model of onlay urethroplasty","volume":"9","author":"Chung","year":"2014","journal-title":"Plos One"},{"key":"10.1016\/j.actbio.2019.11.026_bib0008","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.addr.2014.11.019","article-title":"Acellular matrix in urethral reconstruction","volume":"82-83","author":"Ribeiro-Filho","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2019.11.026_bib0009","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.biomaterials.2015.03.053","article-title":"Vascularization of hollow channel-modified porous silk scaffolds with endothelial cells for tissue regeneration","volume":"56","author":"Zhang","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.11.026_bib0010","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.actbio.2016.06.001","article-title":"Vascularization of three-dimensional engineered tissues for regenerative medicine applications","volume":"41","author":"Kim","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2019.11.026_bib0011","article-title":"Prevascularized bladder acellular matrix hydrogel\/silk fibroin composite scaffolds promote the regeneration of urethra in a rabbit model","volume":"14","author":"Cao","year":"2019","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.actbio.2019.11.026_bib0012","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.tibtech.2008.04.009","article-title":"Vascularization in tissue engineering","volume":"26","author":"Rouwkema","year":"2008","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.actbio.2019.11.026_bib0013","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1007\/s10570-017-1472-x","article-title":"Bacterial cellulose\/gelatin scaffold loaded with VEGF-silk fibroin nanoparticles for improving angiogenesis in tissue regeneration","volume":"24","author":"Wang","year":"2017","journal-title":"Cellulose"},{"key":"10.1016\/j.actbio.2019.11.026_bib0014","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1002\/jbm.a.36496","article-title":"A sulfonated reversible thermal gel for the spatiotemporal control of VEGF delivery to promote therapeutic angiogenesis","volume":"106","author":"Lee","year":"2018","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2019.11.026_bib0015","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1054-8807(03)00089-9","article-title":"Biopolymeric delivery matrices for angiogenic growth factors","volume":"12","author":"Zisch","year":"2003","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.actbio.2019.11.026_bib0016","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/S0022-5347(05)65125-7","article-title":"Regional differences in the extracellular matrix of the human spongy urethra as evidenced by the composition of glycosaminoglycans","volume":"167","author":"da Silva","year":"2002","journal-title":"J. Urol."},{"key":"10.1016\/j.actbio.2019.11.026_bib0017","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1016\/j.actbio.2010.04.023","article-title":"Improving bacterial cellulose for blood vessel replacement: functionalization with a chimeric protein containing a cellulose-binding module and an adhesion peptide","volume":"6","author":"Andrade","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2019.11.026_bib0018","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1016\/j.actbio.2010.01.004","article-title":"Microporous bacterial cellulose as a potential scaffold for bone regeneration","volume":"6","author":"Zaborowska","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2019.11.026_bib0019","doi-asserted-by":"crossref","first-page":"42229","DOI":"10.1039\/C6RA07685H","article-title":"Improved cell infiltration and vascularization of three-dimensional bacterial cellulose nanofibrous scaffolds by template biosynthesis","volume":"6","author":"Li","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.actbio.2019.11.026_bib0020","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1016\/j.biomaterials.2006.02.014","article-title":"Decellularization of tissues and organs","volume":"27","author":"Gilbert","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.11.026_bib0021","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.urology.2014.07.044","article-title":"Reconstruction of penile urethra with the 3-dimensional porous bladder acellular matrix in a rabbit model","volume":"84","author":"Huang","year":"2014","journal-title":"Urology"},{"key":"10.1016\/j.actbio.2019.11.026_bib0022","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/jbm.a.32729","article-title":"Evaluation of the biocompatibility and mechanical properties of naturally derived and synthetic scaffolds for urethral reconstruction","volume":"94A","author":"Feng","year":"2010","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2019.11.026_bib0023","doi-asserted-by":"crossref","first-page":"20330","DOI":"10.1021\/acsami.6b14650","article-title":"Macrofibers with high mechanical performance based on aligned bacterial cellulose nanofibers","volume":"9","author":"Yao","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2019.11.026_bib0024","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.biomaterials.2007.12.014","article-title":"Preparation and rheological characterization of a gel form of the porcine urinary bladder matrix","volume":"29","author":"Freytes","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.11.026_bib0025","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0142-9612(99)00222-7","article-title":"Development of tailor-made collagen-glycosaminoglycan matrices: EDC\/NHS crosslinking, and ultrastructural aspects","volume":"21","author":"Pieper","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.11.026_bib0026","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.biomaterials.2013.10.005","article-title":"Vascularization and bone regeneration in a critical sized defect using 2-N, 6-O-sulfated chitosan nanoparticles incorporating BMP-2","volume":"35","author":"Cao","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.11.026_bib0027","doi-asserted-by":"crossref","first-page":"14357","DOI":"10.1021\/acsami.6b01870","article-title":"Improved endothelial function of endothelial cell monolayer on the soft polyelectrolyte multilayer film with matrix-bound vascular endothelial growth factor","volume":"8","author":"Chang","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2019.11.026_bib0028","doi-asserted-by":"crossref","first-page":"9982","DOI":"10.1021\/acsami.5b02324","article-title":"Enhancement of VEGF-mediated angiogenesis by 2-N, 6-O-sulfated chitosan-coated hierarchical PLGA scaffolds","volume":"7","author":"Yu","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2019.11.026_bib0029","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1089\/ten.tec.2009.0311","article-title":"Development of a porcine bladder acellular matrix with well-preserved extracellular bioactive factors for tissue engineering","volume":"16","author":"Yang","year":"2010","journal-title":"Tsssue Eng. Part C"},{"key":"10.1016\/j.actbio.2019.11.026_bib0030","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1016\/j.biomaterials.2007.05.020","article-title":"Identification and characterization of bioactive factors in bladder submucosa matrix","volume":"28","author":"Chun","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.11.026_bib0031","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.trim.2003.12.016","article-title":"Xenogeneic extracellular matrix as a scaffold for tissue reconstruction","volume":"12","author":"Badylak","year":"2004","journal-title":"Transpl. Immunol."},{"key":"10.1016\/j.actbio.2019.11.026_bib0032","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1002\/adfm.200305197","article-title":"High mechanical strength double-network hydrogel with bacterial cellulose","volume":"14","author":"Nakayama","year":"2004","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2019.11.026_bib0033","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1136\/bjophthalmol-2011-300638","article-title":"Validation of a semi-automated computer-aided technique for quantifying corneal vascularisation and scarring","volume":"95","author":"Tatham","year":"2011","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.actbio.2019.11.026_bib0034","article-title":"The effect of pore size on tissue ingrowth and neovascularization in porous bioceramics of controlled architecture in vivo","volume":"6","author":"Bai","year":"2011","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.actbio.2019.11.026_bib0035","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1021\/acsbiomaterials.5b00259","article-title":"Bacterial cellulose-based biomimetic nanofibrous scaffold with muscle cells for hollow organ tissue engineering","volume":"2","author":"Lv","year":"2016","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.actbio.2019.11.026_bib0036","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0945-053X(96)90133-X","article-title":"Structure and function of fibronectin modules","volume":"15","author":"Potts","year":"1996","journal-title":"Matrix Biol."},{"key":"10.1016\/j.actbio.2019.11.026_bib0037","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.msec.2017.03.222","article-title":"Characterization of bladder acellular matrix hydrogel with inherent bioactive factors","volume":"77","author":"Jiang","year":"2017","journal-title":"Mat. Sci. Eng. C Mater."},{"key":"10.1016\/j.actbio.2019.11.026_bib0038","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.actbio.2015.10.013","article-title":"Preparation and characterization of pro-angiogenic gel derived from small intestinal submucosa","volume":"29","author":"Wang","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2019.11.026_bib0039","doi-asserted-by":"crossref","first-page":"C1181","DOI":"10.1152\/ajpcell.00524.2001","article-title":"Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration","volume":"282","author":"Cao","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.actbio.2019.11.026_bib0040","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/jbm.a.30570","article-title":"In vivo biocompatibility of bacterial cellulose","volume":"76A","author":"Helenius","year":"2006","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2019.11.026_bib0041","doi-asserted-by":"crossref","first-page":"8889","DOI":"10.1016\/j.biomaterials.2010.07.108","article-title":"Tissue-engineered conduit using urine-derived stem cells seeded bacterial cellulose polymer in urinary reconstruction and diversion","volume":"31","author":"Bodin","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2019.11.026_bib0042","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1464-410X.1977.tb04093.x","article-title":"The use of fine double siliconised dacron in urethral replacement","volume":"49","author":"Hakky","year":"1977","journal-title":"J. Urol."},{"key":"10.1016\/j.actbio.2019.11.026_bib0043","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0090-4295(84)90107-9","article-title":"Replacement of partially resected canine urethra by polytetrafluoroethylene","volume":"24","author":"Anwar","year":"1984","journal-title":"Urology"},{"key":"10.1016\/j.actbio.2019.11.026_bib0044","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/74651","article-title":"Mechanisms of angiogenesis and arteriogenesis","volume":"6","author":"Carmeliet","year":"2000","journal-title":"Nat. Med."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706119307767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706119307767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:21:11Z","timestamp":1761672071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706119307767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":44,"alternative-id":["S1742706119307767"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2019.11.026","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urethra-inspired biomimetic scaffold: A therapeutic strategy to promote angiogenesis for urethral regeneration in a rabbit model","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2019.11.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}