{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T01:43:02Z","timestamp":1787276582804,"version":"build-2736575974"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.actbio.2020.01.040","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T03:08:45Z","timestamp":1580958525000},"page":"15-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["The dual character of exosomes in osteoarthritis: Antagonists and therapeutic agents"],"prefix":"10.1016","volume":"105","author":[{"given":"Quan-fa","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-zhi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-jin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2020.01.040_bib0001","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41413-018-0039-2","article-title":"Exosomes-the enigmatic regulators of bone homeostasis","volume":"6","author":"Gao","year":"2018","journal-title":"Bone Res."},{"issue":"5","key":"10.1016\/j.actbio.2020.01.040_bib0002","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1159\/000491469","article-title":"Emerging role of exosomes in the joint diseases","volume":"47","author":"Li","year":"2018","journal-title":"Cell Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0003","first-page":"49","article-title":"Osteoarthritis: diagnosis and treatment","volume":"85","author":"Sinusas","year":"2012","journal-title":"Am. Fam. Physician."},{"issue":"3","key":"10.1016\/j.actbio.2020.01.040_bib0004","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nbt.2816","article-title":"Mesenchymal stem cells: immune evasive, not immune privileged","volume":"32","author":"Ankrum","year":"2014","journal-title":"Nat. Biotechnol"},{"issue":"10-11-12","key":"10.1016\/j.actbio.2020.01.040_bib0005","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1387\/ijdb.160274id","article-title":"Teratomas produced from human pluripotent stem cells xenografted into immunodeficient mice - a histopathology atlas","volume":"60","author":"Damjanov","year":"2016","journal-title":"Int. J. Dev. Biol."},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0006","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13287-017-0540-3","article-title":"The neuroprotective effects of human bone marrow mesenchymal stem cells are dose-dependent in TNBS colitis","volume":"8","author":"Robinson","year":"2017","journal-title":"Stem. Cell Res. Ther."},{"key":"10.1016\/j.actbio.2020.01.040_bib0007","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v2i0.22614","article-title":"Therapeutic MSC exosomes are derived from lipid raft microdomains in the plasma membrane","volume":"2","author":"Tan","year":"2013","journal-title":"J. Extracell Vesicles"},{"issue":"3","key":"10.1016\/j.actbio.2020.01.040_bib0008","doi-asserted-by":"crossref","first-page":"293","DOI":"10.15171\/apb.2016.041","article-title":"Mesenchymal stem cell-derived exosomes: new opportunity in cell-free therapy","volume":"6","author":"Pashoutan Sarvar","year":"2016","journal-title":"Adv. Pharm. Bull."},{"issue":"Suppl 1","key":"10.1016\/j.actbio.2020.01.040_bib0009","first-page":"A86","article-title":"CD39 and CD73 transgenic exosomes and recombinant fusion protein as novel therapeutics for the treatment of inflammatory disease","volume":"74","author":"Finn","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.actbio.2020.01.040_bib0010","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.copbio.2019.01.005","article-title":"Extracellular vesicles: exosomes, microparticles, their parts, and their targets to enable their biomanufacturing and clinical applications","volume":"60","author":"Kao","year":"2019","journal-title":"Curr. Opin. Biotechnol."},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0011","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cellcommunication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat. Cell. Biol."},{"issue":"141","key":"10.1016\/j.actbio.2020.01.040_bib0012","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1126\/stke.2002.141.pe32","article-title":"Multivesicular bodies and multivesicular endosomes: the \"ins and outs\" of endosomal traffic","volume":"2002","author":"Stahl","year":"2002","journal-title":"Sci. STKE"},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbadis.2014.10.008","article-title":"Pathologic function and therapeutic potential of exosomes in cardiovascular disease","volume":"1852","author":"Ailawadi","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.actbio.2020.01.040_bib0014","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri855","article-title":"Exosomes: composition, biogenesis and function","volume":"2","author":"Th\u00e9ry","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.actbio.2020.01.040_bib0015","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"issue":"3","key":"10.1016\/j.actbio.2020.01.040_bib0016","article-title":"Exosome release is regulated by mTORC1","volume":"6","author":"Zou","year":"2018","journal-title":"Adv. Sci. (Weinh)"},{"issue":"8","key":"10.1016\/j.actbio.2020.01.040_bib0017","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2567","article-title":"Membrane vesicles as conveyors of immune responses","volume":"9","author":"Th\u00e9ry","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.actbio.2020.01.040_bib0018","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/ard.52.12.870","article-title":"Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis","volume":"52","author":"Farahat","year":"1993","journal-title":"Ann. Rheum. Dis."},{"issue":"12","key":"10.1016\/j.actbio.2020.01.040_bib0019","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1002\/art.25002","article-title":"Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development","volume":"60","author":"Little","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0020","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1038\/s41598-017-01905-y","article-title":"Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis","volume":"7","author":"Kolhe","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2020.01.040_bib0021","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4814987","article-title":"Characterization of the proinflammatory profile of synovial fluid-derived exosomes of patients with osteoarthritis","volume":"2017","author":"Domenis","year":"2017","journal-title":"Mediators Inflamm."},{"issue":"Suppl 2","key":"10.1016\/j.actbio.2020.01.040_bib0022","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/annrheumdis-2016-eular.5439","article-title":"A role of synovial exosomes in osteoclast differentiation of inflammatory arthritis","volume":"75","author":"Song","year":"2016","journal-title":"Annals. Rheumatic Dis."},{"issue":"10","key":"10.1016\/j.actbio.2020.01.040_bib0023","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.7150\/thno.23547","article-title":"MicroRNA-193b-3p regulates chondrogenesis and chondrocyte metabolism by targeting HDAC3","volume":"8","author":"Meng","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2020.01.040_bib0024","unstructured":"Withrow J., Murphy C., Duke A., Fulzele S., Hamrick M.Synovial fluid exosomal miRNA profiling of osteoarthritis patients and identification of synoviocyte-chondrocyte communication pathway. In: ORS 2016 Annual Meeting."},{"issue":"6","key":"10.1016\/j.actbio.2020.01.040_bib0025","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.molcel.2012.01.015","article-title":"IL6-mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis","volume":"45","author":"Rokavec","year":"2012","journal-title":"Mol. Cell."},{"key":"10.1016\/j.actbio.2020.01.040_bib0026","series-title":"ORS 2016 Annual Meeting","article-title":"Exosome derived from osteoarthritis cartilage induces catabolic factor gene expressions in synovium","author":"Nakasa","year":"2012"},{"issue":"4","key":"10.1016\/j.actbio.2020.01.040_bib0027","doi-asserted-by":"crossref","first-page":"R163","DOI":"10.1186\/ar4679","article-title":"Exosomes from IL-1\u03b2 stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes","volume":"16","author":"Kato","year":"2014","journal-title":"Arthritis Res. Ther."},{"issue":"4","key":"10.1016\/j.actbio.2020.01.040_bib0028","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.bbagrm.2014.01.006","article-title":"NF-\u03baB target microRNAs and their target genes in TNF\u03b1-stimulated hela cells","volume":"1839","author":"Zhou","year":"2014","journal-title":"Biochim. Biophys. Acta."},{"issue":"12","key":"10.1016\/j.actbio.2020.01.040_bib0029","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.joca.2012.08.024","article-title":"Expression of microRNAs during chondrogenesis of human adipose-derived stem cells","volume":"20","author":"Zhang","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0030","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s13287-018-1004-0","article-title":"Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A","volume":"9","author":"Mao","year":"2018","journal-title":"Stem. Cell. Res. Ther."},{"issue":"5","key":"10.1016\/j.actbio.2020.01.040_bib0031","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.matbio.2013.02.005","article-title":"Dual functions for wnt5a during cartilage development and in disease","volume":"32","author":"Hosseini-Farahabadi","year":"2013","journal-title":"Matrix Biol."},{"issue":"11","key":"10.1016\/j.actbio.2020.01.040_bib0032","doi-asserted-by":"crossref","first-page":"5354","DOI":"10.1111\/jcmm.13808","article-title":"Exosomal miR-95-5p regulates chondrogenesis and cartilage degradation via histone deacetylase 2\/8","volume":"22","author":"Mao","year":"2018","journal-title":"J. Cell. Mol. Med."},{"issue":"4","key":"10.1016\/j.actbio.2020.01.040_bib0033","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.joca.2016.11.006","article-title":"MicroRNA-92a-3p regulates the expression of cartilage-specific genes by directly targeting histone deacetylase 2 in chondrogenesis and degradation","volume":"25","author":"Mao","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"10.1016\/j.actbio.2020.01.040_bib0034","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/s41419-019-1739-2","article-title":"The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1\u03b2 production of macrophages and aggravated synovitis in osteoarthritis","volume":"10","author":"Ni","year":"2019","journal-title":"Cell. Death Dis.."},{"issue":"Suppl 2","key":"10.1016\/j.actbio.2020.01.040_bib0035","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1136\/annrheumdis-2019-eular.4692","article-title":"Speed of senescence and joint inflammation via connexin43-positive exosomes released by osteoarthritic chondrocytes","volume":"78","author":"Varela-Eir\u00edn","year":"2019","journal-title":"Ann. Rheum. Dis."},{"issue":"12","key":"10.1016\/j.actbio.2020.01.040_bib0036","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1007\/s00264-018-4093-6","article-title":"Synovial fluid-derived exosomal lncRNA PCGEM1 as biomarker for the different stages of osteoarthritis","volume":"42","author":"Zhao","year":"2018","journal-title":"Int. Orthop."},{"issue":"3","key":"10.1016\/j.actbio.2020.01.040_bib0037","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/jor.23046","article-title":"PCGEM1 stimulates proliferation of osteoarthritic synoviocytes by acting as a sponge for miR-770","volume":"34","author":"Kang","year":"2016","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2020.01.040_bib0038","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jconrel.2016.01.041","article-title":"The potential of protein-nanomaterial interaction for advanced drug delivery","volume":"225","author":"Peng","year":"2016","journal-title":"J. Control Release"},{"issue":"4","key":"10.1016\/j.actbio.2020.01.040_bib0039","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/leu.2014.41","article-title":"MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease","volume":"28","author":"Kordelas","year":"2014","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0040","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1089\/scd.2012.0116","article-title":"Neonatal desensitization supports long-term survial and functional integration of humanebryonic stem cell-derived mesenchymal stem cells in rat joint cartilage without immunosuppression","volume":"22","author":"Zhang","year":"2013","journal-title":"Stem Cells Dev."},{"issue":"3","key":"10.1016\/j.actbio.2020.01.040_bib0041","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jcyt.2017.11.002","article-title":"MSC-exosome: a novel cell-free therapy for cutaneous regeneration","volume":"20","author":"Wu","year":"2018","journal-title":"Cytotherapy"},{"issue":"3","key":"10.1016\/j.actbio.2020.01.040_bib0042","doi-asserted-by":"crossref","first-page":"733","DOI":"10.7150\/thno.17450","article-title":"Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt\/Bad\/Bcl-2 signal pathway","volume":"7","author":"Tao","year":"2017","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.actbio.2020.01.040_bib0043","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41582-018-0126-4","article-title":"Exosomes - beyond stem cells for restorative therapy in stroke and neurological injury","volume":"15","author":"Zhang","year":"2019","journal-title":"Nat. Rev. Neurol."},{"issue":"12","key":"10.1016\/j.actbio.2020.01.040_bib0044","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.joca.2016.06.022","article-title":"Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration","volume":"24","author":"Zhang","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0045","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13287-017-0632-0","article-title":"Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix","volume":"14","author":"Wang","year":"2017","journal-title":"Stem. Cell. Res. Ther."},{"key":"10.1016\/j.actbio.2020.01.040_bib0046","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biomaterials.2019.02.006","article-title":"MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis","volume":"200","author":"Zhang","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2020.01.040_bib0047","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7197598","article-title":"Extracellular vesicles from adipose-derived mesenchymal stem cells downregulate senescence features in osteoarthritic osteoblasts","volume":"2017","author":"Tofi\u00f1o-Vian","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0048","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000489739","article-title":"Microvesicles from human adipose tissue-derived mesenchymal stem cells as a new protective strategy in osteoarthritic chondrocytes","volume":"47","author":"Tofi\u00f1o-Vian","year":"2018","journal-title":"Cell. Physiol. Biochem"},{"key":"10.1016\/j.actbio.2020.01.040_bib0049","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.biomaterials.2019.03.022","article-title":"miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis","volume":"206","author":"Wu","year":"2019","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0050","doi-asserted-by":"crossref","first-page":"16214","DOI":"10.1038\/s41598-017-15376-8","article-title":"Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis","volume":"7","author":"Cosenza","year":"2017","journal-title":"Sci. Rep."},{"issue":"Suppl 2","key":"10.1016\/j.actbio.2020.01.040_bib0051","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1136\/annrheumdis-2018-eular.6112","article-title":"The effect of exosomes from bone marrow mesenchymal stem cells on osteoarthritis","volume":"77","author":"Zhu","year":"2018","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.actbio.2020.01.040_bib0052","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11626-019-00330-x","article-title":"Exosomes derived from mesenchymal stem cells inhibit mitochondrial dysfunction-induced apoptosis of chondrocytes via p38, ERK, and Akt pathways","volume":"55","author":"Qi","year":"2019","journal-title":"In Vitro Cell Dev Biol Anim."},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0053","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13287-017-0510-9","article-title":"Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stemcells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis","volume":"8","author":"Zhu","year":"2017","journal-title":"Stem. Cell. Res. Ther."},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0054","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s13287-018-1047-2","article-title":"Exosomes derived from mature chondrocytes facilitate subcutaneous stable ectopic chondrogenesis of cartilage progenitor cells","volume":"9","author":"Chen","year":"2018","journal-title":"Stem Cell Res Ther."},{"issue":"22","key":"10.1016\/j.actbio.2020.01.040_bib0055","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1042\/BCJ20180675","article-title":"Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis","volume":"475","author":"Liu","year":"2018","journal-title":"Biochem. J."},{"issue":"86","key":"10.1016\/j.actbio.2020.01.040_bib0056","first-page":"1","article-title":"Exosomes: the next generation of endogenous nanomaterials for advanced drug delivery and therapy","volume":"1","author":"Liao","year":"2019","journal-title":"Acta Biomater."},{"issue":"21\u201322","key":"10.1016\/j.actbio.2020.01.040_bib0057","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1080\/15384101.2018.1526603","article-title":"MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1\/miR-206\/GIT1 axis in osteoarthritis","volume":"17","author":"Liu","year":"2018","journal-title":"Cell. Cycle"},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0058","doi-asserted-by":"crossref","first-page":"180","DOI":"10.7150\/thno.17133","article-title":"Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model","volume":"7","author":"Tao","year":"2017","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0059","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jcb.27289","article-title":"Expression of exosomal microRNAs during chondrogenic differentiation of human bone mesenchymal stem cells","volume":"120","author":"Sun","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"24","key":"10.1016\/j.actbio.2020.01.040_bib0060","doi-asserted-by":"crossref","DOI":"10.1080\/15384101.2018.1556063","article-title":"TGF-\u03b21 promoted chondrocyte proliferation by regulating Sp1 through MSC-exosomes derived miR-135b","volume":"17","author":"Wang","year":"2018","journal-title":"Cell. Cycle"},{"key":"10.1016\/j.actbio.2020.01.040_bib0061","doi-asserted-by":"crossref","first-page":"45622","DOI":"10.1038\/srep45622","article-title":"Extracellular vesicle-functionalized decalcified bone matrix scaffolds with enhanced pro-angiogenic and pro-bone regeneration activities","volume":"7","author":"Xie","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2020.01.040_bib0062","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3389\/fphys.2017.00904","article-title":"GMSC-Derived exosomes combined with a chitosan\/silk hydrogel sponge accelerates wound healing in a diabetic rat skin defect model","volume":"8","author":"Shi","year":"2017","journal-title":"Front Physiol."},{"issue":"3","key":"10.1016\/j.actbio.2020.01.040_bib0063","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nm.2328","article-title":"Why don't we get more cancer? a proposed role of the microenvironment in restraining cancer progression","volume":"17","author":"Bissell","year":"2011","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.actbio.2020.01.040_bib0064","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.ajpath.2017.03.015","article-title":"Differentiation affects the release of exosomes from colon cancer cells and their ability to modulate the behavior of recipient cells","volume":"187","author":"Lucchetti","year":"2017","journal-title":"Am J Pathol"},{"issue":"4","key":"10.1016\/j.actbio.2020.01.040_bib0065","article-title":"3D Cellular architecture affects microrna and protein cargo of extracellular vesicles","volume":"6","author":"Rocha","year":"2018","journal-title":"Adv Sci (Weinh)"},{"issue":"8","key":"10.1016\/j.actbio.2020.01.040_bib0066","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.7150\/thno.13944","article-title":"Recapitulating the size and cargo of tumor exosomes in a tissue-engineered model","volume":"6","author":"Villasante","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2020.01.040_bib0067","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neuint.2016.08.003","article-title":"Systemic administration of cell-free exosomes generated by human bone marrow derived mesenchymal stem cells cultured under 2D and 3D conditions improves functional recovery in rats after traumatic brain injury","volume":"111","author":"Zhang","year":"2017","journal-title":"Neurochem. Int."},{"issue":"4","key":"10.1016\/j.actbio.2020.01.040_bib0068","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s13770-018-0139-5","article-title":"Three-Dimensional spheroid culture increases exosome secretion from mesenchymal stem cells","volume":"15","author":"Kim","year":"2018","journal-title":"Tissue Eng. Regen. Med."},{"key":"10.1016\/j.actbio.2020.01.040_bib0069","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7486279","article-title":"Comparison of immunosuppressive and angiogenic properties of human amnion-derived mesenchymal stem cells between 2D and 3D culture systems","volume":"2019","author":"Miceli","year":"2019","journal-title":"Stem. Cells Int."},{"issue":"12","key":"10.1016\/j.actbio.2020.01.040_bib0070","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1016\/j.ymthe.2018.09.015","article-title":"Exosomes produced from 3D cultures of MSCs by tangential flow filtration show higher yield and improved activity","volume":"26","author":"Haraszti","year":"2018","journal-title":"Mol. Ther."},{"issue":"2","key":"10.1016\/j.actbio.2020.01.040_bib0071","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191109","article-title":"Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment","volume":"13","author":"Eguchi","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.actbio.2020.01.040_bib0072","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.actbio.2018.11.024","article-title":"Enhanced extracellular vesicle production and ethanol-mediated vascularization bioactivity via a 3D-printed scaffold-perfusion bioreactor system","volume":"95","author":"Patel","year":"2019","journal-title":"Acta Biomater"},{"issue":"4","key":"10.1016\/j.actbio.2020.01.040_bib0073","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.nano.2017.01.013","article-title":"Smuggling gold nanoparticles across cell types - A new role for exosomes in gene silencing","volume":"13","author":"Roma-Rodrigues","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.actbio.2020.01.040_bib0074","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jconrel.2018.07.039","article-title":"Sphk2 RNAi nanoparticles suppress tumor growth via downregulating cancer cell derived exosomal microRNA","volume":"286","author":"Liang","year":"2018","journal-title":"J. Control Release."},{"issue":"13","key":"10.1016\/j.actbio.2020.01.040_bib0075","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133301","article-title":"In vitro entero-capillary barrier exhibits altered inflammatory and exosomal communication pattern after exposure to silica nanoparticles","volume":"20","author":"Kasper","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0076","doi-asserted-by":"crossref","first-page":"8278","DOI":"10.1038\/s41598-019-44569-6","article-title":"Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood-brain barrier penetration","volume":"9","author":"Khongkow","year":"2019","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.actbio.2020.01.040_bib0077","article-title":"Exosome-Liposome hybrid nanoparticles deliver CRISPR\/Cas9 system in MSCs","volume":"5","author":"Lin","year":"2018","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.actbio.2020.01.040_bib0078","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.biomaterials.2017.04.030","article-title":"Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer","volume":"133","author":"Du","year":"2017","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.actbio.2020.01.040_bib0079","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/jbm.b.33547","article-title":"Polymeric scaffolds in tissue engineering: a literature review","volume":"105","author":"Jafari","year":"2017","journal-title":"J. Biomed. Mater. Res. B. Appl. Biomater"},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0080","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s13287-016-0391-3","article-title":"Exosomes\/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K\/Akt signaling pathway","volume":"7","author":"Zhang","year":"2016","journal-title":"Stem. Cell Res. Ther."},{"issue":"3","key":"10.1016\/j.actbio.2020.01.040_bib0081","doi-asserted-by":"crossref","first-page":"736","DOI":"10.5966\/sctm.2016-0275","article-title":"Chitosan wound dressings incorporating exosomes derived from microrna-126-overexpressing synovium mesenchymal stem cells provide sustained release of exosomes and heal full-thickness skin defects in a diabetic rat model","volume":"6","author":"Tao","year":"2017","journal-title":"Stem. Cells Transl. Med."},{"issue":"7","key":"10.1016\/j.actbio.2020.01.040_bib0082","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1039\/C9BM00101H","article-title":"Human umbilical cord mesenchymal stem cell derived exosomes encapsulated in functional peptide hydrogels promote cardiac repair","volume":"7","author":"Han","year":"2019","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.actbio.2020.01.040_bib0083","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.msec.2019.01.122","article-title":"Delivery of miR-675 by stem cell-derived exosomes encapsulated in silk fibroin hydrogel prevents aging-induced vascular dysfunction in mouse hindlimb","volume":"99","author":"Han","year":"2019","journal-title":"Mater. Sci. Eng. C. Mater. Biol. Appl."},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0084","doi-asserted-by":"crossref","first-page":"65","DOI":"10.7150\/thno.29766","article-title":"Engineering bioactive self-healing antibacterial exosomes hydrogel for promoting chronic diabetic wound healing and complete skin regeneration","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"issue":"36","key":"10.1016\/j.actbio.2020.01.040_bib0085","doi-asserted-by":"crossref","first-page":"30081","DOI":"10.1021\/acsami.8b08449","article-title":"Enhanced therapeutic effects of mesenchymal stem cell-derived exosomes with an injectable hydrogel for hindlimb ischemia treatment","volume":"10","author":"Zhang","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2020.01.040_bib0086","doi-asserted-by":"crossref","first-page":"59","DOI":"10.22203\/eCM.v033a05","article-title":"Recent advances in hydrogels for cartilage tissue engineering","volume":"33","author":"Vega","year":"2017","journal-title":"Eur. Cell Mater."},{"issue":"9","key":"10.1016\/j.actbio.2020.01.040_bib0087","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1002\/bit.26320","article-title":"Characterization of the chondrocyte secretome in photoclickable poly(ethylene glycol) hydrogels","volume":"114","author":"Schneider","year":"2017","journal-title":"Biotechnol. Bioeng."},{"issue":"13","key":"10.1016\/j.actbio.2020.01.040_bib0088","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1039\/C7NR00352H","article-title":"Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration","volume":"9","author":"Liu","year":"2017","journal-title":"Nanoscale"},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0089","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13287-018-0850-0","article-title":"Three-dimensional printed PLA scaffold and human gingival stem cell-derived extracellular vesicles: a new tool for bone defect repair","volume":"13","author":"Diomede","year":"2018","journal-title":"Stem. Cell Res. Ther."},{"issue":"13","key":"10.1016\/j.actbio.2020.01.040_bib0090","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133256","article-title":"3D Printing PLA\/Gingival stem cells\/ EVs upregulate miR-2861 and -210 during osteoangiogenesis commitment","volume":"20","author":"Pizzicannella","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.actbio.2020.01.040_bib0091","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.7150\/thno.31017","article-title":"Desktop-stereolithography 3D printing of a radially oriented extracellular matrix\/mesenchymal stem cell exosome bioink for osteochondral defect regeneration","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.actbio.2020.01.040_bib0092","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. Vesicles"},{"issue":"4","key":"10.1016\/j.actbio.2020.01.040_bib0093","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1042\/BST20180079","article-title":"MSC exosome works through a protein-based mechanism of action","volume":"46","author":"Toh","year":"2018","journal-title":"Biochem. Soc. Trans."},{"issue":"41","key":"10.1016\/j.actbio.2020.01.040_bib0094","doi-asserted-by":"crossref","first-page":"14888","DOI":"10.1073\/pnas.1408301111","article-title":"Quantitative and stoichiometric analysis of the microRNA content of exosomes","volume":"111","author":"Chevillet","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"Suppl 3","key":"10.1016\/j.actbio.2020.01.040_bib0095","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1186\/1471-2164-12-S3-S18","article-title":"Identification of nucleotide patterns enriched in secreted RNAs as putative cis-acting elements targeting them to exosome nano-vesicles","volume":"12","author":"Batagov","year":"2011","journal-title":"BMC Genomics"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120300556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120300556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:23:52Z","timestamp":1761672232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706120300556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":95,"alternative-id":["S1742706120300556"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2020.01.040","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The dual character of exosomes in osteoarthritis: Antagonists and therapeutic agents","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2020.01.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}