{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:09:40Z","timestamp":1790838580995,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["713645"],"award-info":[{"award-number":["713645"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["336267"],"award-info":[{"award-number":["336267"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["268378"],"award-info":[{"award-number":["268378"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["303786"],"award-info":[{"award-number":["303786"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["310466"],"award-info":[{"award-number":["310466"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.actbio.2020.02.020","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T11:47:15Z","timestamp":1581940035000},"page":"145-155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Raman microspectroscopic analysis of the tissue-specific composition of the human osteochondral junction in osteoarthritis: A pilot study"],"prefix":"10.1016","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8905-1231","authenticated-orcid":false,"given":"Shuvashis","family":"Das Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-5759","authenticated-orcid":false,"given":"Mikko A.J.","family":"Finnil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakari S.","family":"Karhula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Kauppinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Joukainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Kr\u00f6ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami K.","family":"Korhonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashvin","family":"Thambyah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lassi","family":"Rieppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2850-5484","authenticated-orcid":false,"given":"Simo","family":"Saarakkala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2020.02.020_bib0001","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1703856114","article-title":"Knee osteoarthritis has doubled in prevalence since the mid-20th century","volume":"114","author":"Wallace","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.actbio.2020.02.020_bib0002","first-page":"487","article-title":"Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation","volume":"47","author":"Buckwalter","year":"1998","journal-title":"Instr. Course Lect."},{"key":"10.1016\/j.actbio.2020.02.020_bib0003","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/jor.23312","article-title":"Association between subchondral bone structure and osteoarthritis histopathological grade","volume":"35","author":"Finnil\u00e4","year":"2017","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2020.02.020_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0173726","article-title":"Subchondral bone histology and grading in osteoarthritis","volume":"12","author":"Aho","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.actbio.2020.02.020_bib0005","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00003086-198612000-00005","article-title":"Role of subchondral bone in the initiation and progression of cartilage damage","volume":"NA","author":"RADIN","year":"1986","journal-title":"Clin. Orthop. Relat. Res"},{"key":"10.1016\/j.actbio.2020.02.020_bib0006","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/1759720X12437353","article-title":"Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis","volume":"4","author":"Goldring","year":"2012","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"10.1016\/j.actbio.2020.02.020_bib0007","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrrheum.2012.130","article-title":"Bone remodelling in osteoarthritis","volume":"8","author":"Burr","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2020.02.020_bib0008","first-page":"103","article-title":"Quantitative morphology of the subchondral plate of the tibial plateau","volume":"185","author":"Milz","year":"1994","journal-title":"J. Anal."},{"key":"10.1016\/j.actbio.2020.02.020_bib0009","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.joca.2014.11.023","article-title":"Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate ligament transection","volume":"23","author":"Florea","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2020.02.020_bib0010","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.joca.2010.01.004","article-title":"In early OA, thinning of the subchondral plate is directly related to cartilage damage: results from a canine ACLT-meniscectomy model","volume":"18","author":"Intema","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2020.02.020_bib0011","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.joca.2003.09.016","article-title":"Anatomy and physiology of the mineralized tissues: role in the pathogenesis of osteoarthrosis","volume":"12","author":"Burr","year":"2004","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2020.02.020_bib0012","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.joca.2007.04.003","article-title":"Variations in articular calcified cartilage by site and exercise in the 18-month-old equine distal metacarpal condyle","volume":"15","author":"Doube","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2020.02.020_bib0013","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.bone.2012.01.024","article-title":"Decreased bone tissue mineralization can partly explain subchondral sclerosis observed in osteoarthritis","volume":"50","author":"Cox","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2020.02.020_bib0014","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1469-7580.2003.00193.x","article-title":"Nanonmechanical properties and mineral concentration in articular calcified cartilage and subchondral bone","volume":"203","author":"Ferguson","year":"2003","journal-title":"J. Anat."},{"key":"10.1016\/j.actbio.2020.02.020_bib0015","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/art.1780361019","article-title":"A longitudinal study of subchondral plate and trabecular bone in cruciate\u2010deficient dogs with osteoarthritis followed up for 54 months","volume":"36","author":"Dedrick","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.actbio.2020.02.020_bib0016","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jsb.2004.10.010","article-title":"Two different correlations between nanoindentation modulus and mineral content in the bone-cartilage interface","volume":"149","author":"Gupta","year":"2005","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.actbio.2020.02.020_bib0017","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1007\/BF01951696","article-title":"Collagen of the calcified layer of human articular cartilage","volume":"41","author":"Roberts","year":"1985","journal-title":"Experientia"},{"key":"10.1016\/j.actbio.2020.02.020_bib0018","first-page":"244","article-title":"Mineral -Matrix interactions in bone and cartilage","volume":"281","author":"AL","year":"1992","journal-title":"Clin Orthop"},{"key":"10.1016\/j.actbio.2020.02.020_bib0019","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1002\/jbmr.2284","article-title":"FTIR-I compositional mapping of the cartilage-to-bone interface as a function of tissue region and age","volume":"29","author":"Khanarian","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.actbio.2020.02.020_bib0020","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1016\/j.bpj.2008.12.3954","article-title":"The mineral phase of calcified cartilage: its molecular structure and interface with the organic matrix","volume":"96","author":"Duer","year":"2009","journal-title":"Biophys. J."},{"key":"10.1016\/j.actbio.2020.02.020_bib0021","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.bone.2003.11.003","article-title":"Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone","volume":"34","author":"Akkus","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2020.02.020_bib0022","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s11914-014-0238-8","article-title":"Vibrational spectroscopic imaging for the evaluation of matrix and mineral chemistry","volume":"12","author":"Gamsjaeger","year":"2014","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.actbio.2020.02.020_bib0023","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.actbio.2015.11.013","article-title":"3D printed Ti6Al4V implant surface promotes bone maturation and retains a higher density of less aged osteocytes at the bone-implant interface","volume":"30","author":"Shah","year":"2016","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2020.02.020_bib0024","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s00198-017-4019-y","article-title":"Vibrational spectroscopic techniques to assess bone quality","volume":"28","author":"Paschalis","year":"2017","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.actbio.2020.02.020_bib0025","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S1047-8477(02)00635-4","article-title":"Characteristics of mineral particles in the human bone\/cartilage interface","volume":"141","author":"Zizak","year":"2003","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.actbio.2020.02.020_bib0026","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00223-005-0301-7","article-title":"Effect of fixation and embedding on Raman spectroscopic analysis of bone tissue","volume":"78","author":"Yeni","year":"2006","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.actbio.2020.02.020_bib0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1117\/1.JBO.23.11.116504","article-title":"Effect of short-term formaldehyde fixation on Raman spectral parameters of bone quality","volume":"23","author":"Fiedler","year":"2018","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.actbio.2020.02.020_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bonekey.2014.115","article-title":"Contributions of Raman spectroscopy to the understanding of bone strength","volume":"4","author":"Mandair","year":"2015","journal-title":"Bonekey Rep"},{"key":"10.1016\/j.actbio.2020.02.020_bib0029","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1021\/acscentsci.6b00222","article-title":"Raman spectroscopy reveals new insights into the zonal organization of native and tissue-engineered articular cartilage","volume":"2","author":"Bergholt","year":"2016","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.actbio.2020.02.020_bib0030","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1039\/c0an00459f","article-title":"Chemical imaging of articular cartilage sections with Raman mapping, employing uni- and multi-variate methods for data analysis","volume":"135","author":"Bonifacio","year":"2010","journal-title":"Analyst"},{"key":"10.1016\/j.actbio.2020.02.020_bib0031","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/jrs.4552","article-title":"Raman analysis of proteoglycans simultaneously in bone and cartilage","volume":"45","author":"Gamsjaeger","year":"2014","journal-title":"J. Raman Spectrosc"},{"key":"10.1016\/j.actbio.2020.02.020_bib0032","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.bone.2009.01.008","article-title":"A comparison of cortical and trabecular bone from C57 Black 6 mice using Raman spectroscopy","volume":"44","author":"Goodyear","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2020.02.020_bib0033","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/art.38360","article-title":"Evidence from raman spectroscopy of a putative link between inherent bone matrix chemistry and degenerative joint disease","volume":"66","author":"Kerns","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.actbio.2020.02.020_bib0034","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1749-6632.2009.05240.x","article-title":"Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis","volume":"1192","author":"Goldring","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.actbio.2020.02.020_bib0035","first-page":"359","article-title":"Adaptation of subchondral bone in osteoarthritis","volume":"41","author":"Day","year":"2004","journal-title":"Biorheology"},{"key":"10.1016\/j.actbio.2020.02.020_bib0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-5320(77)80025-7","article-title":"Electron microscopic observations of bone tissue prepared anhydrously in organic solvents","volume":"59","author":"Landis","year":"1977","journal-title":"J. Ultrasructure Res."},{"key":"10.1016\/j.actbio.2020.02.020_bib0037","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2307\/2346830","article-title":"Algorithm as 136: a K-Means Clustering Algorithm","volume":"28","author":"Hartigan","year":"2006","journal-title":"Appl. Stat."},{"key":"10.1016\/j.actbio.2020.02.020_bib0038","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1007\/s00216-008-1989-9","article-title":"Application of multivariate data-analysis techniques to biomedical diagnostics based on mid-infrared spectroscopy","volume":"391","author":"Wang","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.actbio.2020.02.020_bib0039","first-page":"235","article-title":"Hierarchical grouping to optimize an objective function","volume":"58","author":"Joe H. Ward","year":"1963","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.actbio.2020.02.020_bib0040","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2020.02.020_bib0041","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/00016470216327","article-title":"Problems in orthopedic research: dependent observations","volume":"73","author":"Ranstam","year":"2002","journal-title":"Acta Orthop. Scand."},{"key":"10.1016\/j.actbio.2020.02.020_bib0042","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/jor.1100110602","article-title":"Viscoelastic shear properties of articular cartilage and the effects of glycosidase treatments","volume":"11","author":"Zhu","year":"1993","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2020.02.020_bib0043","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s10439-014-1190-6","article-title":"Engineering complex orthopaedic tissues via strategic biomimicry","volume":"43","author":"Qu","year":"2015","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.actbio.2020.02.020_bib0044","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrrheum.2010.197","article-title":"The bone-cartilage unit in osteoarthritis","volume":"7","author":"Lories","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2020.02.020_bib0045","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/ar.a.20066","article-title":"Remodeling capacity of calcified fibrocartilage of the hip","volume":"279","author":"Bloebaum","year":"2004","journal-title":"Anat. Rec. - Part A Discov. Mol. Cell. Evol. Biol."},{"key":"10.1016\/j.actbio.2020.02.020_bib0046","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/(SICI)1097-0029(19981015)43:2<191::AID-JEMT10>3.0.CO;2-T","article-title":"Active role of chondrocyte apoptosis in endochondral ossification","volume":"43","author":"Gibson","year":"1998","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.actbio.2020.02.020_bib0047","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.joca.2008.09.005","article-title":"On new bone formation in the pre-osteoarthritic joint","volume":"17","author":"Thambyah","year":"2009","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2020.02.020_bib0048","doi-asserted-by":"crossref","DOI":"10.1117\/1.3574525","article-title":"Repeated freeze-thawing of bone tissue affects Raman bone quality measurements","volume":"16","author":"McElderry","year":"2011","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.actbio.2020.02.020_bib0049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bonekey.2014.115","article-title":"Contributions of Raman spectroscopy to the understanding of bone strength","volume":"4","author":"Mandair","year":"2015","journal-title":"Bonekey Rep"},{"key":"10.1016\/j.actbio.2020.02.020_bib0050","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.17.1.017007","article-title":"Identifying compositional and structural changes in spongy and subchondral bone from the hip joints of patients with osteoarthritis using Raman spectroscopy","volume":"17","author":"Buchwald","year":"2012","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.actbio.2020.02.020_bib0051","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/joa.12624","article-title":"Lipid distribution, composition and uptake in bovine articular cartilage studied using Raman micro-spectrometry and confocal microscopy","volume":"231","author":"Mansfield","year":"2017","journal-title":"J. Anat."},{"key":"10.1016\/j.actbio.2020.02.020_bib0052","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/jbio.201300200","article-title":"Ensemble multivariate analysis to improve identification of articular cartilage disease in noisy Raman spectra","volume":"8","author":"Richardson","year":"2015","journal-title":"J. Biophotonics."},{"key":"10.1016\/j.actbio.2020.02.020_bib0053","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/jrs.4607","article-title":"Raman spectroscopy of lipids: a review","volume":"46","author":"Czamara","year":"2015","journal-title":"J. Raman Spectrosc"},{"key":"10.1016\/j.actbio.2020.02.020_bib0054","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/jbmr.1724","article-title":"Fourier transform infrared imaging of femoral neck bone: reduced heterogeneity of mineral-to-matrix and carbonate-to-phosphate and more variable crystallinity in treatment-naive fracture cases compared with fracture-free controls","volume":"28","author":"Gourion-Arsiquaud","year":"2013","journal-title":"J. Bone Miner. Res."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120300994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120300994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:26:35Z","timestamp":1761672395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706120300994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":54,"alternative-id":["S1742706120300994"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2020.02.020","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Raman microspectroscopic analysis of the tissue-specific composition of the human osteochondral junction in osteoarthritis: A pilot study","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2020.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}