{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:26:18Z","timestamp":1790619978214,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012600","name":"ShanghaiTech University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012600","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002081","name":"Irish Research Council","doi-asserted-by":"publisher","award":["ELEVATEPD\/2014\/61"],"award-info":[{"award-number":["ELEVATEPD\/2014\/61"]}],"id":[{"id":"10.13039\/501100002081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.actbio.2020.03.040","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T20:45:25Z","timestamp":1585946725000},"page":"56-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":181,"special_numbering":"C","title":["Conformable hyaluronic acid hydrogel delivers adipose-derived stem cells and promotes regeneration of burn injury"],"prefix":"10.1016","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5670-5224","authenticated-orcid":false,"given":"Yixiao","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meihua","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Hyung","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janos","family":"Barrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7029-6287","authenticated-orcid":false,"given":"Nicola","family":"Elvassore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey C.","family":"Gurtner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.actbio.2020.03.040_bib0001","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2217\/nnm.13.50","article-title":"Advanced biofabrication strategies for skin regeneration and repair","volume":"8","author":"Pereira","year":"2013","journal-title":"Nanomedicine"},{"key":"10.1016\/j.actbio.2020.03.040_bib0002","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.biocel.2014.10.025","article-title":"Skin regeneration: the complexities of translation into clinical practise","volume":"56","author":"Wood","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"5","key":"10.1016\/j.actbio.2020.03.040_bib0003","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.burns.2006.02.025","article-title":"The use of cultured epithelial autograft in the treatment of major burn wounds: eleven years of clinical experience","volume":"32","author":"Wood","year":"2006","journal-title":"Burns"},{"issue":"1","key":"10.1016\/j.actbio.2020.03.040_bib0004","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2217\/rme.13.80","article-title":"The global landscape of stem cell clinical trials","volume":"9","author":"Li","year":"2014","journal-title":"Regen. Med."},{"key":"10.1016\/j.actbio.2020.03.040_bib0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2017.09.018","article-title":"Burn injury: challenges and advances in burn wound healing, infection, pain and scarring","volume":"123","author":"Wang","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"10","key":"10.1016\/j.actbio.2020.03.040_bib0006","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1111\/j.1524-4725.2012.02495.x","article-title":"Effect of human adipose derived stem cells on scar formation and remodeling in a pig model: a pilot study","volume":"38","author":"Yun","year":"2012","journal-title":"Dermatol. Surg."},{"issue":"4","key":"10.1016\/j.actbio.2020.03.040_bib0007","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/PRS.0000000000000504","article-title":"Adipose tissue-derived stromal cells inhibit TGF-beta 1-Induced differentiation of human dermal fibroblasts and keloid scar-derived fibroblasts in a paracrine fashion","volume":"134","author":"Spiekman","year":"2014","journal-title":"Plast. Reconstr. Surg."},{"issue":"6","key":"10.1016\/j.actbio.2020.03.040_bib0008","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/iwj.12034","article-title":"Bone marrow-derived mesenchymal stem cell attenuates skin fibrosis development in mice","volume":"11","author":"Wu","year":"2014","journal-title":"Int. Wound J."},{"issue":"10","key":"10.1016\/j.actbio.2020.03.040_bib0009","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1634\/stemcells.2007-0226","article-title":"Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis","volume":"25","author":"Wu","year":"2007","journal-title":"Stem Cells"},{"issue":"7\u20138","key":"10.1016\/j.actbio.2020.03.040_bib0010","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1089\/ten.tea.2011.0391","article-title":"Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers","volume":"18","author":"Aguado","year":"2012","journal-title":"Tissue Eng. Part A"},{"issue":"11","key":"10.1016\/j.actbio.2020.03.040_bib0011","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1002\/mabi.201100180","article-title":"Pullulan hydrogels improve mesenchymal stem cell delivery into high-oxidative-stress wounds","volume":"11","author":"Wong","year":"2011","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.actbio.2020.03.040_bib0012","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.copbio.2016.02.008","article-title":"Recent advances in hyaluronic acid hydrogels for biomedical applications","volume":"40","author":"Highley","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"issue":"3","key":"10.1016\/j.actbio.2020.03.040_bib0013","first-page":"78","article-title":"Hyaluronic acid in inflammation and tissue regeneration","volume":"28","author":"Litwiniuk","year":"2016","journal-title":"Wounds-a Compendium Clin. Res. Pract."},{"key":"10.1016\/j.actbio.2020.03.040_bib0014","doi-asserted-by":"crossref","first-page":"S1240","DOI":"10.2741\/1183","article-title":"Fetal wound healing","volume":"8","author":"Colwell","year":"2003","journal-title":"Front. Biosci."},{"issue":"4","key":"10.1016\/j.actbio.2020.03.040_bib0015","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1097\/PRS.0b013e3181eae781","article-title":"Scarless fetal wound healing: a basic science review","volume":"126","author":"Larson","year":"2010","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.actbio.2020.03.040_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eurpolymj.2017.12.046","article-title":"Hydrogel wound dressings for bioactive treatment of acute and chronic wounds","volume":"100","author":"Koehler","year":"2018","journal-title":"Eur. Polym. J."},{"issue":"34","key":"10.1016\/j.actbio.2020.03.040_bib0017","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1039\/C5PY00678C","article-title":"A rapid crosslinking injectable hydrogel for stem cell delivery, from multifunctional hyperbranched polymers via raft homopolymerization of Pegda","volume":"6","author":"Dong","year":"2015","journal-title":"Polym. Chem."},{"issue":"12","key":"10.1016\/j.actbio.2020.03.040_bib0018","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1091\/mbc.e02-02-0105","article-title":"Human adipose tissue is a source of multipotent stem cells","volume":"13","author":"Zuk","year":"2002","journal-title":"Mol. Biol. Cell"},{"issue":"17","key":"10.1016\/j.actbio.2020.03.040_bib0019","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800432","article-title":"Acceleration of diabetic wound regeneration using an in situ-formed stem-cell-based skin substitute","volume":"7","author":"Dong","year":"2018","journal-title":"Adv. Healthc. Mater."},{"issue":"24","key":"10.1016\/j.actbio.2020.03.040_bib0020","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201606619","article-title":"Injectable and tunable gelatin hydrogels enhance stem cell retention and improve cutaneous wound healing","volume":"27","author":"Dong","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2020.03.040_bib0021","article-title":"Development of animal model for studying deep second-degree thermal burns","author":"Pereira","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"issue":"2","key":"10.1016\/j.actbio.2020.03.040_bib0022","first-page":"97","article-title":"Collagen and picrosirius red staining: a polarized light assessment of fibrillar hue and spatial distribution","volume":"22","author":"Whittaker","year":"2005","journal-title":"Braz. J. Morphol. Sci."},{"issue":"7","key":"10.1016\/j.actbio.2020.03.040_bib0023","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.biomaterials.2007.10.053","article-title":"Towards development of a dermal rudiment for enhanced wound healing response","volume":"29","author":"Garcia","year":"2008","journal-title":"BiomaterialsBiomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2020.03.040_bib0024","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nm.2574","article-title":"Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling","volume":"18","author":"Wong","year":"2012","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.actbio.2020.03.040_bib0025","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/jid.2013.339","article-title":"YAP and taz regulate skin wound healing","volume":"134","author":"Lee","year":"2014","journal-title":"J. Invest. Dermatol."},{"issue":"5","key":"10.1016\/j.actbio.2020.03.040_bib0026","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ceb.2012.07.001","article-title":"Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche","volume":"24","author":"Brizzi","year":"2012","journal-title":"Curr. Opin. Cell Biol."},{"issue":"48","key":"10.1016\/j.actbio.2020.03.040_bib0027","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1002\/adma.200901808","article-title":"A versatile synthetic extracellular matrix mimic via thiol-norbornene photopolymerization","volume":"21","author":"Fairbanks","year":"2009","journal-title":"Adv. Mater."},{"issue":"9","key":"10.1016\/j.actbio.2020.03.040_bib0028","doi-asserted-by":"crossref","first-page":"5413","DOI":"10.1073\/pnas.0737381100","article-title":"Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics","volume":"100","author":"Lutolf","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"10.1016\/j.actbio.2020.03.040_bib0029","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1534-5807(04)00075-9","article-title":"Cell shape, cytoskeletal tension, and Rhoa regulate stem cell lineage commitment","volume":"6","author":"McBeath","year":"2004","journal-title":"Dev. Cell"},{"issue":"6","key":"10.1016\/j.actbio.2020.03.040_bib0030","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nmat2732","article-title":"Harnessing traction-mediated manipulation of the cell\/matrix interface to control stem-cell fate","volume":"9","author":"Huebsch","year":"2010","journal-title":"Nat. Mater."},{"issue":"5","key":"10.1016\/j.actbio.2020.03.040_bib0031","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nmat3586","article-title":"Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels","volume":"12","author":"Khetan","year":"2013","journal-title":"Nat. Mater."},{"issue":"7303","key":"10.1016\/j.actbio.2020.03.040_bib0032","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nature09198","article-title":"Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics","volume":"466","author":"Grashoff","year":"2010","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.actbio.2020.03.040_bib0033","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/adhm.201200194","article-title":"Directed differentiation of size-controlled embryoid bodies towards endothelial and cardiac lineages in RGD-Modified poly(ethylene glycol) hydrogels","volume":"2","author":"Schukur","year":"2013","journal-title":"Adv. Healthc. Mater."},{"issue":"6","key":"10.1016\/j.actbio.2020.03.040_bib0034","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.burns.2015.12.007","article-title":"Administration of adipose-derived stem cells enhances vascularity, induces collagen deposition, and dermal adipogenesis in burn wounds","volume":"42","author":"Bliley","year":"2016","journal-title":"Burns"},{"key":"10.1016\/j.actbio.2020.03.040_bib0035","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2340725","article-title":"Influence of adipose tissue-derived stem cells on the burn wound healing process","volume":"2019","author":"Franck","year":"2019","journal-title":"Stem Cells Int."},{"issue":"3","key":"10.1016\/j.actbio.2020.03.040_bib0036","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/wrr.12432","article-title":"Current concepts related to hypertrophic scarring in burn injuries","volume":"24","author":"Chiang","year":"2016","journal-title":"Wound Repair Regen."},{"issue":"1","key":"10.1016\/j.actbio.2020.03.040_bib0037","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/jsre.2001.6262","article-title":"Poloxamer-188 improves capillary blood flow and tissue viability in a cutaneous burn wound","volume":"101","author":"Baskaran","year":"2001","journal-title":"J. Surg. Res."},{"issue":"6","key":"10.1016\/j.actbio.2020.03.040_bib0038","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/BCR.0b013e3181f93571","article-title":"A review of the local pathophysiologic bases of burn wound progression","volume":"31","author":"Shupp","year":"2010","journal-title":"J. Burn Care Res."},{"issue":"2","key":"10.1016\/j.actbio.2020.03.040_bib0039","doi-asserted-by":"crossref","first-page":"142","DOI":"10.5966\/sctm.2011-0018","article-title":"Concise review: role of mesenchymal stem cells in wound repair","volume":"1","author":"Maxson","year":"2012","journal-title":"Stem Cells Transl. Med."},{"issue":"3","key":"10.1016\/j.actbio.2020.03.040_bib0040","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/MOP.0b013e3283535790","article-title":"Fetal wound healing: implications for minimal scar formation","volume":"24","author":"Leung","year":"2012","journal-title":"Curr. Opin. Pediatr."},{"issue":"10","key":"10.1016\/j.actbio.2020.03.040_bib0041","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1369\/0022155414545787","article-title":"Picrosirius red staining: a useful tool to appraise collagen networks in normal and pathological tissues","volume":"62","author":"Lattouf","year":"2014","journal-title":"J. Histochem. Cytochem."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120301811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120301811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:29:46Z","timestamp":1761672586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706120301811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":41,"alternative-id":["S1742706120301811"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2020.03.040","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conformable hyaluronic acid hydrogel delivers adipose-derived stem cells and promotes regeneration of burn injury","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2020.03.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}