{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:13:01Z","timestamp":1793113981869,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.actbio.2020.04.003","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T14:38:31Z","timestamp":1587998311000},"page":"82-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Redox injectable gel protects osteoblastic function against oxidative stress and suppresses alveolar bone loss in a rat peri-implantitis model"],"prefix":"10.1016","volume":"110","author":[{"given":"Ryotaro","family":"Ozawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Saita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Sakaue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusaku","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takenori","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Kawamata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobushiro","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Kimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7975-6510","authenticated-orcid":false,"given":"Yukio","family":"Nagasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2020.04.003_bib0001","first-page":"211","article-title":"Osseointegrated implants in the treatment of partially edentulous patients, A preliminary study on 876 consecutively placed fixtures","volume":"4","author":"Jemt","year":"1989","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.actbio.2020.04.003_bib0002","first-page":"272","article-title":"Applicability of osseointegrated oral implants in the rehabilitation of partial edentulism: A prospective multicenter study on 558 fixtures","volume":"5","author":"Steenberghe","year":"1990","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.actbio.2020.04.003_bib0003","first-page":"639","article-title":"Survival of the Br\u00e5nemark implant in partially edentulous jaws: A 10-year prospective multicenter study","volume":"14","author":"Lekholm","year":"1999","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.actbio.2020.04.003_bib0004","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-0501.2012.02541.x","article-title":"The epidemiology of peri-implantitis","volume":"23","author":"Mombelli","year":"2012","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.actbio.2020.04.003_bib0005","doi-asserted-by":"crossref","first-page":"308","DOI":"10.11607\/jomi.2014suppl.g5.2","article-title":"Improvements in implant dentistry over the last decade: Comparison of survival and complication rates in older and newer publications","volume":"29","author":"Pjetursson","year":"2014","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.actbio.2020.04.003_bib0006","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1600-051X.2008.01274.x","article-title":"Definition and prevalence of peri-implant diseases","volume":"35","author":"Zitzmann","year":"2008","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.actbio.2020.04.003_bib0007","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1902\/jop.2012.120592","article-title":"The frequency of peri-implant diseases: A systematic review and metaanalysis","volume":"84","author":"Atieh","year":"2013","journal-title":"J Periodontol"},{"key":"10.1016\/j.actbio.2020.04.003_bib0008","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0300-9785(86)80010-2","article-title":"Marginal tissue reactions at osseointegrated titanium fixtures (I). A 3-year longitudinal prospective study","volume":"15","author":"Adell","year":"1986","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.actbio.2020.04.003_bib0009","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0022-3913(03)00212-9","article-title":"Clinical complications with implants and implant prostheses","volume":"90","author":"Goodacre","year":"2003","journal-title":"J Prosthet Dent"},{"key":"10.1016\/j.actbio.2020.04.003_bib0010","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1902\/jop.1992.63.3.225","article-title":"Soft tissue reactions to non-submerged unloaded titanium implants in beagle dogs","volume":"63","author":"Buser","year":"1992","journal-title":"J. Perodontol"},{"key":"10.1016\/j.actbio.2020.04.003_bib0011","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1600-051X.1994.tb00302.x","article-title":"The topography of the vascular systems in the periodontal and peri-implant tissues in the dog","volume":"21","author":"Berglundh","year":"1994","journal-title":"J. Clin. Periodontol"},{"issue":"3","key":"10.1016\/j.actbio.2020.04.003_bib0012","doi-asserted-by":"crossref","first-page":"987","DOI":"10.2353\/ajpath.2006.060180","article-title":"B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease","volume":"169","author":"Kawai","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.actbio.2020.04.003_bib0013","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1034\/j.1600-051X.2003.300103.x","article-title":"Immunohistochemical characteristics of inflammatory lesions at implants","volume":"30","author":"Gualini","year":"2003","journal-title":"J Clin Periodontol"},{"issue":"4","key":"10.1016\/j.actbio.2020.04.003_bib0014","first-page":"419","article-title":"Reactive oxygen species was measured in saliva samples through thiobarbituric acid reactive substances assay for the three groups","volume":"64","author":"Guo","year":"2015","journal-title":"West Indian Med J"},{"key":"10.1016\/j.actbio.2020.04.003_bib0015","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.freeradbiomed.2008.09.040","article-title":"Effects of vitamin C intake on gingival oxidative stress in rat periodontitis","volume":"46","author":"Tomofuji","year":"2009","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.actbio.2020.04.003_bib0016","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1600-0765.2007.01060.x","article-title":"Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes","volume":"44","author":"Ohnishi","year":"2009","journal-title":"J. Periodontal Res"},{"key":"10.1016\/j.actbio.2020.04.003_bib0017","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.archoralbio.2009.02.006","article-title":"Vitamin C intake attenuates the degree of experimental atherosclerosis induced by periodontitis in the rat by decreasing oxidative stress","volume":"54","author":"Ekuni","year":"2009","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.actbio.2020.04.003_bib0018","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1600-0765.1992.tb02088.x","article-title":"Neutrophil-mediated damage to human gingival epithelial cells","volume":"27","author":"Altman","year":"1992","journal-title":"J. Periodontal Res"},{"key":"10.1016\/j.actbio.2020.04.003_bib0019","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1902\/jop.2001.72.11.1545","article-title":"Polymorphonuclear neutrophils and their mediators in gingival tissues from generalized aggressive periodontitis","volume":"72","author":"Liu","year":"2001","journal-title":"J. Periodontol"},{"key":"10.1016\/j.actbio.2020.04.003_bib0020","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1600-0765.2008.01122.x","article-title":"Periodontitis-induced lipid peroxidation in rat descending aorta is involved in the initiation of atherosclerosis","volume":"44","author":"Ekuni","year":"2009","journal-title":"J. Periodontal Res"},{"key":"10.1016\/j.actbio.2020.04.003_bib0021","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1067\/moe.2003.107","article-title":"Meta-analysis of periodontal disease and risk of coronary heart disease and stroke","volume":"95","author":"Janket","year":"2003","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Rad, Endod"},{"key":"10.1016\/j.actbio.2020.04.003_bib0022","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0891-5849(95)00005-I","article-title":"Hydrogen peroxide as a potent bacteriostatic antibiotic: implications for host defense","volume":"19","author":"Hyslop","year":"1995","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.actbio.2020.04.003_bib0023","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. Biochem Cell Biol"},{"key":"10.1016\/j.actbio.2020.04.003_bib0024","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.jconrel.2013.10.009","article-title":"Redox-active injectable gel using thermo-responsive nanoscale polyion complex flower micelle for noninvasive treatment of local inflammation","volume":"172","author":"Pua","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2020.04.003_bib0025","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1053\/j.gastro.2012.06.043","article-title":"Anorally administered redox nanoparticle that accumulates in the colonic mucosa and reduces colitis in mice","volume":"143","author":"Vong","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.actbio.2020.04.003_bib0026","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.biomaterials.2015.03.037","article-title":"Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer","volume":"55","author":"Vong","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2020.04.003_bib0027","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.biomaterials.2015.10.077","article-title":"Novel antioxidative nanotherapeutics in a rat periodontitis model: Reactive oxygen species scavenging by redox injectable gel suppresses alveolar bone resorption","volume":"76","author":"Saita","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2020.04.003_bib0028","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3164\/jcbn.13-85","article-title":"The behavior of ROS scavengingnanoparticles in blood","volume":"54","author":"Shimizu","year":"2014","journal-title":"J. Clin. Biochem. Nutr"},{"key":"10.1016\/j.actbio.2020.04.003_bib0029","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1021\/acs.macromol.5b00305","article-title":"Dual stimuli-responsive redox-active injectable gel by polyion complex based flower micelles for biomedical applications","volume":"48","author":"Ishii","year":"2015","journal-title":"Macromolecules"},{"key":"10.1016\/j.actbio.2020.04.003_bib0030","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.biomaterials.2015.08.018","article-title":"Design of high-performance anti-adhesion agent using injectable gel with an anti-oxidative stress function","volume":"69","author":"Nakagawa","year":"2015","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.actbio.2020.04.003_bib0031","first-page":"523","article-title":"N-acetyl cysteine protects osteoblastic function from oxidative stress","volume":"99A","author":"Ueno","year":"2011","journal-title":"Journal of biomedicals research"},{"issue":"7","key":"10.1016\/j.actbio.2020.04.003_bib0032","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.biomaterials.2008.11.024","article-title":"Enhanced osteoblast function on ultraviolet light-treated zirconia","volume":"30","author":"Att","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2020.04.003_bib0033","doi-asserted-by":"crossref","unstructured":"F. Yoshino, A. Yoshida, A. Nakajima, S. Wada-Takahashi, S. Takahashi, M. Chang-il Lee, Alteration of the Redox State with Reactive Oxygen Species for 5-Fluorouracil-Induced Oral Mucositis in Hamsters, PLOS ONE8(12) e82834.","DOI":"10.1371\/journal.pone.0082834"},{"key":"10.1016\/j.actbio.2020.04.003_bib0034","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10557-017-6758-6","article-title":"Novel Synthesized Radical-Containing Nanoparticles Limit Infarct Size Following Ischemia and Reperfusion in Canine Hearts","volume":"31","author":"Asanuma","year":"2017","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.actbio.2020.04.003_bib0035","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.archoralbio.2012.05.011","article-title":"Inhibitory effects of Jixueteng on P. gingivalis-induced bone loss and osteoclast differentiation","volume":"57","author":"Toyama","year":"2012","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.actbio.2020.04.003_bib0036","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.archoralbio.2014.06.010","article-title":"Ameliorating effects of Juzentaihoto on restraint stress and P. gingivalis-induced alveolar bone loss","volume":"59","author":"Takeda","year":"2014","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.actbio.2020.04.003_bib0037","doi-asserted-by":"crossref","first-page":"6280","DOI":"10.1016\/j.biomaterials.2005.03.046","article-title":"Ultrastructure localization of laminin-5 (gamma2 chain) in the rat peri- implant oral mucosa around a titanium-dental impkant bu immunoelectron microscopy","volume":"26","author":"Atsuta","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2020.04.003_bib0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2014.10.016","article-title":"Release of titanium ions from an implant surface and their effect on cytokine production related to alveolar bone resorption","volume":"327","author":"Wachi","year":"2015","journal-title":"Toxi"},{"issue":"6","key":"10.1016\/j.actbio.2020.04.003_bib0039","first-page":"1","article-title":"Effect of Ultraviolet Irradiation of the Implant Surface on Progression of Periimplantitis -A Pilot Study in Dogs","volume":"24","author":"Ishii","year":"2015","journal-title":"Implant Dentistry"},{"key":"10.1016\/j.actbio.2020.04.003_bib0040","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.actbio.2016.11.021","article-title":"Optimally oriented grooves on dental implants improve bone quality around implants under repetitive mechanical loading","volume":"48","author":"Kuroshima","year":"2017","journal-title":"Acta Biomaterialia"},{"key":"10.1016\/j.actbio.2020.04.003_bib0041","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.biomaterials.2008.11.004","article-title":"The effect of ultraviolet functionalization of titanium on integration with bone","volume":"30","author":"Aita","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2020.04.003_bib0042","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF00225804","article-title":"Bone formation in Vitro by stromal cells obtained from bone marrow of young adult rats","volume":"254","author":"Maniatopoulos","year":"1988","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.actbio.2020.04.003_bib0043","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10565-006-0018-z","article-title":"Effects of hydrogen peroxide (H2O2) on alkaline phosphatase activity and matrix mineralization of odontoblast and osteoblast cell lines","volume":"22","author":"Lee","year":"2006","journal-title":"Cell Bio Toxicol"},{"key":"10.1016\/j.actbio.2020.04.003_bib0044","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2003.12.073","article-title":"Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB","volume":"314","author":"Bai","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.actbio.2020.04.003_bib0045","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1365-2141.2006.06277.x","article-title":"Oxidative stress and inflammation in iron-overloaded patients with \u03b2-thalassaemia or sickle cell disease","volume":"135","author":"Walter","year":"2006","journal-title":"Br. J. Haematol"},{"key":"10.1016\/j.actbio.2020.04.003_bib0046","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jdiacomp.2013.07.005","article-title":"Association of biomarkers of inflammation and oxidative stress with the risk of chronic kidney disease in Type 2 diabetes mellitus in North Indian population","volume":"27","author":"Gupta","year":"2013","journal-title":"J. Diabetes Complicat"},{"key":"10.1016\/j.actbio.2020.04.003_bib0047","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1021\/bm801278n","article-title":"Design of core-shell-type nanoparticles carrying stable redials in the core","volume":"10","author":"Yoshitomi","year":"2009","journal-title":"Biomacromoleculles"},{"issue":"3","key":"10.1016\/j.actbio.2020.04.003_bib0048","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1021\/acs.molpharmaceut.7b00995","article-title":"Antioxidative Nanoparticles Significantly Enhance Therapeutic Efficacy of an Antibacterial Therapy against Listeria monocytogenes Infection","volume":"15","author":"Ikeda","year":"2018","journal-title":"Mol Pharm"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120302002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120302002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:27:37Z","timestamp":1761672457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706120302002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":48,"alternative-id":["S1742706120302002"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2020.04.003","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Redox injectable gel protects osteoblastic function against oxidative stress and suppresses alveolar bone loss in a rat peri-implantitis model","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2020.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}