{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:52:41Z","timestamp":1790621561249,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51,503,001"],"award-info":[{"award-number":["51,503,001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51,603,001"],"award-info":[{"award-number":["51,603,001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51,803,001"],"award-info":[{"award-number":["51,803,001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002729","name":"Anhui University","doi-asserted-by":"publisher","award":["AU02303203"],"award-info":[{"award-number":["AU02303203"]}],"id":[{"id":"10.13039\/501100002729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018628","name":"Scientific Research Foundation of Education Department of Anhui Province of China","doi-asserted-by":"publisher","award":["KJ2018A0006"],"award-info":[{"award-number":["KJ2018A0006"]}],"id":[{"id":"10.13039\/501100018628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018628","name":"Scientific Research Foundation of Education Department of Anhui Province of China","doi-asserted-by":"publisher","award":["KJ2018ZD003"],"award-info":[{"award-number":["KJ2018ZD003"]}],"id":[{"id":"10.13039\/501100018628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018628","name":"Scientific Research Foundation of Education Department of Anhui Province of China","doi-asserted-by":"publisher","award":["KJ2019A0015"],"award-info":[{"award-number":["KJ2019A0015"]}],"id":[{"id":"10.13039\/501100018628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.actbio.2020.05.035","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T02:10:23Z","timestamp":1591063823000},"page":"234-249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"special_numbering":"C","title":["Oxygen-producing catalase-based prodrug nanoparticles overcoming resistance in hypoxia-mediated chemo-photodynamic therapy"],"prefix":"10.1016","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3521-4888","authenticated-orcid":false,"given":"Xu","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbing","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2885-5049","authenticated-orcid":false,"given":"Rupei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2020.05.035_bib0001","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/jcp.25859","article-title":"Modulating tumor hypoxia by nanomedicine for effective cancer therapy","volume":"233","author":"Jahanban-Esfahlan","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.actbio.2020.05.035_bib0002","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.trecan.2018.02.010","article-title":"Reengineering the tumor vasculature: improving drug delivery and efficacy","volume":"4","author":"Stylianopoulos","year":"2018","journal-title":"Trends Cancer"},{"key":"10.1016\/j.actbio.2020.05.035_bib0003","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nrc3726","article-title":"Hypoxia and the extracellular matrix: drivers of tumor metastasis","volume":"14","author":"Gilkes","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.actbio.2020.05.035_bib0004","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jconrel.2015.08.017","article-title":"Stromal barriers and strategies for the delivery of nanomedicine to desmoplastic tumors","volume":"219","author":"Miao","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2020.05.035_bib0005","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2147\/HP.S93413","article-title":"The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy","volume":"3","author":"Muz","year":"2015","journal-title":"Hypoxia"},{"issue":"12","key":"10.1016\/j.actbio.2020.05.035_bib0006","doi-asserted-by":"crossref","first-page":"12849","DOI":"10.1021\/acsnano.7b08225","article-title":"Oxygen-self-produced nanoplatform for relieving hypoxia and breaking resistance to sonodynamic treatment of pancreatic cancer","volume":"11","author":"Chen","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2020.05.035_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2019.122079","article-title":"Tumor hypoxia relief overcomes multidrug resistance and immune inhibition for self-enhanced photodynamic therapy","author":"He","year":"2019","journal-title":"Chem. Eng. J."},{"issue":"1","key":"10.1016\/j.actbio.2020.05.035_bib0008","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/cancers11010060","article-title":"Hyperthermia: the optimal treatment to overcome radiation resistant hypoxia","volume":"11","author":"Elming","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.actbio.2020.05.035_bib0009","doi-asserted-by":"crossref","first-page":"25740","DOI":"10.1021\/acsami.9b08115","article-title":"Azoreductase-responsive metal-organic framework-based nanodrug for enhanced cancer therapy via breaking hypoxiainduced chemoresistance","volume":"11","author":"Huang","year":"2019","journal-title":"ACS Appl. Mater. Inter."},{"key":"10.1016\/j.actbio.2020.05.035_bib0010","article-title":"Hypoxia-induced gene expression pattern in doxorubicin-resistant MCF-7 Cells","volume":"18","author":"Hammad","year":"2019","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.actbio.2020.05.035_bib0011","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jconrel.2019.06.016","article-title":"Light triggered oxygen-affording engines for repeated hypoxia-resistant photodynamic therapy","volume":"10","author":"Zhou","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2020.05.035_bib0012","article-title":"Aggressive man\u2010made red blood cells for hypoxia\u2010resistant photodynamic therapy","volume":"30","author":"Liu","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2020.05.035_bib0013","first-page":"163","article-title":"Fighting hypoxia to improve PDT","volume":"12","author":"Larue","year":"2019","journal-title":"Pharm"},{"key":"10.1016\/j.actbio.2020.05.035_bib0014","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.biomaterials.2018.08.004","article-title":"Hypoxic tumor therapy by hemoglobin-mediated drug delivery and reversal of hypoxia-induced chemoresistance","volume":"182","author":"Yang","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2020.05.035_bib0015","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jconrel.2016.11.006","article-title":"Drug-induced co-assembly of albumin\/catalase as smart nano-theranostics for deep intra-tumoral penetration, hypoxia relieve, and synergistic combination therapy, J","volume":"263","author":"Chen","year":"2017","journal-title":"Control. Release"},{"key":"10.1016\/j.actbio.2020.05.035_bib0016","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201900047","article-title":"Targeted magnetic resonance imaging and modulation of hypoxia with multifunctional hyaluronic acid\u2010MnO2 nanoparticles in glioma","author":"Fu","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2020.05.035_bib0017","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.biomaterials.2016.10.020","article-title":"TaOx decorated perfluorocarbon nanodroplets as oxygen reservoirs to overcome tumor hypoxia and enhance cancer radiotherapy","volume":"112","author":"Song","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2020.05.035_bib0018","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201703197","article-title":"Cancer cell membrane-biomimetic oxygen nanocarrier for breaking hypoxia-induced chemoresistance","volume":"27","author":"Tian","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2020.05.035_bib0019","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1021\/jacs.6b01784","article-title":"An implantable depot that can generate oxygen in situ for overcoming hypoxia-induced resistance to anticancer drugs in chemotherapy","volume":"138","author":"Huang","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.actbio.2020.05.035_bib0020","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.biomaterials.2016.10.030","article-title":"Oxygen-generating hybrid nanoparticles to enhance fluorescent\/photoacoustic\/ultrasound imaging guided tumor photodynamic therapy","volume":"112","author":"Gao","year":"2017","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.actbio.2020.05.035_bib0021","doi-asserted-by":"crossref","first-page":"990","DOI":"10.7150\/thno.22465","article-title":"O2-generating MnO2 nanoparticles for enhanced photodynamic therapy of bladder cancer by ameliorating hypoxia","volume":"8","author":"Lin","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2020.05.035_bib0022","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejpb.2015.03.018","article-title":"Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy","volume":"93","author":"P\u00e9rez-Herrero","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.actbio.2020.05.035_bib0023","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1039\/C5SC03417E","article-title":"Activating peptides for cellular uptake via polymerization into high density brushes","volume":"7","author":"Blum","year":"2016","journal-title":"Chem. Sci."},{"key":"10.1016\/j.actbio.2020.05.035_bib0024","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201606628","article-title":"Rational design of cancer nanomedicine: nanoproperty integration and synchronization","volume":"29","author":"Sun","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2020.05.035_bib0025","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.2174\/0929867325666180111095913","article-title":"Stimuli responsive nanoparticles for controlled anti-cancer drug release","volume":"25","author":"Tang","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.actbio.2020.05.035_bib0026","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jconrel.2009.09.004","article-title":"Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance","volume":"141","author":"Khdair","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2020.05.035_bib0027","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jconrel.2018.06.008","article-title":"Combination of chemotherapy and photodynamic therapy for cancer treatment with sonoporation effects","volume":"283","author":"Lee","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2020.05.035_bib0028","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1039\/C8CS00787J","article-title":"Stimuli-responsive self-assembly of nanoparticles","volume":"48","author":"Grzelczak","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.actbio.2020.05.035_bib0029","doi-asserted-by":"crossref","first-page":"10636","DOI":"10.1021\/acsnano.8b06104","article-title":"Stimuli-responsive Nano-architecture drug-delivery systems to solid tumor micromilieu: past, present, and future perspectives","volume":"12","author":"El-Sawy","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2020.05.035_bib0030","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.7150\/thno.24015","article-title":"Cascade-amplifying synergistic effects of chemophotodynamic therapy using ROS-responsive polymeric nanocarriers","volume":"8","author":"Sun","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2020.05.035_bib0031","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3390\/polym10060611","article-title":"Synthetic glycopolypeptide micelle for targeted drug delivery to hepatic carcinoma","volume":"10","author":"Li","year":"2018","journal-title":"Polymers"},{"key":"10.1016\/j.actbio.2020.05.035_bib0032","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijpharm.2019.02.032","article-title":"CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment","volume":"561","author":"Tirella","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2020.05.035_bib0033","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201900157","article-title":"Bioinspired multivalent peptide nanotubes for sialic acid targeting and imaging\u2010guided treatment of metastatic melanoma","volume":"15","author":"Lei","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.actbio.2020.05.035_bib0034","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1039\/C4NR04853A","article-title":"Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors","volume":"7","author":"Dixit","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.actbio.2020.05.035_bib0035","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ejpb.2018.05.011","article-title":"Acid-degradable lactobionic acid-modified soy protein nanogels crosslinked by ortho ester linkage for efficient antitumor in vivo","volume":"128","author":"Cheng","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.actbio.2020.05.035_bib0036","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijbiomac.2018.04.076","article-title":"Bromelain-immobilized and lactobionic acid-modified chitosan nanoparticles for enhanced drug penetration in tumor tissues","volume":"115","author":"Wang","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.actbio.2020.05.035_bib0037","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.actbio.2017.01.031","article-title":"Stepwise targeted drug delivery to liver cancer cells for enhanced therapeutic efficacy by galactose-grafted, ultra-pH-sensitive micelles","volume":"51","author":"Yan","year":"2017","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2020.05.035_bib0038","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1039\/C8CS00395E","article-title":"Click and release: bioorthogonal approaches to \u201con-demand\u201d activation of prodrugs","volume":"48","author":"Ji","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.actbio.2020.05.035_bib0039","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1039\/C8CC09185D","article-title":"Engineering graphene oxide with ultrasmall SPIONs and smart drug release for cancer theranostics","volume":"55","author":"Luo","year":"2019","journal-title":"Chem. Commun."},{"key":"10.1016\/j.actbio.2020.05.035_bib0040","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.actbio.2017.12.034","article-title":"pH-responsive gold nanoclusters-based nanoprobes for lung cancer targeted near-infrared fluorescence imaging and chemo-photodynamic therapy","volume":"68","author":"Xia","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2020.05.035_bib0041","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.colsurfb.2015.09.030","article-title":"Acid-responsive PEGylated doxorubicin prodrug nanoparticles for neuropilin-1 receptor-mediated targeted drug delivery","volume":"136","author":"Song","year":"2015","journal-title":"Colloid. Surface. B"},{"key":"10.1016\/j.actbio.2020.05.035_bib0042","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jaap.2013.08.004","article-title":"Total water-soluble sugars quantification in bio-oil using the phenol\u2013sulfuric acid assay","volume":"104","author":"Rove","year":"2013","journal-title":"J. Anal. Appl. Pyrol."},{"key":"10.1016\/j.actbio.2020.05.035_bib0043","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1007\/s11095-009-9949-4","article-title":"Novel biodegradable polylactide\/poly (ethylene glycol) micelles prepared by direct dissolution method for controlled delivery of anticancer drugs","volume":"26","author":"Yang","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.actbio.2020.05.035_bib0044","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0009-8981(91)90067-M","article-title":"A simple method for determination of serum catalase activity and revision of reference range","volume":"196","author":"Goth","year":"1991","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.actbio.2020.05.035_bib0045","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jconrel.2018.12.014","article-title":"Applications of \u03c0-\u03c0 stacking interactions in the design of drug-delivery systems","volume":"294","author":"Zhuang","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2020.05.035_bib0046","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/j.bbamem.2009.06.022","article-title":"Nanoparticles evading the reticuloendothelial system: role of the supported bilayer","volume":"1788","author":"Li","year":"2009","journal-title":"BBA. Biomembrabes"},{"key":"10.1016\/j.actbio.2020.05.035_bib0047","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1039\/c2an35700c","article-title":"BSA-templated MnO2 nanoparticles as both peroxidase and oxidase mimics","volume":"137","author":"Liu","year":"2012","journal-title":"Analyst"},{"key":"10.1016\/j.actbio.2020.05.035_bib0048","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1039\/C9QI01076A","article-title":"A smart tumor-microenvironment responsive nanoprobe for highly selective and efficient combination therapy","volume":"6","author":"Fan","year":"2019","journal-title":"Inorg. Chem. Front."},{"key":"10.1016\/j.actbio.2020.05.035_bib0049","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.biomaterials.2017.05.025","article-title":"Catalase-loaded cisplatin-prodrug-constructed liposomes to overcome tumor hypoxia for enhanced chemo-radiotherapy of cancer","volume":"138","author":"Zhang","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2020.05.035_bib0050","doi-asserted-by":"crossref","first-page":"9714","DOI":"10.1039\/C4CC03385J","article-title":"An H2O2-responsive nanocarrier for dual-release of platinum anticancer drugs and O2: controlled release and enhanced cytotoxicity against cisplatin resistant cancer cells","volume":"50","author":"Chen","year":"2014","journal-title":"Chem. Commun."},{"key":"10.1016\/j.actbio.2020.05.035_bib0051","doi-asserted-by":"crossref","first-page":"34311","DOI":"10.1038\/srep34311","article-title":"Novel injectable BRET-based in vivo imaging probe for detecting the activity of hypoxia-inducible factor regulated by the ubiquitin-proteasome system","volume":"6","author":"Kuchimaru","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.actbio.2020.05.035_bib0052","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/cas.13483","article-title":"Regulatory mechanisms of hypoxia\u2010inducible factor 1 activity: two decades of knowledge","volume":"109","author":"Koyasu","year":"2018","journal-title":"Cancer Sci"},{"key":"10.1016\/j.actbio.2020.05.035_bib0053","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s13402-016-0285-5","article-title":"Hypoxia can impair doxorubicin resistance of non-small cell lung cancer cells by inhibiting MRP1 and P-gp expression and boosting the chemosensitizing effects of MRP1 and P-gp blockers","volume":"39","author":"Chen","year":"2016","journal-title":"Cell. Oncol."},{"key":"10.1016\/j.actbio.2020.05.035_bib0054","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ijpharm.2016.06.017","article-title":"Effect of biomimetic shear stress on intracellular uptake and cell-killing efficiency of doxorubicin in a free and liposomal formulation","volume":"510","author":"Kang","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2020.05.035_bib0055","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1080\/10717544.2018.1482975","article-title":"Multistage delivery of CDs-DOX\/ICG-loaded liposome for highly penetration and effective chemo-photothermal combination therapy","volume":"25","author":"Xue","year":"2018","journal-title":"Drug Deliv."},{"key":"10.1016\/j.actbio.2020.05.035_bib0056","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201802994","article-title":"Rational design of IR820- and Ce6-based versatile micelle for single NIR laser\u2013induced imaging and dual-modal phototherapy","volume":"14","author":"Hu","year":"2018","journal-title":"Small"},{"key":"10.1016\/j.actbio.2020.05.035_bib0057","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1124\/pr.56.2.6","article-title":"Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity","volume":"56","author":"Furusawa","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.actbio.2020.05.035_bib0058","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201702342","article-title":"A tumor\u2010specific cascade amplification drug release nanoparticle for overcoming multidrug resistance in cancers","volume":"29","author":"Ye","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2020.05.035_bib0059","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.actbio.2017.05.003","article-title":"pH-triggered chitosan nanogels via an ortho ester-based linkage for efficient chemotherapy","volume":"60","author":"Yang","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2020.05.035_bib0060","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1021\/nl900031y","article-title":"Mediating tumor targeting efficiency of nanoparticles through design","volume":"9","author":"Perrault","year":"2009","journal-title":"Nano Lett"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120303056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120303056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:32:04Z","timestamp":1761672724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706120303056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":60,"alternative-id":["S1742706120303056"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2020.05.035","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxygen-producing catalase-based prodrug nanoparticles overcoming resistance in hypoxia-mediated chemo-photodynamic therapy","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2020.05.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}