{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:26:49Z","timestamp":1791440809794,"version":"4.3.3"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.actbio.2020.05.037","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T11:51:32Z","timestamp":1591185092000},"page":"225-233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Assessing the targeting and fate of cathepsin k antibody-modified nanoparticles in a rat abdominal aortic aneurysm model"],"prefix":"10.1016","volume":"112","author":[{"given":"Andrew","family":"Camardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Carney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-9283","authenticated-orcid":false,"given":"Anand","family":"Ramamurthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2020.05.037_bib0001","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2741\/1810","article-title":"MMPs\u2013role in cardiovascular development and disease","volume":"11","author":"Brauer","year":"2006","journal-title":"Front. Biosci. J. Virtual Libr."},{"key":"10.1016\/j.actbio.2020.05.037_bib0002","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.2174\/138161209787846685","article-title":"Multiple roles of the extracellular matrix in inflammation","volume":"15","author":"Korpos","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.actbio.2020.05.037_bib0003","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1161\/CIRCULATIONAHA.105.573865","article-title":"Matrix metalloproteinases\/tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structural, functional, and clinical manifestations of hypertensive heart disease","volume":"113","author":"Ahmed","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2020.05.037_bib0004","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bcp.2007.07.004","article-title":"Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease","volume":"75","author":"Raffetto","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.actbio.2020.05.037_bib0005","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s13346-012-0070-6","article-title":"Advances in biomimetic regeneration of elastic matrix structures","volume":"2","author":"Sivaraman","year":"2012","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.actbio.2020.05.037_bib0006","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1161\/01.RES.77.6.1107","article-title":"Decreased Elastin Synthesis in Normal Development and in Long-term Aortic Organ and Cell Cultures Is Related to Rapid and Selective Destabilization of mRNA for Elastin","volume":"77","author":"Johnson","year":"1995","journal-title":"Circ. Res."},{"key":"10.1016\/j.actbio.2020.05.037_bib0007","first-page":"11","article-title":"Abdominal aortic aneurysm: A comprehensive review","volume":"16","author":"Aggarwal","year":"2011","journal-title":"Exp. Clin. Cardiol."},{"key":"10.1016\/j.actbio.2020.05.037_bib0008","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1016\/j.actbio.2013.01.023","article-title":"Multifunctional nanoparticles for doxycycline delivery towards localized elastic matrix stabilization and regenerative repair","volume":"9","author":"Sivaraman","year":"2013","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2020.05.037_bib0009","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1007\/s13346-017-0419-y","article-title":"Multifunctional, JNK-inhibiting nanotherapeutics for augmented elastic matrix regenerative repair in aortic aneurysms","volume":"8","author":"Camardo","year":"2018","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.actbio.2020.05.037_bib0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.addr.2012.04.010","article-title":"Nanoparticles in drug delivery: Past, present and future","volume":"65","author":"Couvreur","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2020.05.037_bib0011","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.2174\/13816128113199990375","article-title":"The Smart Targeting of Nanoparticles","volume":"19","author":"Friedman","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.actbio.2020.05.037_bib0012","first-page":"11","article-title":"Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems","author":"Yoo","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.actbio.2020.05.037_bib0013","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41569-018-0002-3","article-title":"Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials","volume":"15","author":"Liu","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.actbio.2020.05.037_bib0014","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1196\/annals.1383.028","article-title":"Do Cathepsins Play a Role in Abdominal Aortic Aneurysm Pathogenesis?","volume":"1085","author":"Sukhova","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.actbio.2020.05.037_bib0015","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.actbio.2017.01.032","article-title":"Cathepsin K-targeted sub-micron particles for regenerative repair of vascular elastic matrix","volume":"52","author":"Jennewine","year":"2017","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2020.05.037_bib0016","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1089\/ten.tea.2010.0526","article-title":"Elastogenic Inductability of Smooth Muscle Cells from a Rat Model of Late Stage Abdominal Aortic Aneurysms","volume":"17","author":"Gacchina","year":"2011","journal-title":"Tissue Eng. Part A."},{"key":"10.1016\/j.actbio.2020.05.037_bib0017","article-title":"Immuno-nanotherapeutics to Inhibit Macrophage Polarization for Non-Small-Cell Lung Cancers","author":"Seshadri","year":"2017","journal-title":"Case Western Reserve Uni."},{"key":"10.1016\/j.actbio.2020.05.037_bib0018","series-title":"Charact. Nanoparticles Intend. Drug Deliv.","first-page":"149","article-title":"Analysis of Complement Activation by Nanoparticles","author":"Neun","year":"2018"},{"key":"10.1016\/j.actbio.2020.05.037_bib0019","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1089\/ten.tea.2010.0475","article-title":"Evaluating smooth muscle cells from CaCl2-induced rat aortal expansions as a surrogate culture model for study of elastogenic induction of human aneurysmal cells","volume":"17","author":"Gacchina","year":"2011","journal-title":"Tissue Eng. Part A."},{"key":"10.1016\/j.actbio.2020.05.037_bib0020","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/term.1905","article-title":"Spatio-Temporal Mapping of Matrix Remodeling and Evidence of in-situ Elastogenesis in Experimental Abdominal Aortic Aneurysms","volume":"11","author":"Deb","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.actbio.2020.05.037_bib0021","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1002\/sim.4780101016","article-title":"Basic and clinical biostatistics. Beth Dawson-Saunders and Robert G. Trapp, Appleton and Lange, Connecticut, 1990. ISBN: C-8385-4541-4","volume":"10","author":"Thompson","year":"1991","journal-title":", Stat. Med."},{"key":"10.1016\/j.actbio.2020.05.037_bib0022","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1038\/emm.2014.20","article-title":"Quantitative expression and localization of cysteine and aspartic proteases in human abdominal aortic aneurysms","volume":"46","author":"Lohoefer","year":"2014","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.actbio.2020.05.037_bib0023","doi-asserted-by":"crossref","DOI":"10.5772\/21311","article-title":"Role of Cathepsin K, L and S in Blood Vessel Remodeling, in: R. Bush (Ed.)","author":"O.","year":"2011","journal-title":"Aneurysmal Dis. Thorac. Abdom. Aorta"},{"key":"10.1016\/j.actbio.2020.05.037_bib0024","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1161\/01.CIR.82.3.973","article-title":"Elastase-induced experimental aneurysms in rats","volume":"82","author":"Anidjar","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2020.05.037_bib0025","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0741-5214(94)90175-9","article-title":"The elastase infusion model of experimental aortic aneurysms: synchrony of induction of endogenous proteinases with matrix destruction and inflammatory cell response","volume":"20","author":"Halpern","year":"1994","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.actbio.2020.05.037_bib0026","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1365-2613.2012.00819.x","article-title":"Histopathological analysis of cellular localization of cathepsins in abdominal aortic aneurysm wall","volume":"93","author":"Lohoefer","year":"2012","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.actbio.2020.05.037_bib0027","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1172\/JCI181","article-title":"Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells, J","volume":"102","author":"Sukhova","year":"1998","journal-title":"Clin. Invest."},{"key":"10.1016\/j.actbio.2020.05.037_bib0028","series-title":"Chir. Forum DGAV Forum 2009","first-page":"313","article-title":"Cellular expression of cathepsin proteases in symptomatic and asymptomatic AAA","author":"Reeps","year":"2009"},{"key":"10.1016\/j.actbio.2020.05.037_bib0029","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/ATVBAHA.111.235002","article-title":"Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice","volume":"32","author":"Sun","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.actbio.2020.05.037_bib0030","series-title":"Nanotoxicity Methods Protoc.","first-page":"1","article-title":"Vitro Methods for Assessing Nanoparticle Toxicity","author":"Savage","year":"2019"},{"key":"10.1016\/j.actbio.2020.05.037_bib0031","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nmat2344","article-title":"Physical approaches to biomaterial design","volume":"8","author":"Mitragotri","year":"2009","journal-title":"Nat. Mater."},{"key":"10.1016\/j.actbio.2020.05.037_bib0032","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1016\/j.jacc.2018.08.2188","article-title":"A Targeting Nanotherapy for Abdominal Aortic Aneurysms","volume":"72","author":"Cheng","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.actbio.2020.05.037_bib0033","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1161\/CIRCRESAHA.115.307207","article-title":"Prevention of abdominal aortic aneurysm progression by targeted inhibition of matrix metalloproteinase activity with batimastat-loaded nanoparticles","volume":"117","author":"Nosoudi","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.actbio.2020.05.037_bib0034","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jconrel.2014.05.036","article-title":"State-of-the-art in design rules for drug delivery platforms: Lessons learned from FDA-approved nanomedicines","volume":"187","author":"Dawidczyk","year":"2014","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.actbio.2020.05.037_bib0035","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.addr.2008.08.005","article-title":"Active targeting schemes for nanoparticle systems in cancer therapeutics","volume":"60","author":"Byrne","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2020.05.037_bib0036","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of nanoparticle design for overcoming biological barriers to drug delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.actbio.2020.05.037_bib0037","doi-asserted-by":"crossref","first-page":"e1003","DOI":"10.1016\/j.nano.2014.02.002","article-title":"Nanoparticle targeting to diseased vasculature for imaging and therapy","volume":"10","author":"Sinha","year":"2014","journal-title":"Nanomedicine Nanotechnol. Biol. Med."},{"key":"10.1016\/j.actbio.2020.05.037_bib0038","first-page":"609","article-title":"Conjugation of cell-penetrating peptides with poly(lactic-co-glycolic acid)-polyethylene glycol nanoparticles improves ocular drug delivery","volume":"10","author":"Vasconcelos","year":"2015","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.actbio.2020.05.037_bib0039","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1021\/nn301630n","article-title":"The Effect of Nanoparticle Polyethylene Glycol Surface Density on Ligand-directed Tumor Targeting Studied in vivo by Dual Modality Imaging","volume":"6","author":"Hak","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2020.05.037_bib0040","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1006\/bbrc.2000.3553","article-title":"The Slow-Binding Inhibition of Cathepsin K by Its Propeptide","volume":"276","author":"Billington","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.actbio.2020.05.037_bib0041","doi-asserted-by":"crossref","first-page":"6311","DOI":"10.1046\/j.1432-1327.2000.01730.x","article-title":"Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides: Propeptide inhibition of cathepsins K, L and S","volume":"267","author":"Guay","year":"2000","journal-title":"Eur. J. Biochem."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174270612030307X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174270612030307X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:28:16Z","timestamp":1761672496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S174270612030307X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":41,"alternative-id":["S174270612030307X"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2020.05.037","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing the targeting and fate of cathepsin k antibody-modified nanoparticles in a rat abdominal aortic aneurysm model","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2020.05.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}