{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:52:52Z","timestamp":1777459972921,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000009","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01 GM121477"],"award-info":[{"award-number":["R01 GM121477"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.actbio.2020.07.045","type":"journal-article","created":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T01:29:40Z","timestamp":1598146180000},"page":"383-392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Engineering selective molecular tethers to enhance suboptimal drug properties"],"prefix":"10.1016","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2166-6595","authenticated-orcid":false,"given":"Alan","family":"Dogan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9323-8100","authenticated-orcid":false,"given":"Horst","family":"von Recum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.actbio.2020.07.045_bib0001","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41557-018-0187-4","article-title":"Rapamycin-inspired macrocycles with new target specificity","volume":"11","author":"Guo","year":"2019","journal-title":"Nat. Chem."},{"issue":"4","key":"10.1016\/j.actbio.2020.07.045_bib0002","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1021\/op0200165","article-title":"Lipases from Candida a Ntarctica\u00a0: unique biocatalysts from a unique origin","volume":"6","author":"Kirk","year":"2002","journal-title":"Org. Process Res. Dev."},{"issue":"18","key":"10.1016\/j.actbio.2020.07.045_bib0003","doi-asserted-by":"crossref","first-page":"13395","DOI":"10.1074\/jbc.M700498200","article-title":"The Rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain","volume":"282","author":"Edwards","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2020.07.045_bib0004","series-title":"mTOR Inhibition for Cancer Therapy: Past, Present and Future","first-page":"161","article-title":"The clinical pharmacology and toxicity profile of Rapalogs","author":"Su","year":"2016"},{"key":"10.1016\/j.actbio.2020.07.045_bib0005","doi-asserted-by":"crossref","first-page":"B93","DOI":"10.1016\/S0149-2918(00)89026-8","article-title":"Toxicity and efficacy of sirolimus: relationship to whole-blood concentrations","volume":"22","author":"Meier-Kriesche","year":"2000","journal-title":"Clin. Ther."},{"issue":"3","key":"10.1016\/j.actbio.2020.07.045_bib0006","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1159\/000087945","article-title":"Patterns of pulmonary complications associated with sirolimus","volume":"73","author":"Chhajed","year":"2006","journal-title":"Respiration"},{"issue":"2","key":"10.1016\/j.actbio.2020.07.045_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.healun.2009.11.055","article-title":"48: The adverse effects of sirolimus in heart transplant patients: is it worth it?","volume":"29","author":"Kittleson","year":"2010","journal-title":"J. Heart Lung Transpl."},{"issue":"1","key":"10.1016\/j.actbio.2020.07.045_bib0008","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1038\/s41598-019-40404-0","article-title":"Local release of Rapamycin by microparticles delays islet rejection within the anterior chamber of the eye","volume":"9","author":"Fan","year":"2019","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.actbio.2020.07.045_bib0009","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1021\/acs.molpharmaceut.9b00144","article-title":"Cyclodextrin polymer preserves sirolimus activity and local persistence for antifibrotic delivery over the time course of wound healing","volume":"16","author":"Rohner","year":"2019","journal-title":"Mol. Pharm."},{"issue":"3","key":"10.1016\/j.actbio.2020.07.045_bib0010","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/mabi.201000206","article-title":"Affinity-based drug delivery","volume":"11","author":"Wang","year":"2011","journal-title":"Macromol. Biosci."},{"issue":"18","key":"10.1016\/j.actbio.2020.07.045_bib0011","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1039\/C4TB00083H","article-title":"Thermomechanical properties, antibiotic release, and bioactivity of a sterilized cyclodextrin drug delivery system","volume":"2","author":"Halpern","year":"2014","journal-title":"J. Mater. Chem. B"},{"issue":"9","key":"10.1016\/j.actbio.2020.07.045_bib0012","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1007\/s10439-011-0336-z","article-title":"Experimental studies and modeling of drug release from a tunable affinity-based drug delivery platform","volume":"39","author":"Fu","year":"2011","journal-title":"Ann. Biomed. Eng."},{"issue":"6","key":"10.1016\/j.actbio.2020.07.045_bib0013","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/1535370218787770","article-title":"Localized and targeted delivery of nsaids for treatment of inflammation: a review","volume":"244","author":"Haley","year":"2019","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"8","key":"10.1016\/j.actbio.2020.07.045_bib0014","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1177\/1535370216688572","article-title":"Emerging technologies for long-term antimicrobial device coatings: advantages and limitations","volume":"242","author":"Cyphert","year":"2017","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"3","key":"10.1016\/j.actbio.2020.07.045_bib0015","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1021\/acs.molpharmaceut.6b01109","article-title":"Using affinity to provide long-term delivery of antiangiogenic drugs in cancer therapy","volume":"14","author":"Rivera-Delgado","year":"2017","journal-title":"Mol. Pharm."},{"issue":"2","key":"10.1016\/j.actbio.2020.07.045_bib0016","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/11\/2\/025022","article-title":"Local release from affinity-based polymers increases urethral concentration of the stem cell chemokine CCL7 in rats","volume":"11","author":"Rivera-Delgado","year":"2016","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.actbio.2020.07.045_bib0017","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2147\/OTT.S120662","article-title":"Strategies of temozolomide in future glioblastoma treatment","volume":"10","author":"Lee","year":"2017","journal-title":"OncoTargets Ther."},{"issue":"3","key":"10.1016\/j.actbio.2020.07.045_bib0018","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3390\/ijms19030778","article-title":"The role of the mammalian target of Rapamycin (MTOR) in pulmonary fibrosis","volume":"19","author":"Lawrence","year":"2018","journal-title":"IJMS"},{"issue":"1","key":"10.1016\/j.actbio.2020.07.045_bib0019","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1039\/c2ib20107k","article-title":"Multi-armed cationic cyclodextrin: poly(Ethylene Glycol) polyrotaxanes as efficient gene silencing vectors","volume":"5","author":"Kulkarni","year":"2013","journal-title":"Integr. Biol."},{"issue":"7","key":"10.1016\/j.actbio.2020.07.045_bib0020","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1177\/1535370217693115","article-title":"Featured Article: chemotherapeutic delivery using PH-responsive, affinity-based release","volume":"242","author":"Cyphert","year":"2017","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"8","key":"10.1016\/j.actbio.2020.07.045_bib0021","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/j.biomaterials.2009.11.087","article-title":"Cyclodextrin-based device coatings for affinity-based release of antibiotics","volume":"31","author":"Thatiparti","year":"2010","journal-title":"Biomaterials"},{"issue":"22","key":"10.1016\/j.actbio.2020.07.045_bib0022","doi-asserted-by":"crossref","first-page":"11400","DOI":"10.1039\/c3ra47867j","article-title":"Facile functionalization of FK506 for biological studies by the thiol\u2013ene \u2018Click\u2019 reaction","volume":"4","author":"Guo","year":"2014","journal-title":"RSC Adv."},{"issue":"2","key":"10.1016\/j.actbio.2020.07.045_bib0023","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/cbdd.12750","article-title":"Enhanced cytotoxicity to cancer cells by codelivery and controlled release of paclitaxel-loaded sirolimus-conjugated albumin nanoparticles","volume":"88","author":"Behrouz","year":"2016","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.actbio.2020.07.045_bib0024","doi-asserted-by":"crossref","unstructured":"N.A. Rohner, L. Purdue, H.A.V. Recum, Affinity-based polymers provide long-term immunotherapeutic drug delivery across particle size ranges optimal for macrophage targeting, (2019). doi:10.1101\/802801.","DOI":"10.1101\/802801"},{"issue":"3","key":"10.1016\/j.actbio.2020.07.045_bib0025","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1021\/acs.molpharmaceut.6b01109","article-title":"Using affinity to provide long-term delivery of antiangiogenic drugs in cancer therapy","volume":"14","author":"Rivera-Delgado","year":"2017","journal-title":"Mol. Pharm."},{"issue":"3","key":"10.1016\/j.actbio.2020.07.045_bib0026","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1590\/S1806-83242009000300006","article-title":"A simple method to measure cell viability in proliferation and cytotoxicity assays","volume":"23","author":"Borra","year":"2009","journal-title":"Braz. Oral Res."},{"issue":"3","key":"10.1016\/j.actbio.2020.07.045_bib0027","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/diagnostics2030023","article-title":"Comparison of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide based strategies to crosslink antibodies on amine-functionalized platforms for immunodiagnostic applications","volume":"2","author":"Vashist","year":"2012","journal-title":"Diagnostics"},{"issue":"5","key":"10.1016\/j.actbio.2020.07.045_bib0028","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1016\/S0041-1345(98)00587-9","article-title":"Chemical modification of Rapamycin: the discovery of SDZ RAD","volume":"30","author":"Sedrani","year":"1998","journal-title":"Transpl. Proc."},{"issue":"1","key":"10.1016\/j.actbio.2020.07.045_bib0029","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41467-018-07858-8","article-title":"The MTORC1\/4E-BP1 axis represents a critical signaling node during fibrogenesis","volume":"10","author":"Woodcock","year":"2019","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.actbio.2020.07.045_bib0030","doi-asserted-by":"crossref","first-page":"9036","DOI":"10.1021\/la048970d","article-title":"Two-phase channel structures based on \u03b1-cyclodextrin\u2212polyethylene glycol inclusion complexes","volume":"20","author":"Topchieva","year":"2004","journal-title":"Langmuir"},{"key":"10.1016\/j.actbio.2020.07.045_bib0031","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ejpb.2015.08.007","article-title":"Controlled antibiotic release system to prevent orthopedic-implant associated infections: an in vitro study","volume":"96","author":"Gimeno","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"6","key":"10.1016\/j.actbio.2020.07.045_bib0032","article-title":"Rapamycin enhances the anti-cancer effect of dasatinib by suppressing Src\/PI3K\/MTOR pathway in NSCLC cells","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.actbio.2020.07.045_bib0033","doi-asserted-by":"crossref","first-page":"5320","DOI":"10.1039\/C9TB00622B","article-title":"Serum biomolecules unable to compete with drug refilling into cyclodextrin polymers regardless of the form","volume":"7","author":"Rohner","year":"2019","journal-title":"J. Mater. Chem. B"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120304311?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120304311?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:30:35Z","timestamp":1761672635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706120304311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":33,"alternative-id":["S1742706120304311"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2020.07.045","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.02.01.929356","asserted-by":"object"}]},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering selective molecular tethers to enhance suboptimal drug properties","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2020.07.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}