{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:32:38Z","timestamp":1785259958209,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 EB007507"],"award-info":[{"award-number":["T32 EB007507"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31 HL139113"],"award-info":[{"award-number":["F31 HL139113"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.actbio.2020.07.046","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T02:48:26Z","timestamp":1596077306000},"page":"296-306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["How hydrogel inclusions modulate the local mechanical response in early and fully formed post-infarcted myocardium"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6489-0191","authenticated-orcid":false,"given":"David S.","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Avazmohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Rodell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward W.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2006-332X","authenticated-orcid":false,"given":"Jason A.","family":"Burdick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Joseph H.","family":"Gorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Gorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2711-8370","authenticated-orcid":false,"given":"Michael S.","family":"Sacks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.actbio.2020.07.046_sbref0001","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1161\/01.CIR.97.3.282","article-title":"Chronic heart failure in the united states","volume":"97","author":"Gheorghiade","year":"1998","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.actbio.2020.07.046_sbref0002","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0002-9149(64)90123-7","article-title":"Biological significance of cardiac hypertrophy","volume":"14","author":"Badeer","year":"1964","journal-title":"Am. J. Cardiol."},{"issue":"2","key":"10.1016\/j.actbio.2020.07.046_sbref0003","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/mrm.10210","article-title":"Mr tagging early after myocardial infarction in mice demonstrates contractile dysfunction in adjacent and remote regions","volume":"48","author":"Epstein","year":"2002","journal-title":"Magn. Reson. Med."},{"issue":"6","key":"10.1016\/j.actbio.2020.07.046_sbref0004","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S0735-1097(02)02121-6","article-title":"Extension of borderzone myocardium in postinfarction dilated cardiomyopathy","volume":"40","author":"Jackson","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.actbio.2020.07.046_bib0005","doi-asserted-by":"crossref","first-page":"H475","DOI":"10.1152\/ajpheart.00360.2002","article-title":"Border zone geometry increases wall stress after myocardial infarction: contrast echocardiographic assessment","volume":"284","author":"Jackson","year":"2003","journal-title":"Am. J. Physiol. Heart Circul. Physiol."},{"issue":"1","key":"10.1016\/j.actbio.2020.07.046_sbref0006","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI108079","article-title":"Wall stress and patterns of hypertrophy in the human left ventricle","volume":"56","author":"Grossman","year":"1975","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.actbio.2020.07.046_bib0007","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.81.4.1161","article-title":"Ventricular remodeling after myocardial infarction. experimental observations and clinical implications.","volume":"81","author":"Pfeffer","year":"1990","journal-title":"Circulation"},{"issue":"9507","key":"10.1016\/j.actbio.2020.07.046_sbref0008","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0140-6736(06)68074-4","article-title":"Controversies in ventricular remodelling","volume":"367","author":"Opie","year":"2006","journal-title":"The Lancet"},{"issue":"24","key":"10.1016\/j.actbio.2020.07.046_sbref0009","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1161\/CIRCULATIONAHA.106.657270","article-title":"Theoretical impact of the injection of material into the myocardium","volume":"114","author":"Wall","year":"2006","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.actbio.2020.07.046_bib0010","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.athoracsur.2011.04.089","article-title":"A novel method for quantifying the in-vivo mechanical effect of material injected into a myocardial infarction","volume":"92","author":"Wenk","year":"2011","journal-title":"Ann. Thorac. Surg."},{"issue":"11","key":"10.1016\/j.actbio.2020.07.046_sbref0011","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1021\/bm201198x","article-title":"Influence of injectable hyaluronic acid hydrogel degradation behavior on infarction-induced ventricular remodeling","volume":"12","author":"Tous","year":"2011","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2020.07.046_bib0012","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1007\/s10439-013-0937-9","article-title":"Experimental and computational investigation of altered mechanical properties in myocardium after hydrogel injection","volume":"42","author":"Kichula","year":"2014","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.actbio.2020.07.046_sbref0013","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.biomaterials.2015.08.011","article-title":"Mri evaluation of injectable hyaluronic acid-based hydrogel therapy to limit ventricular remodeling after myocardial infarction","volume":"69","author":"Dorsey","year":"2015","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.actbio.2020.07.046_bib0014","first-page":"e004058","article-title":"Injectable shear-thinning hydrogels for minimally invasive delivery to infarcted myocardium to limit left ventricular remodeling","volume":"9","author":"Rodell","year":"2016","journal-title":"Circul.: Cardiovasc. Intervent."},{"key":"10.1016\/j.actbio.2020.07.046_sbref0015","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijcard.2017.09.179","article-title":"Efficacy of intramyocardial injection of Algisyl-LVR for the treatment of ischemic heart failure in swine","volume":"255","author":"Choy","year":"2018","journal-title":"Int. J. Cardiol."},{"issue":"12","key":"10.1016\/j.actbio.2020.07.046_sbref0016","doi-asserted-by":"crossref","DOI":"10.1115\/1.4000165","article-title":"A method for automatically optimizing medical devices for treating heart failure: designing polymeric injection patterns","volume":"131","author":"Wenk","year":"2009","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2020.07.046_sbref0017","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jbiomech.2017.08.024","article-title":"Computational sensitivity investigation of hydrogel injection characteristics for myocardial support","volume":"64","author":"Wang","year":"2017","journal-title":"J. Biomech."},{"key":"10.1016\/j.actbio.2020.07.046_bib0018","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s10237-018-1039-2","article-title":"Effects of hydrogel injection on borderzone contractility post-myocardial infarction","volume":"101","author":"Wang","year":"2018","journal-title":"Biomech. Model Mechanobiol."},{"issue":"8","key":"10.1016\/j.actbio.2020.07.046_sbref0019","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/cnm.2551","article-title":"Outcomes of myocardial infarction hydrogel injection therapy in the human left ventricle dependent on injectate distribution","volume":"29","author":"Miller","year":"2013","journal-title":"Int. J. Numer. Method. Biomed. Eng."},{"key":"10.1016\/j.actbio.2020.07.046_sbref0020","first-page":"103508","article-title":"Insights into the passive mechanical behavior of left ventricular myocardium using a robust constitutive model based on full 3d kinematics","author":"Li","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2020.07.046_bib0021","doi-asserted-by":"crossref","DOI":"10.1007\/s10237-017-0943-1","article-title":"An integrated inverse model-experimental approach to determine soft tissue three-dimensional constitutive parameters: application to post-infarcted myocardium","author":"Avazmohammadi","year":"2018","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"1902","key":"10.1016\/j.actbio.2020.07.046_sbref0022","first-page":"3445","article-title":"Constitutive modelling of passive myocardium: a structurally based framework for material characterization","volume":"367","author":"Holzapfel","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond. A: Math. Phys. Eng. Sci."},{"issue":"4","key":"10.1016\/j.actbio.2020.07.046_sbref0023","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/adfm.201403550","article-title":"Shear-thinning supramolecular hydrogels with secondary autonomous covalent crosslinking to modulate viscoelastic properties in vivo","volume":"25","author":"Rodell","year":"2015","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"10.1016\/j.actbio.2020.07.046_bib0024","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0006-3495(94)80775-1","article-title":"Mr diffusion tensor spectroscopy and imaging","volume":"66","author":"Basser","year":"1994","journal-title":"Biophys. J."},{"key":"10.1016\/j.actbio.2020.07.046_bib0025","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1161\/01.RES.74.5.789","article-title":"Anisotropy of water diffusion in the myocardium of rat","volume":"74","author":"Garrido","year":"1994","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.actbio.2020.07.046_sbref0026","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/mrm.1910340603","article-title":"Imaging myocardial fiber architecture in vivo with magnetic resonance","volume":"34","author":"Reese","year":"1995","journal-title":"Magn. Reson. Med."},{"issue":"6","key":"10.1016\/j.actbio.2020.07.046_bib0027","first-page":"H2308","article-title":"Histological validation of myocardial microstructure obtained from diffusion tensor magnetic resonance imaging","volume":"275","author":"Scollan","year":"1998","journal-title":"Am. J. Physiol."},{"issue":"10","key":"10.1016\/j.actbio.2020.07.046_bib0028","doi-asserted-by":"crossref","DOI":"10.1115\/1.4031419","article-title":"Finite-element extrapolation of myocardial structure alterations across the cardiac cycle in rats","volume":"137","author":"David Gomez","year":"2015","journal-title":"J. Biomech. Eng."},{"issue":"4 Pt 2","key":"10.1016\/j.actbio.2020.07.046_sbref0029","first-page":"H1224","article-title":"Regional deformation and contractile function in canine right ventricular free wall","volume":"260","author":"Chuong","year":"1991","journal-title":"Am. J. Physiol."},{"issue":"03","key":"10.1016\/j.actbio.2020.07.046_bib0030","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1142\/S0218202502001714","article-title":"A constrained mixture model for growth and remodeling of soft tissues","volume":"12","author":"Humphrey","year":"2002","journal-title":"Math. Models Methods Appl. Sci."},{"issue":"160","key":"10.1016\/j.actbio.2020.07.046_bib0031","doi-asserted-by":"crossref","first-page":"20190570","DOI":"10.1098\/rsif.2019.0570","article-title":"Three-dimensional myocardial strain correlates with murine left ventricular remodelling severity post-infarction","volume":"16","author":"Soepriatna","year":"2019","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.actbio.2020.07.046_bib0032","series-title":"Frontiers in Biomechanics","first-page":"117","article-title":"Residual Stress in Arteries","author":"Chuong","year":"1986"},{"issue":"3","key":"10.1016\/j.actbio.2020.07.046_bib0033","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1142\/S0218202502001714","article-title":"A constrained mixture model for growth and remodeling of soft tissues","volume":"12","author":"Humphrey","year":"2002","journal-title":"Math. Models Methods Appl. Sci."},{"key":"10.1016\/j.actbio.2020.07.046_sbref0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2020.04.033","article-title":"Intra-myocardial alginate hydrogel injection acts as a left ventricular mid-wall constraint in swine","author":"Sack","year":"2020","journal-title":"Acta Biomater."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120304323?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120304323?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:32:16Z","timestamp":1761672736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706120304323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":34,"alternative-id":["S1742706120304323"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2020.07.046","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"How hydrogel inclusions modulate the local mechanical response in early and fully formed post-infarcted myocardium","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2020.07.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}