{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:00:24Z","timestamp":1780732824000,"version":"3.54.1"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.actbio.2020.11.034","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T12:48:20Z","timestamp":1606394900000},"page":"621-636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Thermal treatment at 500\u00a0\u00b0C significantly reduces the reaction to irregular tricalcium phosphate granules as foreign bodies: An in vivo study"],"prefix":"10.1016","volume":"121","author":[{"given":"Sarah","family":"Al-Maawi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Barbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Herrera","family":"-Vizca\u00edno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4440-2338","authenticated-orcid":false,"given":"Rainer","family":"Egli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles James","family":"Kirkpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bohner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Ghanaati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2020.11.034_bib0001","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/7\/1\/015005","article-title":"The chemical composition of synthetic bone substitutes influences tissue reactions in vivo\u00a0: histological and histomorphometrical analysis of the cellular inflammatory response to hydroxyapatite, beta-tricalcium phosphate and biphasic calcium phosphate ce","volume":"7","author":"Ghanaati","year":"2012","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.actbio.2020.11.034_bib0002","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jos.2016.01.007","article-title":"Efficacy and safety of porous hydroxyapatite\/type 1 collagen composite implantation for bone regeneration: a randomized controlled study","volume":"21","author":"Sotome","year":"2016","journal-title":"J. Orthop. Sci."},{"key":"10.1016\/j.actbio.2020.11.034_bib0003","doi-asserted-by":"crossref","DOI":"10.1002\/jbm.a.36006","article-title":"Multinucleated giant cells in the implant bed of bone substitutes are foreign body giant cells-New insights into the material-mediated healing process","author":"Barbeck","year":"2017","journal-title":"J. Biomed. Mater. Res. Part A."},{"key":"10.1016\/j.actbio.2020.11.034_bib0004","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/jbm.b.33262","article-title":"The heat-compression technique for the conversion of platelet-rich fibrin preparation to a barrier membrane with a reduced rate of biodegradation","volume":"103","author":"Kawase","year":"2015","journal-title":"J. Biomed. Mater. Res. - Part B Appl. Biomater."},{"key":"10.1016\/j.actbio.2020.11.034_bib0005","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.smim.2017.06.001","article-title":"In vivo cellular reactions to different biomaterials\u2014Physiological and pathological aspects and their consequences","volume":"29","author":"Al-Maawi","year":"2017","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.actbio.2020.11.034_bib0006","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"Anderson","year":"2008","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.actbio.2020.11.034_bib0007","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/jbm.a.30313","article-title":"Lymphocytes and the foreign body response: lymphocyte enhancement of macrophage adhesion and fusion","volume":"74","author":"Brodbeck","year":"2005","journal-title":"J. Biomed. Mater. Res. A."},{"key":"10.1016\/j.actbio.2020.11.034_bib0008","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1002\/jbm.a.35808","article-title":"Macrophage responses to 316\u00a0L stainless steel and cobalt chromium alloys with different surface topographies","volume":"104","author":"Anderson","year":"2016","journal-title":"J. Biomed. Mater. Res. Part A."},{"key":"10.1016\/j.actbio.2020.11.034_bib0009","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3389\/fimmu.2019.00663","article-title":"Immune modulation by transplanted calcium phosphate biomaterials and human mesenchymal stromal cells in bone regeneration","volume":"10","author":"Humbert","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2020.11.034_bib0010","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1034\/j.1600-0501.1997.080308.x","article-title":"Influence of surface treatments developed for oral implants on the physical and biological properties of titanium. (II) Adsorption isotherms and biological activity of immobilized fibronectin","volume":"8","author":"Fran\u00e7ois","year":"1997","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.actbio.2020.11.034_bib0011","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1016\/j.actbio.2010.07.006","article-title":"Influence of \u03b2-tricalcium phosphate granule size and morphology on tissue reaction in vivo","volume":"6","author":"Ghanaati","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2020.11.034_bib0012","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/rb\/rbx024","article-title":"The material and biological characteristics of osteoinductive calcium phosphate ceramics","volume":"5","author":"Tang","year":"2018","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.actbio.2020.11.034_bib0013","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.mattod.2018.10.036","article-title":"A proposed mechanism for material-induced heterotopic ossification","volume":"22","author":"Bohner","year":"2019","journal-title":"Mater. Today."},{"key":"10.1016\/j.actbio.2020.11.034_bib0014","doi-asserted-by":"crossref","first-page":"314","DOI":"10.22203\/eCM.v029a24","article-title":"Influence of surface microstructure and chemistry on osteoinduction and osteoclastogenesis by biphasic calcium phosphate discs","volume":"29","author":"Davison","year":"2015","journal-title":"Eur. Cells Mater."},{"key":"10.1016\/j.actbio.2020.11.034_bib0015","doi-asserted-by":"crossref","first-page":"13614","DOI":"10.1073\/pnas.1003600107","article-title":"Osteoinductive ceramics as a synthetic alternative to autologous bone grafting","volume":"107","author":"Yuan","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.actbio.2020.11.034_bib0016","series-title":"PhD thesis No. 1171","author":"Bohner","year":"1993"},{"key":"10.1016\/j.actbio.2020.11.034_bib0017","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1039\/b706411j","article-title":"Reactivity of calcium phosphate cements","volume":"17","author":"Bohner","year":"2007","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.actbio.2020.11.034_bib0018","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1016\/j.actbio.2009.05.024","article-title":"A physical approach to modify the hydraulic reactivity of \u03b1-tricalcium phosphate powder","volume":"5","author":"Bohner","year":"2009","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2020.11.034_bib0019","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1039\/b804314k","article-title":"Effect of thermal treatments on the reactivity of nanosized tricalcium phosphate powders","volume":"18","author":"Bohner","year":"2008","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.actbio.2020.11.034_bib0020","doi-asserted-by":"crossref","first-page":"6095","DOI":"10.1016\/j.jeurceramsoc.2020.07.028","article-title":"A thermodynamic approach to surface modification of calcium phosphate implants by phosphate evaporation and condensation","volume":"40","author":"D\u00f6belin","year":"2020","journal-title":"J. Eur. Ceram. Soc."},{"key":"10.1016\/j.actbio.2020.11.034_bib0021","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.actbio.2019.11.035","article-title":"In vitro measurement of the chemical changes occurring within \u03b2-tricalcium phosphate bone graft substitutes","volume":"102","author":"Maazouz","year":"2020","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2020.11.034_bib0022","doi-asserted-by":"crossref","first-page":"B102","DOI":"10.1002\/adem.201080037","article-title":"Thermal treatments of calcium phosphate biomaterials to tune the physico-chemical properties and modify the in vitro osteoclast response","volume":"13","author":"Egli","year":"2011","journal-title":"Adv. Eng. Mater."},{"key":"10.1016\/j.actbio.2020.11.034_bib0023","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0022-4596(74)90030-9","article-title":"Crystallographic studies of the role of Mg as a stabilizing impurity in \u03b2-Ca3(PO4)2. The crystal structure of pure \u03b2-Ca3(PO4)2","volume":"10","author":"Dickens","year":"1974","journal-title":"J. Solid State Chem."},{"key":"10.1016\/j.actbio.2020.11.034_bib0024","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1107\/S0567740877006037","article-title":"The crystal structure of \u03b1-Ca3(PO4)2","volume":"33","author":"Mathew","year":"1977","journal-title":"Acta Crystallogr. Sect. B Struct. Crystallogr. Cryst. Chem."},{"key":"10.1016\/j.actbio.2020.11.034_bib0025","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1107\/S0567740869004298","article-title":"Significant precision in crystal structural details. Holly springs hydroxyapatite","volume":"25","author":"Sudarsanan","year":"1969","journal-title":"Acta Crystallogr. Sect. B Struct. Crystallogr. Cryst. Chem."},{"key":"10.1016\/j.actbio.2020.11.034_bib0026","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1107\/S0108270193005608","article-title":"Redetermination of the \u03b2-Ca2P2O7 structure","volume":"49","author":"Boudin","year":"1993","journal-title":"Acta Crystallogr. Sect. C Cryst. Struct. Commun."},{"key":"10.1016\/j.actbio.2020.11.034_bib0027","unstructured":"P.M. Conn, Animal models for the study of human disease, n.d. https:\/\/books.google.de\/books?id=ctm1DQAAQBAJ&pg=PA78&lpg=PA78&dq=large+animals+in+research+sheep+dogs+swine&source=bl&ots=ToM3d6lQnU&sig=kBHaiAtxYTnhGkMPlhH9yPJgMqg&hl=de&sa=X&ved=0ahUKEwiP4aqRmO3bAhULb1AKHVigDQgQ6AEIfDAM#v=onepage&q=largeanimalsin (accessed June 25, 2018)."},{"key":"10.1016\/j.actbio.2020.11.034_bib0028","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1016\/j.actbio.2012.04.041","article-title":"Non-cross-linked porcine-based collagen I-III membranes do not require high vascularization rates for their integration within the implantation bed: a paradigm shift","volume":"8","author":"Ghanaati","year":"2012","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2020.11.034_bib0029","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1016\/j.actbio.2011.07.003","article-title":"An injectable bone substitute composed of beta-tricalcium phosphate granules, methylcellulose and hyaluronic acid inhibits connective tissue influx into its implantation bed in vivo","volume":"7","author":"Ghanaati","year":"2011","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2020.11.034_bib0030","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.biomaterials.2015.02.039","article-title":"Nanostructured medical sutures with antibacterial properties","volume":"52","author":"Serrano","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2020.11.034_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1746-160X-9-1","article-title":"Implantation of silicon dioxide-based nanocrystalline hydroxyapatite and pure phase beta-tricalciumphosphate bone substitute granules in caprine muscle tissue does not induce new bone formation","volume":"9","author":"Ghanaati","year":"2013","journal-title":"Head Face Med"},{"key":"10.1016\/j.actbio.2020.11.034_bib0032","doi-asserted-by":"crossref","unstructured":"Y. Zhang, S. Al\u2010Maawi, X. Wang, R. Sader, C.J. Kirkpatrick, S. Ghanaati, Biomaterial\u2010induced multinucleated giant cells express proinflammatory signaling molecules: a histological study in humans, J. Biomed. Mater. Res. Part A. (2018) jbm.a.36594. doi:10.1002\/jbm.a.36594.","DOI":"10.1002\/jbm.a.36594"},{"key":"10.1016\/j.actbio.2020.11.034_bib0033","first-page":"6","article-title":"In vivo implantation of a Bovine-derived collagen membrane leads to changes in the physiological cellular pattern of wound healing by the induction of multinucleated giant cells: an adverse reaction?","author":"Al-Maawi","year":"2018","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2020.11.034_bib0034","doi-asserted-by":"crossref","DOI":"10.1007\/s00784-020-03219-2","article-title":"Modification of collagen-based sponges can induce an upshift of the early inflammatory response and a chronic inflammatory reaction led by M1 macrophages: an in vivo study","author":"Herrera-Vizca\u00edno","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.actbio.2020.11.034_bib0035","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fbioe.2018.00104","article-title":"In vivo implantation of a Bovine-derived collagen membrane leads to changes in the physiological cellular pattern of wound healing by the induction of multinucleated giant cells: an adverse reaction?","volume":"6","author":"Al-Maawi","year":"2018","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2020.11.034_bib0036","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1563\/aaid-joi-D-14-00155","article-title":"Porcine dermis and pericardium-based, non-cross-linked materials induce multinucleated giant cells after their in vivo implantation: a physiological reaction?","volume":"41","author":"Barbeck","year":"2015","journal-title":"J. Oral Implantol."},{"key":"10.1016\/j.actbio.2020.11.034_bib0037","doi-asserted-by":"crossref","DOI":"10.1007\/s00784-020-03219-2","article-title":"Modification of collagen-based sponges can induce an up shift of the early inflammatory response and a chronic inflammatory reaction led by M1 macrophages: an in vivo study","author":"Herrera-Vizca\u00edno","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.actbio.2020.11.034_bib0038","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.3390\/ma13122730","article-title":"Characterization of the cellular reaction to a collagen-based matrix: an In vivo histological and histomorphometrical analysis","volume":"13","author":"Udeabor","year":"2020","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.actbio.2020.11.034_bib0039","article-title":"Sugar-based collagen membrane cross-linking increases barrier capacity of membranes","author":"Chia-Lai","year":"2017","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.actbio.2020.11.034_bib0040","doi-asserted-by":"crossref","unstructured":"S. Al-maawi, A. Orlowska, R. Sader, C.J. Kirkpatrick, S. Ghanaati, In vivo cellular reactions to di ff erent biomaterials \u2014 Physiological and pathological aspects and their consequences, (2017).","DOI":"10.1016\/j.smim.2017.06.001"},{"key":"10.1016\/j.actbio.2020.11.034_bib0041","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1039\/JR9610004442","article-title":"874. High-temperature studies of the system calcium oxide-phosphorus pentoxide","author":"Welch","year":"1961","journal-title":"J. Chem. Soc."},{"key":"10.1016\/j.actbio.2020.11.034_bib0042","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s11663-011-9509-2","article-title":"Thermodynamic measurement of di-calcium phosphate","volume":"42","author":"Nagai","year":"2011","journal-title":"Metall. Mater. Trans. B Process Metall. Mater. Process. Sci."},{"key":"10.1016\/j.actbio.2020.11.034_bib0043","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s11663-009-9242-2","article-title":"Thermodynamic measurement of calcium phosphates by double knudsen cell mass spectrometry","volume":"40","author":"Nagai","year":"2009","journal-title":"Metall. Mater. Trans. B Process Metall. Mater. Process. Sci."},{"key":"10.1016\/j.actbio.2020.11.034_bib0044","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/(SICI)1097-4636(19980315)39:4<580::AID-JBM12>3.0.CO;2-B","article-title":"Thermal processing of hydroxyapatite for coating production","volume":"39","author":"Gross","year":"1998","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.actbio.2020.11.034_bib0045","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.actbio.2018.09.003","article-title":"Osteogenesis by foamed and 3D-printed nanostructured calcium phosphate scaffolds: effect of pore architecture","volume":"79","author":"Barba","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2020.11.034_bib0046","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jbm.a.36798","article-title":"Modulation of foreign body reaction and macrophage phenotypes concerning microenvironment","volume":"108","author":"Chu","year":"2020","journal-title":"J. Biomed. Mater. Res. Part A."},{"key":"10.1016\/j.actbio.2020.11.034_bib0047","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.actbio.2019.08.014","article-title":"Electrospun acid-neutralizing fibers for the amelioration of inflammatory response","volume":"97","author":"Shen","year":"2019","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2020.11.034_bib0048","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00062752-200001000-00008","article-title":"Multinucleated giant cells","volume":"7","author":"Anderson","year":"2000","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.actbio.2020.11.034_bib0049","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/jbm.a.32218","article-title":"Lymphocyte adhesion and interactions with biomaterial adherent macrophages and foreign body giant cells","volume":"91A","author":"Chang","year":"2009","journal-title":"J. Biomed. Mater. Res. Part A."},{"key":"10.1016\/j.actbio.2020.11.034_bib0050","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/jbm.a.30165","article-title":"Surface chemistry mediates adhesive structure, cytoskeletal organization, and fusion of macrophages","volume":"71A","author":"Dadsetan","year":"2004","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.actbio.2020.11.034_bib0051","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/1097-4636(20010615)55:4<661::AID-JBM1061>3.0.CO;2-F","article-title":"Influence of biomaterial surface chemistry on the apoptosis of adherent cells","volume":"55","author":"Brodbeck","year":"2001","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.actbio.2020.11.034_bib0052","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/cyto.2002.1048","article-title":"Biomaterial surface chemistry dictates adherent monocyte\/macrophage cytokine expression in vitro","volume":"18","author":"Brodbeck","year":"2002","journal-title":"Cytokine"},{"key":"10.1016\/j.actbio.2020.11.034_bib0053","doi-asserted-by":"crossref","first-page":"10744","DOI":"10.1021\/acs.langmuir.6b02601","article-title":"Adsorption of human plasma albumin and fibronectin onto nanostructured black silicon surfaces","volume":"32","author":"Nguyen","year":"2016","journal-title":"Langmuir"},{"key":"10.1016\/j.actbio.2020.11.034_bib0054","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.actbio.2016.09.029","article-title":"Giant cells around bone biomaterials: osteoclasts or multi-nucleated giant cells?","volume":"46","author":"Miron","year":"2016","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2020.11.034_bib0055","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s00223-017-0259-2","article-title":"Bone alkaline phosphatase and tartrate-resistant acid phosphatase: potential co-regulators of bone mineralization","volume":"101","author":"Halling Linder","year":"2017","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.actbio.2020.11.034_bib0056","first-page":"21","article-title":"Molecular signaling pathways and essential metabolic elements in bone remodeling: an implication of therapeutic targets for bone diseases","author":"Sharma","year":"2020","journal-title":"Curr. Drug Targets."},{"key":"10.1016\/j.actbio.2020.11.034_bib0057","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/labinvest.2016.116","article-title":"CD68\/macrosialin: not just a histochemical marker","volume":"97","author":"Chistiakov","year":"2017","journal-title":"Lab. Investig."},{"key":"10.1016\/j.actbio.2020.11.034_bib0058","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.12.017","article-title":"OsteoMacs: key players around bone biomaterials","volume":"82","author":"Miron","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2020.11.034_bib0059","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1089\/ten.teb.2017.0242","article-title":"Multinucleated giant cells: good guys or bad guys?","volume":"24","author":"Miron","year":"2018","journal-title":"Tissue Eng. Part B. Rev."},{"key":"10.1016\/j.actbio.2020.11.034_bib0060","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/jbm.a.35958","article-title":"The pathology of the foreign body reaction against biomaterials","volume":"105","author":"Klopfleisch","year":"2017","journal-title":"J. Biomed. Mater. Res. A."},{"key":"10.1016\/j.actbio.2020.11.034_bib0061","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.actbio.2016.05.002","article-title":"Diversity of multinucleated giant cells by microstructures of hydroxyapatite and plasma components in extraskeletal implantation model","volume":"39","author":"Morishita","year":"2016","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2020.11.034_bib0062","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/BF03402045","article-title":"Expression of the proteinase specialized in bone resorption, cathepsin K, in granulomatous inflammation","volume":"6","author":"D\u00edaz","year":"2000","journal-title":"Mol. Med."},{"key":"10.1016\/j.actbio.2020.11.034_bib0063","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/path.959","article-title":"Cathepsin K - A marker of macrophage differentiation?","volume":"195","author":"B\u00fchling","year":"2001","journal-title":"J. Pathol"},{"key":"10.1016\/j.actbio.2020.11.034_bib0064","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1089\/ten.teb.2017.0242","article-title":"Multinucleated giant cells: good guys or bad guys?","volume":"24","author":"Miron","year":"2018","journal-title":"Tissue Eng. Part B. Rev."},{"key":"10.1016\/j.actbio.2020.11.034_bib0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.actbio.2016.07.003","article-title":"Macrophage reaction against biomaterials in the mouse model - phenotypes, functions and markers","volume":"43","author":"Klopfleisch","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2020.11.034_bib0066","doi-asserted-by":"crossref","DOI":"10.1563\/aaid-joi-D-15-00133","article-title":"Foreign body giant cell-related encapsulation of a synthetic material three years after augmentation","volume":"42","author":"Lorenz","year":"2016","journal-title":"J. Oral Implantol."},{"key":"10.1016\/j.actbio.2020.11.034_bib0067","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.yexmp.2005.06.008","article-title":"Multinucleated giant cell formation exhibits features of phagocytosis with participation of the endoplasmic reticulum","volume":"79","author":"McNally","year":"2005","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.actbio.2020.11.034_bib0068","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/j.celrep.2015.10.065","article-title":"Multinucleated giant cells are specialized for complement-mediated phagocytosis and large target destruction","volume":"13","author":"Milde","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.actbio.2020.11.034_bib0069","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.yexmp.2005.06.008","article-title":"Multinucleated giant cell formation exhibits features of phagocytosis with participation of the endoplasmic reticulum","volume":"79","author":"McNally","year":"2005","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.actbio.2020.11.034_bib0070","article-title":"Multinucleated giant cells within the in vivo implantation bed of a collagen-based biomaterial determine its degradation pattern","author":"Tanneberger","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.actbio.2020.11.034_bib0071","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1016\/j.actbio.2010.07.006","article-title":"Influence of beta-tricalcium phosphate granule size and morphology on tissue reaction in vivo","volume":"6","author":"Ghanaati","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2020.11.034_bib0072","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/path.2092","article-title":"Langhans giant cells from M. tuberculosis -induced human granulomas cannot mediate mycobacterial uptake","volume":"211","author":"Lay","year":"2007","journal-title":"J. Pathol."},{"key":"10.1016\/j.actbio.2020.11.034_bib0073","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/clr.13032","article-title":"Tissue dynamics and regenerative outcome in two resorbable non-cross-linked collagen membranes for guided bone regeneration: a preclinical molecular and histological study in vivo","volume":"29","author":"Omar","year":"2018","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.actbio.2020.11.034_bib0074","doi-asserted-by":"crossref","DOI":"10.1563\/aaid-joi-D-19-00201","article-title":"The biomaterial-induced cellular reaction allows a novel classification system regardless of the biomaterials origin","author":"Al-Maawi","year":"2020","journal-title":"J. Oral Implantol."}],"updated-by":[{"DOI":"10.1016\/j.actbio.2022.01.011","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000}}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120306875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706120306875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:33:22Z","timestamp":1761672802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706120306875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":74,"alternative-id":["S1742706120306875"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2020.11.034","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thermal treatment at 500\u00a0\u00b0C significantly reduces the reaction to irregular tricalcium phosphate granules as foreign bodies: An in vivo study","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2020.11.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}