{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:57:22Z","timestamp":1792699042287,"version":"4.5.0"},"reference-count":151,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.actbio.2021.02.023","type":"journal-article","created":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T09:59:28Z","timestamp":1614506368000},"page":"208-221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"special_numbering":"C","title":["Harnessing the innate and adaptive immune system for tissue repair and regeneration: Considering more than macrophages"],"prefix":"10.1016","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9810-5545","authenticated-orcid":false,"given":"Lianne C.","family":"Shanley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olwyn R.","family":"Mahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisling","family":"Dunne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.actbio.2021.02.023_bib0001","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0002","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.stem.2014.06.009","article-title":"Immune modulation of stem cells and regeneration","volume":"15","author":"Aurora","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.actbio.2021.02.023_bib0003","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.actbio.2017.01.056","article-title":"Promoting tissue regeneration by modulating the immune system","volume":"53","author":"Julier","year":"2017","journal-title":"Acta Biomater"},{"issue":"7","key":"10.1016\/j.actbio.2021.02.023_bib0004","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/wound.2017.0761","article-title":"Immune regulation of skin wound healing: mechanisms and novel therapeutic targets","volume":"7","author":"Larouche","year":"2018","journal-title":"Adv. Wound Care (New Rochelle)"},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0005","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound healing: a cellular perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol. Rev."},{"issue":"23","key":"10.1016\/j.actbio.2021.02.023_bib0006","doi-asserted-by":"crossref","first-page":"9415","DOI":"10.1073\/pnas.1300290110","article-title":"Macrophages are required for adult salamander limb regeneration","volume":"110","author":"Godwin","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.actbio.2021.02.023_bib0007","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.semcdb.2016.08.008","article-title":"Chasing the recipe for a pro-regenerative immune system","volume":"61","author":"Godwin","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"issue":"7","key":"10.1016\/j.actbio.2021.02.023_bib0008","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1089\/wound.2012.0407","article-title":"Disclosure of the culprits: macrophages-versatile regulators of wound healing","volume":"2","author":"Sindrilaru","year":"2013","journal-title":"Adv. Wound Care (New Rochelle)"},{"issue":"11","key":"10.1016\/j.actbio.2021.02.023_bib0009","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1002\/jor.23553","article-title":"Pro-inflammatory M1 macrophages promote osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway","volume":"35","author":"Lu","year":"2017","journal-title":"J. Orthop. Res."},{"issue":"3","key":"10.1016\/j.actbio.2021.02.023_bib0010","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.imbio.2013.09.001","article-title":"Macrophages: supportive cells for tissue repair and regeneration","volume":"219","author":"Chazaud","year":"2014","journal-title":"Immunobiology"},{"issue":"Pt 1","key":"10.1016\/j.actbio.2021.02.023_bib0011","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1113\/jphysiol.2006.118265","article-title":"Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo","volume":"578","author":"Tidball","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.actbio.2021.02.023_bib0012","article-title":"Single cell sequencing analysis of lizard phagocytic cell populations and their role in tail regeneration","volume":"8","author":"Londono","year":"2020","journal-title":"J. Immunol. Regen. Med."},{"issue":"6","key":"10.1016\/j.actbio.2021.02.023_bib0013","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1189\/jlb.1RI0414-195R","article-title":"Functional significance of mononuclear phagocyte populations generated through adult hematopoiesis","volume":"96","author":"Gutknecht","year":"2014","journal-title":"J Leukoc Biol"},{"issue":"45","key":"10.1016\/j.actbio.2021.02.023_bib0014","doi-asserted-by":"crossref","first-page":"16029","DOI":"10.1073\/pnas.1406508111","article-title":"Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart","volume":"111","author":"Lavine","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"10.1016\/j.actbio.2021.02.023_bib0015","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nn.3469","article-title":"M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination","volume":"16","author":"Miron","year":"2013","journal-title":"Nat. Neurosci."},{"issue":"4","key":"10.1016\/j.actbio.2021.02.023_bib0016","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1084\/jem.20141539","article-title":"A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury","volume":"212","author":"Dal-Secco","year":"2015","journal-title":"J. Exp. Med."},{"issue":"12","key":"10.1016\/j.actbio.2021.02.023_bib0017","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"J. Immunol."},{"issue":"20","key":"10.1016\/j.actbio.2021.02.023_bib0018","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1007\/s00018-016-2268-0","article-title":"Transition from inflammation to proliferation: a critical step during wound healing","volume":"73","author":"Land\u00e9n","year":"2016","journal-title":"Cell Mol. Life Sci."},{"issue":"5","key":"10.1016\/j.actbio.2021.02.023_bib0019","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1089\/wound.2012.0406","article-title":"Critical role of transforming growth factor beta in different phases of wound healing","volume":"2","author":"Pakyari","year":"2013","journal-title":"Adv. Wound Care (New Rochelle)"},{"key":"10.1016\/j.actbio.2021.02.023_bib0020","doi-asserted-by":"crossref","first-page":"32231","DOI":"10.1038\/srep32231","article-title":"TGF-\u03b21 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2021.02.023_bib0021","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/978-3-319-54090-0_14","article-title":"Macrophage differentiation in normal and accelerated wound healing","volume":"62","author":"Kotwal","year":"2017","journal-title":"Results Probl. Cell Differ."},{"issue":"3","key":"10.1016\/j.actbio.2021.02.023_bib0022","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1172\/JCI124635","article-title":"Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation","volume":"130","author":"McArthur","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"15","key":"10.1016\/j.actbio.2021.02.023_bib0023","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1016\/j.biomaterials.2012.02.034","article-title":"Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine","volume":"33","author":"Brown","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2021.02.023_bib0024","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.12659\/MSM.907222","article-title":"Cellular mechanisms of hepatoprotection mediated by M2-like macrophages","volume":"24","author":"Bai","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.actbio.2021.02.023_bib0025","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.rvsc.2016.01.014","article-title":"M1 and M2 macrophage recruitment during tendon regeneration induced by amniotic epithelial cell allotransplantation in ovine","volume":"105","author":"Mauro","year":"2016","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.actbio.2021.02.023_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2020.02.031","article-title":"Alternatively activated macrophages promote resolution of necrosis following acute liver injury","author":"Starkey Lewis","year":"2020","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0027","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41467-019-14263-2","article-title":"Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair","volume":"11","author":"Sim\u00f5es","year":"2020","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.actbio.2021.02.023_bib0028","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/imcb.12236","article-title":"Macrophages in wound healing: activation and plasticity","volume":"97","author":"Kim","year":"2019","journal-title":"Immunol. Cell Biol."},{"issue":"11","key":"10.1016\/j.actbio.2021.02.023_bib0029","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/intimm\/dxy054","article-title":"Macrophages in inflammation, repair and regeneration","volume":"30","author":"Oishi","year":"2018","journal-title":"Int. Immunol."},{"issue":"3","key":"10.1016\/j.actbio.2021.02.023_bib0030","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.actbio.2021.02.023_bib0031","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: sensing and reacting to damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0032","doi-asserted-by":"crossref","first-page":"e1458","DOI":"10.1002\/wsbm.1458","article-title":"Neutrophils in innate immunity and systems biology-level approaches","volume":"12","author":"Rungelrath","year":"2020","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"issue":"9","key":"10.1016\/j.actbio.2021.02.023_bib0033","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137550","article-title":"Neutrophil responses to sterile implant materials","volume":"10","author":"Jhunjhunwala","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.actbio.2021.02.023_bib0034","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nri2779","article-title":"Phagocyte partnership during the onset and resolution of inflammation","volume":"10","author":"Soehnlein","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.actbio.2021.02.023_bib0035","doi-asserted-by":"crossref","first-page":"eaar8320","DOI":"10.1126\/sciadv.aar8320","article-title":"PGE","volume":"4","author":"Loynes","year":"2018","journal-title":"Sci. Adv."},{"issue":"8","key":"10.1016\/j.actbio.2021.02.023_bib0036","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nri3024","article-title":"Neutrophils in the activation and regulation of innate and adaptive immunity","volume":"11","author":"Mantovani","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.actbio.2021.02.023_bib0037","first-page":"187","article-title":"Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype","volume":"38","author":"Horckmans","year":"2017","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0038","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1096\/fj.201800752R","article-title":"Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases","volume":"33","author":"Hahn","year":"2019","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.actbio.2021.02.023_bib0039","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nm.3547","article-title":"Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines","volume":"20","author":"Schauer","year":"2014","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.actbio.2021.02.023_bib0040","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nm.3887","article-title":"Diabetes primes neutrophils to undergo NETosis, which impairs wound healing","volume":"21","author":"Wong","year":"2015","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.actbio.2021.02.023_bib0041","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10456-011-9207-3","article-title":"Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma","volume":"14","author":"Bausch","year":"2011","journal-title":"Angiogenesis"},{"issue":"3","key":"10.1016\/j.actbio.2021.02.023_bib0042","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1523\/JNEUROSCI.4918-08.2009","article-title":"Depletion of Ly6G\/Gr-1 leukocytes after spinal cord injury in mice alters wound healing and worsens neurological outcome","volume":"29","author":"Stirling","year":"2009","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.actbio.2021.02.023_bib0043","doi-asserted-by":"crossref","first-page":"eaav2309","DOI":"10.1126\/sciadv.aav2309","article-title":"Novel reprogramming of neutrophils modulates inflammation resolution during atherosclerosis","volume":"5","author":"Geng","year":"2019","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0044","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/cvr\/cvw024","article-title":"Temporal neutrophil polarization following myocardial infarction","volume":"110","author":"Ma","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.actbio.2021.02.023_bib0045","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-020711-075005","article-title":"Controlling natural killer cell responses: integration of signals for activation and inhibition","volume":"31","author":"Long","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.actbio.2021.02.023_bib0046","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coche.2017.11.006","article-title":"CD8","volume":"19","author":"Rosenberg","year":"2018","journal-title":"Curr. Opin. Chem. Eng."},{"issue":"35","key":"10.1016\/j.actbio.2021.02.023_bib0047","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat8116","article-title":"Human natural killer cells mediate adaptive immunity to viral antigens","volume":"4","author":"Nikzad","year":"2019","journal-title":"Sci. Immunol."},{"issue":"4","key":"10.1016\/j.actbio.2021.02.023_bib0048","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/SHK.0b013e31816e2cda","article-title":"Depletion of NK cells in a murine polytrauma model is associated with improved outcome and a modulation of the inflammatory response","volume":"30","author":"Barkhausen","year":"2008","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0049","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/jbmr.185","article-title":"Fracture healing is accelerated in the absence of the adaptive immune system","volume":"26","author":"Toben","year":"2011","journal-title":"J. Bone Miner Res."},{"key":"10.1016\/j.actbio.2021.02.023_bib0050","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3389\/fimmu.2017.00301","article-title":"Immunoregulatory role of NK cells in tissue inflammation and regeneration","volume":"8","author":"Tosello-Trampont","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2021.02.023_bib0051","article-title":"The physiopathological role of IL-33: new highlights in bone biology and a proposed role in periodontal disease","author":"da Luz","year":"2014","journal-title":"Mediators Inflamm."},{"issue":"8","key":"10.1016\/j.actbio.2021.02.023_bib0052","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/intimm\/dxn060","article-title":"IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells","volume":"20","author":"Smithgall","year":"2008","journal-title":"Int. Immunol."},{"issue":"2","key":"10.1016\/j.actbio.2021.02.023_bib0053","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ajpath.2012.04.010","article-title":"NK cells modulate the inflammatory response to corneal epithelial abrasion and thereby support wound healing","volume":"181","author":"Liu","year":"2012","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.actbio.2021.02.023_bib0054","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s12079-018-0448-4","article-title":"Mesenchymal stromal cells of the bone marrow and natural killer cells: cell interactions and cross modulation","volume":"12","author":"Najar","year":"2018","journal-title":"J. Cell Commun. Signal"},{"issue":"3","key":"10.1016\/j.actbio.2021.02.023_bib0055","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1182\/blood-2007-02-074997","article-title":"Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2","volume":"111","author":"Spaggiari","year":"2008","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0056","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1634\/stemcells.2004-0359","article-title":"Interactions between human mesenchymal stem cells and natural killer cells","volume":"24","author":"Sotiropoulou","year":"2006","journal-title":"Stem Cells"},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0057","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2174\/1574888X13666180912125736","article-title":"Mesenchymal stromal cells and natural killer cells: a complex story of love and hate","volume":"14","author":"Najar","year":"2019","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.actbio.2021.02.023_bib0058","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3389\/fimmu.2019.00861","article-title":"Innate lymphoid cells in mucosal immunity","volume":"10","author":"Panda","year":"2019","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.actbio.2021.02.023_bib0059","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s13238-017-0388-4","article-title":"Establishment and function of tissue-resident innate lymphoid cells in the skin","volume":"8","author":"Yang","year":"2017","journal-title":"Protein Cell"},{"issue":"23","key":"10.1016\/j.actbio.2021.02.023_bib0060","doi-asserted-by":"crossref","first-page":"979","DOI":"10.4254\/wjh.v9.i23.979","article-title":"Innate lymphoid cells in tissue homeostasis and diseases","volume":"9","author":"Ignacio","year":"2017","journal-title":"World J. Hepatol."},{"issue":"5","key":"10.1016\/j.actbio.2021.02.023_bib0061","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.cell.2018.07.017","article-title":"Innate lymphoid cells: 10 years on","volume":"174","author":"Vivier","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2021.02.023_bib0062","series-title":"Nat. Mater.","article-title":"ILC1 drive intestinal epithelial and matrix remodelling","author":"Jowett","year":"2020"},{"issue":"3","key":"10.1016\/j.actbio.2021.02.023_bib0063","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20121964","article-title":"Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages","volume":"210","author":"Molofsky","year":"2013","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.actbio.2021.02.023_bib0064","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/eji.201142018","article-title":"Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma","volume":"42","author":"Klein Wolterink","year":"2012","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.actbio.2021.02.023_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004607","article-title":"IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells","volume":"11","author":"Besnard","year":"2015","journal-title":"PLoS Pathog."},{"issue":"2","key":"10.1016\/j.actbio.2021.02.023_bib0066","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41590-018-0297-6","article-title":"IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3","volume":"20","author":"Zhu","year":"2019","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.actbio.2021.02.023_bib0067","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/JID.2015.406","article-title":"IL-33-dependent group 2 innate lymphoid cells promote cutaneous wound healing","volume":"136","author":"Rak","year":"2016","journal-title":"J. Invest. Dermatol."},{"issue":"5","key":"10.1016\/j.actbio.2021.02.023_bib0068","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.4049\/jimmunol.1300974","article-title":"Type 2 innate lymphoid cells drive CD4+ Th2 cell responses","volume":"192","author":"Mirchandani","year":"2014","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.actbio.2021.02.023_bib0069","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/hep.25744","article-title":"Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice","volume":"56","author":"Kong","year":"2012","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.actbio.2021.02.023_bib0070","doi-asserted-by":"crossref","first-page":"e62853","DOI":"10.1371\/journal.pone.0062853","article-title":"IL-22-producing ROR\u03b3t-dependent innate lymphoid cells play a novel protective role in murine acute hepatitis","volume":"8","author":"Matsumoto","year":"2013","journal-title":"PLoS One"},{"issue":"6077","key":"10.1016\/j.actbio.2021.02.023_bib0071","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.1218004","article-title":"Interleukin-22 drives endogenous thymic regeneration in mice","volume":"336","author":"Dudakov","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.actbio.2021.02.023_bib0072","doi-asserted-by":"crossref","first-page":"11394","DOI":"10.1038\/ncomms11394","article-title":"Epidermal Notch1 recruits ROR\u03b3(+) group 3 innate lymphoid cells to orchestrate normal skin repair","volume":"7","author":"Li","year":"2016","journal-title":"Nat. Commun."},{"issue":"7534","key":"10.1016\/j.actbio.2021.02.023_bib0073","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature14189","article-title":"The biology of innate lymphoid cells","volume":"517","author":"Artis","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2021.02.023_bib0074","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3389\/fimmu.2015.00569","article-title":"Tolerogenic dendritic cells for regulatory T cell induction in man","volume":"6","author":"Raker","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2021.02.023_bib0075","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.3389\/fimmu.2017.01764","article-title":"Tolerance through Education: how tolerogenic dendritic cells shape immunity","volume":"8","author":"Domogalla","year":"2017","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.actbio.2021.02.023_bib0076","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1161\/CIRCULATIONAHA.111.052126","article-title":"Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling","volume":"125","author":"Anzai","year":"2012","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0077","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/wrr.12388","article-title":"Dendritic cells modulate burn wound healing by enhancing early proliferation","volume":"24","author":"Vinish","year":"2016","journal-title":"Wound Repair Regen."},{"issue":"13","key":"10.1016\/j.actbio.2021.02.023_bib0078","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1084\/jem.20101102","article-title":"Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons","volume":"207","author":"Gregorio","year":"2010","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.actbio.2021.02.023_bib0079","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2353\/ajpath.2009.080355","article-title":"CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling","volume":"175","author":"Iwata","year":"2009","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.actbio.2021.02.023_bib0080","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/wrr.12584","article-title":"Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions","volume":"25","author":"S\u00eerbulescu","year":"2017","journal-title":"Wound Repair Regen."},{"issue":"3","key":"10.1016\/j.actbio.2021.02.023_bib0081","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1365-2567.2009.03119.x","article-title":"Antibodies to wounded tissue enhance cutaneous wound healing","volume":"128","author":"Nishio","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.actbio.2021.02.023_bib0082","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bone.2014.03.052","article-title":"T and B cells participate in bone repair by infiltrating the fracture callus in a two-wave fashion","volume":"64","author":"K\u00f6nnecke","year":"2014","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0083","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/jre.12606","article-title":"Improved RANKL expression and osteoclastogenesis induction of CD27+CD38- memory B cells: a link between B cells and alveolar bone damage in periodontitis","volume":"54","author":"Han","year":"2019","journal-title":"J. Periodontal Res."},{"issue":"4","key":"10.1016\/j.actbio.2021.02.023_bib0084","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/art.39489","article-title":"Production of RANKL by memory B Cells: a link between B cells and bone erosion in rheumatoid arthritis","volume":"68","author":"Meednu","year":"2016","journal-title":"Arthritis Rheumatol."},{"issue":"177","key":"10.1016\/j.actbio.2021.02.023_bib0085","doi-asserted-by":"crossref","first-page":"177ra36","DOI":"10.1126\/scitranslmed.3004754","article-title":"Terminally differentiated CD8+ T cells negatively affect bone regeneration in humans","volume":"5","author":"Reinke","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.actbio.2021.02.023_bib0086","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1046\/j.1365-2168.2001.01665.x","article-title":"Effect of CD4(+) and CD8(+) cell depletion on wound healing","volume":"88","author":"Davis","year":"2001","journal-title":"Br. J. Surg."},{"issue":"6283","key":"10.1016\/j.actbio.2021.02.023_bib0087","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1126\/science.aad9272","article-title":"Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells","volume":"352","author":"Sadtler","year":"2016","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.actbio.2021.02.023_bib0088","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1089\/wound.2019.0981","article-title":"T Lymphocytes attenuate dermal scarring by regulating inflammation, neovascularization, and extracellular matrix remodeling","volume":"8","author":"Wang","year":"2019","journal-title":"Adv. Wound Care (New Rochelle)"},{"key":"10.1016\/j.actbio.2021.02.023_bib0089","doi-asserted-by":"crossref","DOI":"10.1038\/s41590-020-0688-3","article-title":"A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections","author":"Wu","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.actbio.2021.02.023_bib0090","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3389\/fimmu.2018.00585","article-title":"Regulatory T-cells: potential regulator of tissue repair and regeneration","volume":"9","author":"Li","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2021.02.023_bib0091","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3389\/fphar.2015.00184","article-title":"Regulatory T cell-mediated anti-inflammatory effects promote successful tissue repair in both indirect and direct manners","volume":"6","author":"Lei","year":"2015","journal-title":"Front. Pharmacol."},{"issue":"49","key":"10.1016\/j.actbio.2021.02.023_bib0092","doi-asserted-by":"crossref","first-page":"19446","DOI":"10.1073\/pnas.0706832104","article-title":"CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes\/macrophages","volume":"104","author":"Tiemessen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7378","key":"10.1016\/j.actbio.2021.02.023_bib0093","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nature10664","article-title":"Response to self antigen imprints regulatory memory in tissues","volume":"480","author":"Rosenblum","year":"2011","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.actbio.2021.02.023_bib0094","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.cell.2013.10.054","article-title":"A special population of regulatory T cells potentiates muscle repair","volume":"155","author":"Burzyn","year":"2013","journal-title":"Cell"},{"issue":"258","key":"10.1016\/j.actbio.2021.02.023_bib0095","doi-asserted-by":"crossref","first-page":"258ra142","DOI":"10.1126\/scitranslmed.3009925","article-title":"Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy","volume":"6","author":"Villalta","year":"2014","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.actbio.2021.02.023_bib0096","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.immuni.2012.09.023","article-title":"Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor","volume":"38","author":"Zaiss","year":"2013","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0097","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/CIRCRESAHA.115.303895","article-title":"Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte\/macrophage differentiation","volume":"115","author":"Weirather","year":"2014","journal-title":"Circ. Res."},{"issue":"34","key":"10.1016\/j.actbio.2021.02.023_bib0098","doi-asserted-by":"crossref","first-page":"10762","DOI":"10.1073\/pnas.1509070112","article-title":"IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions","volume":"112","author":"Monticelli","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0099","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1038\/s41467-018-04908-z","article-title":"Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction","volume":"9","author":"Zacchigna","year":"2018","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.actbio.2021.02.023_bib0100","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/cmi.2010.20","article-title":"Regulatory T cells: immune suppression and beyond","volume":"7","author":"Wan","year":"2010","journal-title":"Cell Mol. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0101","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1165\/rcmb.2012-0198OC","article-title":"Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment","volume":"48","author":"Garibaldi","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.actbio.2021.02.023_bib0102","series-title":"Circ. Res.","article-title":"Regulatory T cells license macrophage pro-resolving functions during atherosclerosis regression","author":"Sharma","year":"2020"},{"issue":"47","key":"10.1016\/j.actbio.2021.02.023_bib0103","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aaz9631","article-title":"Regulatory T cells in skin injury: at the crossroads of tolerance and tissue repair","volume":"5","author":"Boothby","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.actbio.2021.02.023_bib0104","doi-asserted-by":"crossref","DOI":"10.1172\/JCI134091","article-title":"IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis","author":"Faust","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"40","key":"10.1016\/j.actbio.2021.02.023_bib0105","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aax4783","article-title":"Interleukin-36\u03b3-producing macrophages drive IL-17-mediated fibrosis","volume":"4","author":"Sommerfeld","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.actbio.2021.02.023_bib0106","article-title":"Immunomodulatory effect of urine-derived stem cells on inflammatory bowel diseases via downregulating Th1\/Th17 immune responses in a PGE2-dependent manner","author":"Zhou","year":"2019","journal-title":"J. Crohns Colitis"},{"issue":"5568","key":"10.1016\/j.actbio.2021.02.023_bib0107","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1126\/science.1069639","article-title":"A role for skin gammadelta T cells in wound repair","volume":"296","author":"Jameson","year":"2002","journal-title":"Science"},{"issue":"42","key":"10.1016\/j.actbio.2021.02.023_bib0108","doi-asserted-by":"crossref","first-page":"10738","DOI":"10.1073\/pnas.1802320115","article-title":"Amphiregulin-producing \u03b3\u03b4 T cells are vital for safeguarding oral barrier immune homeostasis","volume":"115","author":"Krishnan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.actbio.2021.02.023_bib0109","doi-asserted-by":"crossref","first-page":"10928","DOI":"10.1038\/ncomms10928","article-title":"IL-17-producing \u03b3\u03b4 T cells enhance bone regeneration","volume":"7","author":"Ono","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2021.02.023_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2018.09.056","article-title":"The inflammasome in host response to biomaterials: bridging inflammation and tissue regeneration","volume":"83","author":"Vasconcelos","year":"2019","journal-title":"Acta Biomater"},{"issue":"3","key":"10.1016\/j.actbio.2021.02.023_bib0111","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030636","article-title":"Biomaterials: foreign bodies or tuners for the immune response?","volume":"20","author":"Mariani","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2021.02.023_bib0112","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jconrel.2015.03.019","article-title":"Locally controlled delivery of TNF\u03b1 antibody from a novel glucose-sensitive scaffold enhances alveolar bone healing in diabetic conditions","volume":"206","author":"Wang","year":"2015","journal-title":"J. Control Release"},{"key":"10.1016\/j.actbio.2021.02.023_bib0113","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.biomaterials.2015.12.022","article-title":"Knockdown of TNF-\u03b1 by DNAzyme gold nanoparticles as an anti-inflammatory therapy for myocardial infarction","volume":"83","author":"Somasuntharam","year":"2016","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.actbio.2021.02.023_bib0114","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1021\/acsbiomaterials.5b00181","article-title":"High and low molecular weight hyaluronic acid differentially influence macrophage activation","volume":"1","author":"Rayahin","year":"2015","journal-title":"ACS Biomater Sci. Eng."},{"issue":"5","key":"10.1016\/j.actbio.2021.02.023_bib0115","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/jbm.a.34829","article-title":"Effects of hyaluronic acid conjugation on anti-TNF-\u03b1 inhibition of inflammation in burns","volume":"102","author":"Friedrich","year":"2014","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0116","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s13287-020-01740-5","article-title":"TNF\u03b1\/TNFR2 signaling pathway: an active immune checkpoint for mesenchymal stem cell immunoregulatory function","volume":"11","author":"Beldi","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.actbio.2021.02.023_bib0117","doi-asserted-by":"crossref","first-page":"11051","DOI":"10.1038\/ncomms11051","article-title":"Inhibition of IL-1R1\/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration","volume":"7","author":"Martino","year":"2016","journal-title":"Nat. Commun."},{"issue":"24","key":"10.1016\/j.actbio.2021.02.023_bib0118","doi-asserted-by":"crossref","first-page":"eaba7602","DOI":"10.1126\/sciadv.aba7602","article-title":"Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling","volume":"6","author":"Julier","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.actbio.2021.02.023_bib0119","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.biomaterials.2014.12.009","article-title":"Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes","volume":"44","author":"Gutowski","year":"2015","journal-title":"Biomaterials"},{"issue":"Pt 14","key":"10.1016\/j.actbio.2021.02.023_bib0120","first-page":"3052","article-title":"NF-\u03baB controls axonal regeneration and degeneration through cell-specific balance of RelA and p50 in the adult CNS","volume":"127","author":"Haenold","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.actbio.2021.02.023_bib0121","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119987","article-title":"Targeted immunomodulation of inflammatory monocytes across the blood-brain barrier by curcumin-loaded nanoparticles delays the progression of experimental autoimmune encephalomyelitis","volume":"245","author":"Lu","year":"2020","journal-title":"Biomaterials"},{"issue":"23","key":"10.1016\/j.actbio.2021.02.023_bib0122","doi-asserted-by":"crossref","first-page":"9469","DOI":"10.1073\/pnas.1300532110","article-title":"NF-\u03baB inhibits osteogenic differentiation of mesenchymal stem cells by promoting \u03b2-catenin degradation","volume":"110","author":"Chang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.actbio.2021.02.023_bib0123","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.biomaterials.2017.01.008","article-title":"Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy","volume":"122","author":"Wang","year":"2017","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.actbio.2021.02.023_bib0124","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.stemcr.2019.02.013","article-title":"IL-1 and TNF\u03b1 contribute to the inflammatory niche to enhance alveolar regeneration","volume":"12","author":"Katsura","year":"2019","journal-title":"Stem Cell Rep."},{"issue":"6","key":"10.1016\/j.actbio.2021.02.023_bib0125","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1161\/01.CIR.0000112575.66565.84","article-title":"Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice","volume":"109","author":"Oyama","year":"2004","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.actbio.2021.02.023_bib0126","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1172\/JCI31008","article-title":"TLR4 activation mediates kidney ischemia\/reperfusion injury","volume":"117","author":"Wu","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.actbio.2021.02.023_bib0127","doi-asserted-by":"crossref","first-page":"e48777","DOI":"10.15252\/embr.201948777","article-title":"TLR4-dependent shaping of the wound site by MSCs accelerates wound healing","author":"Munir","year":"2020","journal-title":"EMBO Rep."},{"issue":"2","key":"10.1016\/j.actbio.2021.02.023_bib0128","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jdermsci.2013.10.009","article-title":"TLR4, rather than TLR2, regulates wound healing through TGF-\u03b2 and CCL5 expression","volume":"73","author":"Suga","year":"2014","journal-title":"J Dermatol. Sci."},{"issue":"5","key":"10.1016\/j.actbio.2021.02.023_bib0129","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1021\/acs.nanolett.6b04130","article-title":"Extra-large pore mesoporous silica nanoparticles for directing in vivo M2 macrophage polarization by delivering IL-4","volume":"17","author":"Kwon","year":"2017","journal-title":"Nano Lett."},{"key":"10.1016\/j.actbio.2021.02.023_bib0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110508","article-title":"Synergistic regulation of osteoimmune microenvironment by IL-4 and RGD to accelerate osteogenesis","volume":"109","author":"Li","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0131","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12967-020-02251-w","article-title":"Alternatively activated macrophages; a double-edged sword in allergic asthma","volume":"18","author":"Abdelaziz","year":"2020","journal-title":"J. Transl. Med."},{"issue":"42","key":"10.1016\/j.actbio.2021.02.023_bib0132","doi-asserted-by":"crossref","first-page":"10648","DOI":"10.1073\/pnas.1806908115","article-title":"Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice","volume":"115","author":"Raimondo","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.actbio.2021.02.023_bib0133","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3389\/fbioe.2020.00292","article-title":"Engineering immunomodulatory biomaterials for regenerating the infarcted myocardium","volume":"8","author":"Bloise","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2021.02.023_bib0134","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.biomaterials.2014.10.017","article-title":"Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds","volume":"37","author":"Spiller","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2021.02.023_bib0135","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.biomaterials.2015.05.028","article-title":"Macrophage repolarization with targeted alginate nanoparticles containing IL-10 plasmid DNA for the treatment of experimental arthritis","volume":"61","author":"Jain","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2021.02.023_bib0136","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119833","article-title":"Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner","volume":"239","author":"Mahon","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2021.02.023_bib0137","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119550","article-title":"Targeted delivery of anti-inflammatory cytokine by nanocarrier reduces atherosclerosis in Apo E","volume":"226","author":"Kim","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2021.02.023_bib0138","article-title":"Dual delivery of IL-10 and AT-RvD1 from PEG hydrogels polarize immune cells towards pro-regenerative phenotypes","volume":"268","author":"Sok","year":"2020","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.actbio.2021.02.023_bib0139","doi-asserted-by":"crossref","DOI":"10.3390\/jdb4020021","article-title":"Signalling by transforming growth factor beta isoforms in wound healing and tissue regeneration","volume":"4","author":"Gilbert","year":"2016","journal-title":"J. Dev. Biol."},{"issue":"7","key":"10.1016\/j.actbio.2021.02.023_bib0140","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/cbin.10725","article-title":"The role of TGF-\u03b21 during skeletal muscle regeneration","volume":"41","author":"Delaney","year":"2017","journal-title":"Cell Biol. Int."},{"issue":"1","key":"10.1016\/j.actbio.2021.02.023_bib0141","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1523-1747.2000.00010.x","article-title":"Delayed wound healing in immunodeficient TGF-beta 1 knockout mice","volume":"115","author":"Crowe","year":"2000","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.actbio.2021.02.023_bib0142","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biomaterials.2015.11.065","article-title":"Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets","volume":"80","author":"Liu","year":"2016","journal-title":"Biomaterials"},{"issue":"14","key":"10.1016\/j.actbio.2021.02.023_bib0143","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1016\/j.biomaterials.2012.02.009","article-title":"Strategies to reduce dendritic cell activation through functional biomaterial design","volume":"33","author":"Hume","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2021.02.023_bib0144","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1600-065X.2007.00565.x","article-title":"Yin-Yang\u2019 functions of transforming growth factor-beta and T regulatory cells in immune regulation","volume":"220","author":"Wan","year":"2007","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.actbio.2021.02.023_bib0145","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.immuni.2017.03.015","article-title":"Transforming growth factor-\u03b2 signaling in regulatory T cells controls T helper-17 cells and tissue-specific immune responses","volume":"46","author":"Konkel","year":"2017","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.actbio.2021.02.023_bib0146","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/btm2.10063","article-title":"Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine","volume":"2","author":"Andorko","year":"2017","journal-title":"Bioeng. Transl. Med."},{"issue":"4","key":"10.1016\/j.actbio.2021.02.023_bib0147","first-page":"880","article-title":"Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-\u03baB signaling pathway","volume":"5","author":"Chen","year":"2020","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2021.02.023_bib0148","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.actbio.2019.02.048","article-title":"Material stiffness influences the polarization state, function and migration mode of macrophages","volume":"89","author":"Sridharan","year":"2019","journal-title":"Acta Biomater"},{"issue":"6","key":"10.1016\/j.actbio.2021.02.023_bib0149","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/jbm.a.34104","article-title":"The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)-based hydrogels","volume":"100","author":"Blakney","year":"2012","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"2","key":"10.1016\/j.actbio.2021.02.023_bib0150","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/jbm.a.32893","article-title":"Biomaterial topography alters healing in vivo and monocyte\/macrophage activation in vitro","volume":"95","author":"Bota","year":"2010","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"11","key":"10.1016\/j.actbio.2021.02.023_bib0151","article-title":"Immune modulation by design: using topography to control human monocyte attachment and macrophage differentiation","volume":"7","author":"Vassey","year":"2020","journal-title":"Adv. Sci. (Weinh)"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706121001185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706121001185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:44:31Z","timestamp":1761673471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706121001185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":151,"alternative-id":["S1742706121001185"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2021.02.023","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Harnessing the innate and adaptive immune system for tissue repair and regeneration: Considering more than macrophages","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2021.02.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}