{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:38:03Z","timestamp":1789501083513,"version":"build-2803163510"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010032","name":"Health and Family Planning Commission of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014175","name":"Shanghai Municipal Commission of Health and Family Planning","doi-asserted-by":"publisher","award":["201840109"],"award-info":[{"award-number":["201840109"]}],"id":[{"id":"10.13039\/501100014175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2017ZD12"],"award-info":[{"award-number":["YG2017ZD12"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.actbio.2021.06.015","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T19:44:04Z","timestamp":1623527044000},"page":"395-408","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Ultrasound-assisted C3F8-filled PLGA nanobubbles for enhanced FGF21 delivery and improved prophylactic treatment of diabetic cardiomyopathy"],"prefix":"10.1016","volume":"130","author":[{"given":"Jiameng","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheying","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daxiang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.actbio.2021.06.015_bib0001","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1136\/heart.85.3.247","article-title":"Diabetic cardiomyopathy: fact or fiction?","volume":"85","author":"Francis","year":"2001","journal-title":"Heart"},{"issue":"6","key":"10.1016\/j.actbio.2021.06.015_bib0002","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0002-9149(72)90595-4","article-title":"New type of cardiomyopathy associated with diabetic glomerulosclerosis","volume":"30","author":"Rubler","year":"1972","journal-title":"Am. J. Cardiol."},{"issue":"13","key":"10.1016\/j.actbio.2021.06.015_bib0003","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1001\/jama.1974.03230510023016","article-title":"Diabetic cardiomyopathy","volume":"229","author":"Hamby","year":"1974","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.actbio.2021.06.015_bib0004","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11906-007-0086-3","article-title":"Diabetic cardiomyopathy","volume":"9","author":"Karnik","year":"2007","journal-title":"Curr. Hypertens. Rep."},{"issue":"39","key":"10.1016\/j.actbio.2021.06.015_bib0005","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1093\/eurheartj\/ehz687","volume":"40","author":"Grant","year":"2019","journal-title":"Eur. Heart J."},{"issue":"3","key":"10.1016\/j.actbio.2021.06.015_bib0006","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/dom.12821","article-title":"Cardiovascular events and all-cause mortality associated with sulphonylureas compared with other antihyperglycaemic drugs: a Bayesian meta-analysis of survival data","volume":"19","author":"Bain","year":"2017","journal-title":"Diabetes Obes. Metab."},{"issue":"11","key":"10.1016\/j.actbio.2021.06.015_bib0007","doi-asserted-by":"crossref","first-page":"740","DOI":"10.7326\/M15-2650","article-title":"Diabetes Medications as monotherapy or metformin-based combination therapy for type 2 diabetes: a systematic review and meta-analysis","volume":"164","author":"Maruthur","year":"2016","journal-title":"Ann. Intern. Med."},{"issue":"3","key":"10.1016\/j.actbio.2021.06.015_bib0008","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1054\/jcaf.2003.31","article-title":"Survival and hospitalization in heart failure patients with or without diabetes treated with beta-blockers","volume":"9","author":"Bobbio","year":"2003","journal-title":"J. Card. Fail."},{"issue":"5","key":"10.1016\/j.actbio.2021.06.015_bib0009","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.jacc.2005.05.051","article-title":"Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of randomized clinical trials","volume":"46","author":"Abuissa","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"10.1016\/j.actbio.2021.06.015_bib0010","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI23606","article-title":"FGF-21 as a novel metabolic regulator","volume":"115","author":"Kharitonenkov","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.actbio.2021.06.015_bib0011","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.1210\/en.2008-0816","article-title":"Fibroblast growth factor 21 corrects obesity in mice","volume":"149","author":"Coskun","year":"2008","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.actbio.2021.06.015_bib0012","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0167-4781(00)00067-1","article-title":"Identification of a novel FGF, FGF-21, preferentially expressed in the liver","volume":"1492","author":"Nishimura","year":"2000","journal-title":"Biochim. Biophys. Acta."},{"issue":"12","key":"10.1016\/j.actbio.2021.06.015_bib0013","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.2337\/db14-0595","article-title":"Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding","volume":"63","author":"Markan","year":"2014","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.actbio.2021.06.015_bib0014","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1055\/a-0879-2968","article-title":"Circulating FGF21 levels in human health and metabolic disease","volume":"128","author":"Keuper","year":"2020","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.actbio.2021.06.015_bib0015","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1038\/ncomms3019","article-title":"Fibroblast growth factor 21 protects against cardiac hypertrophy in mice","volume":"4","author":"Planavila","year":"2013","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.actbio.2021.06.015_bib0016","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1210\/me.2007-0313","article-title":"betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c","volume":"22","author":"Suzuki","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.actbio.2021.06.015_bib0017","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1038\/srep02767","article-title":"Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue","volume":"3","author":"Liu","year":"2013","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.actbio.2021.06.015_bib0018","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1007\/s00125-015-3630-8","article-title":"Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1\/2-dependent signalling pathway","volume":"58","author":"Zhang","year":"2015","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.actbio.2021.06.015_bib0019","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41419-018-0307-5","article-title":"Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.actbio.2021.06.015_bib0020","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41574-020-0386-0","article-title":"The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic","volume":"16","author":"Geng","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"issue":"9","key":"10.1016\/j.actbio.2021.06.015_bib0021","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1042\/BCJ20160004","article-title":"FAP finds FGF21 easy to digest","volume":"473","author":"Gillum","year":"2016","journal-title":"Biochem J"},{"issue":"11","key":"10.1016\/j.actbio.2021.06.015_bib0022","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.1074\/jbc.M115.710582","article-title":"Fibroblast activation protein cleaves and inactivates fibroblast growth factor 21","volume":"291","author":"Dunshee","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.actbio.2021.06.015_bib0023","doi-asserted-by":"crossref","first-page":"e58575","DOI":"10.1371\/journal.pone.0058575","article-title":"Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319","volume":"8","author":"Kharitonenkov","year":"2013","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.actbio.2021.06.015_bib0024","first-page":"515","article-title":"Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics","volume":"2","author":"Tran","year":"2007","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.actbio.2021.06.015_bib0025","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/1556-276X-9-252","article-title":"A sight on the current nanoparticle-based gene delivery vectors","volume":"9","author":"Dizaj","year":"2014","journal-title":"Nanoscale Res. Lett."},{"issue":"3","key":"10.1016\/j.actbio.2021.06.015_bib0026","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.3892\/mmr.2015.3941","article-title":"Diagnostic and therapeutic research on ultrasound microbubble\/nanobubble contrast agents (Review)","volume":"12","author":"Ma","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"11","key":"10.1016\/j.actbio.2021.06.015_bib0027","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.7150\/thno.43233","article-title":"Myocardium-targeted transplantation of PHD2 shRNA-modified bone mesenchymal stem cells through ultrasound-targeted microbubble destruction protects the heart from acute myocardial infarction","volume":"10","author":"Sun","year":"2020","journal-title":"Theranostics"},{"issue":"8","key":"10.1016\/j.actbio.2021.06.015_bib0028","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.biomaterials.2012.11.041","article-title":"The use of cationic microbubbles to improve ultrasound-targeted gene delivery to the ischemic myocardium","volume":"34","author":"Sun","year":"2013","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.actbio.2021.06.015_bib0029","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.biomaterials.2013.10.043","article-title":"The use of MMP2 antibody-conjugated cationic microbubble to target the ischemic myocardium, enhance Timp3 gene transfection and improve cardiac function","volume":"35","author":"Yan","year":"2014","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.actbio.2021.06.015_bib0030","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1039\/C9BM00301K","article-title":"Improving acute cardiac transplantation rejection therapy using ultrasound-targeted FK506-loaded microbubbles in rats","volume":"7","author":"Liu","year":"2019","journal-title":"Biomater. Sci."},{"issue":"20","key":"10.1016\/j.actbio.2021.06.015_bib0031","doi-asserted-by":"crossref","first-page":"6002","DOI":"10.7150\/thno.36135","article-title":"Biodegradable, pH-Sensitive hollow mesoporous organosilica nanoparticle (HMON) with controlled release of pirfenidone and ultrasound-target-microbubble-destruction (UTMD) for Pancreatic cancer treatment","volume":"9","author":"Gao","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2021.06.015_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109161","article-title":"The effects of ultrasound-targeted microbubble destruction (UTMD) carrying IL-8 monoclonal antibody on the inflammatory responses and stability of atherosclerotic plaques","volume":"118","author":"Yang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.actbio.2021.06.015_bib0033","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jconrel.2020.06.008","article-title":"Ultrasound and microbubble mediated therapeutic delivery: underlying mechanisms and future outlook","volume":"326","author":"Chowdhury","year":"2020","journal-title":"J. Control Release"},{"issue":"8","key":"10.1016\/j.actbio.2021.06.015_bib0034","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.ultrasmedbio.2012.03.018","article-title":"Effects of acoustic radiation force on the binding efficiency of BR55, a VEGFR2-specific ultrasound contrast agent","volume":"38","author":"Frinking","year":"2012","journal-title":"Ultrasound Med. Biol."},{"issue":"41","key":"10.1016\/j.actbio.2021.06.015_bib0035","doi-asserted-by":"crossref","first-page":"16486","DOI":"10.1073\/pnas.1208198109","article-title":"Spatiotemporally controlled single cell sonoporation","volume":"109","author":"Fan","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.actbio.2021.06.015_bib0036","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.21037\/jtd.2018.01.101","article-title":"The present and future role of ultrasound targeted microbubble destruction in preclinical studies of cardiac gene therapy","volume":"10","author":"Qian","year":"2018","journal-title":"J. Thorac. Dis."},{"issue":"1","key":"10.1016\/j.actbio.2021.06.015_bib0037","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jconrel.2010.04.010","article-title":"The correlation between acoustic cavitation and sonoporation involved in ultrasound-mediated DNA transfection with polyethylenimine (PEI) in vitro","volume":"145","author":"Qiu","year":"2010","journal-title":"J. Control Release"},{"issue":"5","key":"10.1016\/j.actbio.2021.06.015_bib0038","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/CIRCRESAHA.108.183806","article-title":"Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation","volume":"104","author":"Meijering","year":"2009","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.actbio.2021.06.015_bib0039","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.amjcard.2013.09.038","article-title":"Comparison of two- and three-dimensional unenhanced and contrast-enhanced echocardiographies versus cineventriculography versus cardiac magnetic resonance for determination of left ventricular function","volume":"113","author":"Hoffmann","year":"2014","journal-title":"Am. J. Cardiol."},{"issue":"47","key":"10.1016\/j.actbio.2021.06.015_bib0040","doi-asserted-by":"crossref","first-page":"32159","DOI":"10.1021\/acsami.6b10175","article-title":"Dual-Targeting magnetic PLGA nanoparticles for codelivery of paclitaxel and curcumin for brain tumor therapy","volume":"8","author":"Cui","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2021.06.015_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115128","article-title":"Polyethylenimine-coated PLGA nanoparticles-encapsulated Angelica sinensis polysaccharide as an adjuvant to enhance immune responses","volume":"223","author":"Gu","year":"2019","journal-title":"Carbohydr. Polym."},{"issue":"2","key":"10.1016\/j.actbio.2021.06.015_bib0042","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ijpharm.2015.10.037","article-title":"Design and evaluation of surface and adjuvant modified PLGA microspheres for uptake by dendritic cells to improve vaccine responses","volume":"496","author":"Salvador","year":"2015","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.actbio.2021.06.015_bib0043","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/mabi.201200255","article-title":"A serum-resistant low-generation polyamidoamine with PEI 423 outer layer for gene delivery vector","volume":"13","author":"Pan","year":"2013","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.actbio.2021.06.015_bib0044","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jconrel.2019.08.023","article-title":"Effects of encapsulated gas on stability of lipid-based microbubbles and ultrasound-triggered drug delivery","volume":"311-312","author":"Omata","year":"2019","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.actbio.2021.06.015_bib0045","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1038\/s41598-018-21502-x","article-title":"Preparation and imaging investigation of dual-targeted C3F8-filled PLGA nanobubbles as a novel ultrasound contrast agent for breast cancer","volume":"8","author":"Du","year":"2018","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.actbio.2021.06.015_bib0046","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.2337\/db08-0617","article-title":"Rac1 is required for cardiomyocyte apoptosis during hyperglycemia","volume":"58","author":"Shen","year":"2009","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.actbio.2021.06.015_bib0047","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.actbio.2021.06.015_bib0048","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/s41427-018-0094-6","article-title":"Surface-engineered nanobubbles with pH-\/light-responsive drug release and charge-switchable behaviors for active NIR\/MR\/US imaging-guided tumor therapy","volume":"10","author":"Li","year":"2018","journal-title":"NPG Asia Mater."},{"issue":"1","key":"10.1016\/j.actbio.2021.06.015_bib0049","first-page":"23","article-title":"Cytotoxic impacts of linear and branched polyethylenimine nanostructures in a431 cells","volume":"1","author":"Kafil","year":"2011","journal-title":"Bioimpacts"},{"issue":"1","key":"10.1016\/j.actbio.2021.06.015_bib0050","doi-asserted-by":"crossref","first-page":"e12701","DOI":"10.1111\/cpr.12701","article-title":"Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFalpha-NLRP3 signalling axis","volume":"53","author":"Peng","year":"2020","journal-title":"Cell Prolif."},{"issue":"4","key":"10.1016\/j.actbio.2021.06.015_bib0052","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1159\/000487690","article-title":"Type I diabetic Akita mouse model is characterized by abnormal cardiac deformation during early stages of diabetic cardiomyopathy with speckle-tracking based strain imaging","volume":"45","author":"Zhou","year":"2018","journal-title":"Cell Physiol. Biochem."},{"issue":"2","key":"10.1016\/j.actbio.2021.06.015_bib0053","doi-asserted-by":"crossref","first-page":"462","DOI":"10.7150\/thno.37593","article-title":"Micro\/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications","volume":"10","author":"Duan","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2021.06.015_bib0054","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.biomaterials.2018.04.054","article-title":"Ultrasound assisted gene and photodynamic synergistic therapy with multifunctional FOXA1-siRNA loaded porphyrin microbubbles for enhancing therapeutic efficacy for breast cancer","volume":"173","author":"Zhao","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2021.06.015_bib0055","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.biomaterials.2016.05.028","article-title":"Enhanced brain-derived neurotrophic factor delivery by ultrasound and microbubbles promotes white matter repair after stroke","volume":"100","author":"Rodriguez-Frutos","year":"2016","journal-title":"Biomaterials"},{"issue":"51","key":"10.1016\/j.actbio.2021.06.015_bib0056","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201905375","article-title":"Reversible cavitation-induced junctional opening in an artificial endothelial layer","volume":"15","author":"Silvani","year":"2019","journal-title":"Small"},{"issue":"36","key":"10.1016\/j.actbio.2021.06.015_bib0057","doi-asserted-by":"crossref","first-page":"9983","DOI":"10.1073\/pnas.1606915113","article-title":"Biophysical insight into mechanisms of sonoporation","volume":"113","author":"Helfield","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"11","key":"10.1016\/j.actbio.2021.06.015_bib0058","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142725","article-title":"A novel dynamic neonatal blood-brain barrier on a chip","volume":"10","author":"Deosarkar","year":"2015","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.actbio.2021.06.015_bib0059","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4093\/dmj.2016.40.1.22","article-title":"Fibroblast growth factor 21 protects against atherosclerosis via fine-tuning the multiorgan crosstalk","volume":"40","author":"Jin","year":"2016","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.actbio.2021.06.015_bib0060","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fendo.2015.00133","article-title":"FGF21 and cardiac physiopathology","volume":"6","author":"Planavila","year":"2015","journal-title":"Front. Endocrinol"},{"issue":"3","key":"10.1016\/j.actbio.2021.06.015_bib0061","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cmet.2018.06.013","article-title":"A2A receptor activation attenuates hypertensive cardiac remodeling via promoting brown adipose tissue-derived FGF21","volume":"28","author":"Ruan","year":"2018","journal-title":"Cell Metab."},{"issue":"8","key":"10.1016\/j.actbio.2021.06.015_bib0062","doi-asserted-by":"crossref","first-page":"e3018","DOI":"10.1038\/cddis.2017.410","article-title":"Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the SIRT1\/LKB1\/AMPK pathway","volume":"8","author":"Wang","year":"2017","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.actbio.2021.06.015_bib0063","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/CS20150623","article-title":"Fenofibrate increases cardiac autophagy via FGF21\/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice","volume":"130","author":"Zhang","year":"2016","journal-title":"Clin. Sci"},{"issue":"7","key":"10.1016\/j.actbio.2021.06.015_bib0064","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1111\/jcmm.12530","article-title":"FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation","volume":"19","author":"Yan","year":"2015","journal-title":"J. Cell Mol. Med."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706121003895?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706121003895?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:41:37Z","timestamp":1761673297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706121003895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":63,"alternative-id":["S1742706121003895"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2021.06.015","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultrasound-assisted C3F8-filled PLGA nanobubbles for enhanced FGF21 delivery and improved prophylactic treatment of diabetic cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2021.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}