{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:13:56Z","timestamp":1788473636171,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T00:00:00Z","timestamp":1660435200000},"content-version":"am","delay-in-days":347,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-15-1-0107"],"award-info":[{"award-number":["W81XWH-15-1-0107"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010941","name":"University of Vermont","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.actbio.2021.06.048","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T14:42:42Z","timestamp":1625668962000},"page":"222-235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Development of alginate and gelatin-based pleural and tracheal sealants"],"prefix":"10.1016","volume":"131","author":[{"given":"Nathan","family":"Gasek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heon E.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Uriarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska E.","family":"Uhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Pouliot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Riveron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tovah","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Louie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishna","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benefsha","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Dearborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Garner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Finck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2021.06.048_bib0001","unstructured":"2008 Medicare De-Identified Database. https:\/\/www.cms.gov\/Research-Statistics-Data-and-Systems\/Statistics-Trends-and-Reports\/BSAPUFS\/index.html?redirect=\/BSAPUFS\/03_Inpatient_Claims.asp."},{"key":"10.1016\/j.actbio.2021.06.048_bib0002","unstructured":"http:\/\/www.health.mil\/~\/media\/MHS\/Presentation%20Files\/Eastridge_DHB%20Death%20on%20the%20Battlefield%20Final.ashx."},{"issue":"4","key":"10.1016\/j.actbio.2021.06.048_bib0003","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1177\/0194599817725713","article-title":"The Joint Facial and Invasive Neck Trauma (J-FAINT) project, Iraq and Afghanistan: 2011-2016","volume":"157","author":"Lanigan","year":"2017","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.actbio.2021.06.048_bib0004","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/S0003-4975(01)02468-7","article-title":"Randomized controlled trial of a synthetic sealant for preventing alveolar air leaks after lobectomy","volume":"71","author":"Porte","year":"2001","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.actbio.2021.06.048_bib0005","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/S0003-4975(01)02537-1","article-title":"Trial of a novel synthetic sealant in preventing air leaks after lung resection","volume":"71","author":"Wain","year":"2001","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.actbio.2021.06.048_bib0006","unstructured":"Health FaDACfDaR. Summary of Safety and Effectiveness Data (for FocalSeal-L Synthetic Absorbable Sealant). 2000."},{"key":"10.1016\/j.actbio.2021.06.048_bib0007","first-page":"52010","article-title":"Initial experience with a synthetic sealant PleuraSealTM after pulmonary resections: a prospective study with retrospective case matched controls","volume":"5","author":"Dango","year":"2021","journal-title":"J. Cardiothorac. Surg."},{"key":"10.1016\/j.actbio.2021.06.048_bib0008","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/S0003-4975(02)04994-9","article-title":"Fibrin glue in pulmonary resection: a prospective, randomized, blinded study","volume":"75","author":"Fabian","year":"2003","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.actbio.2021.06.048_bib0009","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.athoracsur.2003.10.049","article-title":"3\u00a0M Surgical Sealant Study Group Prospective randomized study evaluating a biodegradable polymeric sealant for sealing intraoperative air leaks that occur during pulmonary resection","volume":"77","author":"Allen","year":"2004","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.actbio.2021.06.048_bib0010","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/j.athoracsur.2007.01.042","article-title":"Management of iatrogenic tracheobronchial injuries: a retrospective analysis of 29 cases","volume":"83","author":"Schneider","year":"2007","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.actbio.2021.06.048_bib0011","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0003-4975(02)04109-7","article-title":"Development of tracheal surgery: a historical review. Part 2.: treatment of tracheal diseases","volume":"75","author":"Grillo","year":"2003","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.actbio.2021.06.048_bib0012","first-page":"29","article-title":"Histological benefits of sealants in tracheal lesions in wistar rats","author":"Cerezal-Garrido","year":"2016","journal-title":"Surg. Technol. Int."},{"key":"10.1016\/j.actbio.2021.06.048_bib0013","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1749-8090-8-90","article-title":"Reduction of intraoperative air leaks with Progel in pulmonary resection: a comprehensive review","volume":"8","author":"Fuller","year":"2013","journal-title":"J. Cardiothorac. Surg."},{"key":"10.1016\/j.actbio.2021.06.048_bib0014","unstructured":"Progel Pleural Air Leak Sealant Value Analysis Committee Product Information Kit. Bard Davol, Inc. http:\/\/www.davol.com\/default\/assets\/File\/Progel%20VAC%20Brochure.pdf."},{"key":"10.1016\/j.actbio.2021.06.048_bib0015","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1089\/ten.tea.2016.0266","article-title":"Direct bonding of chitosan biomaterials to tissues using transglutaminase for surgical repair or device implantation","volume":"23","author":"Fernandez","year":"2017","journal-title":"Tissue Eng. Part A"},{"issue":"410","key":"10.1016\/j.actbio.2021.06.048_bib0016","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aai7466","article-title":"Engineering a highly elastic human protein-based sealant for surgical applications","volume":"9","author":"Annabi","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"9\u201310","key":"10.1016\/j.actbio.2021.06.048_bib0017","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1089\/ten.tea.2017.0299","article-title":"Functional mechanics of a pectin-based pleural sealant after lung injury","volume":"24","author":"Servais","year":"2018","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.actbio.2021.06.048_bib0018","first-page":"1","article-title":"Design and synthesis of an artificial pulmonary pleura for high throughput studies in acellular human lungs","author":"Wagner","year":"2014","journal-title":"Cell. Mol. Bioeng."},{"key":"10.1016\/j.actbio.2021.06.048_bib0019","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/978-3-319-16298-0_31","article-title":"Chemically modified natural polysaccharides to form gels","author":"Garner","year":"2015","journal-title":"Polysaccharides"},{"issue":"1","key":"10.1016\/j.actbio.2021.06.048_bib0020","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1039\/c0py00215a","article-title":"Oxidant-induced dopamine polymerization for multifunctional coatings","volume":"2010","author":"Wei","year":"2010","journal-title":"Polym. Chem."},{"issue":"1","key":"10.1016\/j.actbio.2021.06.048_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190880","article-title":"Comparison of eosin and fluorescein conjugates for the photoinitiation of cell-compatible polymer coatings","volume":"13","author":"Lilly","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.actbio.2021.06.048_bib0022","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1063\/1.5144896","article-title":"Effect of temperature on gelation and cross-linking of gelatin methacryloyl for biomedical applications","volume":"32","author":"Park","year":"2020","journal-title":"Phys. Fluids"},{"key":"10.1016\/j.actbio.2021.06.048_bib0023","unstructured":"ASTM F2258-05(2015) Standard Test Method for Strength Properties of Tissue Adhesives in Tension. Book of Standards Volume: 13.01."},{"key":"10.1016\/j.actbio.2021.06.048_bib0024","unstructured":"ASTM D638-14 Standard Test Method for Tensile Properties of Plastics. Book of Standards Volume: 08.01 2021"},{"key":"10.1016\/j.actbio.2021.06.048_bib0025","unstructured":"ASTM F2255-05(2015) Standard Test Method for Strength Properties of Tissue Adhesives in Lap-Shear by Tension Loading. Book of Standards Volume: 13.01."},{"key":"10.1016\/j.actbio.2021.06.048_bib0026","unstructured":"ASTM F2256-05 (2015) Standard Test Method for Strength Properties of Tissue Adhesives in T-Peel by Tension Loading. Book of Standards Volume: 13.01."},{"key":"10.1016\/j.actbio.2021.06.048_bib0027","unstructured":"ASTM-F2392\u201304 Standard Test Method for Burst Strength of Surgical Sealants Annu. Book ASTM Stand. 2015"},{"issue":"8","key":"10.1016\/j.actbio.2021.06.048_bib0028","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/jcb.25095","article-title":"Differential susceptibility of human pleural and peritoneal mesothelial cells to asbestos exposure","volume":"116","author":"Dragon","year":"2015","journal-title":"J. Cell. Biochem."},{"issue":"10","key":"10.1016\/j.actbio.2021.06.048_bib0029","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nbt.3354","article-title":"Engineering pulmonary vasculature in decellularized rat and human lungs","volume":"33","author":"Ren","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.actbio.2021.06.048_bib0030","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.actbio.2016.08.017","article-title":"Enhanced bioadhesivity of dopamine-functionalized polysaccharidic membranes for general surgery applications","volume":"44","author":"Scognamiglio","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2021.06.048_bib0031","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000334281","article-title":"Endoscopic closure of a tracheal access site using bioglue after transtracheal thoracoscopy in a non-survival canine surgery model","volume":"48","author":"Chen","year":"2012","journal-title":"Eur. Surg. Res."},{"key":"10.1016\/j.actbio.2021.06.048_bib0032","doi-asserted-by":"crossref","first-page":"N7","DOI":"10.1177\/1553350611403769","article-title":"Secure closure of the tracheal incision after natural orifice transluminal endoscopic surgery with a surgical sealant (CoSeal)","volume":"18","author":"Liu","year":"2011","journal-title":"Surg. Innov."},{"issue":"3","key":"10.1016\/j.actbio.2021.06.048_bib0033","article-title":"Major tracheobronchial injuries: management of two rare cases","volume":"73","author":"Huei","year":"2018","journal-title":"Med. J. Malaysia"},{"key":"10.1016\/j.actbio.2021.06.048_bib0034","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.progpolymsci.2011.06.003","article-title":"Alginate: properties and biomedical applications","volume":"37","author":"Lee","year":"2012","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.actbio.2021.06.048_bib0035","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1016\/j.biomaterials.2012.01.007","article-title":"Alginate derivatization: a review of chemistry, properties and applications","volume":"33","author":"Pawar","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2021.06.048_bib0036","doi-asserted-by":"crossref","first-page":"93","DOI":"10.5301\/IJAO.2011.6397","article-title":"Preparation and evaluation of hydrogel-composites from methacrylated hyaluronic acid, alginate, and gelatin for tissue engineering","volume":"34","author":"Moller","year":"2011","journal-title":"Int. J. Artif. Organs."},{"key":"10.1016\/j.actbio.2021.06.048_bib0037","first-page":"945","article-title":"Degradation and partially oxidized alginate and its potential application for tissue engineering","volume":"17","author":"Bouhadir","year":"2001","journal-title":"BiotechProgress"},{"issue":"5","key":"10.1016\/j.actbio.2021.06.048_bib0038","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.biomaterials.2011.10.067","article-title":"Enzyme-catalyzed crosslinkable hydrogels: emerging strategies for tissue engineering","volume":"33","author":"Teixeira","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2021.06.048_bib0039","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jmbbm.2016.02.003","article-title":"Mechanical properties and failure analysis of visible light crosslinked alginate-based tissue sealants","volume":"59","author":"Charron","year":"2016","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2021.06.048_bib0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jmps.2013.08.015","article-title":"Molecular mechanics of mussel adhesion proteins","volume":"62","author":"Qin","year":"2014","journal-title":"J Mech. Phys. Solid."},{"key":"10.1016\/j.actbio.2021.06.048_bib0041","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.biomaterials.2016.10.005","article-title":"3D printing of biomaterials with mussel-inspired nanostructures for tumor therapy and tissue regeneration","volume":"111","author":"Ma","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2021.06.048_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.jiec.2017.09.014","article-title":"Preparation and characterization of dual-crosslinked gelatin hydrogel via Dopa-Fe3+ complexation and fenton reaction","volume":"58","author":"Kim","year":"2018","journal-title":"J Industrial and Engineering Chemistry"},{"key":"10.1016\/j.actbio.2021.06.048_bib0043","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.biomaterials.2017.06.004","article-title":"A highly adhesive and naturally derived sealant","volume":"140","author":"Assmann","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2021.06.048_bib0045","doi-asserted-by":"crossref","first-page":"8675","DOI":"10.1002\/adma.201602606","article-title":"Supramolecular metallo-bioadhesive for minimally invasive use","volume":"28","author":"Hong","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2021.06.048_bib0046","article-title":"Multipurpose intraperitoneal adhesive patches","volume":"29","author":"Ryu","year":"2019","journal-title":"Adv. Funct. Mater."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706121004311?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706121004311?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:22:51Z","timestamp":1778624571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706121004311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":45,"alternative-id":["S1742706121004311"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2021.06.048","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of alginate and gelatin-based pleural and tracheal sealants","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2021.06.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}