{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:59:23Z","timestamp":1780469963657,"version":"3.54.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900995"],"award-info":[{"award-number":["31900995"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1904206"],"award-info":[{"award-number":["U1904206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2020CDJQY-A041"],"award-info":[{"award-number":["2020CDJQY-A041"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.actbio.2021.07.055","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T12:06:16Z","timestamp":1627387576000},"page":"633-648","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["In Situ biomimetic Nanoformulation for metastatic cancer immunotherapy"],"prefix":"10.1016","volume":"134","author":[{"given":"Xuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjie","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunfang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xichun","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haigang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2021.07.055_bib0001","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.coi.2016.01.002","article-title":"Cancer immunoprevention","volume":"39","author":"Finn","year":"2016","journal-title":"Curr. Opin. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2021.07.055_bib0002","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrc3180","article-title":"Treating metastatic cancer with nanotechnology","volume":"12","author":"Schroeder","year":"2011","journal-title":"Nature Rev. Cancer"},{"key":"10.1016\/j.actbio.2021.07.055_bib0003","doi-asserted-by":"crossref","DOI":"10.1038\/s41568-020-00320-2","article-title":"The metabolism of cancer cells during metastasis","author":"Bergers","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"6","key":"10.1016\/j.actbio.2021.07.055_bib0004","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nrd2372","article-title":"Strategies for the discovery and development of therapies for metastatic breast cancer, Nature reviews","volume":"11","author":"Eckhardt","year":"2012","journal-title":"Drug Discov."},{"key":"10.1016\/j.actbio.2021.07.055_bib0005","doi-asserted-by":"crossref","DOI":"10.1038\/s41551-020-00644-2","article-title":"Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in lung metastases","author":"Zhao","year":"2020","journal-title":"Nature Biomed. Eng."},{"issue":"6024","key":"10.1016\/j.actbio.2021.07.055_bib0006","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1126\/science.1203486","article-title":"Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion","volume":"331","author":"Schreiber","year":"2011","journal-title":"Science (New York, N.Y.)"},{"issue":"9","key":"10.1016\/j.actbio.2021.07.055_bib0007","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nri.2017.49","article-title":"Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy","volume":"17","author":"Nagarsheth","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.actbio.2021.07.055_bib0008","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41591-018-0014-x","article-title":"Understanding the tumor immune microenvironment (TIME) for effective therapy","volume":"24","author":"Binnewies","year":"2018","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.actbio.2021.07.055_bib0009","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"7655","key":"10.1016\/j.actbio.2021.07.055_bib0010","doi-asserted-by":"crossref","first-page":"495-+","DOI":"10.1038\/nature22396","article-title":"PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity","volume":"545","author":"Gordon","year":"2017","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.actbio.2021.07.055_bib0011","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1182\/blood-2010-11-321752","article-title":"Myeloid-derived suppressor cells express the death receptor Fas and apoptose in response to T cell-expressed FasL","volume":"117","author":"Sinha","year":"2011","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.actbio.2021.07.055_bib0012","article-title":"Signatures of T-cell dysfunction and exclusion predict cancer immunotherapy response","volume":"7","author":"Jiang","year":"2019","journal-title":"Cancer Immunol. Res."},{"issue":"18","key":"10.1016\/j.actbio.2021.07.055_bib0013","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1056\/NEJMra1514296","article-title":"Molecular and biochemical aspects of the PD-1 checkpoint pathway","volume":"375","author":"Boussiotis","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"47","key":"10.1016\/j.actbio.2021.07.055_bib0014","doi-asserted-by":"crossref","first-page":"23714","DOI":"10.1073\/pnas.1906346116","article-title":"Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma","volume":"116","author":"Zhang","year":"2019","journal-title":"PNAS"},{"key":"10.1016\/j.actbio.2021.07.055_bib0015","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.freeradbiomed.2019.12.018","article-title":"Scavenging reactive oxygen species selectively inhibits M2 macrophage polarization and their pro-tumorigenic function in part, via Stat3 suppression","volume":"147","author":"Griess","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.actbio.2021.07.055_bib0016","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jconrel.2016.11.013","article-title":"Tumor-targeted delivery of sunitinib base enhances vaccine therapy for advanced melanoma by remodeling the tumor microenvironment","volume":"245","author":"Huo","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2021.07.055_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2018.00315","article-title":"Immuno-oncology: emerging targets and combination therapies","volume":"8","author":"Marshall","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.actbio.2021.07.055_bib0018","doi-asserted-by":"crossref","first-page":"952","DOI":"10.3389\/fphar.2017.00952","article-title":"Modulating the tumor microenvironment to enhance tumor nanomedicine delivery","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.actbio.2021.07.055_bib0019","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1172\/JCI86437","article-title":"BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models","volume":"126","author":"Kagoya","year":"2016","journal-title":"J. Clin. Invest."},{"issue":"22","key":"10.1016\/j.actbio.2021.07.055_bib0020","article-title":"BET Bromodomain inhibition selectively targets the Epstein-barr virus oncogene LMP1 while promoting Virus-Specific","volume":"128","author":"Smith","year":"2016","journal-title":"Adaptive Anti-Tumor Activity, Blood"},{"issue":"50","key":"10.1016\/j.actbio.2021.07.055_bib0021","doi-asserted-by":"crossref","first-page":"46626","DOI":"10.1021\/acsami.9b18730","article-title":"JQ1-Loaded Polydopamine Nanoplatform Inhibits c-MYC\/Programmed Cell Death Ligand 1 to Enhance Photothermal Therapy for Triple-Negative Breast Cancer","volume":"11","author":"Tian","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5","key":"10.1016\/j.actbio.2021.07.055_bib0022","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1055\/s-0030-1265897","article-title":"The role of immunity and inflammation in lung senescence and susceptibility to infection in the elderly","volume":"31","author":"Meyer","year":"2010","journal-title":"Seminar. Respir. Crit. Care Med."},{"key":"10.1016\/j.actbio.2021.07.055_bib0023","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.cis.2015.10.002","article-title":"Effects of nanoparticles on the mechanical functioning of the lung","volume":"225","author":"Arick","year":"2015","journal-title":"Adv. Colloid Interface Sci."},{"issue":"36","key":"10.1016\/j.actbio.2021.07.055_bib0024","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc4373","article-title":"GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer","volume":"6","author":"Zhou","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.actbio.2021.07.055_bib0025","series-title":"Metformin Mediated PD-L1 downregulation in combination with photodynamic-immunotherapy for treatment of breast cancer","author":"Hu","year":"2021"},{"key":"10.1016\/j.actbio.2021.07.055_bib0026","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.addr.2012.09.006","article-title":"Nanoparticles in cancer therapy and diagnosis","volume":"64","author":"Brigger","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"32","key":"10.1016\/j.actbio.2021.07.055_bib0027","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201900262","article-title":"Nanoparticle-based nanomedicines to promote cancer immunotherapy: recent advances and future directions","volume":"15","author":"Liu","year":"2019","journal-title":"Small"},{"issue":"5","key":"10.1016\/j.actbio.2021.07.055_bib0028","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s40005-018-0399-z","article-title":"Nano delivery systems and cancer immunotherapy","volume":"48","author":"Le","year":"2018","journal-title":"J. Pharmaceutic. Investigat."},{"issue":"5","key":"10.1016\/j.actbio.2021.07.055_bib0029","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.201700347","article-title":"Immunostimulation and Immunosuppression: nanotechnology on the Brink","volume":"2","author":"Fontana","year":"2018","journal-title":"Small Methods"},{"issue":"10","key":"10.1016\/j.actbio.2021.07.055_bib0030","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1586\/erv.10.115","article-title":"Virus-like particles in vaccine development","volume":"9","author":"Rold\u00e3o","year":"2010","journal-title":"Expert Rev. Vaccines"},{"issue":"3","key":"10.1016\/j.actbio.2021.07.055_bib0031","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1021\/acs.nanolett.8b04722","article-title":"Bioengineered Nanocage from HBc protein for combination cancer immunotherapy","volume":"19","author":"Shan","year":"2019","journal-title":"Nano Lett."},{"key":"10.1016\/j.actbio.2021.07.055_bib0032","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.01412","article-title":"Arginine-Based Poly(I:C)-Loaded Nanocomplexes for the Polarization of Macrophages Toward M1-Antitumoral Effectors","volume":"11","author":"Dacoba","year":"2020","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.actbio.2021.07.055_bib0033","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.nano.2017.12.002","article-title":"Modularized peptides modified HBc virus-like particles for encapsulation and tumor-targeted delivery of doxorubicin","volume":"14","author":"Shan","year":"2018","journal-title":"Nanomed.-Nanotechnol. Biol. Med."},{"issue":"3","key":"10.1016\/j.actbio.2021.07.055_bib0034","doi-asserted-by":"crossref","first-page":"295-+","DOI":"10.1038\/nnano.2015.292","article-title":"In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer","volume":"11","author":"Lizotte","year":"2016","journal-title":"Nat. Nanotechnol."},{"issue":"105","key":"10.1016\/j.actbio.2021.07.055_bib0035","doi-asserted-by":"crossref","DOI":"10.3791\/53424","article-title":"Metabolic characterization of polarized M1 and M2 bone marrow-derived macrophages using real-time extracellular flux analysis","author":"Van den Bossche","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.actbio.2021.07.055_bib0036","doi-asserted-by":"crossref","DOI":"10.1186\/s40425-019-0568-2","article-title":"Immunotherapeutic effects of intratumoral nanoplexed poly I:C","volume":"7","author":"Aznar","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.actbio.2021.07.055_bib0037","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-017-0459-2","article-title":"Vaccination with poly (IC: LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer","volume":"10","author":"Mehrotra","year":"2017","journal-title":"J. Hematol. Oncol."},{"issue":"3","key":"10.1016\/j.actbio.2021.07.055_bib0038","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41423-020-00613-4","article-title":"Tumor-associated myeloid cells: diversity and therapeutic targeting","volume":"18","author":"Mantovani","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2021.07.055_bib0039","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41467-017-00231-1","article-title":"CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors","volume":"8","author":"Nawaz","year":"2017","journal-title":"Nat. Commun."},{"issue":"6480","key":"10.1016\/j.actbio.2021.07.055_bib0040","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau0810","article-title":"Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity","volume":"367","author":"Wang","year":"2020","journal-title":"Science (New York, N.Y.)"},{"issue":"10","key":"10.1016\/j.actbio.2021.07.055_bib0041","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ni.2703","article-title":"Innate and adaptive immune cells in the tumor microenvironment","volume":"14","author":"Gajewski","year":"2013","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.actbio.2021.07.055_bib0042","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1158\/2326-6066.CIR-15-0313","article-title":"The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis","volume":"4","author":"Liang","year":"2016","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.actbio.2021.07.055_bib0043","doi-asserted-by":"crossref","DOI":"10.1186\/s13058-015-0621-0","article-title":"Human breast cancer cells educate macrophages toward the M2 activation status","volume":"17","author":"Sousa","year":"2015","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.actbio.2021.07.055_bib0044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijid.2013.09.023","article-title":"Monocyte-derived dendritic cells: targets as potent antigen-presenting cells for the design of vaccines against infectious diseases","volume":"19","author":"Qu","year":"2014","journal-title":"Int. J. Infect. Dis."},{"issue":"25","key":"10.1016\/j.actbio.2021.07.055_bib0045","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1016\/j.vaccine.2014.03.078","article-title":"How advances in immunology provide insight into improving vaccine efficacy","volume":"32","author":"Slifka","year":"2014","journal-title":"Vaccine"},{"issue":"10","key":"10.1016\/j.actbio.2021.07.055_bib0046","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1371\/journal.ppat.1006618","article-title":"The immune battlefield: the impact of inflammatory cytokines on CD8(+) T-cell immunity","volume":"13","author":"Condotta","year":"2017","journal-title":"PLoS Pathog"},{"issue":"10","key":"10.1016\/j.actbio.2021.07.055_bib0047","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0960-9822(95)00219-3","article-title":"Antigen-presenting cells: professionals and amateurs","volume":"5","author":"Sprent","year":"1995","journal-title":"Curr. Biol."},{"issue":"10","key":"10.1016\/j.actbio.2021.07.055_bib0048","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41577-018-0044-0","article-title":"CD4+ T cell help in cancer immunology and immunotherapy","volume":"18","author":"Borst","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.actbio.2021.07.055_bib0049","doi-asserted-by":"crossref","first-page":"8509","DOI":"10.1002\/jcp.27782","article-title":"CD8(+) cytotoxic T lymphocytes in cancer immunotherapy: a review","volume":"234","author":"Farhood","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.actbio.2021.07.055_bib0050","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1002\/jcb.27646","article-title":"Macrophage polarity in cancer: a review","volume":"120","author":"Najafi","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"202","key":"10.1016\/j.actbio.2021.07.055_bib0051","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1126\/scisignal.2002058","article-title":"Protein Kinase C eta is required for T cell activation and homeostatic proliferation","volume":"4","author":"Fu","year":"2011","journal-title":"Sci. Signal."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706121004931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706121004931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:47:37Z","timestamp":1761673657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706121004931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":51,"alternative-id":["S1742706121004931"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2021.07.055","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In Situ biomimetic Nanoformulation for metastatic cancer immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2021.07.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}